Brief Information of the Compound and Protein
Compound Name
3-methoxy-5-[5-[4-(1-methylpiperidin-4-yl)oxyphenyl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]pyridine-2-carbonitrile
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PubChem ID
CID: 130229902
Canonical SMILES
COc1cc(cnc1C#N)N1C(=S)N(c2ccc(OC3CCN(C)CC3)cc2)C2(CCC2)C1=O
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Compound Formula C25H27N5O3S
Compound Structure
Protein Name
Androgen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 4
Uniprot ID
P10275
Gene Name
AR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 649 nM
   TI
   LI
   LO
   TS
CL000141 LNCaP Homo sapiens (Human)  2
1
IC50 = 214 nM
   TI
   LI
   LO
   TS
2
IC50 = 302 nM
   TI
   LI
   LO
   TS