General Information of the Compound
Compound ID
CP0450689
Compound Name
(E)-1-(3,5-dibromo-2-hydroxyphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
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Structure
Formula
C15H10Br2O3
Molecular Weight
398.05
Canonical SMILES
Oc1ccccc1\C=C\C(=O)c1cc(Br)cc(Br)c1O
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InChI
InChI=1S/C15H10Br2O3/c16-10-7-11(15(20)12(17)8-10)14(19)6-5-9-3-1-2-4-13(9)18/h1-8,18,20H/b6-5+
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InChIKey
OQMLMTPYIWKAJJ-AATRIKPKSA-N
Physicochemical Property
logP
4.5189
Rotatable Bonds
3
Heavy Atom Count
20
Polar Areas
57.53
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145993790
ChEMBL ID
CHEMBL4294994
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 2870 nM
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