General Information of the Compound
Compound ID
CP0523437
Compound Name
CHEMBL1916254
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Formula
C23H28ClN5O3
Molecular Weight
457.962
Canonical SMILES
CN(C)C(=O)Cn1ccc(n1)C(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(Cl)c2)C1(C)C
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InChI
InChI=1S/C23H28ClN5O3/c1-22(2)20(26-19(31)17-9-10-29(27-17)13-18(30)28(5)6)23(3,4)21(22)32-15-8-7-14(12-25)16(24)11-15/h7-11,20-21H,13H2,1-6H3,(H,26,31)/t20-,21-
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InChIKey
BQRYLDCZCTUJSL-MEMLXQNLSA-N
Physicochemical Property
logP
3.10838
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
100.25
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 134425782
ChEMBL ID
CHEMBL1916254
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 174 nM
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