General Information of the Compound
Compound ID
CP0865414
Compound Name
2-(4-(4-nitrophenyl)thiazol-2-yl)isoindoline-1,3-dione
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Structure
Formula
C17H9N3O4S
Molecular Weight
351.343
Canonical SMILES
O=C1c2ccccc2C(=O)N1c1nc(-c2ccc([N+](=O)[O-])cc2)cs1
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InChI
InChI=1S/C17H9N3O4S/c21-15-12-3-1-2-4-13(12)16(22)19(15)17-18-14(9-25-17)10-5-7-11(8-6-10)20(23)24/h1-9H
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InChIKey
ZJCQGJBGMQDAQH-UHFFFAOYSA-N
Physicochemical Property
logP
3.5189
Rotatable Bonds
3
Heavy Atom Count
25
Polar Areas
93.41
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137652389
ChEMBL ID
CHEMBL4079171
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 13170 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000048 PC-3 Homo sapiens (Human)  1
1
IC50 = 41800 nM
   TI
   LI
   LO
   TS