General Information of the Compound
Compound ID
CP0517670
Compound Name
CHEMBL1916253
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Formula
C22H26ClN5O3
Molecular Weight
443.935
Canonical SMILES
CNC(=O)Cn1ccc(n1)C(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(Cl)c2)C1(C)C
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InChI
InChI=1S/C22H26ClN5O3/c1-21(2)19(26-18(30)16-8-9-28(27-16)12-17(29)25-5)22(3,4)20(21)31-14-7-6-13(11-24)15(23)10-14/h6-10,19-20H,12H2,1-5H3,(H,25,29)(H,26,30)/t19-,20-
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InChIKey
QZVUDGBPCSXUBE-MXVIHJGJSA-N
Physicochemical Property
logP
2.76618
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
109.04
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 134425781
ChEMBL ID
CHEMBL1916253
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 163 nM
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