General Information of the Compound
Compound ID
CP0564986
Compound Name
2-(5,6,7-trifluoro-1H-indol-3-yl)-5-(trifluoromethyl)quinoline
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Structure
Formula
C18H8F6N2
Molecular Weight
366.264
Canonical SMILES
Fc1cc2c(c[nH]c2c(F)c1F)-c1ccc2c(cccc2n1)C(F)(F)F
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InChI
InChI=1S/C18H8F6N2/c19-12-6-9-10(7-25-17(9)16(21)15(12)20)14-5-4-8-11(18(22,23)24)2-1-3-13(8)26-14/h1-7,25H
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InChIKey
HTBJZSAUGVSIOK-UHFFFAOYSA-N
Physicochemical Property
logP
5.8192
Rotatable Bonds
1
Heavy Atom Count
26
Polar Areas
28.68
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118449741
ChEMBL ID
CHEMBL4871449
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 550 nM
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