General Information of the Compound
Compound ID
CP0731051
Compound Name
6-(4-{4-[2-(1-Methyl-1H-pyrazol-5-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine
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Structure
Formula
C23H24F3N7O
Molecular Weight
471.487
Canonical SMILES
Cn1nccc1CCOc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1
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InChI
InChI=1S/C23H24F3N7O/c1-31-18(8-12-27-31)11-15-34-19-4-2-16(3-5-19)17-9-13-32(14-10-17)21-7-6-20-28-29-22(23(24,25)26)33(20)30-21/h2-8,12,17H,9-11,13-15H2,1H3
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InChIKey
ZMYKWWZQOCYJDE-UHFFFAOYSA-N
Physicochemical Property
logP
3.8821
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
73.37
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 42635876
SID: 81074927
ChEMBL ID
CHEMBL2346973
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 234.42 nM
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