| Compound ID |
Compound Name |
Compound Formula |
|
CP0222429
|
RESINIFERATOXIN
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|
C37H40O9
|
1
|
| 1 |
EC50 = 0.019 nM
|
|
|
|
CP0510419
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
Show/Hide
|
C38H40O9
|
1
|
| 1 |
EC50 = 0.15 nM
|
|
|
|
CP0407746
|
[(Z,7R)-18-[(4-hydroxy-3-methoxyphenyl)methylamino]-18-oxooctadec-9-en-7-yl] acetate
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|
C28H45NO5
|
1
|
| 1 |
EC50 = 0.3981 nM
|
|
|
|
CP0067816
|
(5Z,8Z,11Z,14Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]icosa-5,8,11,14-tetraenamide
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|
C28H41NO3
|
1
|
| 1 |
EC50 = 0.5012 nM
|
|
|
|
CP0262336
|
(9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-9-enamide
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|
C26H43NO3
|
1
|
| 1 |
EC50 = 0.5012 nM
|
|
|
|
CP0492029
|
(2E,6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-3,7,11-trimethyldodeca-2,6,10-trienamide
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|
C23H33NO3
|
1
|
| 1 |
EC50 = 0.5012 nM
|
|
|
|
CP0480022
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-acetyloxy-2-(4-hydroxy-3-methoxyphenyl)acetate
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|
C39H42O11
|
1
|
| 1 |
EC50 = 0.65 nM
|
|
|
|
CP0458864
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)propanoate
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|
C38H42O9
|
1
|
| 1 |
EC50 = 0.98 nM
|
|
|
|
CP0405506
|
(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-11-en-9-ynamide
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|
C26H39NO3
|
1
|
| 1 |
EC50 = 1.259 nM
|
|
|
|
CP0499510
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-[(1S,2R)-2-octylcyclopropyl]octanamide
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|
C27H45NO3
|
1
|
| 1 |
EC50 = 1.259 nM
|
|
|
|
CP0464475
|
(E)-3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
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|
C38H42O9
|
1
|
| 1 |
EC50 = 1.5 nM
|
|
|
|
CP0496769
|
(E)-N,N'-bis[(3-hydroxy-4-methoxyphenyl)methyl]icos-6-enediamide
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|
C36H54N2O6
|
1
|
| 1 |
EC50 = 1.585 nM
|
|
|
|
CP0544163
|
4-(5-chloropyridin-2-yl)-N-(1H-indazol-6-yl)piperazine-1-carboxamide
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|
C17H17ClN6O
|
1
|
| 1 |
EC50 = 1.62 nM
|
|
|
|
CP0493587
|
4-hydroxy-3-iodo-5-methoxy-benzoic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
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|
C36H39IO9
|
1
|
| 1 |
EC50 = 1.9 nM
|
|
|
|
CP0377552
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]undec-10-enamide
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|
C19H29NO3
|
1
|
| 1 |
EC50 = 1.995 nM
|
|
|
|
CP0539828
|
(E,7R,11R)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-3,7,11,15-tetramethylhexadec-2-enamide
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|
C28H47NO3
|
1
|
| 1 |
EC50 = 1.995 nM
|
|
|
|
CP0406743
|
(E)-3-(4-hydroxy-3-methoxyphenyl)-1-piperidin-1-ylprop-2-en-1-one
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|
C15H19NO3
|
1
|
| 1 |
EC50 = 1.995 nM
|
|
|
|
CP0425287
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]-2-methyl-2-(4,8,12-trimethyltridecyl)cyclopropane-1-carboxamide
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|
C29H49NO3
|
1
|
| 1 |
EC50 = 2.512 nM
|
|
|
|
CP0049976
|
(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
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|
C18H27NO3
|
8
|
| 1 |
EC50 = 2.512 nM
|
|
|
| 2 |
EC50 = 3.9 nM
|
|
|
| 3 |
EC50 = 5.3 nM
|
|
|
| 4 |
EC50 = 19.95 nM
|
|
|
| 5 |
EC50 = 20 nM
|
|
|
| 6 |
EC50 = 29 nM
|
|
|
| 7 |
EC50 = 40 nM
|
|
|
| 8 |
IC50 = 8 nM
|
|
|
|
CP0383639
|
(E)-3-(4-hydroxy-3-methoxyphenyl)-1-morpholin-4-ylprop-2-en-1-one
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|
C14H17NO4
|
1
|
| 1 |
EC50 = 2.512 nM
|
|
|
|
CP0383640
|
(E)-3-(4-hydroxy-3-methoxyphenyl)-1-thiomorpholin-4-ylprop-2-en-1-one
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|
C14H17NO3S
|
1
|
| 1 |
EC50 = 2.512 nM
|
|
|
|
CP0406231
|
(Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]henicos-12-enamide
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|
C29H49NO3
|
1
|
| 1 |
EC50 = 3.162 nM
|
|
|
|
CP0457110
|
(Z,12R)-12-hydroxy-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-9-enamide
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|
C26H43NO4
|
1
|
| 1 |
EC50 = 3.162 nM
|
|
|
|
CP0457239
|
9-cyclopropyl-N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
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|
C20H31NO3
|
1
|
| 1 |
EC50 = 3.162 nM
|
|
|
|
CP0421035
|
(2E,4E,6E,8E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide
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|
C28H37NO3
|
1
|
| 1 |
EC50 = 3.981 nM
|
|
|
|
CP0567013
|
3-(4-hydroxy-3-methoxy-phenyl)-propionic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
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|
C38H44O9
|
1
|
| 1 |
EC50 = 4.6 nM
|
|
|
|
CP0553238
|
[(1R,2R,6R,10S,11R,15R,17R)-6-hydroxy-4,17-dimethyl-5-oxo-1-phenylmethoxy-15-prop-1-en-2-yl-12,14-dioxatetracyclo[8.7.0.02,6.011,15]heptadeca-3,8-dien-8-yl]methyl 2-phenylacetate
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|
C36H40O7
|
1
|
| 1 |
EC50 = 4.7 nM
|
|
|
|
CP0503349
|
(12R)-12-hydroxy-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadecanamide
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|
C26H45NO4
|
1
|
| 1 |
EC50 = 5.012 nM
|
|
|
|
CP0511232
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-[2-[(2R)-2-hydroxyoctyl]cyclopropyl]octanamide
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|
C27H45NO4
|
1
|
| 1 |
EC50 = 5.012 nM
|
|
|
|
CP0453307
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]-12-oxooctadecanamide
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|
C26H43NO4
|
1
|
| 1 |
EC50 = 6.31 nM
|
|
|
|
CP0071322
|
PIPERLONGUMININE
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|
C16H19NO3
|
1
|
| 1 |
EC50 = 6.31 nM
|
|
|
|
CP0468567
|
(E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-methylpropyl)prop-2-enamide
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|
C14H19NO3
|
1
|
| 1 |
EC50 = 6.31 nM
|
|
|
|
CP0427194
|
3-(4-hydroxy-2-iodo-5-methoxy-phenyl)-propionic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
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|
C38H43IO9
|
1
|
| 1 |
EC50 = 7.9 nM
|
|
|
|
CP0503725
|
3-(4-hydroxy-3-iodo-5-methoxy-phenyl)-propionic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
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|
C38H43IO9
|
1
|
| 1 |
EC50 = 8.6 nM
|
|
|
|
CP0484223
|
4-hydroxy-3-methoxy-benzoic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
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|
C36H40O9
|
1
|
| 1 |
EC50 = 9.4 nM
|
|
|
|
CP0048192
|
2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol
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|
C24H40O3
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0434896
|
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(4-chlorophenyl)penta-2,4-dienamide
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|
C18H14ClNO3
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0499505
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-9-ynamide
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|
C26H41NO3
|
1
|
| 1 |
EC50 = 12.59 nM
|
|
|
|
CP0411145
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-methoxyphenyl) carbonate
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|
C36H38O10
|
1
|
| 1 |
EC50 = 13.7 nM
|
|
|
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CP0444970
|
4-hydroxy-2-iodo-5-methoxy-benzoic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
Show/Hide
|
C36H39IO9
|
1
|
| 1 |
EC50 = 15.2 nM
|
|
|
|
CP0542731
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)-2-methoxyacetate
Show/Hide
|
C38H42O10
|
1
|
| 1 |
EC50 = 17.4 nM
|
|
|
|
CP0920451
|
(1S,2S)-N-Oleoylcyclopropanolamide
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|
C19H37NO2
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0542730
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetate
Show/Hide
|
C37H40O10
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0443288
|
N-(4-tert-butylphenyl)-6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
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|
C22H25N3O2
|
2
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
IC50 = 1 nM
|
|
|
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CP0404799
|
N,N'-bis[(3-hydroxy-4-methoxyphenyl)methyl]decanediamide
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|
C26H36N2O6
|
1
|
| 1 |
EC50 = 19.95 nM
|
|
|
|
CP0452320
|
[2-methoxy-4-[[[(Z)-octadec-9-enoyl]amino]methyl]phenyl]boronic acid
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|
C26H44BNO4
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
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CP0406689
|
[4-[[[(Z)-octadec-9-enoyl]amino]methyl]phenyl]boronic acid
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|
C25H42BNO3
|
2
|
| 1 |
EC50 = 22 nM
|
|
|
| 2 |
IC50 = 47 nM
|
|
|
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CP0525745
|
[(1R,2R,6R,10S,11R,15R,17R)-6-hydroxy-4,17-dimethyl-5-oxo-1-phenylmethoxy-15-prop-1-en-2-yl-12,14-dioxatetracyclo[8.7.0.02,6.011,15]heptadeca-3,8-dien-8-yl]methyl benzoate
Show/Hide
|
C35H38O7
|
1
|
| 1 |
EC50 = 25.5 nM
|
|
|
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CP0569483
|
N-(1H-indazol-6-yl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
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|
C18H17F3N6O
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0544167
|
4-(3-bromopyridin-2-yl)-N-(1H-indazol-6-yl)piperazine-1-carboxamide
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|
C17H17BrN6O
|
1
|
| 1 |
EC50 = 34 nM
|
|
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CP0383036
|
(2E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-3,7-dimethylocta-2,6-dienamide
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|
C18H25NO3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
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CP0493725
|
cyclopropanolamide, rac-9c
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|
C19H37NO2
|
1
|
| 1 |
EC50 = 40 nM
|
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CP0544165
|
4-(2,3-dichlorophenyl)-N-(1H-indazol-6-yl)piperazine-1-carboxamide
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|
C18H17Cl2N5O
|
1
|
| 1 |
EC50 = 40 nM
|
|
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CP0568507
|
4-(5-chloropyridin-2-yl)-N-(1H-indazol-5-yl)piperazine-1-carboxamide
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|
C17H17ClN6O
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
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CP0575010
|
N-(1H-indazol-6-yl)-4-(2-methylphenyl)piperazine-1-carboxamide
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|
C19H21N5O
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
|
CP0298207
|
cyclopropanolamide, 11a
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|
C23H37NO2
|
1
|
| 1 |
EC50 = 47 nM
|
|
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CP0390488
|
[2-methoxy-4-[(8-phenyloctanoylamino)methyl]phenyl]boronic acid
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|
C22H30BNO4
|
2
|
| 1 |
EC50 = 51 nM
|
|
|
| 2 |
IC50 = 34 nM
|
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CP0503726
|
3-phenyl-propionic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
Show/Hide
|
C37H42O7
|
1
|
| 1 |
EC50 = 51.5 nM
|
|
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CP0543542
|
4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(1H-indazol-6-yl)piperazine-1-carboxamide
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|
C18H16ClF3N6O
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
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CP0445105
|
(E)-3-phenyl-acrylic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
Show/Hide
|
C37H40O7
|
1
|
| 1 |
EC50 = 69.5 nM
|
|
|
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CP0457397
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]-11-[(1R,2S)-2-octylcyclopropyl]undecanamide
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|
C30H51NO3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
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CP0544162
|
N-(1H-indazol-5-yl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
Show/Hide
|
C18H17F3N6O
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
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CP0562602
|
4-(3-bromopyridin-2-yl)-N-(1H-indazol-5-yl)piperazine-1-carboxamide
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|
C17H17BrN6O
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
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CP0544161
|
4-(3-chloropyridin-2-yl)-N-(1H-indazol-6-yl)piperazine-1-carboxamide
Show/Hide
|
C17H17ClN6O
|
1
|
| 1 |
EC50 = 89 nM
|
|
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CP0853766
|
(E)-1-(4-Hydroxyphenyl)-11-phenylundec-4-en-3-one
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|
C23H28O2
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
IC50 = 1200 nM
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CP0438027
|
5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-11-phenylundecan-3-one
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|
C24H32O4
|
2
|
| 1 |
EC50 = 110 nM
|
|
|
| 2 |
IC50 = 110 nM
|
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|
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CP0420376
|
N-cyclopropyl-8-[3-methoxy-5-(2-methyloctan-2-yl)phenoxy]octanamide
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|
C27H45NO3
|
2
|
| 1 |
EC50 = 120 nM
|
|
|
| 2 |
IC50 = 800 nM
|
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|
CP0378815
|
(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-N-[(4-hydroxy-3-methoxyphenyl)methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxamide
Show/Hide
|
C38H57NO4
|
1
|
| 1 |
EC50 = 125.89 nM
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CP0544164
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4-(2-chlorophenyl)-N-(1H-indazol-6-yl)piperazine-1-carboxamide
Show/Hide
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C18H18ClN5O
|
1
|
| 1 |
EC50 = 130 nM
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CP0543543
|
4-(2,3-dichlorophenyl)-N-(1H-indazol-5-yl)-1,4-diazepane-1-carboxamide
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C19H19Cl2N5O
|
1
|
| 1 |
EC50 = 140 nM
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CP0562601
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N-(1H-indazol-6-yl)-4-(3-methylpyridin-2-yl)piperazine-1-carboxamide
Show/Hide
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C18H20N6O
|
1
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| 1 |
EC50 = 149 nM
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CP0385238
|
6-hydroxy-N-(4-phenylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
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C24H21N3O2
|
2
|
| 1 |
EC50 = 170 nM
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| 2 |
IC50 = 140 nM
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CP0388760
|
2-(4-hydroxyphenyl)-N-(7-phenylheptyl)acetamide
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C21H27NO2
|
2
|
| 1 |
EC50 = 170 nM
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| 2 |
IC50 = 260 nM
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CP0919485
|
(1R,2S)-N-Oleoylcyclopropanolamide
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C19H37NO2
|
1
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| 1 |
EC50 = 180 nM
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CP0459889
|
2-[(2S,4aS,8S,8aS)-8-hydroxy-4a,8-dimethyl-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]-N-[(4-hydroxy-3-methoxyphenyl)methyl]prop-2-enamide
Show/Hide
|
C23H33NO4
|
1
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| 1 |
EC50 = 199.53 nM
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CP0509918
|
(1S,3R)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxamide
Show/Hide
|
C18H25NO3
|
1
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| 1 |
EC50 = 199.53 nM
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CP0037555
|
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
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C22H37NO2
|
2
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| 1 |
EC50 = 200 nM
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| 2 |
EC50 = 490 nM
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CP0386413
|
1-(4-Hydroxy-3-methoxybenzyl)-3-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]urea
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|
C19H30N2O3
|
1
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| 1 |
EC50 = 230 nM
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CP0499684
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(5Z,8Z,11Z,14Z)-N-(2-hydroxyethoxy)icosa-5,8,11,14-tetraenamide
Show/Hide
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C22H37NO3
|
1
|
| 1 |
EC50 = 250 nM
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CP0468611
|
4-tert-Butyl-N-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]benzamide
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C21H33NO
|
1
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| 1 |
EC50 = 250 nM
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CP0380514
|
N-cyclohexyl-N-methyl-5-[(4-phenylphenyl)methyl]tetrazole-2-carboxamide
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C22H25N5O
|
2
|
| 1 |
EC50 = 250 nM
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| 2 |
IC50 = 9200 nM
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CP0376378
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(5Z,8Z,11Z,14Z)-N-hydroxy-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
Show/Hide
|
C22H37NO3
|
1
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| 1 |
EC50 = 260 nM
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CP0443292
|
6-hydroxy-N-[4-(trifluoromethyl)phenyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
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C19H16F3N3O2
|
2
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| 1 |
EC50 = 260 nM
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| 2 |
IC50 = 330 nM
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CP0373098
|
4-butyl-N-pyridin-3-ylbenzamide
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C16H18N2O
|
2
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| 1 |
EC50 = 300 nM
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| 2 |
Ki = 626 nM
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CP0468328
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[4-[2-oxo-2-[(4-phenylphenyl)methylamino]ethyl]phenyl]boronic acid
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C21H20BNO3
|
2
|
| 1 |
EC50 = 310 nM
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| 2 |
IC50 = 5530 nM
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CP0376404
|
(Z)-N-(2-hydroxyethoxy)octadec-9-enamide
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|
C20H39NO3
|
1
|
| 1 |
EC50 = 320 nM
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CP0257148
|
6-Shogaol
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C17H24O3
|
2
|
| 1 |
EC50 = 320 nM
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| 2 |
IC50 = 290 nM
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CP0385985
|
[4-[(3-phenylpropanoylamino)methyl]phenyl]boronic acid
Show/Hide
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C16H18BNO3
|
2
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| 1 |
EC50 = 320 nM
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| 2 |
IC50 = 230 nM
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CP0570769
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N-(1H-indazol-6-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
Show/Hide
|
C18H17F3N6O
|
1
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| 1 |
EC50 = 321 nM
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CP0429229
|
[4-[2-oxo-2-(7-phenylheptylamino)ethyl]phenyl]boronic acid
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C21H28BNO3
|
2
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| 1 |
EC50 = 370 nM
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| 2 |
IC50 = 370 nM
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CP0496099
|
N-[2-[[3-(trifluoromethyl)phenyl]methylsulfanyl]ethyl]thiomorpholine-4-carboxamide
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C15H19F3N2OS2
|
1
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| 1 |
EC50 = 390 nM
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CP0501992
|
(Z)-N-hydroxy-N-(2-hydroxyethyl)octadec-9-enamide
Show/Hide
|
C20H39NO3
|
1
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| 1 |
EC50 = 400 nM
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CP0380928
|
(4-tert-butylphenyl) 6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C22H24N2O3
|
2
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| 1 |
EC50 = 400 nM
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| 2 |
IC50 = 550 nM
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CP0389436
|
2-(4-chlorophenyl)-N-[(2Z)-3,7-dimethylocta-2,6-dienyl]acetamide
Show/Hide
|
C18H24ClNO
|
2
|
| 1 |
EC50 = 430 nM
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| 2 |
IC50 = 530 nM
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CP0570770
|
N-(1H-indazol-5-yl)-4-(2-methylphenyl)piperazine-1-carboxamide
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
EC50 = 460 nM
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CP0443287
|
6-hydroxy-1-methyl-N-[4-(trifluoromethyl)phenyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
|
C20H18F3N3O2
|
2
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| 1 |
EC50 = 470 nM
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| 2 |
IC50 = 310 nM
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CP0392638
|
5-hydroxy-1-(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-11-phenylundecan-3-one
Show/Hide
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C27H38O3
|
2
|
| 1 |
EC50 = 500 nM
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| 2 |
IC50 = 1300 nM
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CP0522584
|
N,N'-bis[(3-hydroxy-4-methoxyphenyl)methyl]icosanediamide
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C36H56N2O6
|
1
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| 1 |
EC50 = 501.19 nM
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CP0390487
|
[4-[(4-tert-butylbenzoyl)amino]phenyl]boronic acid
Show/Hide
|
C17H20BNO3
|
2
|
| 1 |
EC50 = 520 nM
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| 2 |
IC50 = 780 nM
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CP0380920
|
(4-tert-butylphenyl)-(6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)methanone
Show/Hide
|
C22H24N2O2
|
2
|
| 1 |
EC50 = 540 nM
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| 2 |
IC50 = 440 nM
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CP0577179
|
4-(2-chlorophenyl)-N-(1H-indazol-5-yl)piperazine-1-carboxamide
Show/Hide
|
C18H18ClN5O
|
1
|
| 1 |
EC50 = 580 nM
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CP0562603
|
N-(1H-indazol-5-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
Show/Hide
|
C18H17F3N6O
|
1
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| 1 |
EC50 = 587 nM
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CP0409385
|
N-hydroxy-N-(2-hydroxyethyl)hexadecanamide
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|
C18H37NO3
|
1
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| 1 |
EC50 = 600 nM
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CP0511821
|
2-phenyl-N-(7-phenylheptyl)acetamide
Show/Hide
|
C21H27NO
|
2
|
| 1 |
EC50 = 660 nM
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| 2 |
IC50 = 1210 nM
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CP0421977
|
4-propyl-N-pyridin-3-ylbenzamide
Show/Hide
|
C15H16N2O
|
1
|
| 1 |
EC50 = 700 nM
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CP0570768
|
N-(1H-indazol-5-yl)-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
Show/Hide
|
C18H17F3N6O
|
1
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| 1 |
EC50 = 736 nM
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CP0499507
|
(4R)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-4-prop-1-en-2-ylcyclohexene-1-carboxamide
Show/Hide
|
C18H23NO3
|
1
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| 1 |
EC50 = 794.33 nM
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CP0457228
|
N,N'-bis[(3-hydroxy-4-methoxyphenyl)methyl]nonanediamide
Show/Hide
|
C25H34N2O6
|
1
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| 1 |
EC50 = 794.33 nM
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CP0035557
|
(Z)-N-(2-hydroxyethyl)octadec-9-enamide
Show/Hide
|
C20H39NO2
|
2
|
| 1 |
EC50 = 890 nM
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| 2 |
EC50 = 3650 nM
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CP0373097
|
4-Pentyl-N-pyridin-3-yl-benzamide
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C17H20N2O
|
3
|
| 1 |
EC50 = 900 nM
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| 2 |
EC50 = 1700 nM
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| 3 |
Ki = 421 nM
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CP0543582
|
4-(3-chloropyridin-2-yl)-N-(1H-indazol-5-yl)piperazine-1-carboxamide
Show/Hide
|
C17H17ClN6O
|
1
|
| 1 |
EC50 = 940 nM
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CP0374275
|
1-Adamantyl-3-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]urea
Show/Hide
|
C21H36N2O
|
1
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| 1 |
EC50 = 1000 nM
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CP0373442
|
5-hydroxy-1-(4-hydroxyphenyl)-6-phenylhexan-3-one
Show/Hide
|
C18H20O3
|
2
|
| 1 |
EC50 = 1000 nM
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| 2 |
IC50 = 33500 nM
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CP0390489
|
[4-[(8-phenyloctanoylamino)methyl]phenyl]boronic acid
Show/Hide
|
C21H28BNO3
|
2
|
| 1 |
EC50 = 1000 nM
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| 2 |
IC50 = 500 nM
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CP0543546
|
4-(2,3-dichlorophenyl)-N-(1H-indazol-5-yl)piperazine-1-carboxamide
Show/Hide
|
C18H17Cl2N5O
|
1
|
| 1 |
EC50 = 1020 nM
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CP0426642
|
2-(4-chlorophenyl)-N-[(2E)-3,7-dimethylocta-2,6-dienyl]acetamide
Show/Hide
|
C18H24ClNO
|
2
|
| 1 |
EC50 = 1100 nM
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| 2 |
IC50 = 890 nM
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CP0392835
|
5-hydroxy-1-(4-hydroxyphenyl)decan-3-one
Show/Hide
|
C16H24O3
|
2
|
| 1 |
EC50 = 1200 nM
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| 2 |
IC50 = 10500 nM
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CP0465399
|
N-(4-tert-butylphenyl)-6-hydroxy-1-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
|
C23H27N3O2
|
2
|
| 1 |
EC50 = 1200 nM
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| 2 |
IC50 = 98 nM
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CP0544166
|
4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(1H-indazol-5-yl)piperazine-1-carboxamide
Show/Hide
|
C18H16ClF3N6O
|
1
|
| 1 |
EC50 = 1262 nM
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CP0569849
|
N-(1H-indazol-5-yl)-4-(3-methylpyridin-2-yl)piperazine-1-carboxamide
Show/Hide
|
C18H20N6O
|
1
|
| 1 |
EC50 = 1400 nM
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CP0455581
|
[2-methoxy-4-[(6-phenylhexanoylamino)methyl]phenyl]boronic acid
Show/Hide
|
C20H26BNO4
|
2
|
| 1 |
EC50 = 1460 nM
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| 2 |
IC50 = 1530 nM
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CP0380516
|
N-methyl-N-(4-phenylbutyl)-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
Show/Hide
|
C26H27N5O
|
2
|
| 1 |
EC50 = 1500 nM
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| 2 |
IC50 = 7100 nM
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CP0406659
|
[4-[(6-phenylhexanoylamino)methyl]phenyl]boronic acid
Show/Hide
|
C19H24BNO3
|
2
|
| 1 |
EC50 = 1530 nM
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| 2 |
IC50 = 2890 nM
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CP0567842
|
N-(1H-indazol-6-yl)-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
Show/Hide
|
C18H17F3N6O
|
1
|
| 1 |
EC50 = 1564 nM
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CP0380781
|
N-methyl-N-(4-phenylbutyl)-5-[(4-phenylphenyl)methyl]tetrazole-2-carboxamide
Show/Hide
|
C26H27N5O
|
2
|
| 1 |
EC50 = 1700 nM
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| 2 |
IC50 = 47600 nM
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CP0380917
|
1-(3-chlorophenyl)-3-[(2Z)-3,7-dimethylocta-2,6-dienyl]urea
Show/Hide
|
C17H23ClN2O
|
2
|
| 1 |
EC50 = 1700 nM
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| 2 |
IC50 = 380 nM
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CP0380782
|
[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]-piperidin-1-ylmethanone
Show/Hide
|
C20H21N5O
|
2
|
| 1 |
EC50 = 1800 nM
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| 2 |
IC50 = 7400 nM
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CP0390993
|
(2R,3'S)-1',1',3'-trimethyl-6-pentylspiro[3H-1-benzofuran-2,2'-cyclohexane]-4-ol
Show/Hide
|
C21H32O2
|
2
|
| 1 |
EC50 = 1800 nM
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| 2 |
IC50 = 7100 nM
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CP0447620
|
N-(3-tert-butylphenyl)-6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
|
C22H25N3O2
|
2
|
| 1 |
EC50 = 1890 nM
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| 2 |
IC50 = 5350 nM
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CP0474176
|
[4-[2-oxo-2-(4-phenylbutylamino)ethyl]phenyl]boronic acid
Show/Hide
|
C18H22BNO3
|
2
|
| 1 |
EC50 = 1990 nM
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| 2 |
IC50 = 2190 nM
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CP0388759
|
[4-[2-oxo-2-(5-phenylpentylamino)ethyl]phenyl]boronic acid
Show/Hide
|
C19H24BNO3
|
2
|
| 1 |
EC50 = 2250 nM
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| 2 |
IC50 = 2530 nM
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CP0379655
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6-hydroxy-N-(3-phenylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
|
C24H21N3O2
|
2
|
| 1 |
EC50 = 2270 nM
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| 2 |
IC50 = 1860 nM
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CP0398425
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cyclopropanolamide, 14a
Show/Hide
|
C23H37NO2
|
1
|
| 1 |
EC50 = 2400 nM
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CP0379651
|
(3-phenylphenyl) 1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C24H20N2O2
|
2
|
| 1 |
EC50 = 2400 nM
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| 2 |
IC50 = 7010 nM
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CP0484150
|
N-methyl-N-(naphthalen-2-ylmethyl)-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
Show/Hide
|
C27H23N5O
|
2
|
| 1 |
EC50 = 2500 nM
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| 2 |
IC50 = 7600 nM
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CP0400241
|
1-(3-chlorophenyl)-3-[(2E)-3,7-dimethylocta-2,6-dienyl]urea
Show/Hide
|
C17H23ClN2O
|
2
|
| 1 |
EC50 = 2500 nM
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| 2 |
IC50 = 710 nM
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CP0003558
|
(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-morpholin-4-ylpenta-2,4-dien-1-one
Show/Hide
|
C16H17NO4
|
1
|
| 1 |
EC50 = 2511.89 nM
|
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CP0050997
|
N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
Show/Hide
|
C19H21ClN2O2S
|
4
|
| 1 |
EC50 = 2511.89 nM
|
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|
| 2 |
IC50 = 56.2 nM
|
|
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| 3 |
IC50 = 100 nM
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| 4 |
Ki = 120 nM
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CP0396602
|
(8aR,10aS)-8,8,10a-trimethyl-3-pentyl-6,7,8a,9-tetrahydro-5H-xanthen-1-ol
Show/Hide
|
C21H32O2
|
2
|
| 1 |
EC50 = 2600 nM
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| 2 |
IC50 = 5900 nM
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CP0407990
|
4-ethyl-N-pyridin-3-ylbenzamide
Show/Hide
|
C14H14N2O
|
1
|
| 1 |
EC50 = 2700 nM
|
|
|
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CP0373096
|
4-octyl-N-pyridin-3-ylbenzamide
Show/Hide
|
C20H26N2O
|
2
|
| 1 |
EC50 = 2900 nM
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| 2 |
Ki = 546 nM
|
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CP0006549
|
(E,E)-1-piperoylpiperidine
Show/Hide
|
C17H19NO3
|
1
|
| 1 |
EC50 = 3162.28 nM
|
|
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CP0456278
|
6G [6]-gingerol
Show/Hide
|
C17H26O4
|
2
|
| 1 |
EC50 = 3300 nM
|
|
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| 2 |
IC50 = 5000 nM
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CP0578668
|
4-(5-chloropyridin-2-yl)-N-(1-methylindazol-6-yl)piperazine-1-carboxamide
Show/Hide
|
C18H19ClN6O
|
1
|
| 1 |
EC50 = 3556 nM
|
|
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CP0412405
|
4-heptyl-N-pyridin-3-ylbenzamide
Show/Hide
|
C19H24N2O
|
2
|
| 1 |
EC50 = 3700 nM
|
|
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| 2 |
Ki = 1740 nM
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|
CP0516456
|
[4-[(4-phenylphenyl)carbamoyl]phenyl]boronic acid
Show/Hide
|
C19H16BNO3
|
2
|
| 1 |
EC50 = 3970 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0406741
|
PIPERANINE
Show/Hide
|
C17H21NO3
|
1
|
| 1 |
EC50 = 3981.07 nM
|
|
|
|
CP0410522
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 3-phenylpropanoate
Show/Hide
|
C19H26O2
|
2
|
| 1 |
EC50 = 4000 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0386418
|
4-Chloro-N-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]benzamide
Show/Hide
|
C17H24ClNO
|
1
|
| 1 |
EC50 = 4100 nM
|
|
|
|
CP0405205
|
4-pentyl-N-(pyridin-3-ylmethyl)benzamide
Show/Hide
|
C18H22N2O
|
2
|
| 1 |
EC50 = 4200 nM
|
|
|
| 2 |
Ki > 3000 nM
|
|
|
|
CP0468313
|
[4-[[(4-phenylbenzoyl)amino]methyl]phenyl]boronic acid
Show/Hide
|
C20H18BNO3
|
2
|
| 1 |
EC50 = 4230 nM
|
|
|
| 2 |
IC50 = 7110 nM
|
|
|
|
CP0399471
|
N,N-dimethyl-5-[[4-(4-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide
Show/Hide
|
C18H19N5O
|
2
|
| 1 |
EC50 = 4800 nM
|
|
|
| 2 |
IC50 = 20600 nM
|
|
|
|
CP0380919
|
1-cyclohexyl-3-[(2E)-3,7-dimethylocta-2,6-dienyl]urea
Show/Hide
|
C17H30N2O
|
2
|
| 1 |
EC50 = 4800 nM
|
|
|
| 2 |
IC50 = 9900 nM
|
|
|
|
CP0390986
|
(2R,3'R)-1',1',3'-trimethyl-6-pentylspiro[3H-1-benzofuran-2,2'-cyclohexane]-4-ol
Show/Hide
|
C21H32O2
|
2
|
| 1 |
EC50 = 4900 nM
|
|
|
| 2 |
IC50 = 37000 nM
|
|
|
|
CP0155529
|
5-((biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
Show/Hide
|
C17H17N5O
|
2
|
| 1 |
EC50 = 5000 nM
|
|
|
| 2 |
IC50 = 31300 nM
|
|
|
|
CP0440796
|
(3-tert-butylphenyl) 6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C22H24N2O3
|
2
|
| 1 |
EC50 = 5100 nM
|
|
|
| 2 |
IC50 = 6200 nM
|
|
|
|
CP0380922
|
(3-phenylphenyl) 6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C24H20N2O3
|
2
|
| 1 |
EC50 = 5200 nM
|
|
|
| 2 |
IC50 = 9600 nM
|
|
|
|
CP0440793
|
(4-tert-butylphenyl) 1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C22H24N2O2
|
2
|
| 1 |
EC50 = 5290 nM
|
|
|
| 2 |
IC50 = 13260 nM
|
|
|
|
CP0395551
|
2-methoxy-4-[2-[(Z)-octadec-9-enyl]tetrazol-5-yl]phenol
Show/Hide
|
C26H42N4O2
|
2
|
| 1 |
EC50 = 5500 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0386409
|
3-tert-Butylphenyl-(1R,2S,5R)-2-isopropyl-5-methylcyclohexylcarbamate
Show/Hide
|
C21H33NO2
|
1
|
| 1 |
EC50 = 5800 nM
|
|
|
|
CP0399475
|
[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]-piperidin-1-ylmethanone
Show/Hide
|
C20H21N5O
|
2
|
| 1 |
EC50 = 5900 nM
|
|
|
| 2 |
IC50 = 22600 nM
|
|
|
|
CP0396989
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 4-methylbenzoate
Show/Hide
|
C18H24O2
|
2
|
| 1 |
EC50 = 6000 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0071320
|
5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpentan-1-one
Show/Hide
|
C17H23NO3
|
1
|
| 1 |
EC50 = 6309.57 nM
|
|
|
|
CP0440795
|
(6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)-(4-phenylphenyl)methanone
Show/Hide
|
C24H20N2O2
|
2
|
| 1 |
EC50 = 6420 nM
|
|
|
| 2 |
IC50 = 3130 nM
|
|
|
|
CP0380918
|
(4-tert-butylphenyl) N-[(2Z)-3,7-dimethylocta-2,6-dienyl]carbamate
Show/Hide
|
C21H31NO2
|
2
|
| 1 |
EC50 = 6500 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0379905
|
8-[3-hydroxy-5-(2-methyloctan-2-yl)phenoxy]-N-prop-2-enyloctanamide
Show/Hide
|
C26H43NO3
|
2
|
| 1 |
EC50 = 6900 nM
|
|
|
| 2 |
IC50 = 23900 nM
|
|
|
|
CP0403776
|
2-methoxy-4-(2-nonyltetrazol-5-yl)phenol
Show/Hide
|
C17H26N4O2
|
2
|
| 1 |
EC50 = 6900 nM
|
|
|
| 2 |
IC50 = 36000 nM
|
|
|
|
CP0376719
|
Biphenyl-3-yl-(1R,2S,5R)-2-isopropyl-5-methylcyclohexylcarbamate
Show/Hide
|
C23H29NO2
|
1
|
| 1 |
EC50 = 7100 nM
|
|
|
|
CP0380927
|
6-hydroxy-N-[3-(trifluoromethyl)phenyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
|
C19H16F3N3O2
|
2
|
| 1 |
EC50 = 7430 nM
|
|
|
| 2 |
IC50 = 13820 nM
|
|
|
|
CP0458788
|
3-Chloro-N-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]benzamide
Show/Hide
|
C17H24ClNO
|
1
|
| 1 |
EC50 = 7600 nM
|
|
|
|
CP0471319
|
(4-phenylphenyl) 6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C24H20N2O3
|
2
|
| 1 |
EC50 = 7750 nM
|
|
|
| 2 |
IC50 = 11380 nM
|
|
|
|
CP0386346
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] N-(4-tert-butylphenyl)carbamate
Show/Hide
|
C21H31NO2
|
2
|
| 1 |
EC50 = 7800 nM
|
|
|
| 2 |
IC50 = 74600 nM
|
|
|
|
CP0379935
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 2-(4-methoxyphenyl)acetate
Show/Hide
|
C19H26O3
|
2
|
| 1 |
EC50 = 8000 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0426638
|
1-(4-tert-butylphenyl)-3-[(2E)-3,7-dimethylocta-2,6-dienyl]urea
Show/Hide
|
C21H32N2O
|
2
|
| 1 |
EC50 = 8700 nM
|
|
|
| 2 |
IC50 = 76800 nM
|
|
|
|
CP0379933
|
1-cyclohexyl-3-[(2Z)-3,7-dimethylocta-2,6-dienyl]urea
Show/Hide
|
C17H30N2O
|
2
|
| 1 |
EC50 = 8900 nM
|
|
|
| 2 |
IC50 = 15700 nM
|
|
|
|
CP0098948
|
Impulsin
Show/Hide
|
C18H37NO2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0433062
|
4-methyl-N-pyridin-3-ylbenzamide
Show/Hide
|
C13H12N2O
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0264441
|
2-(2-methylpropyl)-5-[(4-phenylphenyl)methyl]tetrazole
Show/Hide
|
C18H20N4
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0396992
|
(4-tert-butylphenyl) N-[(2E)-3,7-dimethylocta-2,6-dienyl]carbamate
Show/Hide
|
C21H31NO2
|
2
|
| 1 |
EC50 = 10700 nM
|
|
|
| 2 |
IC50 = 92300 nM
|
|
|
|
CP0447598
|
1-(6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)-2-(3-phenylphenyl)ethanone
Show/Hide
|
C25H22N2O2
|
2
|
| 1 |
EC50 = 11800 nM
|
|
|
| 2 |
IC50 = 19450 nM
|
|
|
|
CP0380779
|
N-methyl-N-(naphthalen-2-ylmethyl)-5-[(4-phenylphenyl)methyl]tetrazole-2-carboxamide
Show/Hide
|
C27H23N5O
|
2
|
| 1 |
EC50 = 11900 nM
|
|
|
| 2 |
IC50 = 4500 nM
|
|
|
|
CP0381259
|
N-cyclohexyl-N-methyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
Show/Hide
|
C22H25N5O
|
2
|
| 1 |
EC50 = 13400 nM
|
|
|
| 2 |
IC50 = 18300 nM
|
|
|
|
CP0455122
|
5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-6-phenylhexan-3-one
Show/Hide
|
C19H22O4
|
2
|
| 1 |
EC50 = 14300 nM
|
|
|
| 2 |
IC50 = 13200 nM
|
|
|
|
CP0392921
|
5-hydroxy-1-(4-hydroxyphenyl)-11-phenylundecan-3-one
Show/Hide
|
C23H30O3
|
2
|
| 1 |
EC50 = 14600 nM
|
|
|
| 2 |
IC50 = 9400 nM
|
|
|
|
CP0436659
|
N-[[1-(2-methylpropyl)tetrazol-5-yl]methyl]-4-phenylbenzamide
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
EC50 = 15000 nM
|
|
|
|
CP0410527
|
N-[(2E)-3,7-dimethylocta-2,6-dienyl]-3-phenylpropanamide
Show/Hide
|
C19H27NO
|
2
|
| 1 |
EC50 = 16200 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0401430
|
4-tert-Butylphenyl-(1R,2S,5R)-2-isopropyl-5-methylcyclohexylcarbamate
Show/Hide
|
C21H33NO2
|
1
|
| 1 |
EC50 = 18300 nM
|
|
|
|
CP0482957
|
3-Chlorophenyl-(1R,2S,5R)-2-isopropyl-5-methylcyclohexylcarbamate
Show/Hide
|
C17H24ClNO2
|
1
|
| 1 |
EC50 = 19200 nM
|
|
|
|
CP0003565
|
ANTIEPILEPSIRINE
Show/Hide
|
C15H17NO3
|
1
|
| 1 |
EC50 = 19952.62 nM
|
|
|
|
CP0376029
|
N,N-dimethyl-5-[[4-(4-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide
Show/Hide
|
C18H19N5O
|
2
|
| 1 |
EC50 = 22500 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0407813
|
5-[[4-(3-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
Show/Hide
|
C17H17N5O2
|
2
|
| 1 |
EC50 = 25000 nM
|
|
|
| 2 |
IC50 = 67400 nM
|
|
|
|
CP0395030
|
cyclopropanolamide, rac-10c
Show/Hide
|
C19H37NO2
|
1
|
| 1 |
EC50 = 26400 nM
|
|
|
|
CP0349723
|
methyl 2-[5-[[(4-phenylbenzoyl)amino]methyl]tetrazol-1-yl]acetate
Show/Hide
|
C18H17N5O3
|
1
|
| 1 |
EC50 = 29600 nM
|
|
|
|
CP0405207
|
4-decyl-N-pyridin-3-ylbenzamide
Show/Hide
|
C22H30N2O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
Ki = 607 nM
|
|
|
|
CP0412553
|
N-methyl-4-pentyl-N-pyridin-3-ylbenzamide
Show/Hide
|
C18H22N2O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
Ki = 15000 nM
|
|
|
|
CP0380515
|
5-[[4-(3-carbamoylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
Show/Hide
|
C18H18N6O2
|
2
|
| 1 |
EC50 = 32300 nM
|
|
|
| 2 |
IC50 > 100000 nM
|
|
|
|
CP0378697
|
4-[2-[(Z,12R)-12-hydroxyoctadec-9-enyl]tetrazol-5-yl]-2-methoxyphenol
Show/Hide
|
C26H42N4O3
|
2
|
| 1 |
EC50 = 37500 nM
|
|
|
| 2 |
IC50 = 57500 nM
|
|
|
|
CP0376720
|
4-Chlorophenyl-(1R,2S,5R)-2-isopropyl-5-methylcyclohexylcarbamate
Show/Hide
|
C17H24ClNO2
|
1
|
| 1 |
EC50 = 42800 nM
|
|
|
|
CP0479976
|
1-(2-(5-Hydroxy-1H-indol-2-yl)ethyl)-3-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]urea
Show/Hide
|
C21H31N3O2
|
1
|
| 1 |
EC50 = 52200 nM
|
|
|
|
CP0433647
|
N-[[2-(2-methylpropyl)tetrazol-5-yl]methyl]-4-phenylbenzamide
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
EC50 = 53500 nM
|
|
|
|
CP0386416
|
4-Methoxyphenyl-(1R,2S,5R)-2-isopropyl-5-methylcyclohexylcarbamate
Show/Hide
|
C18H27NO3
|
1
|
| 1 |
EC50 = 53800 nM
|
|
|
|
CP0156558
|
N-[[2-(cyanomethyl)tetrazol-5-yl]methyl]-4-phenylbenzamide
Show/Hide
|
C17H14N6O
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0158548
|
N-[[2-(2-oxopropyl)tetrazol-5-yl]methyl]-4-phenylbenzamide
Show/Hide
|
C18H17N5O2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0161399
|
methyl 2-[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]acetate
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0161400
|
1-(2-methylpropyl)-5-[(4-phenylphenyl)methyl]tetrazole
Show/Hide
|
C18H20N4
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0162473
|
methyl 2-[5-[[(4-phenylbenzoyl)amino]methyl]tetrazol-2-yl]acetate
Show/Hide
|
C18H17N5O3
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0254925
|
N,N-dimethyl-2-[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]acetamide
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0264439
|
N-[[2-[2-(dimethylamino)-2-oxoethyl]tetrazol-5-yl]methyl]-4-phenylbenzamide
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0307239
|
N-[[1-(cyanomethyl)tetrazol-5-yl]methyl]-4-phenylbenzamide
Show/Hide
|
C17H14N6O
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0307240
|
2-[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]acetonitrile
Show/Hide
|
C16H13N5
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0310721
|
2-[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]acetonitrile
Show/Hide
|
C16H13N5
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0337167
|
N,N-dimethyl-2-[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]acetamide
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0349724
|
1-[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]propan-2-one
Show/Hide
|
C17H16N4O
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0357844
|
methyl 2-[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]acetate
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0369272
|
N-[[1-(2-oxopropyl)tetrazol-5-yl]methyl]-4-phenylbenzamide
Show/Hide
|
C18H17N5O2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0369273
|
1-[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]propan-2-one
Show/Hide
|
C17H16N4O
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0394199
|
N-(4-pentylphenyl)pyridine-3-carboxamide
Show/Hide
|
C17H20N2O
|
2
|
| 1 |
EC50 > 5000 nM
|
|
|
| 2 |
Ki > 3000 nM
|
|
|
|
CP0394200
|
N-[(4-pentylphenyl)methyl]pyridin-3-amine
Show/Hide
|
C17H22N2
|
2
|
| 1 |
EC50 > 5000 nM
|
|
|
| 2 |
Ki > 3000 nM
|
|
|
|
CP0436484
|
2-(4-pentylphenyl)-N-pyridin-3-ylacetamide
Show/Hide
|
C18H22N2O
|
2
|
| 1 |
EC50 > 5000 nM
|
|
|
| 2 |
Ki = 7260 nM
|
|
|
|
CP0524340
|
(4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyridin-2-yl)-pteridin-4-yl]amine
Show/Hide
|
C19H10F6N6
|
1
|
| 1 |
IC50 = 0.21 nM
|
|
|
|
CP0522049
|
3-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)pyrido[2,3-b]pyrazin-8-amine
Show/Hide
|
C19H10F6N6
|
1
|
| 1 |
IC50 = 0.23 nM
|
|
|
|
CP0472490
|
1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C23H24F3N5O2
|
1
|
| 1 |
IC50 = 0.27 nM
|
|
|
|
CP0162405
|
(4-Hydroxy-3-iodo-5-methoxy-phenyl)-acetic acid (2R,3S,3aR,5R,5aR,8bR,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester
Show/Hide
|
C37H41IO9
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0536461
|
(4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyridin-2-yl)-pyrido[3,2-d]pyrimidin-4-yl]amine
Show/Hide
|
C20H11F6N5
|
1
|
| 1 |
IC50 = 0.63 nM
|
|
|
|
CP0567959
|
1-[[2-(3-methylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C22H18F3N5O2
|
1
|
| 1 |
IC50 = 0.64 nM
|
|
|
|
CP0552919
|
1-(2-oxo-1H-quinolin-5-yl)-3-[[2-piperidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
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C22H22F3N5O2
|
1
|
| 1 |
IC50 = 0.75 nM
|
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CP0526830
|
(4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyridin-2-yl)-pyrido[2,3-d]pyrimidin-4-yl]amine
Show/Hide
|
C20H11F6N5
|
1
|
| 1 |
IC50 = 0.83 nM
|
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CP0514686
|
(5-Trifluoromethylpyridin-2-yl)-[7-(3-trifluoromethylpyridin-2-yl)quinazolin-4-yl]amine
Show/Hide
|
C20H11F6N5
|
1
|
| 1 |
IC50 = 0.85 nM
|
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CP0570090
|
1-(2-oxo-1H-quinolin-5-yl)-3-[[2-(3-propan-2-ylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]urea
Show/Hide
|
C24H22F3N5O2
|
1
|
| 1 |
IC50 = 0.88 nM
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CP0487432
|
1-(2-oxo-1H-quinolin-5-yl)-3-[[2-pyrrolidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C21H20F3N5O2
|
1
|
| 1 |
IC50 = 0.94 nM
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CP0467595
|
(3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)phenyl)methanol
Show/Hide
|
C19H12Cl2F3N5OS
|
1
|
| 1 |
IC50 = 1 nM
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CP0506318
|
2-N-(2,6-dichlorophenyl)-7-N-(4-pyrrolidin-1-ylsulfonylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C21H18Cl2N6O2S2
|
1
|
| 1 |
IC50 = 1 nM
|
|
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CP0484810
|
US8969325, 166
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 1 nM
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CP0364236
|
(4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyridin-2-yl)-quinazolin-4-yl]amine
Show/Hide
|
C21H12F6N4
|
1
|
| 1 |
IC50 = 1.1 nM
|
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CP0487434
|
1-(2-oxo-1H-quinolin-5-yl)-3-[[2-phenylmethoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C24H19F3N4O3
|
1
|
| 1 |
IC50 = 1.2 nM
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CP0533911
|
1-[[2-(3-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C21H15F4N5O2
|
1
|
| 1 |
IC50 = 1.28 nM
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CP0567958
|
1-(2-oxo-1H-quinolin-5-yl)-3-[[2-(3-propan-2-ylphenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C26H23F3N4O2
|
1
|
| 1 |
IC50 = 1.35 nM
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CP0517020
|
1-[[2-(4-methylcyclohexyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C24H25F3N4O2
|
1
|
| 1 |
IC50 = 1.44 nM
|
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CP0553054
|
1-[[2-(cyclobutylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C22H21F3N4O3
|
1
|
| 1 |
IC50 = 1.49 nM
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CP0487431
|
1-[[2-(4-benzylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C29H28F3N5O2
|
1
|
| 1 |
IC50 = 1.59 nM
|
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CP0401465
|
7-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)-pyridin-2-yl]quinolin-4-amine
Show/Hide
|
C21H12F6N4
|
1
|
| 1 |
IC50 = 1.65 nM
|
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CP0533910
|
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C21H15ClF3N5O2
|
1
|
| 1 |
IC50 = 1.71 nM
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CP0552011
|
1-[[2-(4-fluorophenyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C23H16F4N4O2
|
1
|
| 1 |
IC50 = 1.93 nM
|
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CP0486397
|
2-N-(2,6-dichlorophenyl)-5-N-(2-methylpropyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C22H19Cl2F3N6S
|
1
|
| 1 |
IC50 = 2 nM
|
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CP0384344
|
1-(1-(4-(trifluoromethyl)benzyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C29H26F3N3O2
|
2
|
| 1 |
IC50 = 2 nM
|
|
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| 2 |
Ki = 2 nM
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CP0410398
|
1-[(4R)-6-fluoro-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-isoquinolin-5-ylurea
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
IC50 = 2 nM
|
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CP0507961
|
N-[2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C26H27N3O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0442519
|
US8802711, 76
Show/Hide
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C22H21F2N3O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0550752
|
US9422293, 244
Show/Hide
|
C26H26F6N6
|
1
|
| 1 |
IC50 = 2 nM
|
|
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CP0533909
|
1-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C23H23F3N4O2S
|
1
|
| 1 |
IC50 = 2.15 nM
|
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CP0533908
|
1-[[2-(cyclopentylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C23H23F3N4O3
|
1
|
| 1 |
IC50 = 2.18 nM
|
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CP0128074
|
7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1,8-naphthyridin-4-amine
Show/Hide
|
C20H11F6N5
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0554147
|
US8802711, 81
Show/Hide
|
C22H22FN3O2
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
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CP0393051
|
N-isoquinolin-5-yl-4-pentylbenzamide
Show/Hide
|
C21H22N2O
|
2
|
| 1 |
IC50 = 2.4 nM
|
|
|
| 2 |
Ki = 71 nM
|
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CP0487433
|
1-[[2-(2-methylpropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
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CP0567957
|
1-(2-oxo-1H-quinolin-5-yl)-3-[[2-pentoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C22H23F3N4O3
|
1
|
| 1 |
IC50 = 2.72 nM
|
|
|
|
CP0448133
|
2-[2-[2-(2-phenylethynyl)-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C24H20N2O
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0463094
|
2-[2-[2-[2-[4-(trifluoromethyl)phenyl]ethyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C25H23F3N2O
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0399930
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-methyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11Cl3F3N5S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0474067
|
5-N-(cyclopropylmethyl)-2-N-(2,6-dichlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C22H17Cl2F3N6S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0082813
|
1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea
Show/Hide
|
C18H14F3N3O
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
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CP0089515
|
1-(4-tert-Butyl-benzyl)-3-isoquinolin-5-yl-urea
Show/Hide
|
C21H23N3O
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
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CP0383332
|
1-[2-(4-tert-Butyl-phenyl)-ethyl]-3-isoquinolin-5-yl-urea
Show/Hide
|
C22H25N3O
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
Ki = 1.3 nM
|
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|
CP0453250
|
1-Isoquinolin-5-yl-3-(4-trifluoromethoxy-benzyl)-urea
Show/Hide
|
C18H14F3N3O2
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
Ki = 1.3 nM
|
|
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CP0400710
|
1-[(4R)-7-fluoro-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H22FN3O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0536265
|
US8969325, 165
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0535980
|
US9422293, 362
Show/Hide
|
C24H23F6N5O3S2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0562937
|
1-[[2-hexoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C23H25F3N4O3
|
1
|
| 1 |
IC50 = 3.19 nM
|
|
|
|
CP0506969
|
US8802711, 82
Show/Hide
|
C22H21F2N3O
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0531675
|
US8802711, 74
Show/Hide
|
C22H21F2N3O
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0504844
|
1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethyl-benzyl)-urea
Show/Hide
|
C19H15F3N2O2
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
Ki = 1 nM
|
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|
CP0531910
|
1-(3,4-Dichloro-benzyl)-3-isoquinolin-5-yl-urea
Show/Hide
|
C17H13Cl2N3O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
Ki = 9 nM
|
|
|
|
CP0211580
|
(R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea
Show/Hide
|
C21H24N4O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0381979
|
1-[(4R)-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-isoquinolin-5-ylurea
Show/Hide
|
C21H21N3O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0480532
|
1-[(4R)-7-fluoro-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-isoquinolin-5-ylurea
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0503775
|
US8969325, 35
Show/Hide
|
C20H18F3N3O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0503798
|
US8969325, 30
Show/Hide
|
C21H20ClF2N3O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0483212
|
US8802711, A
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0509214
|
US8802711, G
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0531651
|
US8802711, 6
Show/Hide
|
C22H22FN3O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0492918
|
US9422293, 157
Show/Hide
|
C26H25F7N6
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0518407
|
US9422293, 159
Show/Hide
|
C29H34F3N7O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0565107
|
1-[[2-butoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0538571
|
1-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C24H24ClN5O2
|
1
|
| 1 |
IC50 = 4.41 nM
|
|
|
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CP0391498
|
2-[2-[2-[2-[4-(trifluoromethyl)phenyl]ethynyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C25H19F3N2O
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0450286
|
US8969325, 323
Show/Hide
|
C20H18ClF2N3O4
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0187224
|
JNJ-39439335
Show/Hide
|
C25H21F3N2O
|
4
|
| 1 |
IC50 = 4.6 nM
|
|
|
| 2 |
IC50 = 6.8 nM
|
|
|
| 3 |
IC50 = 23 nM
|
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|
| 4 |
Ki = 6.5 nM
|
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CP0464650
|
2-[2-[2-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C25H21F3N2O
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0480313
|
2-N-(2,6-dichlorophenyl)-7-N-(4-methylsulfonylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H13Cl2N5O2S2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0533145
|
1-(2-(4-fluorophenyl)-3-phenylpropyl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C25H22FN3O
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0404216
|
3-(4-tert-Butyl-phenyl)-N-isoquinolin-5-yl-acrylamide
Show/Hide
|
C22H22N2O
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
Ki = 1.2 nM
|
|
|
|
CP0381983
|
1-[(4R)-7-cyclopropyl-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C25H25F2N3O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0539770
|
1-[(4R)-8-fluoro-2,2-dimethyl-7-(trifluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C23H21F4N3O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0539771
|
1-[(4R)-7,8-difluoro-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H21F2N3O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0566886
|
1-[(4R)-7-fluoro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H20F3N3O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0572405
|
US8969325, 167
Show/Hide
|
C22H23ClF2N4O3
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0519041
|
US8802711, F
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0520311
|
US8802711, E
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0530418
|
US8802711, 20
Show/Hide
|
C22H22FN3O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0556837
|
US8802711, C
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0515416
|
US9422293, 320
Show/Hide
|
C32H39F3N6O3S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0533907
|
1-[[2-(dipropylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C23H26F3N5O2
|
1
|
| 1 |
IC50 = 5.21 nM
|
|
|
|
CP0449990
|
US8802711, 83
Show/Hide
|
C22H21F2N3O
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0550569
|
US8802711, 84
Show/Hide
|
C22H21F2N3O
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0416063
|
2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H24F6N6
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0516142
|
US8802711, 70
Show/Hide
|
C22H21F2N3O
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0448134
|
2-[2-[2-[(E)-2-(4-chlorophenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C24H21ClN2O
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0554993
|
2-[2-[2-[(E)-2-[4-(trifluoromethoxy)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C25H21F3N2O2
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0444912
|
US9422293, 6
Show/Hide
|
C30H30F3N5
|
1
|
| 1 |
IC50 = 5.9 nM
|
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|
|
CP0475800
|
1-(4-Chloro-3-trifluoromethyl-benzyl)-3-isoquinolin-5-yl-urea
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|
C18H13ClF3N3O
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
Ki = 0.8 nM
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|
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CP0481577
|
1-(4-Chloro-benzyl)-3-isoquinolin-5-yl-urea
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|
C17H14ClN3O
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
Ki = 31 nM
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|
|
CP0386113
|
2-morpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H24F6N6O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0411437
|
1-[(4R)-2,2-diethyl-6-fluoro-3,4-dihydrochromen-4-yl]-3-isoquinolin-5-ylurea
Show/Hide
|
C23H24FN3O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0548582
|
1-[(4R)-2,2-dimethyl-7-(trifluoromethoxy)-3,4-dihydrochromen-4-yl]-3-isoquinolin-5-ylurea
Show/Hide
|
C22H20F3N3O3
|
1
|
| 1 |
IC50 = 6 nM
|
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|
|
CP0416651
|
2-[2-[2-[4-(trifluoromethyl)phenyl]ethyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C22H18F3N3O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0482645
|
2-[2-[(E)-2-[4-(trifluoromethoxy)phenyl]ethenyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C22H16F3N3O3S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0506836
|
US8802711, B
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0414906
|
(4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyridin-2-yl)-[1,8]naphthyridin-4-ylamine
Show/Hide
|
C21H12F6N4
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0570091
|
1-[[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]methyl]-3-(2-oxo-1H-quinolin-5-yl)urea
Show/Hide
|
C24H24FN5O2
|
1
|
| 1 |
IC50 = 6.17 nM
|
|
|
|
CP0450221
|
US8802711, 78
Show/Hide
|
C22H22FN3O2
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0122651
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
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|
C20H25ClN4O
|
6
|
| 1 |
IC50 = 6.7 nM
|
|
|
| 2 |
IC50 = 7 nM
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|
|
| 3 |
IC50 = 16 nM
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| 4 |
IC50 = 29.8 nM
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| 5 |
IC50 = 34 nM
|
|
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| 6 |
Ki = 2.5 nM
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|
|
CP0529401
|
US9422293, 47
Show/Hide
|
C28H33F3N6O
|
1
|
| 1 |
IC50 = 6.8 nM
|
|
|
|
CP0411438
|
1-[(4R)-7-fluoro-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-[(7S)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]urea
Show/Hide
|
C22H25FN2O3
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0487701
|
1-[(4R)-7-fluoro-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-[(7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]urea
Show/Hide
|
C22H25FN2O3
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0886672
|
(R)-1-(7-Fluoro-2,2-dimethylchroman-4-yl)-3-(1-methyl-1H-indazol-4-yl)urea
Show/Hide
|
C20H21FN4O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0554990
|
2-[2-[2-[(Z)-2-[4-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C25H21F3N2O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0554992
|
2-[2-[(E)-2-(4-fluorophenyl)ethenyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C21H16FN3O2S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0566710
|
2-[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C22H16F3N3O2S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0553847
|
US8969325, 34
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0450218
|
US8802711, 27
Show/Hide
|
C22H22FN3O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0868081
|
(6-Trifluoromethylpyridin-3-yl)-[7-(3-trifluoromethylpyridin-2-yl)quinazolin-4-yl]amine Hydrochloride
Show/Hide
|
C20H12ClF6N5
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0554991
|
2-[2-[(E)-2-[3-(trifluoromethoxy)phenyl]ethenyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C22H16F3N3O3S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0529237
|
US8969325, 96
Show/Hide
|
C20H18ClN3O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0553789
|
US8969325, 134
Show/Hide
|
C21H20ClF2N3O4
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0531654
|
US8802711, 65
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0450219
|
US8802711, 66
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0440272
|
(R)-2-Methyl-4-(4-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C21H29N5O
|
2
|
| 1 |
IC50 = 8.5 nM
|
|
|
| 2 |
IC50 = 15.2 nM
|
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|
|
CP0491392
|
(S)-1-oxo-3-phenyl-2-(pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C26H23F3N4O2
|
2
|
| 1 |
IC50 = 8.5 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0554144
|
US8802711, 71
Show/Hide
|
C22H21F2N3O
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0530468
|
US8802711, 85
Show/Hide
|
C22H21F2N3O
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0413475
|
US9422293, 93B
Show/Hide
|
C25H26F6N6O
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0378966
|
2-N-(2-chloro-6-methylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H13ClF3N5S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0494323
|
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H20ClF2N3O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0550565
|
US8802711, 7
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0478716
|
N-[2-[2-[(E)-2-(4-propan-2-ylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C25H25N3O2S
|
1
|
| 1 |
IC50 = 9.2 nM
|
|
|
|
CP0511753
|
(S)-N-(4-tert-butylphenyl)-1-oxo-2,3-diphenyl-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C30H33N3O2
|
2
|
| 1 |
IC50 = 9.4 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0485146
|
(R)-4-(6-Chloro-4-methyl-pyridazin-3-yl)-2-methyl-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C21H28ClN5O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 67.5 nM
|
|
|
|
CP0465748
|
2-N-(2,6-dichlorophenyl)-7-N-(4-propan-2-ylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C20H17Cl2N5S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0049381
|
N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26INO3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0445065
|
1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C28H23F4N3O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0405904
|
1-[2-(3,4-Dichloro-phenyl)-ethyl]-3-isoquinolin-5-yl-urea
Show/Hide
|
C18H15Cl2N3O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0487700
|
1-[(4R)-2,2-dimethyl-7-(trifluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C23H22F3N3O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0416653
|
[2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]methanol
Show/Hide
|
C26H26N2O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0489333
|
N-[2-[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C23H18F3N3O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0418308
|
US8969325, 1
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0506952
|
US8969325, 19
Show/Hide
|
C22H22FN3O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0521282
|
US8969325, 86
Show/Hide
|
C21H18F3N3O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0490548
|
US8802711, 62
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0554146
|
US8802711, 80
Show/Hide
|
C22H22FN3O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0406838
|
US9422293, 240
Show/Hide
|
C27H28F6N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0413283
|
US9422293, 235
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0413284
|
US9422293, 237
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0413506
|
US9422293, 14
Show/Hide
|
C24H24Cl2F3N5
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0444904
|
US9422293, 332
Show/Hide
|
C29H31F6N5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0444905
|
US9422293, 333
Show/Hide
|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0474803
|
US9422293, 354
Show/Hide
|
C27H27F6N5S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0480853
|
US9422293, 353
Show/Hide
|
C28H23F6N5S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0480855
|
US9422293, 390
Show/Hide
|
C25H24ClF6N7
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0480868
|
US9422293, 363
Show/Hide
|
C26H25F6N5O3S2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0481148
|
US9422293, 253
Show/Hide
|
C30H37F3N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0482798
|
US9422293, 236
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0482800
|
US9422293, 242
Show/Hide
|
C26H24F8N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0495308
|
US9422293, 245
Show/Hide
|
C26H25ClF6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0501437
|
US9422293, 241
Show/Hide
|
C24H20F8N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0507285
|
US9422293, 381
Show/Hide
|
C25H23ClF6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0515441
|
US9422293, 222
Show/Hide
|
C27H28F6N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0518412
|
US9422293, 224
Show/Hide
|
C27H27ClF6N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0526061
|
US9422293, 223
Show/Hide
|
C26H27F6N7
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0545602
|
US9422293, 214
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0399364
|
7-N-(4-tert-butylphenyl)-2-N-(2,6-dichlorophenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C21H19Cl2N5S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0151495
|
3-isoquinolin-5-yl-1-{[3-(trifluoromethyl)phenyl]methyl}urea
Show/Hide
|
C18H14F3N3O
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
Ki = 23 nM
|
|
|
|
CP0429808
|
1-Isoquinolin-5-yl-3-[2-(4-trifluoromethoxy-phenyl)-ethyl]-urea
Show/Hide
|
C19H16F3N3O2
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0381458
|
2-(4-isobutylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C29H33F6N7
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 67 nM
|
|
|
|
CP0465879
|
2-(4-cyclopropylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C28H29F6N7
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0450204
|
US8969325, 90
Show/Hide
|
C22H20F3N3O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0577847
|
US8969325, 140
Show/Hide
|
C23H28N4O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0490550
|
US8802711, 79
Show/Hide
|
C22H22FN3O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0557100
|
US8802711, 67
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0399365
|
2-N-(2,6-dichlorophenyl)-5-pyrrolidin-1-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C22H17Cl2F3N6S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0422280
|
2-N-(2,6-dichlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10Cl2F3N5S
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 19 nM
|
|
|
|
CP0434502
|
1-(1-benzyl-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C27H24FN3O
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0265144
|
(R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H19F3N2O2
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0883411
|
(E)-1-(2-{2-[2-(4-tert-Butyl-phenyl)-vinyl]-1H-benzoimidazol-5-yl}-phenyl)-ethanol
Show/Hide
|
C27H28N2O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0383967
|
US8969325, 139
Show/Hide
|
C23H27FN4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0524446
|
US8969325, 28
Show/Hide
|
C22H21F2N3O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0556133
|
US8969325, 320
Show/Hide
|
C22H20F5N3O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0556396
|
US8969325, 41
Show/Hide
|
C22H21ClFN3O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0450220
|
US8802711, 69
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0480314
|
2-N-(2,6-dichlorophenyl)-5-N-propan-2-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C21H17Cl2F3N6S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0412899
|
1-(1-(3-chlorobenzyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C28H26ClN3O2
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0454368
|
3-[4-(1,1-Dimethyl-propyl)-phenyl]-N-isoquinolin-5-yl-propionamide
Show/Hide
|
C23H26N2O
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0555073
|
2-[2-[2-[(E)-2-[2-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C25H21F3N2O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0557310
|
US8969325, 252
Show/Hide
|
C21H20ClF2N3O2S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0442518
|
US8802711, 51
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0500327
|
US8802711, 13
Show/Hide
|
C22H22FN3O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0556838
|
US8802711, D
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0378967
|
2-N-(2,6-dichlorophenyl)-7-N-[6-(trifluoromethyl)pyridin-3-yl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C17H9Cl2F3N6S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0384341
|
1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)-3-phenylpropyl)urea
Show/Hide
|
C26H25N3O2
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0461759
|
N-[2-(4,7-dihydroxynaphthalen-1-yl)propyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C21H18F3NO4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0536254
|
US8969325, 39
Show/Hide
|
C21H21ClFN3O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0550072
|
US8969325, 64
Show/Hide
|
C21H18F3N3O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0554142
|
US8802711, 56
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0554148
|
US8802711, 94
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0566196
|
US8802711, 103
Show/Hide
|
C20H21FN4O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0399258
|
N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H15F6N5
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0453440
|
1-(3,4-Dichloro-benzyl)-3-(7-hydroxy-naphthalen-1-yl)-urea
Show/Hide
|
C18H14Cl2N2O2
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0472372
|
2-(4-cyclopentylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C30H33F6N7
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0400598
|
US8969325, 66
Show/Hide
|
C24H26FN3O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0400602
|
US8969325, 91
Show/Hide
|
C23H22F3N3O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0506799
|
US8969325, 290
Show/Hide
|
C23H23F4N3O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0521229
|
US8969325, 22
Show/Hide
|
C22H21ClFN3O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0553791
|
US8969325, 154
Show/Hide
|
C22H23FN4O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0445069
|
1-(1-benzyl-5-chloro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C27H24ClN3O
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0886675
|
(R)-1-(7-Fluoro-2,2-dimethylchroman-4-yl)-3-(1H-indazol-4-yl)-urea
Show/Hide
|
C19H19FN4O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0383972
|
US8969325, 150
Show/Hide
|
C22H23F3N4O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0383974
|
US8969325, 155
Show/Hide
|
C23H27FN4O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0550494
|
US8969325, 23
Show/Hide
|
C22H22ClN3O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0530469
|
US8802711, 99
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0495041
|
N-[(2-bromo-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26BrNO3
|
1
|
| 1 |
IC50 = 16.1 nM
|
|
|
|
CP0471367
|
1-(1-benzyl-6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C27H24BrN3O
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0437748
|
3-(3,4-Dichloro-phenyl)-N-(7-hydroxy-naphthalen-1-yl)-propionamide
Show/Hide
|
C19H15Cl2NO2
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
Ki = 4.6 nM
|
|
|
|
CP0539769
|
1-[(4R)-6-fluoro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H20F3N3O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0445774
|
N-[2-[2-[(E)-2-[4-(trifluoromethoxy)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C23H18F3N3O3S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0524445
|
US8969325, 5
Show/Hide
|
C21H22ClFN4O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0556399
|
US8969325, 67
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0556400
|
US8969325, 97
Show/Hide
|
C21H18F3N3O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0562475
|
US8969325, 10
Show/Hide
|
C21H21ClF2N4O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0450006
|
US8802711, 42
Show/Hide
|
C20H19F3N4O
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0536253
|
US8969325, 25
Show/Hide
|
C22H20F3N3O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0550564
|
US8802711, 4
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0501431
|
2-phenyl-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H21F6N5
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0516746
|
US9422293, 42
Show/Hide
|
C29H35F3N6
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0518498
|
US9422293, 48
Show/Hide
|
C26H31F3N6
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0378295
|
1-(2-(4-fluorophenyl)-3-(3-(trifluoromethyl)phenyl)propyl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C26H21F4N3O
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0109255
|
3-isoquinolin-5-yl-1-{2-[3-(trifluoromethyl)phenyl]ethyl}urea
Show/Hide
|
C19H16F3N3O
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
Ki = 41 nM
|
|
|
|
CP0250795
|
3-isoquinolin-5-yl-1-{2-[4-(trifluoromethyl)phenyl]ethyl}urea
Show/Hide
|
C19H16F3N3O
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
Ki = 22 nM
|
|
|
|
CP0459407
|
2-[2-[2-[(E)-2-[4-(trifluoromethylsulfonyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol
Show/Hide
|
C25H21F3N2O3S
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0400557
|
US8969325, 324
Show/Hide
|
C21H18F5N3O4
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0516803
|
US8969325, 92
Show/Hide
|
C23H20F5N3O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0516804
|
US8969325, 94
Show/Hide
|
C22H22FN3O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0521281
|
US8969325, 74
Show/Hide
|
C24H26FN3O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0529236
|
US8969325, 73
Show/Hide
|
C23H22FN3O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0536260
|
US8969325, 83
Show/Hide
|
C20H18FN3O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0495300
|
US9422293, 3
Show/Hide
|
C27H30F3N5
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0371746
|
1-(1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C27H25N3O
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0554989
|
2-[2-[2-[4-(trifluoromethyl)phenyl]ethynyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C22H14F3N3O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0384542
|
AMG 517
Show/Hide
|
C20H13F3N4O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0524447
|
US8969325, 33
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0557311
|
US8969325, 255
Show/Hide
|
C22H22ClF2N3O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0557592
|
US8969325, 68
Show/Hide
|
C24H27N3O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0577809
|
US8969325, 211
Show/Hide
|
C22H20F5N3O4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0553813
|
US8802711, 21
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0559773
|
US8802711, 88
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0406833
|
US9422293, 215
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0413276
|
US9422293, 168
Show/Hide
|
C29H29F3N6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0416066
|
2-methyl-2-(4-(2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanenitrile
Show/Hide
|
C29H32F3N7
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0451528
|
US9422293, 150
Show/Hide
|
C25H19F6N5S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0474816
|
US9422293, 337
Show/Hide
|
C26H25F6N5O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0480856
|
US9422293, 260
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0493143
|
US9422293, 149
Show/Hide
|
C25H19F6N5S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0493153
|
US9422293, 238
Show/Hide
|
C26H24F8N6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0497654
|
2-methyl-2-(4-(2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanenitrile
Show/Hide
|
C28H30F3N7O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0501434
|
N,N-dimethyl-4-[[2-piperidin-1-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]benzenesulfonamide
Show/Hide
|
C27H32F3N7O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0502126
|
2-(4-(2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propan-2-ol
Show/Hide
|
C28H33F3N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0515440
|
2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H24F6N8
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0554997
|
US9422293, 258
Show/Hide
|
C25H23ClF6N6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0565736
|
US9422293, 160
Show/Hide
|
C26H29F3N6S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0563033
|
N-(4-tert-butylphenyl)-3-[7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]propanamide
Show/Hide
|
C28H27ClFN3O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0378968
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H9Cl3F3N5S
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0371747
|
1-(1-(4-cyanobenzyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C29H26N4O2
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0423171
|
3-(4-Chloro-phenyl)-N-(7-hydroxy-naphthalen-1-yl)-propionamide
Show/Hide
|
C19H16ClNO2
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
Ki = 9.8 nM
|
|
|
|
CP0379827
|
(3S)-1-(3-chloropyridin-2-yl)-3-methyl-N-[4-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide
Show/Hide
|
C19H17ClF3N3O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0399873
|
US8969325, 24
Show/Hide
|
C22H22FN3O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0399877
|
US8969325, 48
Show/Hide
|
C23H25F3N4O4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0400558
|
US8969325, 325
Show/Hide
|
C20H19ClFN3O4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0469962
|
US8969325, 321
Show/Hide
|
C20H18ClF2N3O4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0503675
|
US8969325, 15
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0555312
|
US8969325, 27
Show/Hide
|
C22H20F3N3O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0565584
|
US8969325, 257
Show/Hide
|
C22H24FN3O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0536332
|
US8802711, 75
Show/Hide
|
C23H24FN3O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0412905
|
1-(1-(4-bromobenzyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C28H26BrN3O2
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0436461
|
4-[cyclohexyl(methyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C23H25N3O
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0381982
|
1-[(4R)-8-fluoro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H20F3N3O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0445842
|
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(6-fluoro-3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H19ClF3N3O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0537752
|
2-[2-[(E)-2-phenylethenyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C21H17N3O2S
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0549172
|
2-[2-[(E)-2-[4-(trifluoromethylsulfonyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C22H16F3N3O4S2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0520703
|
US8969325, 40
Show/Hide
|
C22H21ClFN3O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0482811
|
2-thiomorpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H24F6N6S
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0473883
|
2-N-(2,6-dimethylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C20H16F3N5S
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0461671
|
N-[(6-hydroxy-9-methyl-1,2,3,4-tetrahydrocarbazol-4-yl)methyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C22H21F3N2O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0520675
|
US8969325, 84
Show/Hide
|
C23H21F4N3O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0555313
|
US8969325, 85
Show/Hide
|
C22H21ClFN3O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0954423
|
2-(piperidin-1-ylmethyl)-N-(quinolin-7-yl)biphenyl-4-carboxamide dihydrobromide
Show/Hide
|
C28H29Br2N3O
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0518260
|
2-(4-cyclobutylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C29H31F6N7
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0484786
|
US8969325, 75
Show/Hide
|
C26H30FN3O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0506937
|
US8969325, 143
Show/Hide
|
C23H27FN4O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0519186
|
2-(azetidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H22F6N6
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0371745
|
1-(1-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C28H27N3O2
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0489334
|
1-[2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]ethanone
Show/Hide
|
C27H26N2O
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0400593
|
US8969325, 26
Show/Hide
|
C22H21F2N3O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0418309
|
US8969325, 3
Show/Hide
|
C21H20ClF3N4O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0520307
|
US8802711, 100
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0471834
|
7-chloro-5-(2-fluorophenyl)-3-(3-oxo-4-phenylbutyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Show/Hide
|
C25H20ClFN2O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0464746
|
1-(7-Hydroxy-naphthalen-1-yl)-3-(3-trifluoromethyl-benzyl)-urea
Show/Hide
|
C19H15F3N2O2
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
Ki = 2.1 nM
|
|
|
|
CP0549171
|
2-[2-(2-phenylethynyl)-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C21H15N3O2S
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0506800
|
US8969325, 291
Show/Hide
|
C22H23ClFN3O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0550492
|
US8969325, 21
Show/Hide
|
C22H19ClF3N3O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0563939
|
US8969325, 292
Show/Hide
|
C22H23F2N3O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0531652
|
US8802711, 45
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0428456
|
1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethoxy-benzyl)-urea
Show/Hide
|
C19H15F3N2O3
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0501432
|
2-N,2-N-dimethyl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C23H22F6N6
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0479191
|
US8969325, 141
Show/Hide
|
C23H28N4O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0536257
|
US8969325, 65
Show/Hide
|
C24H25N3O3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0536262
|
US8969325, 87
Show/Hide
|
C21H18F3N3O4
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0545603
|
US9422293, 52
Show/Hide
|
C22H19F6N5S
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0924650
|
(5-Trifluoromethylpyridin-2-yl)-[7-(3-trifluoromethylpyridin-2-yl)cinnolin-4-yl]amine
Show/Hide
|
C20H11F6N5
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0520673
|
US8969325, 71
Show/Hide
|
C22H20F3N3O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0521273
|
US8969325, 158
Show/Hide
|
C21H24N4O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0536927
|
US8969325, 70
Show/Hide
|
C24H26ClN3O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0490549
|
US8802711, 64
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0518206
|
US8802711, 2
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0958881
|
N-(1-Methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(thiomorpholin-4-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C28H30ClN3O2S
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0480316
|
2-N-(2,6-dichlorophenyl)-5-morpholin-4-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C22H17Cl2F3N6OS
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0559770
|
US8802711, 14
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0400420
|
US9422293, 318
Show/Hide
|
C29H31F6N5O3S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0444922
|
US9422293, 180
Show/Hide
|
C28H30F6N6O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0478109
|
US9422293, 259
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0479616
|
US9422293, 372
Show/Hide
|
C29H35F3N6S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0479620
|
US9422293, 339
Show/Hide
|
C26H25F6N5O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0481140
|
US9422293, 200
Show/Hide
|
C29H36F3N7
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0486373
|
US9422293, 338
Show/Hide
|
C27H27F6N5O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0489526
|
US9422293, 164
Show/Hide
|
C31H38F3N7
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0490167
|
US9422293, 355
Show/Hide
|
C24H23F6N5S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0490933
|
US9422293, 335
Show/Hide
|
C29H33F3N6O4S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0493154
|
US9422293, 239
Show/Hide
|
C27H28F6N6
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0499653
|
US9422293, 319
Show/Hide
|
C26H25F6N5O3S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0561630
|
US9422293, 65B
Show/Hide
|
C26H28F3N7
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0480317
|
2-(4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)phenyl)-2-methylpropanoic acid
Show/Hide
|
C21H17Cl2N5O2S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0383965
|
US8969325, 135
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0550074
|
US8969325, 89
Show/Hide
|
C22H22BrN3O3
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0495311
|
2-(4-isopropylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C28H31F6N7
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 91 nM
|
|
|
|
CP0491441
|
(S)-N-((1r,4S)-4-tert-butylcyclohexyl)-1-oxo-2,3-diphenyl-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C30H39N3O2
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 49 nM
|
|
|
|
CP0440992
|
1-(3,5-Bis-trifluoromethyl-phenyl)-3-isoquinolin-5-yl-urea
Show/Hide
|
C18H11F6N3O
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
Ki = 1.4 nM
|
|
|
|
CP0448971
|
1-Isoquinolin-5-yl-3-(3-trifluoromethyl-phenyl)-urea
Show/Hide
|
C17H12F3N3O
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0406204
|
1-[(4R)-6,8-difluoro-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H21F2N3O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0547708
|
1-[(4R)-2,2-dimethyl-7-(trifluoromethoxy)-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C23H22F3N3O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0506803
|
US8969325, 326
Show/Hide
|
C22H22F3N3O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0521231
|
US8969325, 76
Show/Hide
|
C25H26F3N3O4
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0521241
|
US8969325, 222
Show/Hide
|
C23H26FN3O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0556525
|
US8969325, 236
Show/Hide
|
C20H18F3N3O4
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0564917
|
US8969325, 12
Show/Hide
|
C21H22F2N4O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0530392
|
US8802711, 61
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0457266
|
(R)-6-tert-butyl-2-(2-methyl-4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C22H26F3N5
|
2
|
| 1 |
IC50 = 32.4 nM
|
|
|
| 2 |
IC50 = 1778 nM
|
|
|
|
CP0378970
|
2-N-(2,6-dichlorophenyl)-7-N-(4-methylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H13Cl2N5S
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0548246
|
7-chloro-5-(2-fluorophenyl)-3-(3-oxo-3-thiomorpholin-4-ylpropyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Show/Hide
|
C22H21ClFN3O2S
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0539772
|
1-[(4R)-2,2-diethyl-8-fluoro-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C24H26FN3O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0400594
|
US8969325, 36
Show/Hide
|
C21H20F3N3O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0400607
|
US8969325, 128
Show/Hide
|
C21H19F4N3O4
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0435295
|
(E)-Octadec-9-enal
Show/Hide
|
C18H34O
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0450049
|
US8796328, C
Show/Hide
|
C21H23N3OS
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0418302
|
US8969325, 224
Show/Hide
|
C24H26F3N3O3
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0564920
|
US8969325, 31
Show/Hide
|
C21H20ClF2N3O3
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0566198
|
US8802711, J
Show/Hide
|
C21H23N3OS
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0485362
|
1-(1-(4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C29H29N3O3
|
2
|
| 1 |
IC50 = 36 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0555334
|
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-[3-methyl-7-(trifluoromethyl)isoquinolin-5-yl]urea
Show/Hide
|
C23H19ClF5N3O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0400589
|
US8969325, 2
Show/Hide
|
C21H21ClF2N4O3
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0503677
|
US8969325, 32
Show/Hide
|
C22H22F3N3O3
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0400539
|
US8969325, 223
Show/Hide
|
C23H27N3O3
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0503773
|
US8969325, 4
Show/Hide
|
C21H24N4O3
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0506798
|
US8969325, 240
Show/Hide
|
C19H18FN3O2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0561139
|
US8802711, 55
Show/Hide
|
C20H20N4O
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0542273
|
US9422293, 62
Show/Hide
|
C22H19F6N5O
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0511939
|
N-isoquinolin-5-yl-3-[4-(trifluoromethyl)phenyl]propanamide
Show/Hide
|
C19H15F3N2O
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
Ki = 60 nM
|
|
|
|
CP0383970
|
US8969325, 146
Show/Hide
|
C22H21F5N4O3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0469954
|
US8969325, 247
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0479190
|
US8969325, 138
Show/Hide
|
C20H19F3N4O4
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0553790
|
US8969325, 137
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0555353
|
US8969325, 230
Show/Hide
|
C25H30FN3O3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0492903
|
2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H23F6N7O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0480318
|
2-N-(2,6-dichlorophenyl)-5-N-(2-morpholin-4-ylethyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C24H22Cl2F3N7OS
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0536928
|
US8969325, 93
Show/Hide
|
C23H22F3N3O3
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0539774
|
1-[(4R)-2,2-diethyl-6-fluoro-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C24H26FN3O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0486858
|
2-[2-[(E)-2-(4-ethoxyphenyl)ethenyl]-3H-benzimidazol-5-yl]benzenesulfonamide
Show/Hide
|
C23H21N3O3S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0554995
|
2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]benzamide
Show/Hide
|
C26H25N3O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0413298
|
US9422293, 257
Show/Hide
|
C28H35F3N6O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0444927
|
US9422293, 274
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0474983
|
US9422293, 378
Show/Hide
|
C26H26F6N6O2S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0479621
|
US9422293, 343
Show/Hide
|
C25H25F6N5O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0480871
|
N,N-dimethyl-4-[[2-morpholin-4-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]benzenesulfonamide
Show/Hide
|
C26H30F3N7O3S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0486293
|
US9422293, 334
Show/Hide
|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0494954
|
US9422293, 233
Show/Hide
|
C26H25ClF6N6
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0501436
|
US9422293, 229
Show/Hide
|
C25H25ClF6N6O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0512597
|
US9422293, 166
Show/Hide
|
C26H25F7N6
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0543805
|
US9422293, 272
Show/Hide
|
C25H26F6N6
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0399257
|
2-N-(2,6-dichlorophenyl)-5-N-(2-methoxyethyl)-5-N-methyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C22H19Cl2F3N6OS
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0485733
|
4-tert-butyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C20H20N2O
|
2
|
| 1 |
IC50 = 41 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0501842
|
2-(4-(pentan-3-yl)piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C30H35F6N7
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0550073
|
US8969325, 77
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0455578
|
[3-[[(E)-3-(4-chlorophenyl)prop-2-enoyl]amino]phenyl]boronic acid
Show/Hide
|
C15H13BClNO3
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0479610
|
2-methyl-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C22H19F6N5
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0485750
|
4-butyl-N-(7-hydroxynaphthalen-1-yl)benzamide
Show/Hide
|
C21H21NO2
|
2
|
| 1 |
IC50 = 42 nM
|
|
|
| 2 |
Ki = 29 nM
|
|
|
|
CP0418289
|
US8969325, 160
Show/Hide
|
C20H19F3N4O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0503796
|
US8969325, 6
Show/Hide
|
C21H23ClN4O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0557296
|
US8802711, 48
Show/Hide
|
C19H18N4O
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0451350
|
US9422293, 45
Show/Hide
|
C23H21ClF6N6
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0480315
|
2-N-(2-methylsulfanylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H14F3N5S2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0372595
|
(S)-N-(4-isopropylphenyl)-1-oxo-2,3-diphenyl-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C29H31N3O2
|
2
|
| 1 |
IC50 = 43 nM
|
|
|
| 2 |
IC50 = 81 nM
|
|
|
|
CP0520704
|
US8969325, 45
Show/Hide
|
C24H30N4O4
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0550496
|
US8969325, 102
Show/Hide
|
C22H25N3O4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0557313
|
US8969325, 276
Show/Hide
|
C21H20F3N3O4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0454407
|
1-benzyl-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H16N2O2
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
Ki = 94 nM
|
|
|
|
CP0431483
|
1-Isoquinolin-5-yl-3-(4-methoxy-benzyl)-urea
Show/Hide
|
C18H17N3O2
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
Ki = 193 nM
|
|
|
|
CP0897801
|
(trans)-1-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzoimidazol-5-yl}-phenyl)-ethanol
Show/Hide
|
C24H19F3N2O
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0529235
|
US8969325, 50
Show/Hide
|
C24H29FN4O4
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0506802
|
US8969325, 322
Show/Hide
|
C20H18ClF2N3O4
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0474806
|
US9422293, 102
Show/Hide
|
C32H31F6N7
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0540550
|
3-[7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-N,N-dimethylpropanamide
Show/Hide
|
C20H19ClFN3O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0399889
|
US8969325, 239
Show/Hide
|
C20H18F3N3O3
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0469945
|
US8969325, 157
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0526783
|
2-N-(2,6-dichlorophenyl)-5-N,5-N-diethyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C22H19Cl2F3N6S
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0450182
|
US8969325, 18
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0536330
|
US8802711, 68
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0557589
|
US8969325, 37
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0413282
|
US9422293, 234
Show/Hide
|
C25H25F6N7
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0416064
|
2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H25F6N7
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0445024
|
2-(4-(2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propan-2-ol
Show/Hide
|
C27H31F3N6O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0474817
|
US9422293, 340
Show/Hide
|
C25H23F6N5O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0478111
|
US9422293, 325
Show/Hide
|
C27H27F6N5O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0493152
|
US9422293, 194
Show/Hide
|
C26H27F6N7
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0493392
|
US9422293, 393
Show/Hide
|
C27H28ClF3N6O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0494946
|
US9422293, 336
Show/Hide
|
C28H29F6N5O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0499648
|
US9422293, 268
Show/Hide
|
C27H26F6N6
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0512598
|
2-methyl-2-(4-(2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanoic acid
Show/Hide
|
C29H33F3N6O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0515425
|
US9422293, 380
Show/Hide
|
C26H27F3N6O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0451812
|
N-[(2-chloro-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26ClNO3
|
1
|
| 1 |
IC50 = 50.3 nM
|
|
|
|
CP0474068
|
2-N-(2-methylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H14F3N5S
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0555301
|
(5E,8E,11E,14E)-Icosa-5,8,11,14-tetraenal
Show/Hide
|
C20H32O
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0500192
|
US8969325, 7
Show/Hide
|
C21H22ClFN4O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0472370
|
tert-butyl 3-[methyl-[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]amino]piperidine-1-carboxylate
Show/Hide
|
C32H37F6N7O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0400601
|
US8969325, 81
Show/Hide
|
C22H21F2N3O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0520699
|
US8969325, 13
Show/Hide
|
C21H22F2N4O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0557312
|
US8969325, 274
Show/Hide
|
C22H24FN3O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0565583
|
US8969325, 250
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0505207
|
4-[methyl(pentyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C22H25N3O
|
2
|
| 1 |
IC50 = 54 nM
|
|
|
| 2 |
Ki = 38 nM
|
|
|
|
CP0515024
|
US8796328, 10
Show/Hide
|
C21H21F6N3O4S
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0469960
|
US8969325, 299
Show/Hide
|
C22H23F2N3O3
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0557593
|
US8969325, 72
Show/Hide
|
C22H19F4N3O3
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0565289
|
US8802711, 98
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0418307
|
US8796328, B
Show/Hide
|
C24H21F3N4
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0450187
|
US8969325, 69
Show/Hide
|
C25H26F3N3O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0561107
|
US8969325, 285
Show/Hide
|
C20H20FN3O2
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0556061
|
US8802711, 3
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0550498
|
US8969325, 114
Show/Hide
|
C20H20ClN3O4
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0556395
|
US8969325, 38
Show/Hide
|
C20H20FN3O4
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0563915
|
US8969325, 219
Show/Hide
|
C21H22FN3O3
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0555988
|
US8802711, 36
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0554200
|
US8969325, 314
Show/Hide
|
C22H24F2N4O4
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0464609
|
(R)-2-Methyl-4-(4-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
Show/Hide
|
C18H20F3N5O
|
2
|
| 1 |
IC50 = 57.7 nM
|
|
|
| 2 |
IC50 = 250.7 nM
|
|
|
|
CP0400606
|
US8969325, 126
Show/Hide
|
C20H18F3N3O4
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0553846
|
US8969325, 20
Show/Hide
|
C22H20ClF2N3O3
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0503962
|
US8802711, 95
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0372296
|
5-(azetidin-1-yl)-N2-(2,6-dichlorophenyl)-N7-(4-(trifluoromethyl)phenyl)thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C21H15Cl2F3N6S
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0457532
|
2-N-(2,6-dichlorophenyl)-5-N,5-N-dimethyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C20H15Cl2F3N6S
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0401368
|
N-(4-tert-butylphenyl)-3-oxo-2-phenyl-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C24H29N3O2
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
IC50 = 80 nM
|
|
|
|
CP0412897
|
1-(1-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C29H28N2O3
|
2
|
| 1 |
IC50 = 60 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0539775
|
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(7-fluoro-3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H19ClF3N3O2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0517128
|
US8969325, 215
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0406834
|
US9422293, 216
Show/Hide
|
C27H24F6N6O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0444921
|
US9422293, 175
Show/Hide
|
C30H35F3N6O2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0445022
|
US9422293, 341
Show/Hide
|
C24H23F6N5O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0445125
|
US9422293, 144
Show/Hide
|
C25H19F6N5O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0445127
|
US9422293, 167
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0451529
|
US9422293, 156
Show/Hide
|
C27H29F3N6O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0493149
|
US9422293, 172
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0519702
|
US9422293, 350
Show/Hide
|
C27H21F6N5O2S2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0563914
|
US8969325, 212
Show/Hide
|
C21H20ClF2N3O3
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0413507
|
US9422293, 43B
Show/Hide
|
C22H21F6N7
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0518259
|
N-methyl-N-[1-[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]pyrrolidin-3-yl]acetamide
Show/Hide
|
C28H29F6N7O
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0555356
|
US8969325, 300
Show/Hide
|
C25H27ClF2N4O4
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0465803
|
US9422293, 95B
Show/Hide
|
C25H24F6N6
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0490273
|
2-N-(2,6-dichlorophenyl)-5-piperidin-1-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C23H19Cl2F3N6S
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0412904
|
1-(1-benzyl-6-chloro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C27H24ClN3O
|
2
|
| 1 |
IC50 = 63 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0400600
|
US8969325, 80
Show/Hide
|
C22H21F2N3O3
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0503774
|
US8969325, 14
Show/Hide
|
C21H22ClFN4O3
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0521280
|
US8969325, 58
Show/Hide
|
C23H24F4N4O4
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0524426
|
US8969325, 95
Show/Hide
|
C22H20F3N3O3
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0559774
|
US8802711, 96
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0378971
|
2-N-(2-chlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H11ClF3N5S
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0491522
|
US8802711, 28
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0560294
|
US8802711, 57
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0518511
|
US9422293, 72B
Show/Hide
|
C22H22F3N7O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0377757
|
2-(4-(2-methoxyethyl)piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C28H31F6N7O
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0503678
|
US8969325, 44
Show/Hide
|
C24H29FN4O4
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0536272
|
US8969325, 266
Show/Hide
|
C26H32FN3O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0445131
|
US9422293, 80B
Show/Hide
|
C23H20ClF6N5O
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0436405
|
4-[butyl(methyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C21H23N3O
|
2
|
| 1 |
IC50 = 66 nM
|
|
|
| 2 |
Ki = 83 nM
|
|
|
|
CP0531672
|
US8802711, 49
Show/Hide
|
C19H26N4O
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0550500
|
US8969325, 127
Show/Hide
|
C21H19F4N3O4
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0572422
|
US8969325, 298
Show/Hide
|
C22H22F3N3O3
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0400556
|
US8969325, 308
Show/Hide
|
C20H22N4O4
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0388328
|
3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)benzamide
Show/Hide
|
C19H11Cl2F3N6OS
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0464904
|
US8802711, 97
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0461146
|
N-(4-tert-butylphenyl)-4-(1,1,2,2-tetrafluoroethoxy)benzamide
Show/Hide
|
C19H19F4NO2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0503797
|
US8969325, 17
Show/Hide
|
C19H19ClN4O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0553810
|
US8802711, 5
Show/Hide
|
C21H23N3O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0553811
|
US8802711, 18
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0413509
|
US9422293, 135
Show/Hide
|
C24H26F3N5S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0480870
|
US9422293, 376
Show/Hide
|
C29H33F3N6O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0492557
|
US9422293, 231
Show/Hide
|
C24H21ClF6N6
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0512599
|
US9422293, 373
Show/Hide
|
C29H35F3N6OS
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0515867
|
US9422293, 331
Show/Hide
|
C25H23F6N5O4S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0535991
|
US9422293, 375
Show/Hide
|
C24H23F6N5S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0561264
|
US9422293, 136
Show/Hide
|
C23H23F3N6O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0374502
|
(R)-6-tert-butyl-2-(2-methyl-4-(3-methylpyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C22H29N5
|
2
|
| 1 |
IC50 = 70.4 nM
|
|
|
| 2 |
IC50 = 597 nM
|
|
|
|
CP0553792
|
US8969325, 178
Show/Hide
|
C23H28N4O3
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0851405
|
N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C29H32ClN3O2
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0379168
|
4-(6-Chloro-4-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C20H26ClN5O
|
2
|
| 1 |
IC50 = 72.6 nM
|
|
|
| 2 |
IC50 = 300.7 nM
|
|
|
|
CP0481149
|
US9422293, 59B
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0891807
|
N-(1,3-Benzothiazol-5-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C26H26ClN3OS
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0465749
|
2-N-[2-(trifluoromethyl)phenyl]-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11F6N5S
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0374853
|
3-(4-Chloro-phenyl)-N-isoquinolin-5-yl-propionamide
Show/Hide
|
C18H15ClN2O
|
2
|
| 1 |
IC50 = 74 nM
|
|
|
| 2 |
Ki = 98 nM
|
|
|
|
CP0487703
|
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3,6-dimethylisoquinolin-5-yl)urea
Show/Hide
|
C23H22ClF2N3O2
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0418303
|
US8969325, 229
Show/Hide
|
C23H26FN3O3
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0506834
|
US8802711, 121
Show/Hide
|
C17H19N5OS
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0516745
|
US9422293, 22
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0464120
|
N-[2-(4,7-dihydroxynaphthalen-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H16F3NO4
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0554994
|
N-[2-[2-[(E)-2-(4-chlorophenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C22H18ClN3O2S
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0551288
|
US8969325, 231
Show/Hide
|
C21H19ClF3N3O3
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0565648
|
US8969325, 313
Show/Hide
|
C22H25ClN4O4
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0400554
|
US8969325, 278
Show/Hide
|
C21H20F3N3O4
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0542050
|
US8969325, 251
Show/Hide
|
C19H18ClN3O2
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0516163
|
US8802711, 50
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0531671
|
US8802711, 40
Show/Hide
|
C20H22N4O2
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0932316
|
2-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]pyrido-[3,4-b]pyrazin-5-amine
Show/Hide
|
C19H10F6N6
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0536334
|
US8802711, 92
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0520310
|
US8802711, 86
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0554145
|
US8802711, 72
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0561402
|
US8802711, 16
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0480862
|
US9422293, 145
Show/Hide
|
C28H28F3N5O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0493147
|
US9422293, 163
Show/Hide
|
C29H34F3N7
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0515866
|
US9422293, 328
Show/Hide
|
C30H35F3N6O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0550660
|
US9422293, 345
Show/Hide
|
C23H21F6N5O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0556231
|
US9422293, 143
Show/Hide
|
C27H31F3N6O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0516457
|
N-[1-(7-hydroxynaphthalen-1-yl)propan-2-yl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C21H18F3NO3
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0554443
|
US9422293, 17
Show/Hide
|
C20H16F6N6
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0479609
|
US9422293, 15
Show/Hide
|
C25H28F3N5
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0412903
|
1-(6-fluoro-1-(furan-3-ylmethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C25H22FN3O2
|
2
|
| 1 |
IC50 = 83 nM
|
|
|
| 2 |
Ki = 16 nM
|
|
|
|
CP0532567
|
US8802711, 10
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0559769
|
US8802711, 11
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0485101
|
3-oxo-1,2-diphenyl-N-[4-(trifluoromethyl)phenyl]-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C27H24F3N3O2
|
2
|
| 1 |
IC50 = 85 nM
|
|
|
| 2 |
IC50 = 103 nM
|
|
|
|
CP0557290
|
US8802711, 24
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0378296
|
1-(1-benzyl-7-chloro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C27H24ClN3O
|
2
|
| 1 |
IC50 = 86 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0422077
|
4-[hexyl(methyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C23H27N3O
|
2
|
| 1 |
IC50 = 86 nM
|
|
|
| 2 |
Ki = 70 nM
|
|
|
|
CP0399890
|
US8969325, 242
Show/Hide
|
C22H22FN3O3
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0555352
|
US8969325, 184
Show/Hide
|
C22H23F3N4O3
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0507324
|
US9422293, 94B
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0943158
|
N-(1-ethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C30H34ClN3O2
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0518321
|
US8802711, 46
Show/Hide
|
C20H22N4OS
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0536333
|
US8802711, 89
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0490498
|
1-[2-(3,4-Dichloro-phenyl)-ethyl]-3-(7-hydroxy-naphthalen-1-yl)-urea
Show/Hide
|
C19H16Cl2N2O2
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0536270
|
US8969325, 234
Show/Hide
|
C20H18F3N3O4
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0556132
|
US8969325, 200
Show/Hide
|
C20H19F3N4O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0413480
|
US9422293, 316
Show/Hide
|
C32H39F3N6O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0419411
|
US9422293, 137
Show/Hide
|
C26H30F3N5
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0451357
|
US9422293, 212
Show/Hide
|
C25H24F6N6O2S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0515421
|
US9422293, 67B
Show/Hide
|
C26H30F3N5O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0516342
|
US9422293, 218
Show/Hide
|
C23H23F6N7
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0518487
|
US9422293, 162
Show/Hide
|
C29H35F3N6
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0518499
|
US9422293, 228
Show/Hide
|
C24H25F6N7O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0520517
|
2-(4-(2-isopropyl-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propan-2-ol
Show/Hide
|
C26H30F3N5O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0550735
|
US9422293, 76B
Show/Hide
|
C23H21F6N5O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0474438
|
(R)-6-tert-butyl-2-(4-(3-chloropyridin-2-yl)-2-methylpiperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C21H26ClN5
|
2
|
| 1 |
IC50 = 90.4 nM
|
|
|
| 2 |
IC50 = 104 nM
|
|
|
|
CP0400599
|
US8969325, 78
Show/Hide
|
C21H18F3N3O4
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0529238
|
US8969325, 99
Show/Hide
|
C21H18ClF2N3O3
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0578144
|
US8969325, 177
Show/Hide
|
C23H27FN4O3
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0490552
|
US8802711, 93
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0479175
|
US8969325, 8
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0524448
|
US8969325, 43
Show/Hide
|
C22H25FN4O4
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0529239
|
US8969325, 106
Show/Hide
|
C21H20F3N3O4
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0561106
|
US8969325, 284
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0417566
|
3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)benzonitrile
Show/Hide
|
C19H9Cl2F3N6S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0400603
|
US8969325, 101
Show/Hide
|
C22H24FN3O4
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0521275
|
US8969325, 161
Show/Hide
|
C19H19ClN4O3
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0960406
|
N-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C28H30ClN3O2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0474069
|
2-N-(2,6-dichlorophenyl)-7-N-(4-methylsulfanylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H13Cl2N5S2
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0551601
|
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(3,8-dimethylisoquinolin-5-yl)urea
Show/Hide
|
C23H22ClF2N3O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0553849
|
US8969325, 63
Show/Hide
|
C22H25BrN4O4
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0530470
|
US8802711, 104
Show/Hide
|
C20H21FN4O
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0961919
|
N-(2-oxo-1,2-dihydroquinolin-7-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C28H28ClN3O2
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0400555
|
US8969325, 295
Show/Hide
|
C22H23F3N4O3
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0485363
|
1-(1-allyl-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C23H22FN3O
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0527081
|
2-N-(piperidin-2-ylmethyl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0486863
|
1-(3-Methylpyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide
Show/Hide
|
C19H18F3N3O3S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0400630
|
US8969325, 173
Show/Hide
|
C22H21F5N4O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0536264
|
US8969325, 148
Show/Hide
|
C21H21ClF2N4O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0553794
|
US8969325, 226
Show/Hide
|
C23H25Cl2N3O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0564918
|
US8969325, 16
Show/Hide
|
C22H23F3N4O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0564919
|
US8969325, 29
Show/Hide
|
C20H18ClF2N3O4
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0519043
|
US8802711, 137
Show/Hide
|
C20H21N3O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0568596
|
US8802711, L
Show/Hide
|
C20H19F3N4O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0413275
|
US9422293, 147
Show/Hide
|
C28H28F3N5O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0474985
|
US9422293, 387
Show/Hide
|
C27H29F3N6O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0518488
|
US9422293, 171
Show/Hide
|
C29H29F3N6
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0520871
|
US9422293, 140
Show/Hide
|
C24H22F7N5
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0545595
|
US9422293, 361
Show/Hide
|
C24H23F6N5O2S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0362623
|
1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea
Show/Hide
|
C17H16BrF3N4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0504046
|
3-oxo-1,2-diphenyl-N-(4-propan-2-ylphenyl)-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C29H31N3O2
|
2
|
| 1 |
IC50 = 101 nM
|
|
|
| 2 |
IC50 = 113 nM
|
|
|
|
CP0489378
|
(R)-4-(6-Chloro-4-methyl-pyridazin-3-yl)-2-methyl-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
|
C18H18ClFN6OS
|
2
|
| 1 |
IC50 = 103.3 nM
|
|
|
| 2 |
IC50 = 226.3 nM
|
|
|
|
CP0441933
|
US8796328, 1
Show/Hide
|
C22H28FN3O3S
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0518205
|
US8802711, 1
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0494173
|
US8796328, 9
Show/Hide
|
C21H23F4N3O4S
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0532575
|
US8802711, 90
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0479192
|
US8969325, 142
Show/Hide
|
C23H28N4O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0479196
|
US8969325, 249
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0550506
|
US8969325, 253
Show/Hide
|
C22H24FN3O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0556401
|
US8969325, 103
Show/Hide
|
C23H24F3N3O4
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0416065
|
2-isopropyl-N-(5-(trifluoromethyl)pyrazin-2-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C22H21F6N7
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0445126
|
US9422293, 153
Show/Hide
|
C26H21F6N5S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0474804
|
US9422293, 356
Show/Hide
|
C24H23F6N5OS
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0549197
|
US9422293, 61B
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0469286
|
2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-5,6-dimethyl-1H-benzoimidazole
Show/Hide
|
C19H22ClN5
|
2
|
| 1 |
IC50 = 113 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0442521
|
US8802711, 142
Show/Hide
|
C25H30N4O3
|
1
|
| 1 |
IC50 = 116 nM
|
|
|
|
CP0421869
|
N-(4-tert-butylphenyl)-4-(trifluoromethoxy)benzamide
Show/Hide
|
C18H18F3NO2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0373102
|
4-[heptyl(methyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C24H29N3O
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0566711
|
1-[2-[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]ethanone
Show/Hide
|
C24H17F3N2O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0418293
|
US8969325, 183
Show/Hide
|
C22H21F5N4O4
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0443869
|
US8969325, 117
Show/Hide
|
C20H19F2N3O4
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0506795
|
US8969325, 164
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0536267
|
US8969325, 176
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0536930
|
US8969325, 129
Show/Hide
|
C20H19ClFN3O4
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0550511
|
US8969325, 294
Show/Hide
|
C22H23ClFN3O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0551343
|
US8969325, 149
Show/Hide
|
C22H21F5N4O4
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0553795
|
US8969325, 228
Show/Hide
|
C22H22FN3O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0445132
|
US9422293, 266
Show/Hide
|
C24H25F6N7
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0492904
|
US9422293, 44
Show/Hide
|
C22H21F6N7
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0495309
|
US9422293, 249
Show/Hide
|
C27H31F3N6
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0515426
|
2-methyl-2-(4-(2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanoic acid
Show/Hide
|
C28H31F3N6O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0544273
|
US9422293, 292
Show/Hide
|
C27H34FN5
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0554143
|
US8802711, 63
Show/Hide
|
C19H18N4O
|
1
|
| 1 |
IC50 = 122 nM
|
|
|
|
CP0442514
|
US8802711, 8
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0378973
|
2-N-[4-(aminomethyl)-2,6-dichlorophenyl]-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H13Cl2F3N6S
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0438991
|
N-[(4-hydroxy-3-iodo-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26INO3
|
1
|
| 1 |
IC50 = 126.2 nM
|
|
|
|
CP0505208
|
4-propyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C19H18N2O
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
Ki = 60 nM
|
|
|
|
CP0418291
|
US8969325, 170
Show/Hide
|
C21H21ClF2N4O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0469946
|
US8969325, 162
Show/Hide
|
C22H23ClF2N4O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0469959
|
US8969325, 296
Show/Hide
|
C22H22F3N3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0484816
|
US8969325, 225
Show/Hide
|
C23H26ClN3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0491401
|
US8969325, 254
Show/Hide
|
C22H22ClF2N3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0516806
|
US8969325, 109
Show/Hide
|
C22H24FN3O4
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0521244
|
US8969325, 246
Show/Hide
|
C21H21ClFN3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0536266
|
US8969325, 174
Show/Hide
|
C20H19F3N4O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0550502
|
US8969325, 201
Show/Hide
|
C20H19F3N4O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0551290
|
US8969325, 260
Show/Hide
|
C24H29N3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0551342
|
US8969325, 144
Show/Hide
|
C24H27F3N4O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0563941
|
US8969325, 297
Show/Hide
|
C22H24BrN3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0577818
|
US8969325, 241
Show/Hide
|
C21H21ClFN3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0413278
|
US9422293, 196
Show/Hide
|
C24H25F6N7O
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0444909
|
US9422293, 317
Show/Hide
|
C26H25F6N5O3S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0444924
|
US9422293, 206
Show/Hide
|
C27H31F3N6S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0481139
|
US9422293, 197
Show/Hide
|
C23H21F6N7
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0492921
|
US9422293, 269
Show/Hide
|
C29H32F6N6
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0515415
|
US9422293, 128
Show/Hide
|
C24H22ClF6N5
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0542266
|
US9422293, 385
Show/Hide
|
C27H28F4N6O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0394538
|
2-(4-ethylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 132 nM
|
|
|
|
CP0567293
|
US8802711, 131
Show/Hide
|
C17H16F3N5OS
|
1
|
| 1 |
IC50 = 133 nM
|
|
|
|
CP0445647
|
6-tert-Butyl-2-[4-(3-chloro-pyridin-2-yl)-piperazin-1-yl]-1H-benzoimidazole
Show/Hide
|
C20H24ClN5
|
2
|
| 1 |
IC50 = 136 nM
|
|
|
| 2 |
IC50 = 1688 nM
|
|
|
|
CP0557289
|
US8802711, 23
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 138 nM
|
|
|
|
CP0412388
|
1-(6-fluoro-1-(thiophen-2-ylmethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C25H22FN3OS
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0465883
|
tert-butyl 3-[[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]amino]piperidine-1-carboxylate
Show/Hide
|
C31H35F6N7O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0554987
|
2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenol
Show/Hide
|
C25H24N2O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0578113
|
US8969325, 232
Show/Hide
|
C21H22FN3O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0444913
|
US9422293, 23
Show/Hide
|
C23H22F6N6
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0451456
|
US9422293, 383
Show/Hide
|
C29H35F3N6O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0495310
|
US9422293, 55B
Show/Hide
|
C24H22F6N6
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0959820
|
N-(2-Oxo-2,3-dihydro-1H-indol-6-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C27H28ClN3O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0565290
|
US8802711, 143
Show/Hide
|
C26H32N4O3
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0464121
|
N-[2-(7-hydroxynaphthalen-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H16F3NO3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0407998
|
4-[methyl(nonyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C26H33N3O
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
Ki = 23 nM
|
|
|
|
CP0485735
|
4-hexyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C22H24N2O
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
Ki = 190 nM
|
|
|
|
CP0465881
|
N-[1-[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]pyrrolidin-3-yl]acetamide
Show/Hide
|
C27H27F6N7O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0379347
|
1-[(4R)-8-fluoro-2,2-dipropyl-3,4-dihydrochromen-4-yl]-3-(3-methylisoquinolin-5-yl)urea
Show/Hide
|
C26H30FN3O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0400547
|
US8969325, 237
Show/Hide
|
C23H26FN3O5
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0551294
|
US8969325, 311
Show/Hide
|
C26H33FN4O4
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0555314
|
US8969325, 110
Show/Hide
|
C24H28FN3O4
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0444920
|
US9422293, 170
Show/Hide
|
C25H19F6N7
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0486282
|
US9422293, 54
Show/Hide
|
C27H22F6N6
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0515437
|
US9422293, 173
Show/Hide
|
C26H19ClF6N6
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0542271
|
US9422293, 213
Show/Hide
|
C24H24F6N6O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0550737
|
US9422293, 261
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0549781
|
3-[[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl]-N-(1-methyl-2-oxo-3,4-dihydroquinolin-7-yl)-4-phenylbenzamide;oxalic acid
Show/Hide
|
C32H35N3O7
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0851404
|
N-(1-Methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(morpholin-4-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C28H30ClN3O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0943159
|
2-(piperidin-1-ylmethyl)-N-(quinolin-3-yl)biphenyl-4-carboxamide dihydrochloride
Show/Hide
|
C28H29Cl2N3O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0530399
|
US8802711, 134
Show/Hide
|
C20H21FN4OS
|
1
|
| 1 |
IC50 = 156 nM
|
|
|
|
CP0383968
|
US8969325, 145
Show/Hide
|
C23H27ClN4O3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0539816
|
US8969325, 248
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0377755
|
2-(4-methylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C26H27F6N7
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 367 nM
|
|
|
|
CP0479618
|
US9422293, 322
Show/Hide
|
C26H25F6N5O4S
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0536331
|
US8802711, 73
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 164 nM
|
|
|
|
CP0400595
|
US8969325, 47
Show/Hide
|
C24H29ClN4O4
|
1
|
| 1 |
IC50 = 169 nM
|
|
|
|
CP0557295
|
US8802711, 44
Show/Hide
|
C20H19F3N4O
|
1
|
| 1 |
IC50 = 169 nM
|
|
|
|
CP0478158
|
4-[cyclohexylmethyl(methyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C24H27N3O
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
Ki = 16 nM
|
|
|
|
CP0394348
|
1-(3,4-Dichloro-phenyl)-3-isoquinolin-5-yl-urea
Show/Hide
|
C16H11Cl2N3O
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0506794
|
US8969325, 151
Show/Hide
|
C25H31FN4O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0524397
|
US8969325, 258
Show/Hide
|
C20H21N3O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0524398
|
US8969325, 264
Show/Hide
|
C24H27Cl2N3O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0551344
|
US8969325, 153
Show/Hide
|
C21H20F4N4O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0562478
|
US8969325, 119
Show/Hide
|
C18H16ClN3O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0577810
|
US8969325, 213
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0578114
|
US8969325, 271
Show/Hide
|
C26H32FN3O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0402539
|
2-isopropyl-7-(3-(methylsulfonyl)pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H26F3N5O2S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0474807
|
US9422293, 394
Show/Hide
|
C26H28ClF3N6O
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0499649
|
US9422293, 275
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0515210
|
US9422293, 205
Show/Hide
|
C25H27F3N6S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0399933
|
2-N-(2,6-dichlorophenyl)-7-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C17H11Cl2N5S
|
1
|
| 1 |
IC50 = 176 nM
|
|
|
|
CP0392526
|
4-(4-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C19H25N5O
|
2
|
| 1 |
IC50 = 176.6 nM
|
|
|
| 2 |
IC50 = 2783.7 nM
|
|
|
|
CP0550566
|
US8802711, 15
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 179 nM
|
|
|
|
CP0491403
|
US8969325, 272
Show/Hide
|
C25H28F3N3O4
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0577811
|
US8969325, 214
Show/Hide
|
C21H19F4N3O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0556839
|
US8802711, K
Show/Hide
|
C19H17F3N4O2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0451337
|
US9422293, 342
Show/Hide
|
C27H21F6N5O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0492556
|
US9422293, 50B
Show/Hide
|
C22H22ClF3N6
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0526071
|
US9422293, 271
Show/Hide
|
C26H26F6N6O2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0549196
|
US9422293, 254
Show/Hide
|
C29H38F3N7
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0480319
|
2-N-(2,6-dichlorophenyl)-5-(4-propan-2-ylpiperazin-1-yl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C25H24Cl2F3N7S
|
1
|
| 1 |
IC50 = 184 nM
|
|
|
|
CP0424764
|
1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)-3-(pyridin-3-yl)propyl)urea
Show/Hide
|
C25H24N4O2
|
2
|
| 1 |
IC50 = 184 nM
|
|
|
| 2 |
Ki = 578 nM
|
|
|
|
CP0381456
|
(S)-2-(3-(dimethylamino)pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 185 nM
|
|
|
|
CP0510796
|
4-[methyl(octyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C25H31N3O
|
2
|
| 1 |
IC50 = 190 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0566713
|
N-[2-[2-[(E)-2-(4-methylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C23H21N3O2S
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0400604
|
US8969325, 111
Show/Hide
|
C23H24F3N3O5
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0450166
|
US8969325, 179
Show/Hide
|
C23H28N4O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0484815
|
US8969325, 220
Show/Hide
|
C19H19N3O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0551293
|
US8969325, 310
Show/Hide
|
C26H33FN4O4
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0563910
|
US8969325, 156
Show/Hide
|
C25H31FN4O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0385971
|
(2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
Show/Hide
|
C16H14ClNO2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0499652
|
US9422293, 314
Show/Hide
|
C28H31F3N6O4S
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0512600
|
US9422293, 374
Show/Hide
|
C31H37F3N6OS
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0445068
|
1-(1-benzyl-6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C27H25N3O2
|
2
|
| 1 |
IC50 = 200 nM
|
|
|
| 2 |
Ki = 280 nM
|
|
|
|
CP0513661
|
N-[(6-hydroxy-2,3,4,9-tetrahydro-1H-carbazol-4-yl)methyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C21H19F3N2O3
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0418294
|
US8969325, 189
Show/Hide
|
C23H27FN4O3
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0555107
|
US8969325, 104
Show/Hide
|
C22H24ClN3O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0557594
|
US8969325, 120
Show/Hide
|
C19H16F3N3O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0577820
|
US8969325, 302
Show/Hide
|
C26H29ClF2N4O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0578117
|
US8969325, 312
Show/Hide
|
C22H24ClFN4O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0413467
|
US9422293, 217
Show/Hide
|
C23H21F6N7
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0481137
|
US9422293, 4
Show/Hide
|
C23H21ClF3N5
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0499623
|
US9422293, 46
Show/Hide
|
C22H22BrF3N6
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0516791
|
US9422293, 146
Show/Hide
|
C25H19F6N5O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0550726
|
US9422293, 11
Show/Hide
|
C24H23F6N5O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0550738
|
US9422293, 265
Show/Hide
|
C25H24F6N6O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0959818
|
N-(3-Oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C27H28ClN3O3
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0464123
|
N-[2-(2,6-dichlorophenyl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C16H12Cl2F3NO2
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0485102
|
3-oxo-1,2-diphenyl-N-[5-(trifluoromethyl)pyridin-2-yl]-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C26H23F3N4O2
|
2
|
| 1 |
IC50 = 205 nM
|
|
|
| 2 |
IC50 = 318 nM
|
|
|
|
CP0556062
|
US8802711, 9
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0399259
|
2-N-(2,6-dichlorophenyl)-7-N-[3-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10Cl2F3N5S
|
1
|
| 1 |
IC50 = 206 nM
|
|
|
|
CP0512162
|
US8802711, 12
Show/Hide
|
C21H23N3O2
|
1
|
| 1 |
IC50 = 207 nM
|
|
|
|
CP0566471
|
US8796328, 14
Show/Hide
|
C22H27ClFN3O4S
|
1
|
| 1 |
IC50 = 209 nM
|
|
|
|
CP0552999
|
N-(2,3-dihydro-1H-inden-5-yl)-4-(trifluoromethoxy)benzamide
Show/Hide
|
C17H14F3NO2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0549187
|
2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]aniline
Show/Hide
|
C25H25N3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0551292
|
US8969325, 273
Show/Hide
|
C22H21ClF3N3O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0557307
|
US8969325, 185
Show/Hide
|
C25H31FN4O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0563911
|
US8969325, 181
Show/Hide
|
C23H27ClN4O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0572407
|
US8969325, 172
Show/Hide
|
C21H22ClFN4O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0477022
|
US9422293, 326
Show/Hide
|
C28H29F6N5O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0490555
|
US8802711, 102
Show/Hide
|
C20H21FN4O
|
1
|
| 1 |
IC50 = 218 nM
|
|
|
|
CP0371854
|
N-(4-tert-butylphenyl)-4-(trifluoromethyl)benzamide
Show/Hide
|
C18H18F3NO
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0486815
|
4-(trifluoromethoxy)-N-(4-(trifluoromethyl)phenyl)benzamide
Show/Hide
|
C15H9F6NO2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0491399
|
US8969325, 163
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0542051
|
US8969325, 270
Show/Hide
|
C24H28FN3O3
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0550503
|
US8969325, 202
Show/Hide
|
C19H19FN4O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0561105
|
US8969325, 261
Show/Hide
|
C25H28F3N3O3
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0565581
|
US8969325, 216
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0578112
|
US8969325, 227
Show/Hide
|
C25H30FN3O3
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0555951
|
US9422293, 312
Show/Hide
|
C27H27F6N5O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0530419
|
US8802711, 43
Show/Hide
|
C20H19F3N4O
|
1
|
| 1 |
IC50 = 221 nM
|
|
|
|
CP0378972
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-methylsulfanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11Cl3F3N5S2
|
1
|
| 1 |
IC50 = 224 nM
|
|
|
|
CP0429578
|
1-Isoquinolin-5-yl-3-(4-trifluoromethyl-phenyl)-urea
Show/Hide
|
C17H12F3N3O
|
2
|
| 1 |
IC50 = 225 nM
|
|
|
| 2 |
Ki = 160 nM
|
|
|
|
CP0532825
|
(S)-1-oxo-2,3-diphenyl-N-(4-(2-phenylpropan-2-yl)phenyl)-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C35H35N3O2
|
1
|
| 1 |
IC50 = 226 nM
|
|
|
|
CP0412389
|
1-(1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C29H29N3O3
|
2
|
| 1 |
IC50 = 230 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0407959
|
4-butyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C20H20N2O
|
2
|
| 1 |
IC50 = 230 nM
|
|
|
| 2 |
Ki = 53 nM
|
|
|
|
CP0550509
|
US8969325, 289
Show/Hide
|
C23H23F4N3O3
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0563846
|
US8969325, 180
Show/Hide
|
C24H27F3N4O3
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0565647
|
US8969325, 304
Show/Hide
|
C24H27ClF2N4O4
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0445129
|
US9422293, 179
Show/Hide
|
C26H27F6N5O
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0480869
|
US9422293, 366
Show/Hide
|
C25H25F6N5S
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0504045
|
(S)-N-((1s,4R)-4-tert-butylcyclohexyl)-1-oxo-2,3-diphenyl-2,7-diazaspiro[3.5]nonane-7-carboxamide
Show/Hide
|
C30H39N3O2
|
2
|
| 1 |
IC50 = 232 nM
|
|
|
| 2 |
IC50 = 528 nM
|
|
|
|
CP0465750
|
2-N-(2-methylsulfonylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H14F3N5O2S2
|
1
|
| 1 |
IC50 = 234 nM
|
|
|
|
CP0515177
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-(3-pentylphenyl)acetamide
Show/Hide
|
C23H28N2O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0445773
|
N-[2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C24H24N4O2S
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0516805
|
US8969325, 108
Show/Hide
|
C21H20FN3O4
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0521279
|
US8969325, 206
Show/Hide
|
C22H22F4N4O3
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0539865
|
US9422293, 188
Show/Hide
|
C23H21ClF6N6
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0394540
|
(R)-2-(3-(dimethylamino)pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 243 nM
|
|
|
|
CP0506832
|
US8802711, 87
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 248 nM
|
|
|
|
CP0465884
|
tert-butyl 2-[[[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]amino]methyl]piperidine-1-carboxylate
Show/Hide
|
C32H37F6N7O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0445775
|
N-[2-[2-[(E)-2-(3,4-difluorophenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C22H17F2N3O2S
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0520674
|
US8969325, 82
Show/Hide
|
C20H18FN3O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0494957
|
US9422293, 248
Show/Hide
|
C28H33F3N6
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0431262
|
N-[(3-bromo-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26BrNO3
|
1
|
| 1 |
IC50 = 251.6 nM
|
|
|
|
CP0522349
|
N-(4-tert-butylphenyl)-4-(trifluoromethylsulfanyl)benzamide
Show/Hide
|
C18H18F3NOS
|
1
|
| 1 |
IC50 = 253 nM
|
|
|
|
CP0494176
|
US8796328, 37
Show/Hide
|
C21H22F5N3O4S
|
1
|
| 1 |
IC50 = 256 nM
|
|
|
|
CP0480146
|
4-tert-butylphenyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C21H24F3N3O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0399879
|
US8969325, 54
Show/Hide
|
C21H21F3N4O4
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0536259
|
US8969325, 79
Show/Hide
|
C24H26FN3O5
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0556381
|
US8969325, 286
Show/Hide
|
C23H24FN3O3
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0477023
|
US9422293, 327
Show/Hide
|
C24H24F6N6O
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0079298
|
(5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide
Show/Hide
|
C30H42N2O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0469949
|
US8969325, 193
Show/Hide
|
C21H24N4O3
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0521245
|
US8969325, 293
Show/Hide
|
C22H23F2N3O3
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0572451
|
US9422293, 291
Show/Hide
|
C24H22F6N6O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0388486
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-methylsulfonyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11Cl3F3N5O2S2
|
1
|
| 1 |
IC50 = 274 nM
|
|
|
|
CP0509499
|
4-(4-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid biphenyl-4-ylamide
Show/Hide
|
C22H23N5O
|
2
|
| 1 |
IC50 = 279 nM
|
|
|
| 2 |
IC50 = 5727.7 nM
|
|
|
|
CP0371855
|
N-(4-iodophenyl)-4-(trifluoromethoxy)benzamide
Show/Hide
|
C14H9F3INO2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0416652
|
tert-butyl N-[2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]carbamate
Show/Hide
|
C30H33N3O2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0521276
|
US8969325, 192
Show/Hide
|
C21H20ClF3N4O3
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0553798
|
US8969325, 245
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0556521
|
US8969325, 195
Show/Hide
|
C20H19F3N4O4
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0444903
|
US9422293, 310
Show/Hide
|
C27H27F6N5O
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0445128
|
US9422293, 169
Show/Hide
|
C26H19ClF6N6
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0474957
|
US9422293, 221
Show/Hide
|
C26H26ClF6N7
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0492954
|
US9422293, 96
Show/Hide
|
C25H26F3N5O
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0442515
|
US8802711, 22
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 286 nM
|
|
|
|
CP0563912
|
US8969325, 188
Show/Hide
|
C22H23FN4O3
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0563913
|
US8969325, 209
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0565573
|
US8802711, 47
Show/Hide
|
C21H25N5O
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0493146
|
US9422293, 161
Show/Hide
|
C27H31F3N6
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0442517
|
US8802711, 35
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 292 nM
|
|
|
|
CP0565306
|
3-[7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-N,N-diethylpropanamide
Show/Hide
|
C22H23ClFN3O2
|
1
|
| 1 |
IC50 = 297 nM
|
|
|
|
CP0566712
|
N-[2-[2-[(E)-2-[4-(2,2,2-trifluoroethoxy)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]methanesulfonamide
Show/Hide
|
C24H20F3N3O3S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0529233
|
US8969325, 9
Show/Hide
|
C21H22F2N4O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0487180
|
5-tert-Butyl-2-[(R)-4-(3-chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-benzooxazole
Show/Hide
|
C21H25ClN4O
|
2
|
| 1 |
IC50 = 305 nM
|
|
|
| 2 |
IC50 = 1409 nM
|
|
|
|
CP0536462
|
7-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)-pyridin-2-yl]-1,5-naphthyridin-4-amine
Show/Hide
|
C20H11F6N5
|
1
|
| 1 |
IC50 = 308 nM
|
|
|
|
CP0562476
|
US8969325, 100
Show/Hide
|
C20H20FN3O4
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0451537
|
US9422293, 243
Show/Hide
|
C25H22F8N6
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0515422
|
US9422293, 282
Show/Hide
|
C23H25F3N6O2S
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0491523
|
US8802711, 41
Show/Hide
|
C20H19F3N4O
|
1
|
| 1 |
IC50 = 311 nM
|
|
|
|
CP0507583
|
4-Chloro-N-(7-hydroxy-naphthalen-1-yl)-benzamide
Show/Hide
|
C17H12ClNO2
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0456430
|
N-[6-(dimethylamino)pyridin-3-yl]-4-phenyl-3-(piperidin-1-ylmethyl)benzamide
Show/Hide
|
C26H30N4O
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0891806
|
N-(1-methyl-1,2,3,4-tetrahydroquinolin-7-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide oxalate
Show/Hide
|
C31H35N3O5
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0530397
|
US8802711, 132
Show/Hide
|
C20H21FN4OS
|
1
|
| 1 |
IC50 = 324 nM
|
|
|
|
CP0491994
|
6-Chloro-2-[(R)-4-(3-chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-1H-benzoimidazole
Show/Hide
|
C17H17Cl2N5
|
1
|
| 1 |
IC50 = 325 nM
|
|
|
|
CP0555399
|
US8796328, 5
Show/Hide
|
C19H19F4N3O3S
|
1
|
| 1 |
IC50 = 325 nM
|
|
|
|
CP0436330
|
N-(4-iodophenyl)-4-(trifluoromethyl)benzamide
Show/Hide
|
C14H9F3INO
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0555348
|
US8796328, 8
Show/Hide
|
C22H26Cl2FN3O4S
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0450206
|
US8969325, 125
Show/Hide
|
C20H18F3N3O4
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0469950
|
US8969325, 207
Show/Hide
|
C21H22F2N4O3
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0557590
|
US8969325, 51
Show/Hide
|
C22H25FN4O4
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0444910
|
US9422293, 321
Show/Hide
|
C29H33F3N6O
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0560295
|
US8802711, 60
Show/Hide
|
C20H22N2O2
|
1
|
| 1 |
IC50 = 331 nM
|
|
|
|
CP0490551
|
US8802711, 91
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 338 nM
|
|
|
|
CP0451538
|
US9422293, 58B
Show/Hide
|
C28H31F6N7
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0512607
|
US9422293, 308
Show/Hide
|
C27H27F6N5O3S
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0450057
|
US8796328, 38
Show/Hide
|
C21H22F5N3O4S
|
1
|
| 1 |
IC50 = 345 nM
|
|
|
|
CP0412900
|
1-(1-(cyclopropylmethyl)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C24H24FN3O
|
2
|
| 1 |
IC50 = 350 nM
|
|
|
| 2 |
Ki = 0.8 nM
|
|
|
|
CP0381980
|
1-[(4R)-7-chloro-2,2-bis(fluoromethyl)-3,4-dihydrochromen-4-yl]-3-(6-chloro-3-methylisoquinolin-5-yl)urea
Show/Hide
|
C22H19Cl2F2N3O2
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0521243
|
US8969325, 233
Show/Hide
|
C21H21ClFN3O3
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0554196
|
US8969325, 198
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0959815
|
N-(3-methoxyphenyl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamidehydrochloride
Show/Hide
|
C26H29ClN2O2
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0471872
|
3-[7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-N,N-dipropylpropanamide
Show/Hide
|
C24H27ClFN3O2
|
1
|
| 1 |
IC50 = 352 nM
|
|
|
|
CP0394961
|
N-[(3-ethyl-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C19H31NO3
|
1
|
| 1 |
IC50 = 355.3 nM
|
|
|
|
CP0509005
|
US8796328, 23
Show/Hide
|
C20H22ClF2N3O4S
|
1
|
| 1 |
IC50 = 358 nM
|
|
|
|
CP0412898
|
1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C29H24F4N2O2
|
2
|
| 1 |
IC50 = 360 nM
|
|
|
| 2 |
Ki = 22 nM
|
|
|
|
CP0521233
|
US8969325, 131
Show/Hide
|
C20H19F2N3O4
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0490937
|
US9422293, 19
Show/Hide
|
C23H20F6N6
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0515017
|
US8802711, 111
Show/Hide
|
C21H24N2O
|
1
|
| 1 |
IC50 = 362 nM
|
|
|
|
CP0556397
|
US8969325, 46
Show/Hide
|
C25H29F3N4O4
|
1
|
| 1 |
IC50 = 367 nM
|
|
|
|
CP0516459
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-phenylbenzamide
Show/Hide
|
C24H22N2O2
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0515199
|
US9422293, 103
Show/Hide
|
C25H26F3N5O2
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0518514
|
US9422293, 86
Show/Hide
|
C23H25F3N6
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0512163
|
US8802711, 17
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
IC50 = 373 nM
|
|
|
|
CP0436329
|
5-bromo-2-(4-(1,1,2,2-tetrafluoroethoxy)phenyl)-1H-benzo[d]imidazole
Show/Hide
|
C15H9BrF4N2O
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0484812
|
US8969325, 182
Show/Hide
|
C23H26Cl2N4O3
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0553848
|
US8969325, 57
Show/Hide
|
C22H25FN4O4
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0563936
|
US8969325, 267
Show/Hide
|
C22H22F3N3O3
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0444926
|
US9422293, 270
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0499650
|
US9422293, 279
Show/Hide
|
C28H24F6N6
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0498465
|
N-[(3-ethenyl-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C19H29NO3
|
1
|
| 1 |
IC50 = 389.6 nM
|
|
|
|
CP0427748
|
4-[methyl(propyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C20H21N3O
|
2
|
| 1 |
IC50 = 390 nM
|
|
|
| 2 |
Ki = 267 nM
|
|
|
|
CP0469956
|
US8969325, 256
Show/Hide
|
C23H24F3N3O3
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0492902
|
US9422293, 31
Show/Hide
|
C23H27ClN6
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0494952
|
US9422293, 199
Show/Hide
|
C27H33F3N6
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0515209
|
US9422293, 174
Show/Hide
|
C28H32F3N5O2
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0436323
|
N-[2-(5-methoxy-1H-indol-3-yl)propyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H19F3N2O3
|
2
|
| 1 |
IC50 = 400 nM
|
|
|
| 2 |
Kd = 144.54 nM
|
|
|
|
CP0445776
|
N-[2-[2-[(E)-2-(4-tert-butylphenyl)ethenyl]-3H-benzimidazol-5-yl]phenyl]acetamide
Show/Hide
|
C27H27N3O
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0506797
|
US8969325, 205
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0524427
|
US8969325, 107
Show/Hide
|
C24H28FN3O4
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0500329
|
US8802711, 129
Show/Hide
|
C17H16F3N5OS
|
1
|
| 1 |
IC50 = 404 nM
|
|
|
|
CP0404300
|
3-(4-tert-Butyl-phenyl)-N-isoquinolin-5-yl-propionamide
Show/Hide
|
C22H24N2O
|
2
|
| 1 |
IC50 = 410 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0561373
|
US8969325, 282
Show/Hide
|
C20H20FN3O3
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0480860
|
US9422293, 37
Show/Hide
|
C26H28N6
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0501443
|
US9422293, 290
Show/Hide
|
C27H31F3N6O2
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0450135
|
US8796328, 13
Show/Hide
|
C22H27F2N3O4S
|
1
|
| 1 |
IC50 = 418 nM
|
|
|
|
CP0474958
|
US9422293, 296
Show/Hide
|
C28H37N5O2S
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0488609
|
US9422293, 141
Show/Hide
|
C26H28F3N5
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0488615
|
US9422293, 66B
Show/Hide
|
C30H37F3N6
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0557293
|
US8802711, 37
Show/Hide
|
C23H28N4O
|
1
|
| 1 |
IC50 = 427 nM
|
|
|
|
CP0504976
|
JMC506554 Compound 1m
Show/Hide
|
C24H22N2O2
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0556524
|
US8969325, 217
Show/Hide
|
C21H20ClF2N3O3
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0545522
|
US9422293, 264
Show/Hide
|
C28H33F3N6O
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0557099
|
US8802711, 59
Show/Hide
|
C20H22N2O2
|
1
|
| 1 |
IC50 = 435 nM
|
|
|
|
CP0484819
|
US8969325, 306
Show/Hide
|
C25H29ClF2N4O4
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0500127
|
US8969325, 112
Show/Hide
|
C20H21N3O4
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0413287
|
US9422293, 63B
Show/Hide
|
C22H21Cl2F3N6
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0536269
|
US8969325, 191
Show/Hide
|
C24H27F3N4O4
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0556131
|
US8969325, 190
Show/Hide
|
C25H31FN4O3
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0413296
|
US9422293, 109
Show/Hide
|
C23H22Cl2F3N5
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0416067
|
4-(2-isopropyl-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)-N,N-dimethylbenzenesulfonamide
Show/Hide
|
C25H29F3N6O2S
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0474959
|
US9422293, 297
Show/Hide
|
C27H31F3N6O2S
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0495320
|
2-(2-(piperidin-1-yl)-4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)pyridine-3-sulfonamide
Show/Hide
|
C25H28F3N7O2S
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0429316
|
7-chloro-5-(2-fluorophenyl)-3-[3-oxo-3-(4-phenylpiperazin-1-yl)propyl]-1,3-dihydro-1,4-benzodiazepin-2-one
Show/Hide
|
C28H26ClFN4O2
|
1
|
| 1 |
IC50 = 458 nM
|
|
|
|
CP0939981
|
(5-Trifluoromethylpyridin-2-yl)[2-(3-trifluoromethylpyridin-2-yl)[1,7]naphthyridin-5-yl]amine
Show/Hide
|
C20H11F6N5
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0400553
|
US8969325, 262
Show/Hide
|
C24H28ClN3O3
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0550497
|
US8969325, 105
Show/Hide
|
C22H23Cl2N3O4
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0518766
|
US9422293, 13
Show/Hide
|
C25H27ClF3N5
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0557845
|
3-[3-(4-benzoylpiperazin-1-yl)-3-oxopropyl]-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Show/Hide
|
C29H26ClFN4O3
|
1
|
| 1 |
IC50 = 461 nM
|
|
|
|
CP0535635
|
US8796328, 19
Show/Hide
|
C23H27F4N3O5S
|
1
|
| 1 |
IC50 = 466 nM
|
|
|
|
CP0515179
|
(9Z,12Z,15Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadeca-9,12,15-trienamide
Show/Hide
|
C28H40N2O2
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0556129
|
US8969325, 152
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0413294
|
US9422293, 104
Show/Hide
|
C24H23F6N5S
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0553427
|
US9422293, 133
Show/Hide
|
C28H33F3N6
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0563437
|
US9422293, 252
Show/Hide
|
C29H36F3N7
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0953887
|
N-(1H-Indazol-5-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide dihydrochloride
Show/Hide
|
C26H28Cl2N4O
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0382521
|
2-N-(pyridin-2-ylmethyl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H23F6N7
|
1
|
| 1 |
IC50 = 476 nM
|
|
|
|
CP0421865
|
5-tert-butyl-2-(4-(1,1,2,2-tetrafluoroethoxy)phenyl)-1H-benzo[d]imidazole
Show/Hide
|
C19H18F4N2O
|
1
|
| 1 |
IC50 = 477 nM
|
|
|
|
CP0480145
|
4-tert-butylphenyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C20H24ClN3O2
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0493142
|
US9422293, 148
Show/Hide
|
C23H22F3N7S
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0943157
|
N-(1H-Benzimidazol-5-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide dihydrochloride
Show/Hide
|
C26H28Cl2N4O
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0522346
|
N-[(6-methoxy-9-methyl-1,2,3,4-tetrahydrocarbazol-4-yl)methyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C23H23F3N2O3
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0437136
|
1-(4-Butyl-phenyl)-3-isoquinolin-5-yl-urea
Show/Hide
|
C20H21N3O
|
2
|
| 1 |
IC50 = 490 nM
|
|
|
| 2 |
Ki = 330 nM
|
|
|
|
CP0465882
|
2-(4-(4-(4-(trifluoromethyl)phenylamino)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-2-yl)piperazin-1-yl)ethanol
Show/Hide
|
C27H29F6N7O
|
1
|
| 1 |
IC50 = 498 nM
|
|
|
|
CP0557294
|
US8802711, 38
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
IC50 = 499 nM
|
|
|
|
CP0484817
|
US8969325, 263
Show/Hide
|
C23H22F5N3O3
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0465801
|
US9422293, 53
Show/Hide
|
C22H19F6N5O2S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0479615
|
US9422293, 349
Show/Hide
|
C27H21F6N5S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0397141
|
2-N-(2,6-dichlorophenyl)-2-N-methyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H12Cl2F3N5S
|
1
|
| 1 |
IC50 = 502 nM
|
|
|
|
CP0530398
|
US8802711, 133
Show/Hide
|
C20H21FN4OS
|
1
|
| 1 |
IC50 = 507 nM
|
|
|
|
CP0399876
|
US8969325, 42
Show/Hide
|
C22H25FN4O4
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0469958
|
US8969325, 279
Show/Hide
|
C24H28FN3O5
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0555354
|
US8969325, 238
Show/Hide
|
C20H18F3N3O3
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0490969
|
7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C20H17ClF3N5
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0494953
|
US9422293, 207
Show/Hide
|
C25H28F3N5O2S
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0386790
|
N-(1-methyl-2-oxo-3,4-dihydroquinolin-7-yl)-3-[[(2R)-2-methylpyrrolidin-1-yl]methyl]-4-phenylbenzamide;hydrochloride
Show/Hide
|
C29H32ClN3O2
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0517235
|
US9422293, 125
Show/Hide
|
C25H26Cl2F3N5
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0520868
|
US9422293, 12
Show/Hide
|
C25H27F4N5
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0954424
|
N-(3-hydroxyphenyl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C25H27ClN2O2
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0399360
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C24H13Cl3F3N5S
|
1
|
| 1 |
IC50 = 539 nM
|
|
|
|
CP0563937
|
US8969325, 269
Show/Hide
|
C23H24FN3O3
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0481138
|
US9422293, 176
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0500328
|
US8802711, 26
Show/Hide
|
C21H23N3O2
|
1
|
| 1 |
IC50 = 544 nM
|
|
|
|
CP0464122
|
N-[2-(5-hydroxy-1H-indol-3-yl)propyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C19H17F3N2O3
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0518515
|
US9422293, 97
Show/Hide
|
C24H23F3N6
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0479619
|
US9422293, 323
Show/Hide
|
C28H31F3N6O2
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0482793
|
US9422293, 201
Show/Hide
|
C27H33F3N6
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0565732
|
US9422293, 262
Show/Hide
|
C25H25F6N7O
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0570767
|
4-(2,3-dichlorophenyl)-N-(1H-indazol-4-yl)piperazine-1-carboxamide
Show/Hide
|
C18H17Cl2N5O
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0413479
|
US9422293, 273
Show/Hide
|
C27H28F6N6O2
|
1
|
| 1 |
IC50 = 570 nM
|
|
|
|
CP0497600
|
US9422293, 129
Show/Hide
|
C27H29F3N6
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0891805
|
N-(2-Oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C26H26ClN3O3
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0494175
|
US8796328, 36
Show/Hide
|
C20H21F4N3O4S
|
1
|
| 1 |
IC50 = 587 nM
|
|
|
|
CP0536274
|
US8969325, 318
Show/Hide
|
C22H24F2N4O4
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0506801
|
US8969325, 317
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0521274
|
US8969325, 159
Show/Hide
|
C19H19FN4O3
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0556128
|
US8969325, 147
Show/Hide
|
C23H26Cl2N4O3
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0482791
|
US9422293, 190
Show/Hide
|
C25H19F6N7
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0519051
|
US8796328, 25
Show/Hide
|
C20H23ClFN3O4S
|
1
|
| 1 |
IC50 = 602 nM
|
|
|
|
CP0554199
|
US8969325, 303
Show/Hide
|
C26H31FN4O4
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0474960
|
US9422293, 306
Show/Hide
|
C22H21ClF3N5OS
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0442522
|
US8802711, 145
Show/Hide
|
C21H25N3O2
|
1
|
| 1 |
IC50 = 614 nM
|
|
|
|
CP0515010
|
US8796328, 39
Show/Hide
|
C20H22ClF2N3O4S
|
1
|
| 1 |
IC50 = 615 nM
|
|
|
|
CP0479734
|
US9422293, 83
Show/Hide
|
C24H27F3N6
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0488612
|
US9422293, 152
Show/Hide
|
C27H31F3N6O2S
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0493144
|
US9422293, 155
Show/Hide
|
C24H22F7N5
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0471871
|
N,N-dibutyl-3-[7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]propanamide
Show/Hide
|
C26H31ClFN3O2
|
1
|
| 1 |
IC50 = 621 nM
|
|
|
|
CP0464902
|
US8802711, 25
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
IC50 = 628 nM
|
|
|
|
CP0465798
|
US9422293, 124
Show/Hide
|
C25H27ClF3N5
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0480866
|
US9422293, 359
Show/Hide
|
C28H23F6N5O2S2
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0526072
|
US9422293, 278
Show/Hide
|
C28H24F6N6
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0550725
|
US9422293, 10
Show/Hide
|
C24H23F6N5
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0451813
|
N-[(3-chloro-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26ClNO3
|
1
|
| 1 |
IC50 = 631 nM
|
|
|
|
CP0413280
|
US9422293, 220
Show/Hide
|
C25H26F6N8
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0480867
|
US9422293, 360
Show/Hide
|
C27H27F6N5O2S2
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0529403
|
US9422293, 118
Show/Hide
|
C25H27F4N5
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0491526
|
US8802711, 115
Show/Hide
|
C22H25FN4O3
|
1
|
| 1 |
IC50 = 653 nM
|
|
|
|
CP0484818
|
US8969325, 265
Show/Hide
|
C23H24F3N3O3
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0478050
|
US9422293, 77B
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0494629
|
2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-methoxy-1H-benzoimidazole
Show/Hide
|
C18H20ClN5O
|
1
|
| 1 |
IC50 = 665 nM
|
|
|
|
CP0514880
|
(4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyridin-2-yl)-pyrimido[4,5-d]pyrimidin-4-yl]amine
Show/Hide
|
C19H10F6N6
|
1
|
| 1 |
IC50 = 665 nM
|
|
|
|
CP0489287
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-9-phenylnonanamide
Show/Hide
|
C25H32N2O2
|
1
|
| 1 |
IC50 = 680 nM
|
|
|
|
CP0372297
|
2-N-(2,6-dichlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[4,5-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10Cl2F3N5S
|
1
|
| 1 |
IC50 = 680 nM
|
|
|
|
CP0434501
|
1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)propyl)urea
Show/Hide
|
C20H21N3O2
|
2
|
| 1 |
IC50 = 680 nM
|
|
|
| 2 |
Ki = 1290 nM
|
|
|
|
CP0451311
|
1-Isoquinolin-5-yl-3-[2-(4-methoxy-phenyl)-ethyl]-urea
Show/Hide
|
C19H19N3O2
|
2
|
| 1 |
IC50 = 680 nM
|
|
|
| 2 |
Ki = 1290 nM
|
|
|
|
CP0472000
|
3-[7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-N,N-di(propan-2-yl)propanamide
Show/Hide
|
C24H27ClFN3O2
|
1
|
| 1 |
IC50 = 684 nM
|
|
|
|
CP0486285
|
US9422293, 78B
Show/Hide
|
C23H22F3N7
|
1
|
| 1 |
IC50 = 690 nM
|
|
|
|
CP0551310
|
US8969325, 56
Show/Hide
|
C23H25FN4O4
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0493150
|
US9422293, 181
Show/Hide
|
C27H32F3N5O
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0517232
|
US9422293, 29
Show/Hide
|
C23H19F3N6
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0904953
|
N-[3-(Dimethylamino)phenyl]-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamidehydrochloride
Show/Hide
|
C27H32ClN3O
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0464767
|
3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1-(3-phenylphenyl)urea
Show/Hide
|
C23H21N3O2
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0491528
|
US8802711, 119
Show/Hide
|
C17H19N5OS
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0471218
|
US8802711, 130
Show/Hide
|
C17H16F3N5OS
|
1
|
| 1 |
IC50 = 721 nM
|
|
|
|
CP0485008
|
2-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-5,6-dimethyl-1H-benzoimidazole
Show/Hide
|
C18H20ClN5
|
2
|
| 1 |
IC50 = 726 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0464217
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]dodecanamide
Show/Hide
|
C22H34N2O2
|
1
|
| 1 |
IC50 = 740 nM
|
|
|
|
CP0454105
|
N-[1-(6-hydroxyquinolin-4-yl)propan-2-yl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H17F3N2O3
|
1
|
| 1 |
IC50 = 740 nM
|
|
|
|
CP0492610
|
US8796328, 7
Show/Hide
|
C20H23F2N3O4S
|
1
|
| 1 |
IC50 = 747 nM
|
|
|
|
CP0379653
|
N-(4-tert-butylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
IC50 = 750 nM
|
|
|
|
CP0385972
|
[4-[(4-tert-butylphenyl)carbamoyl]phenyl]boronic acid
Show/Hide
|
C17H20BNO3
|
1
|
| 1 |
IC50 = 750 nM
|
|
|
|
CP0427901
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]undecanamide
Show/Hide
|
C21H32N2O2
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
|
CP0484813
|
US8969325, 187
Show/Hide
|
C21H20F4N4O3
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
|
CP0398602
|
2-(3,4-Dichloro-phenyl)-N-(7-hydroxy-naphthalen-1-yl)-acetamide
Show/Hide
|
C18H13Cl2NO2
|
2
|
| 1 |
IC50 = 770 nM
|
|
|
| 2 |
Ki = 1830 nM
|
|
|
|
CP0443868
|
US8969325, 113
Show/Hide
|
C20H20FN3O4
|
1
|
| 1 |
IC50 = 770 nM
|
|
|
|
CP0510746
|
N-[2-(2-chlorophenyl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C16H13ClF3NO2
|
1
|
| 1 |
IC50 = 776 nM
|
|
|
|
CP0446681
|
6-tert-Butyl-2-[(R)-4-(4-chloro-[1,2,5]thiadiazol-3-yl)-2-methyl-piperazin-1-yl]-1H-benzoimidazole
Show/Hide
|
C18H23ClN6S
|
2
|
| 1 |
IC50 = 776 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0446523
|
N-(4-iodophenyl)-4-(2,2,2-trifluoroacetyl)benzamide
Show/Hide
|
C15H9F3INO2
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0516169
|
US8796328, 20
Show/Hide
|
C20H20ClF4N3O4S
|
1
|
| 1 |
IC50 = 791 nM
|
|
|
|
CP0550567
|
US8802711, 32
Show/Hide
|
C21H21F3N4O
|
1
|
| 1 |
IC50 = 795 nM
|
|
|
|
CP0490557
|
US8802711, 117
Show/Hide
|
C22H25FN4O3
|
1
|
| 1 |
IC50 = 804 nM
|
|
|
|
CP0530395
|
US8802711, 108
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 = 804 nM
|
|
|
|
CP0501444
|
US9422293, 324
Show/Hide
|
C29H33F3N6O
|
1
|
| 1 |
IC50 = 810 nM
|
|
|
|
CP0399260
|
methyl 3,5-dichloro-4-[[7-[4-(trifluoromethyl)anilino]-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino]benzoate
Show/Hide
|
C20H12Cl2F3N5O2S
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0536273
|
US8969325, 281
Show/Hide
|
C22H22F3N3O3
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0554198
|
US8969325, 210
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0512596
|
US9422293, 21
Show/Hide
|
C26H25F3N6
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0953888
|
N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-7-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C31H36ClN3O2
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0469961
|
US8969325, 315
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0506833
|
US8802711, 114
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0550740
|
US9422293, 313
Show/Hide
|
C26H25F6N5O2
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0416069
|
2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)pyridine-3-sulfonamide
Show/Hide
|
C20H19F3N6O2S
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0495315
|
US9422293, 87
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0536329
|
US8802711, 39
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
IC50 = 862 nM
|
|
|
|
CP0551195
|
US8796328, 15
Show/Hide
|
C21H21F6N3O5S
|
1
|
| 1 |
IC50 = 863 nM
|
|
|
|
CP0526060
|
US9422293, 182
Show/Hide
|
C25H28F3N5O
|
1
|
| 1 |
IC50 = 870 nM
|
|
|
|
CP0456431
|
N-(1-methyl-2-oxo-3,4-dihydroquinolin-7-yl)-3-[[(2S)-2-methylpyrrolidin-1-yl]methyl]-4-phenylbenzamide;hydrochloride
Show/Hide
|
C29H32ClN3O2
|
1
|
| 1 |
IC50 = 890 nM
|
|
|
|
CP0437098
|
4-(5-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C20H27N5O
|
1
|
| 1 |
IC50 = 893 nM
|
|
|
|
CP0554996
|
US9422293, 210
Show/Hide
|
C24H26F3N5O2S
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0492612
|
US8796328, 32
Show/Hide
|
C19H19F4N3O4S
|
1
|
| 1 |
IC50 = 913 nM
|
|
|
|
CP0418320
|
US8969325, 275
Show/Hide
|
C22H23ClFN3O3
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0491527
|
US8802711, 116
Show/Hide
|
C22H25FN4O3
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0386112
|
4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C21H18F6N6
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0374496
|
6-tert-Butyl-2-[(S)-4-(3-chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-1H-benzoimidazole
Show/Hide
|
C21H26ClN5
|
2
|
| 1 |
IC50 = 948 nM
|
|
|
| 2 |
IC50 = 3608 nM
|
|
|
|
CP0489297
|
(6Z,9Z,12Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadeca-6,9,12-trienamide
Show/Hide
|
C28H40N2O2
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0503679
|
US8969325, 52
Show/Hide
|
C20H21FN4O4
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0520308
|
US8802711, 105
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 = 956 nM
|
|
|
|
CP0516458
|
N-[2-(7-hydroxy-3,4-dihydro-2H-quinolin-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C19H19F3N2O3
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0565644
|
US8969325, 280
Show/Hide
|
C22H23F2N3O3
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0471217
|
US8802711, 126
Show/Hide
|
C17H19N5O2
|
1
|
| 1 |
IC50 = 997 nM
|
|
|
|
CP0430446
|
1-Isoquinolin-5-yl-3-phenethyl-urea
Show/Hide
|
C18H17N3O
|
2
|
| 1 |
IC50 = 1000 nM
|
|
|
| 2 |
Ki = 1440 nM
|
|
|
|
CP0474599
|
4-(trifluoromethyl)phenyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C18H15F6N3O2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0555109
|
US8969325, 130
Show/Hide
|
C20H19F2N3O4
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0479622
|
US9422293, 352
Show/Hide
|
C32H33F3N6S
|
1
|
| 1 |
IC50 = 1010 nM
|
|
|
|
CP0515414
|
US9422293, 123
Show/Hide
|
C25H27ClF3N5
|
1
|
| 1 |
IC50 = 1020 nM
|
|
|
|
CP0442516
|
US8802711, 30
Show/Hide
|
C21H21F3N4O
|
1
|
| 1 |
IC50 = 1050 nM
|
|
|
|
CP0451338
|
US9422293, 365
Show/Hide
|
C28H29F6N5S
|
1
|
| 1 |
IC50 = 1090 nM
|
|
|
|
CP0517234
|
US9422293, 119
Show/Hide
|
C25H27BrF3N5
|
1
|
| 1 |
IC50 = 1090 nM
|
|
|
|
CP0521277
|
US8969325, 197
Show/Hide
|
C21H22F2N4O3
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0518506
|
US9422293, 38
Show/Hide
|
C23H28N6
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0542267
|
US9422293, 33
Show/Hide
|
C30H36N6
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0530396
|
US8802711, 123
Show/Hide
|
C17H19N5O2
|
1
|
| 1 |
IC50 = 1114 nM
|
|
|
|
CP0501445
|
US9422293, 329
Show/Hide
|
C29H33F3N6O2
|
1
|
| 1 |
IC50 = 1120 nM
|
|
|
|
CP0507325
|
US9422293, 263
Show/Hide
|
C24H23F6N7O
|
1
|
| 1 |
IC50 = 1130 nM
|
|
|
|
CP0551196
|
US8796328, 29
Show/Hide
|
C20H22F3N3O4S
|
1
|
| 1 |
IC50 = 1150 nM
|
|
|
|
CP0560003
|
4-cyclohexyl-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)benzamide
Show/Hide
|
C24H28N2O2
|
1
|
| 1 |
IC50 = 1160 nM
|
|
|
|
CP0545350
|
(E)-N-(3-iodophenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H11IN2O3
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0542018
|
US8969325, 61
Show/Hide
|
C22H24ClFN4O4
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0551291
|
US8969325, 268
Show/Hide
|
C22H21F4N3O3
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0556130
|
US8969325, 168
Show/Hide
|
C19H20N4O3
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0413279
|
US9422293, 204
Show/Hide
|
C23H21F6N5S
|
1
|
| 1 |
IC50 = 1220 nM
|
|
|
|
CP0436320
|
N-[2-(6-hydroxyquinolin-4-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C19H15F3N2O3
|
1
|
| 1 |
IC50 = 1230 nM
|
|
|
|
CP0509006
|
US8796328, 44
Show/Hide
|
C22H26FN3O4S
|
1
|
| 1 |
IC50 = 1280 nM
|
|
|
|
CP0418323
|
US8969325, 307
Show/Hide
|
C23H25F3N4O4
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0550512
|
US8969325, 301
Show/Hide
|
C25H29FN4O4
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0553796
|
US8969325, 235
Show/Hide
|
C21H22ClN3O3
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0554197
|
US8969325, 208
Show/Hide
|
C21H22F3N5O3
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0557591
|
US8969325, 60
Show/Hide
|
C22H24F2N4O4
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0572406
|
US8969325, 171
Show/Hide
|
C21H22F2N4O3
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0451339
|
US9422293, 367
Show/Hide
|
C25H25F6N5OS
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0903477
|
N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-(pyrrolidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C28H30ClN3O2
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0421862
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C19H17F3N2O3
|
1
|
| 1 |
IC50 = 1310 nM
|
|
|
|
CP0490545
|
US8802711, 54
Show/Hide
|
C20H18F2N4O
|
1
|
| 1 |
IC50 = 1342 nM
|
|
|
|
CP0522343
|
N-[2-(7-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H20F3NO3
|
1
|
| 1 |
IC50 = 1350 nM
|
|
|
|
CP0566197
|
US8802711, 112
Show/Hide
|
C21H24N2O
|
1
|
| 1 |
IC50 = 1369 nM
|
|
|
|
CP0480863
|
US9422293, 346
Show/Hide
|
C22H20F6N6O
|
1
|
| 1 |
IC50 = 1380 nM
|
|
|
|
CP0452321
|
[4-[[(E)-3-(4-chlorophenyl)prop-2-enoyl]amino]phenyl]boronic acid
Show/Hide
|
C15H13BClNO3
|
1
|
| 1 |
IC50 = 1390 nM
|
|
|
|
CP0507323
|
US9422293, 193
Show/Hide
|
C25H26F6N8
|
1
|
| 1 |
IC50 = 1390 nM
|
|
|
|
CP0454106
|
N-[2-(7-methoxynaphthalen-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C21H18F3NO3
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0461155
|
6,7-dichloro-5-(1-(pyridin-2-yl)propyl)quinoxaline-2,3(1H,4H)-dione
Show/Hide
|
C16H13Cl2N3O2
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0552997
|
2-(4-tert-butylphenyl)-5-(trifluoromethoxy)-1H-benzo[d]imidazole
Show/Hide
|
C18H17F3N2O
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0475723
|
2-(4-(2-isopropyl-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)-2-methylpropanoic acid
Show/Hide
|
C27H30F3N5O2
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0490559
|
US8802711, 125
Show/Hide
|
C20H21FN4O2
|
1
|
| 1 |
IC50 = 1464 nM
|
|
|
|
CP0569481
|
4-(2-chlorophenyl)-N-(1H-indazol-4-yl)piperazine-1-carboxamide
Show/Hide
|
C18H18ClN5O
|
1
|
| 1 |
IC50 = 1480 nM
|
|
|
|
CP0372948
|
(E)-N-isoquinolin-5-yl-3-phenylprop-2-enamide
Show/Hide
|
C18H14N2O
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
Ki = 400 nM
|
|
|
|
CP0400597
|
US8969325, 59
Show/Hide
|
C22H24ClFN4O4
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0520671
|
US8969325, 62
Show/Hide
|
C22H24F3N5O4
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0536268
|
US8969325, 186
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0490971
|
US9422293, 34
Show/Hide
|
C27H27F3N6
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0499622
|
US9422293, 35
Show/Hide
|
C27H24F6N6
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0489658
|
US9422293, 315
Show/Hide
|
C28H30F6N6O
|
1
|
| 1 |
IC50 = 1540 nM
|
|
|
|
CP0521278
|
US8969325, 204
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0529241
|
US8969325, 124
Show/Hide
|
C22H23N3O4
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0577813
|
US8969325, 221
Show/Hide
|
C21H22FN3O3
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0515151
|
US9422293, 187
Show/Hide
|
C22H24F3N7
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0436536
|
(R)-4-(6-Chloro-5-methyl-pyridazin-3-yl)-2-methyl-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
|
C18H18ClFN6OS
|
2
|
| 1 |
IC50 = 1623 nM
|
|
|
| 2 |
IC50 = 13469 nM
|
|
|
|
CP0510748
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-(1,1,2,2-tetrafluoroethoxy)benzamide
Show/Hide
|
C20H18F4N2O3
|
1
|
| 1 |
IC50 = 1640 nM
|
|
|
|
CP0451527
|
US9422293, 142
Show/Hide
|
C26H25F3N6O
|
1
|
| 1 |
IC50 = 1660 nM
|
|
|
|
CP0402597
|
US9422293, 284
Show/Hide
|
C26H34N6
|
1
|
| 1 |
IC50 = 1670 nM
|
|
|
|
CP0515442
|
US9422293, 226
Show/Hide
|
C26H28ClF6N7
|
1
|
| 1 |
IC50 = 1710 nM
|
|
|
|
CP0371848
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C18H15F3N2O3
|
1
|
| 1 |
IC50 = 1730 nM
|
|
|
|
CP0557291
|
US8802711, 29
Show/Hide
|
C24H30N4O
|
1
|
| 1 |
IC50 = 1730 nM
|
|
|
|
CP0494948
|
US9422293, 32
Show/Hide
|
C27H30N6
|
1
|
| 1 |
IC50 = 1740 nM
|
|
|
|
CP0523543
|
2-N-[(1-methylpiperidin-2-yl)methyl]-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C28H31F6N7
|
1
|
| 1 |
IC50 = 1756 nM
|
|
|
|
CP0444902
|
US9422293, 305
Show/Hide
|
C23H24F3N5O2S2
|
1
|
| 1 |
IC50 = 1780 nM
|
|
|
|
CP0479735
|
US9422293, 281
Show/Hide
|
C24H27F3N6O2S
|
1
|
| 1 |
IC50 = 1780 nM
|
|
|
|
CP0471219
|
US8802711, 135
Show/Hide
|
C20H21FN4OS
|
1
|
| 1 |
IC50 = 1789 nM
|
|
|
|
CP0400596
|
US8969325, 53
Show/Hide
|
C21H21F3N4O4
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0450167
|
US8969325, 194
Show/Hide
|
C20H19F3N4O4
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0520872
|
US9422293, 88
Show/Hide
|
C23H23F3N6O2
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0851401
|
N-(2-Oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide hydrochloride
Show/Hide
|
C29H32ClN3O2
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0556518
|
US8796328, 3
Show/Hide
|
C18H19ClFN3O3S
|
1
|
| 1 |
IC50 = 1810 nM
|
|
|
|
CP0501822
|
(9Z,12Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadeca-9,12-dienamide
Show/Hide
|
C28H42N2O2
|
1
|
| 1 |
IC50 = 1820 nM
|
|
|
|
CP0490543
|
US8802711, 31
Show/Hide
|
C21H21F3N4O
|
1
|
| 1 |
IC50 = 1840 nM
|
|
|
|
CP0480864
|
US9422293, 347
Show/Hide
|
C26H27F3N6O
|
1
|
| 1 |
IC50 = 1860 nM
|
|
|
|
CP0436326
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-phenoxybenzamide
Show/Hide
|
C24H22N2O3
|
1
|
| 1 |
IC50 = 1890 nM
|
|
|
|
CP0565649
|
US8969325, 316
Show/Hide
|
C22H23ClF2N4O4
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0492920
|
US9422293, 108
Show/Hide
|
C25H26Cl2F3N5
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0515018
|
US8802711, 120
Show/Hide
|
C17H19N5OS
|
1
|
| 1 |
IC50 = 1912 nM
|
|
|
|
CP0475722
|
2-isopropyl-N-(6-methoxy-5-(trifluoromethyl)pyridin-2-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H24F6N6O
|
1
|
| 1 |
IC50 = 1940 nM
|
|
|
|
CP0429226
|
[4-[(4-tert-butylphenyl)carbamoylamino]phenyl]boronic acid
Show/Hide
|
C17H21BN2O3
|
1
|
| 1 |
IC50 = 1950 nM
|
|
|
|
CP0518507
|
US9422293, 122
Show/Hide
|
C27H38F3N5
|
1
|
| 1 |
IC50 = 1960 nM
|
|
|
|
CP0465880
|
2-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C29H34F6N8
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0400605
|
US8969325, 116
Show/Hide
|
C20H18F3N3O4
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0577821
|
US8969325, 305
Show/Hide
|
C25H31FN4O4
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0512606
|
US9422293, 303
Show/Hide
|
C23H21ClF3N5O2S
|
1
|
| 1 |
IC50 = 2030 nM
|
|
|
|
CP0465799
|
US9422293, 183
Show/Hide
|
C25H25F6N5O
|
1
|
| 1 |
IC50 = 2060 nM
|
|
|
|
CP0529404
|
US9422293, 126
Show/Hide
|
C26H30F3N5O
|
1
|
| 1 |
IC50 = 2060 nM
|
|
|
|
CP0522348
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C19H17F3N2O2
|
1
|
| 1 |
IC50 = 2090 nM
|
|
|
|
CP0497951
|
(E)-N-(3-methoxyphenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C16H14N2O4
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0515178
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-8-phenyloctanamide
Show/Hide
|
C24H30N2O2
|
1
|
| 1 |
IC50 = 2130 nM
|
|
|
|
CP0564118
|
US9422293, 230
Show/Hide
|
C25H27Cl2F3N6O
|
1
|
| 1 |
IC50 = 2130 nM
|
|
|
|
CP0522475
|
5-tert-Butyl-2-[4-(3-chloro-pyridin-2-yl)-piperazin-1-yl]-benzooxazole
Show/Hide
|
C20H23ClN4O
|
2
|
| 1 |
IC50 = 2143 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0516168
|
US8796328, 18
Show/Hide
|
C22H27F2N3O4S
|
1
|
| 1 |
IC50 = 2150 nM
|
|
|
|
CP0439008
|
4-(6-Chloro-4-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
|
C17H16ClFN6OS
|
2
|
| 1 |
IC50 = 2178 nM
|
|
|
| 2 |
IC50 = 3262 nM
|
|
|
|
CP0489655
|
US9422293, 371
Show/Hide
|
C32H39F3N6S
|
1
|
| 1 |
IC50 = 2190 nM
|
|
|
|
CP0567766
|
US9422293, 151
Show/Hide
|
C24H26F3N5
|
1
|
| 1 |
IC50 = 2310 nM
|
|
|
|
CP0378655
|
3-pentylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
|
C22H26N2O3
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0478163
|
4-butyl-N-isoquinolin-5-ylbenzamide
Show/Hide
|
C20H20N2O
|
2
|
| 1 |
IC50 = 2400 nM
|
|
|
| 2 |
Ki = 72 nM
|
|
|
|
CP0551024
|
US8796328, 35
Show/Hide
|
C20H21F4N3O4S
|
1
|
| 1 |
IC50 = 2440 nM
|
|
|
|
CP0413299
|
US9422293, 267
Show/Hide
|
C29H32F6N6
|
1
|
| 1 |
IC50 = 2480 nM
|
|
|
|
CP0497952
|
(E)-N-(3-bromophenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H11BrN2O3
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0520676
|
US8969325, 88
Show/Hide
|
C23H22FN3O3
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0553788
|
US8969325, 133
Show/Hide
|
C19H18FN3O4
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0522347
|
N-[2-(2,4-dichlorophenyl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C16H12Cl2F3NO2
|
1
|
| 1 |
IC50 = 2560 nM
|
|
|
|
CP0530285
|
(9Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadec-9-enamide
Show/Hide
|
C28H44N2O2
|
1
|
| 1 |
IC50 = 2570 nM
|
|
|
|
CP0486800
|
N-(2-naphthalen-1-ylethyl)-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H16F3NO2
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0510747
|
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C18H14F4N2O2
|
1
|
| 1 |
IC50 = 2620 nM
|
|
|
|
CP0464768
|
3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1-(3-pentylphenyl)urea
Show/Hide
|
C22H27N3O2
|
1
|
| 1 |
IC50 = 2630 nM
|
|
|
|
CP0377758
|
2-N-[2-(dimethylamino)ethyl]-2-N-methyl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C26H29F6N7
|
1
|
| 1 |
IC50 = 2667 nM
|
|
|
|
CP0489542
|
US9422293, 377
Show/Hide
|
C27H31F3N6
|
1
|
| 1 |
IC50 = 2690 nM
|
|
|
|
CP0506796
|
US8969325, 196
Show/Hide
|
C23H27FN4O5
|
1
|
| 1 |
IC50 = 2700 nM
|
|
|
|
CP0495042
|
N-[(3-ethynyl-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C19H27NO3
|
1
|
| 1 |
IC50 = 2740 nM
|
|
|
|
CP0382523
|
2-(3-(methylamino)pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C26H27F6N7
|
1
|
| 1 |
IC50 = 2790 nM
|
|
|
|
CP0377915
|
4-(6-Chloro-4-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
Show/Hide
|
C17H17ClF3N5O
|
2
|
| 1 |
IC50 = 2796 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0378656
|
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-yl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
|
C31H44N2O3
|
1
|
| 1 |
IC50 = 2820 nM
|
|
|
|
CP0479736
|
US9422293, 289
Show/Hide
|
C27H34N6O2
|
1
|
| 1 |
IC50 = 2840 nM
|
|
|
|
CP0516167
|
US8796328, 6
Show/Hide
|
C20H21ClF3N3O4S
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0481142
|
US9422293, 202
Show/Hide
|
C25H28F3N5S
|
1
|
| 1 |
IC50 = 2930 nM
|
|
|
|
CP0416068
|
7-(3-(methylsulfonyl)pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C21H20F3N5O2S
|
1
|
| 1 |
IC50 = 2990 nM
|
|
|
|
CP0475724
|
5-chloro-6-(2-isopropyl-4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)nicotinic acid
Show/Hide
|
C24H23ClF3N5O2
|
1
|
| 1 |
IC50 = 2990 nM
|
|
|
|
CP0481126
|
US9422293, 348
Show/Hide
|
C21H18F6N6O2S
|
1
|
| 1 |
IC50 = 3020 nM
|
|
|
|
CP0515025
|
US8796328, 17
Show/Hide
|
C21H23F2N3O4S
|
1
|
| 1 |
IC50 = 3030 nM
|
|
|
|
CP0523542
|
2-N-(1-methylpiperidin-3-yl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 3080 nM
|
|
|
|
CP0436319
|
N-[1-(7-methoxynaphthalen-1-yl)propan-2-yl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C22H20F3NO3
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
|
CP0485018
|
2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-1,5,6-trimethyl-1H-benzoimidazole
Show/Hide
|
C20H24ClN5
|
1
|
| 1 |
IC50 = 3128 nM
|
|
|
|
CP0436322
|
N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)propyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H19F3N2O3
|
1
|
| 1 |
IC50 = 3280 nM
|
|
|
|
CP0386114
|
2-(piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H25F6N7
|
2
|
| 1 |
IC50 = 3300 nM
|
|
|
| 2 |
IC50 = 3350 nM
|
|
|
|
CP0406839
|
US9422293, 57B
Show/Hide
|
C27H26F6N6O2
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
|
CP0472373
|
2-N-methyl-2-N-[(1-methylpiperidin-2-yl)methyl]-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C29H33F6N7
|
1
|
| 1 |
IC50 = 3330 nM
|
|
|
|
CP0501457
|
N-[(4-hydroxy-2-iodo-3-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26INO3
|
1
|
| 1 |
IC50 = 3383 nM
|
|
|
|
CP0528688
|
2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)nicotinamide
Show/Hide
|
C21H19F3N6O
|
1
|
| 1 |
IC50 = 3390 nM
|
|
|
|
CP0371843
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
Show/Hide
|
C19H18F3N3O3
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0391980
|
7-Hydroxy-8-methoxy-3-nonanoyl-3,4-dihydro-1H-quinazolin-2-one
Show/Hide
|
C18H26N2O4
|
1
|
| 1 |
IC50 = 3402 nM
|
|
|
|
CP0467160
|
4-isobutyl-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)benzamide
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 3430 nM
|
|
|
|
CP0550739
|
US9422293, 301
Show/Hide
|
C22H22F3N5O2S
|
1
|
| 1 |
IC50 = 3430 nM
|
|
|
|
CP0421870
|
N-[2-(2-fluorophenyl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C16H13F4NO2
|
1
|
| 1 |
IC50 = 3490 nM
|
|
|
|
CP0539862
|
US9422293, 165
Show/Hide
|
C26H30F3N7
|
1
|
| 1 |
IC50 = 3510 nM
|
|
|
|
CP0436321
|
N-[2-(6-methoxyindol-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C19H17F3N2O3
|
1
|
| 1 |
IC50 = 3550 nM
|
|
|
|
CP0472371
|
2-N-methyl-2-N-piperidin-3-yl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0550504
|
US8969325, 218
Show/Hide
|
C22H22F3N3O3
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0486283
|
US9422293, 68B
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0560004
|
N-[2-(3,4-dichlorophenyl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C16H12Cl2F3NO2
|
1
|
| 1 |
IC50 = 3700 nM
|
|
|
|
CP0394539
|
2-(3-aminopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H25F6N7
|
1
|
| 1 |
IC50 = 3700 nM
|
|
|
|
CP0550495
|
US8969325, 98
Show/Hide
|
C22H22FN3O3
|
1
|
| 1 |
IC50 = 3700 nM
|
|
|
|
CP0436327
|
N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C18H14ClF3N2O2
|
1
|
| 1 |
IC50 = 3720 nM
|
|
|
|
CP0515176
|
1-[(4-tert-butylphenyl)methyl]-3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]urea
Show/Hide
|
C22H27N3O2
|
1
|
| 1 |
IC50 = 3800 nM
|
|
|
|
CP0566472
|
US8796328, 31
Show/Hide
|
C19H19F4N3O4S
|
1
|
| 1 |
IC50 = 3800 nM
|
|
|
|
CP0377927
|
4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C19H24ClN5O
|
2
|
| 1 |
IC50 = 3825.8 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0438927
|
3-(trifluoromethyl)phenyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C17H15ClF3N3O2
|
1
|
| 1 |
IC50 = 3900 nM
|
|
|
|
CP0485507
|
3-[5-Hydroxy-4-methoxy-2-(nonanoylamino-methyl)-phenyl]-acrylic acid methyl ester
Show/Hide
|
C21H31NO5
|
1
|
| 1 |
IC50 = 3932 nM
|
|
|
|
CP0421860
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-6-phenylpyridine-3-carboxamide
Show/Hide
|
C23H21N3O2
|
1
|
| 1 |
IC50 = 3940 nM
|
|
|
|
CP0407829
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-iodo-5-methoxyphenyl)acetate
Show/Hide
|
C37H39IO9
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0488360
|
US9422293, 300
Show/Hide
|
C28H34F3N7O2S
|
1
|
| 1 |
IC50 = 4070 nM
|
|
|
|
CP0410844
|
(E)-3-(3-nitrophenyl)-N-(3-propan-2-ylphenyl)prop-2-enamide
Show/Hide
|
C18H18N2O3
|
1
|
| 1 |
IC50 = 4100 nM
|
|
|
|
CP0551345
|
US8969325, 175
Show/Hide
|
C19H20N4O3
|
1
|
| 1 |
IC50 = 4100 nM
|
|
|
|
CP0390491
|
[4-[[(4-tert-butylphenyl)carbamoylamino]methyl]phenyl]boronic acid
Show/Hide
|
C18H23BN2O3
|
1
|
| 1 |
IC50 = 4130 nM
|
|
|
|
CP0491404
|
US8969325, 277
Show/Hide
|
C22H24ClN3O3
|
1
|
| 1 |
IC50 = 4200 nM
|
|
|
|
CP0467162
|
N-[2-(1H-indol-3-yl)ethyl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C18H15F3N2O
|
1
|
| 1 |
IC50 = 4230 nM
|
|
|
|
CP0413297
|
US9422293, 255
Show/Hide
|
C27H29Cl2F3N6
|
1
|
| 1 |
IC50 = 4290 nM
|
|
|
|
CP0488338
|
N-(3-iodophenyl)-3-(3-nitrophenyl)propanamide
Show/Hide
|
C15H13IN2O3
|
1
|
| 1 |
IC50 = 4300 nM
|
|
|
|
CP0380925
|
N-[4-(trifluoromethyl)phenyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide
Show/Hide
|
C19H16F3N3O
|
1
|
| 1 |
IC50 = 4360 nM
|
|
|
|
CP0444923
|
US9422293, 195
Show/Hide
|
C25H28F6N8
|
1
|
| 1 |
IC50 = 4420 nM
|
|
|
|
CP0522345
|
N-[2-(3,4-dihydro-2H-quinolin-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C19H19F3N2O2
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
|
CP0502852
|
4-chlorophenyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C17H15ClF3N3O2
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
|
CP0461148
|
N-[2-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C21H22F3NO3
|
1
|
| 1 |
IC50 = 4650 nM
|
|
|
|
CP0512605
|
US9422293, 295
Show/Hide
|
C20H17F4N5
|
1
|
| 1 |
IC50 = 4660 nM
|
|
|
|
CP0530591
|
US8969325, 259
Show/Hide
|
C24H28FN3O3
|
1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0431293
|
5-hydroxy-1-(4-hydroxy-2-methyl-5-propan-2-ylphenyl)decan-3-one
Show/Hide
|
C20H32O3
|
1
|
| 1 |
IC50 = 4800 nM
|
|
|
|
CP0556378
|
US8969325, 283
Show/Hide
|
C20H20ClN3O2
|
1
|
| 1 |
IC50 = 4800 nM
|
|
|
|
CP0469953
|
US8969325, 243
Show/Hide
|
C21H22FN3O3
|
1
|
| 1 |
IC50 = 4900 nM
|
|
|
|
CP0436328
|
2-(4-tert-butylcyclohexyl)-5-(trifluoromethoxy)-1H-benzo[d]imidazole
Show/Hide
|
C18H23F3N2O
|
1
|
| 1 |
IC50 = 4970 nM
|
|
|
|
CP0467594
|
2-N-(2,6-dichlorophenyl)-5-piperazin-1-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C22H18Cl2F3N7S
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0551325
|
US8969325, 319
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0499651
|
US9422293, 311
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0485132
|
4-(5-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C19H25N5O
|
2
|
| 1 |
IC50 = 5021 nM
|
|
|
| 2 |
IC50 = 20336 nM
|
|
|
|
CP0421859
|
N-[2-(5-methoxy-2-methyl-1H-indol-3-yl)propyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C21H21F3N2O3
|
1
|
| 1 |
IC50 = 5070 nM
|
|
|
|
CP0380924
|
(3-pentylphenyl) 6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C23H26N2O3
|
1
|
| 1 |
IC50 = 5100 nM
|
|
|
|
CP0489524
|
7-(pyrimidin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C19H17F3N6
|
1
|
| 1 |
IC50 = 5200 nM
|
|
|
|
CP0421857
|
4-tert-butylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
|
C21H24N2O3
|
1
|
| 1 |
IC50 = 5250 nM
|
|
|
|
CP0515011
|
US8796328, 41
Show/Hide
|
C20H22F3N3O4S
|
1
|
| 1 |
IC50 = 5280 nM
|
|
|
|
CP0515989
|
N-[2-(1,2,3,4-tetrahydronaphthalen-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C20H20F3NO2
|
1
|
| 1 |
IC50 = 5400 nM
|
|
|
|
CP0509707
|
2-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-1,5,6-trimethyl-1H-benzoimidazole
Show/Hide
|
C19H22ClN5
|
2
|
| 1 |
IC50 = 5447 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0404701
|
4-Pyridazin-3-yl-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C18H23N5O
|
2
|
| 1 |
IC50 = 5745 nM
|
|
|
| 2 |
IC50 = 13286 nM
|
|
|
|
CP0506835
|
US8802711, 127
Show/Hide
|
C20H21FN4O2
|
1
|
| 1 |
IC50 = 5755 nM
|
|
|
|
CP0374501
|
2-[(S)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-5,6-dimethyl-1H-benzoimidazole
Show/Hide
|
C19H22ClN5
|
2
|
| 1 |
IC50 = 5773 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0371853
|
5-(4-bromophenyl)-2-(4-(trifluoromethyl)phenyl)-1H-imidazole
Show/Hide
|
C16H10BrF3N2
|
1
|
| 1 |
IC50 = 6000 nM
|
|
|
|
CP0410842
|
(E)-N-[3-(hydroxymethyl)phenyl]-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C16H14N2O4
|
1
|
| 1 |
IC50 = 6100 nM
|
|
|
|
CP0529234
|
US8969325, 49
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
IC50 = 6100 nM
|
|
|
|
CP0445882
|
4-(4-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
|
C17H17FN6OS
|
2
|
| 1 |
IC50 = 6169 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0529537
|
(7-Hydroxy-naphthalen-1-yl)-carbamic acid phenyl ester
Show/Hide
|
C17H13NO3
|
2
|
| 1 |
IC50 = 6300 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0409228
|
[3-(trifluoromethyl)phenyl] 6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Show/Hide
|
C19H15F3N2O3
|
1
|
| 1 |
IC50 = 6400 nM
|
|
|
|
CP0519129
|
US8796328, 43
Show/Hide
|
C20H21F4N3O4S
|
1
|
| 1 |
IC50 = 6410 nM
|
|
|
|
CP0490558
|
US8802711, 124
Show/Hide
|
C21H24N2O
|
1
|
| 1 |
IC50 = 6484 nM
|
|
|
|
CP0510745
|
N-(2-isoquinolin-8-ylethyl)-4-(trifluoromethoxy)benzamide
Show/Hide
|
C19H15F3N2O2
|
1
|
| 1 |
IC50 = 6700 nM
|
|
|
|
CP0557309
|
US8969325, 199
Show/Hide
|
C19H19FN4O3
|
1
|
| 1 |
IC50 = 6700 nM
|
|
|
|
CP0499286
|
(E)-N-(3-chlorophenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H11ClN2O3
|
1
|
| 1 |
IC50 = 7100 nM
|
|
|
|
CP0565582
|
US8969325, 244
Show/Hide
|
C23H25N3O3
|
1
|
| 1 |
IC50 = 7100 nM
|
|
|
|
CP0522344
|
N-(2-indol-1-ylethyl)-4-(trifluoromethoxy)benzamide
Show/Hide
|
C18H15F3N2O2
|
1
|
| 1 |
IC50 = 7300 nM
|
|
|
|
CP0520705
|
US8969325, 55
Show/Hide
|
C20H21FN4O3
|
1
|
| 1 |
IC50 = 7300 nM
|
|
|
|
CP0461150
|
N-[2-(1H-indol-3-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C18H15F3N2O2
|
1
|
| 1 |
IC50 = 7350 nM
|
|
|
|
CP0529361
|
US8796328, 21
Show/Hide
|
C20H24FN3O4S
|
1
|
| 1 |
IC50 = 7560 nM
|
|
|
|
CP0556617
|
US8796328, 22
Show/Hide
|
C20H23F2N3O4S
|
1
|
| 1 |
IC50 = 7591 nM
|
|
|
|
CP0491525
|
US8802711, 113
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
IC50 = 7705 nM
|
|
|
|
CP0388761
|
[4-[[(4-tert-butylphenyl)carbamoylamino]methyl]-2-methoxyphenyl]boronic acid
Show/Hide
|
C19H25BN2O4
|
1
|
| 1 |
IC50 = 8110 nM
|
|
|
|
CP0442322
|
(R)-4-(6-Chloro-5-methyl-pyridazin-3-yl)-2-methyl-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C21H28ClN5O
|
2
|
| 1 |
IC50 = 8118.8 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0485145
|
(R)-2-Methyl-4-(5-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C21H29N5O
|
2
|
| 1 |
IC50 = 8590.7 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0557098
|
US8802711, 33
Show/Hide
|
C21H21F3N4O
|
1
|
| 1 |
IC50 = 8640 nM
|
|
|
|
CP0519042
|
US8802711, 128
Show/Hide
|
C17H19N5O2
|
1
|
| 1 |
IC50 = 8642 nM
|
|
|
|
CP0511998
|
US8802711, 58
Show/Hide
|
C19H20N4O2
|
1
|
| 1 |
IC50 = 8645 nM
|
|
|
|
CP0126566
|
(4-nonylphenyl)boranediol
Show/Hide
|
C15H25BO2
|
1
|
| 1 |
IC50 = 9100 nM
|
|
|
|
CP0489288
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-7-phenylheptanamide
Show/Hide
|
C23H28N2O2
|
1
|
| 1 |
IC50 = 9120 nM
|
|
|
|
CP0414052
|
(5Z,8Z,11Z,14Z)-1-(6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)icosa-5,8,11,14-tetraen-1-one
Show/Hide
|
C31H42N2O2
|
1
|
| 1 |
IC50 = 9300 nM
|
|
|
|
CP0419429
|
US9422293, 293
Show/Hide
|
C21H17F3N6
|
1
|
| 1 |
IC50 = 9340 nM
|
|
|
|
CP0572937
|
N-(1H-indazol-4-yl)-4-(2-methylphenyl)piperazine-1-carboxamide
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
IC50 = 9540 nM
|
|
|
|
CP0469528
|
N-[(2-acetamido-4-hydroxy-3-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C19H30N2O4
|
1
|
| 1 |
IC50 = 9544 nM
|
|
|
|
CP0516166
|
US8802711, 140
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C23H24FN3O
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1
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| 1 |
IC50 = 9599 nM
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CP0417716
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1-(6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)-8-phenyloctan-1-one
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C25H30N2O2
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1
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| 1 |
IC50 = 9600 nM
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CP0377916
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4-(6-Chloro-5-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
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C19H24ClN5O
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1
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| 1 |
IC50 > 10000 nM
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CP0377928
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4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
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C18H22ClN5O
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1
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| 1 |
IC50 > 10000 nM
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CP0377929
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4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
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C16H15ClF3N5O2
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1
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| 1 |
IC50 > 10000 nM
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CP0379169
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4-(6-Chloro-5-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
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C20H26ClN5O
|
1
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| 1 |
IC50 > 10000 nM
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CP0455640
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4-Pyridazin-3-yl-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
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C16H16F3N5O2
|
1
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| 1 |
IC50 > 10000 nM
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CP0464489
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4-(6-Phenyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
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C22H20F3N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0498496
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4-(6-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
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C17H18F3N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0498516
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4-(5-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
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C17H17FN6OS
|
1
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| 1 |
IC50 > 10000 nM
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CP0505504
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(R)-2-Methyl-4-(5-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
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C18H20F3N5O
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
IC50 > 25000 nM
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CP0506271
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4-(5-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
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C17H18F3N5O2
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1
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| 1 |
IC50 > 10000 nM
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CP0527462
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4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
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C22H25N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0540282
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4-Pyridazin-3-yl-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
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C16H16F3N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0551769
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4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
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C20H18F3N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0377917
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4-(6-Chloro-5-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
Show/Hide
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C17H17ClF3N5O2
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1
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| 1 |
IC50 > 10000 nM
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CP0377926
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4-(6-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
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C20H27N5O
|
1
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| 1 |
IC50 > 10000 nM
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CP0379167
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4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
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C16H14ClFN6OS
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1
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| 1 |
IC50 > 10000 nM
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CP0379176
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4-(6-Chloro-5-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
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C17H16ClFN6OS
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1
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| 1 |
IC50 > 10000 nM
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CP0379302
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4-(6-Phenyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
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C22H20F3N5O2
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1
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| 1 |
IC50 > 10000 nM
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CP0403423
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4-Pyridazin-3-yl-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
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C16H15FN6OS
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1
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| 1 |
IC50 > 10000 nM
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CP0431060
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4-(6-Methoxy-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
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C17H17FN6O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0461647
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4-(6-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
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C17H17FN6OS
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1
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| 1 |
IC50 > 10000 nM
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CP0485133
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4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
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C23H27N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0485492
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4-Phthalazin-1-yl-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
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C20H17FN6OS
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1
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| 1 |
IC50 > 10000 nM
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CP0485915
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4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
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C20H18F3N5O2
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1
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| 1 |
IC50 > 10000 nM
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CP0496888
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4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
Show/Hide
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C16H15ClF3N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0497395
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4-(6-Phenyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
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C24H27N5O
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1
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| 1 |
IC50 > 10000 nM
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CP0497397
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4-(6-Phenyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (6-fluoro-benzothiazol-2-yl)-amide
Show/Hide
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C22H19FN6OS
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1
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| 1 |
IC50 > 10000 nM
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CP0498498
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4-(6-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
Show/Hide
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C17H18F3N5O2
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1
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| 1 |
IC50 > 10000 nM
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CP0498503
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4-(6-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
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C19H25N5O
|
1
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| 1 |
IC50 > 10000 nM
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CP0371974
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4-methoxyphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
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C18H18N2O4
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1
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| 1 |
IC50 > 10000 nM
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CP0371975
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(9Z,12Z)-octadeca-9,12-dien-1-yl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
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C29H44N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0378658
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(9Z,12Z,15Z)-octadeca-9,12,15-trien-1-yl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
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C29H42N2O3
|
1
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| 1 |
IC50 > 10000 nM
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CP0391040
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3-phenylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
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C23H20N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0421882
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N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-4-[3-(3-pentylphenyl)phenyl]butanamide
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C31H36N2O2
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1
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| 1 |
IC50 > 10000 nM
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CP0461684
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3-chlorophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
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C17H15ClN2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0464206
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4-chlorophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
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C17H15ClN2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0489289
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5-(1,2-dithiolan-3-yl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]pentanamide
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C18H24N2O2S2
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1
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| 1 |
IC50 > 10000 nM
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CP0489301
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3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1-[2-(4-phenylphenyl)ethyl]urea
Show/Hide
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C25H25N3O2
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1
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| 1 |
IC50 > 10000 nM
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CP0489303
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1-[2-(4-chlorophenyl)ethyl]-3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]urea
Show/Hide
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C19H20ClN3O2
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1
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| 1 |
IC50 > 10000 nM
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CP0489304
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N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-4-(7-pentylnaphthalen-2-yl)butanamide
Show/Hide
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C29H34N2O2
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1
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| 1 |
IC50 > 10000 nM
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CP0500551
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4-(trifluoromethyl)phenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
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C18H15F3N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0504977
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3-(trifluoromethyl)phenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
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C18H15F3N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0504978
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3-tert-butylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
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C21H24N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0515180
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4-iodophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
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C17H15IN2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0515181
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3-iodophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
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C17H15IN2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0515182
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(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-yl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
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C29H42N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0530286
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N-arachidonoylserotonin carbamate analogue, 3o
Show/Hide
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C21H18N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0553009
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4-(benzyloxy)phenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate
Show/Hide
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C24H22N2O4
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1
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| 1 |
IC50 > 10000 nM
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CP0553010
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3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1-[2-(4-phenoxyphenyl)ethyl]urea
Show/Hide
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C25H25N3O3
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1
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| 1 |
IC50 > 10000 nM
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CP0565507
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3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1-(2-phenylethyl)urea
Show/Hide
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C19H21N3O2
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1
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| 1 |
IC50 > 10000 nM
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CP0371845
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N-[2-(5-tert-butyl-1H-indol-3-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
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C22H23F3N2O2
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1
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| 1 |
IC50 > 10000 nM
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CP0371850
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5-tert-butyl-2-(4-tert-butylphenyl)-1H-indole
Show/Hide
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C22H27N
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1
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| 1 |
IC50 > 10000 nM
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CP0378522
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4-iodo-N-(4-(trifluoromethyl)phenyl)benzamide
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C14H9F3INO
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1
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| 1 |
IC50 > 10000 nM
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CP0421858
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N-[2-(4,7-dimethoxynaphthalen-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
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C22H20F3NO4
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1
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| 1 |
IC50 > 10000 nM
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CP0421866
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N-(4-phenylphenyl)-4-(trifluoromethoxy)benzamide
Show/Hide
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C20H14F3NO2
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1
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| 1 |
IC50 > 10000 nM
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CP0421867
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N-(4-cyclohexylphenyl)-4-(trifluoromethoxy)benzamide
Show/Hide
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C20H20F3NO2
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1
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| 1 |
IC50 > 10000 nM
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CP0436324
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N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-6-(trifluoromethyl)pyridine-3-carboxamide
Show/Hide
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C18H16F3N3O2
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1
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| 1 |
IC50 > 10000 nM
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CP0436325
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4-(2-(dimethylamino)ethoxy)-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)benzamide
Show/Hide
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C22H27N3O3
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1
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| 1 |
IC50 > 10000 nM
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CP0454107
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N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-pyridin-4-ylbenzamide
Show/Hide
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C23H21N3O2
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1
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| 1 |
IC50 > 10000 nM
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CP0461149
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N-[2-(7-methoxy-3,4-dihydro-2H-quinolin-1-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
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C20H21F3N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0461151
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2-(4-tert-butylphenyl)-5-(4-(trifluoromethyl)phenyl)-2H-tetrazole
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C18H17F3N4
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1
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| 1 |
IC50 > 10000 nM
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CP0461152
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N-(4-tert-butylphenyl)-N-methyl-4-(trifluoromethoxy)benzamide
Show/Hide
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C19H20F3NO2
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1
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| 1 |
IC50 > 10000 nM
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CP0461153
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1-(4-iodophenyl)-3-(4-(trifluoromethyl)phenyl)urea
Show/Hide
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C14H10F3IN2O
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1
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| 1 |
IC50 > 10000 nM
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CP0461154
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N-(3,5-ditert-butylphenyl)-4-(trifluoromethoxy)benzamide
Show/Hide
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C22H26F3NO2
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1
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| 1 |
IC50 > 10000 nM
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CP0464119
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N-[1-(6-methoxyquinolin-4-yl)propan-2-yl]-4-(trifluoromethoxy)benzamide
Show/Hide
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C21H19F3N2O3
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1
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| 1 |
IC50 > 10000 nM
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CP0464124
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N-(4-iodophenyl)-3-(trifluoromethyl)benzamide
Show/Hide
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C14H9F3INO
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1
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| 1 |
IC50 > 10000 nM
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CP0467161
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N-[2-(1-methylindol-3-yl)ethyl]-4-(trifluoromethyl)benzamide
Show/Hide
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C19H17F3N2O
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1
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| 1 |
IC50 > 10000 nM
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CP0486801
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N-(4-iodophenyl)-4-methylsulfonylbenzamide
Show/Hide
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C14H12INO3S
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1
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| 1 |
IC50 > 10000 nM
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CP0486814
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2-(4-tert-butylphenyl)-1-(4-(trifluoromethyl)phenyl)ethanone
Show/Hide
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C19H19F3O
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1
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| 1 |
IC50 > 10000 nM
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CP0510749
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(Z)-3-(4-tert-butylphenyl)-2-(4-(trifluoromethyl)phenyl)acrylonitrile
Show/Hide
|
C20H18F3N
|
1
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| 1 |
IC50 > 10000 nM
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CP0513659
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N-[2-(6-methoxyquinolin-4-yl)ethyl]-4-(trifluoromethoxy)benzamide
Show/Hide
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C20H17F3N2O3
|
1
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| 1 |
IC50 > 10000 nM
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CP0513660
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N-(2-quinolin-4-ylethyl)-4-(trifluoromethoxy)benzamide
Show/Hide
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C19H15F3N2O2
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1
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| 1 |
IC50 > 10000 nM
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CP0516460
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N-(4-tert-butylphenyl)-4-(2,2,2-trifluoroethoxy)benzamide
Show/Hide
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C19H20F3NO2
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1
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| 1 |
IC50 > 10000 nM
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CP0522350
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N-(4-iodophenyl)-2-(trifluoromethyl)benzamide
Show/Hide
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C14H9F3INO
|
1
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| 1 |
IC50 > 10000 nM
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CP0552998
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2-amino-2-(4-tert-butylphenyl)-1-(4-(trifluoromethoxy)phenyl)ethanone
Show/Hide
|
C19H20F3NO2
|
1
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| 1 |
IC50 > 10000 nM
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CP0560005
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4-acetyl-N-(4-iodophenyl)benzamide
Show/Hide
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C15H12INO2
|
1
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| 1 |
IC50 > 10000 nM
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CP0394201
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4-[cyclohexyl(propyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
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C25H29N3O
|
2
|
| 1 |
IC50 = 10000 nM
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| 2 |
Ki = 85 nM
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CP0432067
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4-(cyclohexylamino)-N-quinolin-3-ylbenzamide
Show/Hide
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C22H23N3O
|
2
|
| 1 |
IC50 = 10000 nM
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| 2 |
Ki = 156 nM
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CP0378648
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1-Benzyl-1-ethyl-3-(7-hydroxy-naphthalen-1-yl)-urea
Show/Hide
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C20H20N2O2
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2
|
| 1 |
IC50 > 10000 nM
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| 2 |
Ki = 1110 nM
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CP0428602
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1,1-Dibenzyl-3-(7-hydroxy-naphthalen-1-yl)-urea
Show/Hide
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C25H22N2O2
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
Ki = 3280 nM
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CP0496409
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1-Benzyl-3-(7-hydroxy-naphthalen-1-yl)-1-methyl-urea
Show/Hide
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C19H18N2O2
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
Ki > 10000 nM
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CP0299384
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N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide
Show/Hide
|
C21H22N4O
|
1
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| 1 |
IC50 > 10000 nM
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CP0421666
|
(3-phenylphenyl) 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate
Show/Hide
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C22H20ClN3O2
|
1
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| 1 |
IC50 > 10000 nM
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CP0430688
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
IC50 > 10000 nM
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CP0438928
|
4-chlorophenyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C16H15Cl2N3O2
|
1
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| 1 |
IC50 > 10000 nM
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CP0438929
|
3-chlorophenyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C16H15Cl2N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0438930
|
4-(trifluoromethyl)phenyl 4-(pyridin-2-ylmethyl)piperazine-1-carboxylate
Show/Hide
|
C18H18F3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0438931
|
4-chlorophenyl 4-(quinolin-2-ylmethyl)piperazine-1-carboxylate
Show/Hide
|
C21H20ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0470134
|
3-chlorophenyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C17H15ClF3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0489536
|
4-(trifluoromethyl)phenyl 4-(quinolin-2-ylmethyl)piperazine-1-carboxylate
Show/Hide
|
C22H20F3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0491262
|
4-(trifluoromethyl)phenyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C17H15ClF3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0491264
|
3-(trifluoromethyl)phenyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C18H15F6N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0494486
|
4-(3-chloropyridin-2-yl)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)piperazine-1-carboxamide
Show/Hide
|
C20H22ClN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0494664
|
(3-phenylphenyl) 4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxylate
Show/Hide
|
C23H20F3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0494665
|
4-chlorophenyl 4-(pyridin-2-ylmethyl)piperazine-1-carboxylate
Show/Hide
|
C17H18ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0494668
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
Show/Hide
|
C21H22F3N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0502248
|
3-tert-butylphenyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate
Show/Hide
|
C21H24F3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0526342
|
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-4-(pyridin-2-ylmethyl)piperazine-1-carboxamide
Show/Hide
|
C21H25N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0536500
|
1-(4-(3-(3-tert-butylphenyl)prop-1-en-2-yl)cyclohexyl)-2-methylbenzene
Show/Hide
|
C20H24ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0392639
|
1-(1,3-benzodioxol-5-yl)-5-hydroxy-11-phenylundecan-3-one
Show/Hide
|
C24H30O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0392832
|
5-hydroxy-1-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-11-phenylundecan-3-one
Show/Hide
|
C29H42O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0401166
|
5-hydroxy-1,11-diphenylundecan-3-one
Show/Hide
|
C23H30O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0410503
|
(E)-N-(2-bromophenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H11BrN2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0410504
|
(E)-N-(3-tert-butylphenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C19H20N2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0410843
|
(E)-N-(2-chlorophenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H11ClN2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0415162
|
(E)-N-[2-(hydroxymethyl)phenyl]-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C16H14N2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0415313
|
(E)-N-(3-hydroxyphenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H12N2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0415314
|
(E)-N-(2-hydroxyphenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H12N2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441394
|
(E)-N-(3-methylphenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C16H14N2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441395
|
(E)-3-(3-nitrophenyl)-N-(2-propan-2-ylphenyl)prop-2-enamide
Show/Hide
|
C18H18N2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0445932
|
(E)-N-(2-methylphenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C16H14N2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0543187
|
(E)-N-(2-iodophenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C15H11IN2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0544764
|
(E)-N-[2-(methanesulfonamido)phenyl]-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C16H15N3O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0101210
|
2-nitro-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C21H23F3N4O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0556528
|
US8969325, 288
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0063789
|
1-methoxy-4-[(E)-2-(4-methoxyphenyl)vinyl]benzene
Show/Hide
|
C16H16O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0089122
|
4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenol
Show/Hide
|
C14H12O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0115263
|
CHEBI:8227
Show/Hide
|
C15H14O2
|
3
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
IC50 = 15000 nM
|
|
|
| 3 |
IC50 = 23700 nM
|
|
|
|
CP0124683
|
(E)-4-(3,5-dimethoxystyryl)phenol
Show/Hide
|
C16H16O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0227831
|
4-[(E)-2-phenylethenyl]phenol
Show/Hide
|
C14H12O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0274708
|
1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
Show/Hide
|
C17H18O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0300605
|
1-methoxy-2-[(E)-2-phenylethenyl]benzene
Show/Hide
|
C15H14O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0312435
|
TRIACETYLRESVERATROL
Show/Hide
|
C20H18O6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0325424
|
US8980954, 6r
Show/Hide
|
C16H16O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0350016
|
(E)-3-STILBENOL
Show/Hide
|
C14H12O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0358758
|
(E)-3,5-stilbenediol
Show/Hide
|
C14H12O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0385336
|
Trans-Acetic acid 4-styryl-phenyl ester (7)
Show/Hide
|
C16H14O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0385340
|
(E)-3,4'-STILBENDIOL
Show/Hide
|
C14H12O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0417743
|
2-[(E)-2-phenylethenyl]phenol
Show/Hide
|
C14H12O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0458970
|
(E)-5-METHOXY-4'-STILBENOL
Show/Hide
|
C15H14O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0462024
|
1,3-dimethoxy-5-[(E)-2-phenylethenyl]benzene
Show/Hide
|
C16H16O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0472155
|
4-[(E)-2-(4-methoxyphenyl)ethenyl]phenol
Show/Hide
|
C15H14O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0512491
|
1-methoxy-3-[(E)-2-phenylethenyl]benzene
Show/Hide
|
C15H14O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0519361
|
[2-[(E)-2-phenylethenyl]phenyl] acetate
Show/Hide
|
C16H14O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0532723
|
CHEBI:35094
Show/Hide
|
C15H14O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0151767
|
(4-phenylphenyl)boranediol
Show/Hide
|
C12H11BO2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0385973
|
[4-(8-phenyloctanoylamino)phenyl]boronic acid
Show/Hide
|
C20H26BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0391134
|
[4-[2-(4-tert-butylanilino)-2-oxoethyl]phenyl]boronic acid
Show/Hide
|
C18H22BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0404681
|
[4-(5-phenylpentylcarbamoyl)phenyl]boronic acid
Show/Hide
|
C18H22BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0429227
|
[4-(benzylcarbamoyl)phenyl]boronic acid
Show/Hide
|
C14H14BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0429228
|
[4-(6-phenylhexanoylamino)phenyl]boronic acid
Show/Hide
|
C18H22BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0452322
|
[4-[[[(E)-3-(4-chlorophenyl)prop-2-enoyl]amino]methyl]phenyl]boronic acid
Show/Hide
|
C16H15BClNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0452690
|
[4-[[2-(4-phenylphenyl)acetyl]amino]phenyl]boronic acid
Show/Hide
|
C20H18BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0468013
|
[4-[(4-phenylphenyl)methylcarbamoyl]phenyl]boronic acid
Show/Hide
|
C20H18BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0509267
|
[4-[2-(4-hydroxyphenyl)ethylcarbamoyl]phenyl]boronic acid
Show/Hide
|
C15H16BNO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0515296
|
[4-(4-phenylbutylcarbamoyl)phenyl]boronic acid
Show/Hide
|
C17H20BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0573661
|
[4-[2-(benzylamino)-2-oxoethyl]phenyl]boronic acid
Show/Hide
|
C15H16BNO3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0488312
|
US8796328, 40
Show/Hide
|
C20H22F3N3O4S
|
1
|
| 1 |
IC50 = 10100 nM
|
|
|
|
CP0495043
|
N-[(3-acetyl-4-hydroxy-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C19H29NO4
|
1
|
| 1 |
IC50 = 10380 nM
|
|
|
|
CP0380923
|
(Z)-1-(6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)octadec-9-en-1-one
Show/Hide
|
C29H44N2O2
|
1
|
| 1 |
IC50 = 10600 nM
|
|
|
|
CP0543186
|
(E)-N-(2-methoxyphenyl)-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C16H14N2O4
|
1
|
| 1 |
IC50 = 10700 nM
|
|
|
|
CP0394962
|
N-[(4-hydroxy-3-methoxy-2-nitrophenyl)methyl]nonanamide
Show/Hide
|
C17H26N2O5
|
1
|
| 1 |
IC50 = 10970 nM
|
|
|
|
CP0561108
|
US8969325, 287
Show/Hide
|
C22H24FN3O3
|
1
|
| 1 |
IC50 = 13000 nM
|
|
|
|
CP0437099
|
4-(5-Methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
Show/Hide
|
C17H18F3N5O
|
1
|
| 1 |
IC50 = 13602 nM
|
|
|
|
CP0413295
|
US9422293, 105
Show/Hide
|
C21H22F3N7
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0450055
|
US8796328, 4
Show/Hide
|
C18H19F2N3O3S
|
1
|
| 1 |
IC50 = 16500 nM
|
|
|
|
CP0435296
|
(2E,4E,6E,8E)-9-(6,6-Dimethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenal
Show/Hide
|
C19H26O
|
1
|
| 1 |
IC50 = 17490 nM
|
|
|
|
CP0578116
|
US8969325, 309
Show/Hide
|
C23H23F5N4O4
|
1
|
| 1 |
IC50 = 18000 nM
|
|
|
|
CP0469527
|
N-[(4-hydroxy-3-methoxy-5-phenylphenyl)methyl]nonanamide
Show/Hide
|
C23H31NO3
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0495044
|
N-[[4-hydroxy-3-[2-hydroxy-3-methoxy-5-[(nonanoylamino)methyl]phenyl]-5-methoxyphenyl]methyl]nonanamide
Show/Hide
|
C34H52N2O6
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0413288
|
US9422293, 70B
Show/Hide
|
C23H25F3N6
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0451536
|
US9422293, 211
Show/Hide
|
C24H21F6N5O4S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0480852
|
US9422293, 344
Show/Hide
|
C21H17F6N5O
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0480861
|
US9422293, 120
Show/Hide
|
C24H24Cl2F3N5
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0481146
|
US9422293, 107
Show/Hide
|
C21H22F3N7
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0481147
|
US9422293, 227
Show/Hide
|
C26H30Cl2F3N7
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0482792
|
US9422293, 198
Show/Hide
|
C23H25F3N6
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0488611
|
US9422293, 208
Show/Hide
|
C27H31F3N6O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0492560
|
2-(1,1-dioxo-1,4-thiazinan-4-yl)-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine
Show/Hide
|
C25H24F6N6O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0494958
|
US9422293, 71B
Show/Hide
|
C22H24F3N7O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0495304
|
US9422293, 127
Show/Hide
|
C26H29F3N6O
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0501433
|
US9422293, 121
Show/Hide
|
C24H25ClF3N5
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0520869
|
US9422293, 117
Show/Hide
|
C25H25F6N5
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0529417
|
US9422293, 73B
Show/Hide
|
C23H23Cl2F3N6
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0536001
|
US9422293, 203
Show/Hide
|
C22H18ClF6N5S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0544416
|
US9422293, 116
Show/Hide
|
C24H24F6N6
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0515019
|
US8802711, 122
Show/Hide
|
C17H19N5O2
|
1
|
| 1 |
IC50 = 20529 nM
|
|
|
|
CP0490544
|
US8802711, 52
Show/Hide
|
C19H20N4O3
|
1
|
| 1 |
IC50 = 22388 nM
|
|
|
|
CP0539846
|
US8796328, 27
Show/Hide
|
C20H22F3N3O4S
|
1
|
| 1 |
IC50 = 22500 nM
|
|
|
|
CP0494174
|
US8796328, 16
Show/Hide
|
C20H20F5N3O4S
|
1
|
| 1 |
IC50 = 22800 nM
|
|
|
|
CP0517127
|
US8969325, 203
Show/Hide
|
C22H23FN4O3
|
1
|
| 1 |
IC50 = 28000 nM
|
|
|
|
CP0556618
|
US8796328, 28
Show/Hide
|
C20H21F4N3O4S
|
1
|
| 1 |
IC50 = 29500 nM
|
|
|
|
CP0394203
|
4-nonyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C25H30N2O
|
2
|
| 1 |
IC50 > 30000 nM
|
|
|
| 2 |
Ki = 980 nM
|
|
|
|
CP0394205
|
4-octyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C24H28N2O
|
2
|
| 1 |
IC50 > 30000 nM
|
|
|
| 2 |
Ki = 2080 nM
|
|
|
|
CP0407962
|
4-[methyl(tetradecyl)amino]-N-quinolin-3-ylbenzamide
Show/Hide
|
C31H43N3O
|
2
|
| 1 |
IC50 > 30000 nM
|
|
|
| 2 |
Ki = 1471 nM
|
|
|
|
CP0407964
|
N-methyl-4-propyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0485734
|
4-heptyl-N-quinolin-3-ylbenzamide
Show/Hide
|
C23H26N2O
|
2
|
| 1 |
IC50 > 30000 nM
|
|
|
| 2 |
Ki = 3520 nM
|
|
|
|
CP0485746
|
4-butyl-N-phenylbenzamide
Show/Hide
|
C17H19NO
|
2
|
| 1 |
IC50 > 30000 nM
|
|
|
| 2 |
Ki = 6272 nM
|
|
|
|
CP0420135
|
N-[(1R)-2-amino-2-oxo-1-phenylethyl]-N-[(1R)-1-(3,5-difluorophenyl)ethyl]benzamide
Show/Hide
|
C23H20F2N2O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0557305
|
US8969325, 132
Show/Hide
|
C20H18F3N3O4
|
1
|
| 1 |
IC50 = 31000 nM
|
|
|
|
CP0450048
|
US8796328, 42
Show/Hide
|
C20H22F4N4O4S
|
1
|
| 1 |
IC50 = 32800 nM
|
|
|
|
CP0495451
|
5-hydroxy-1-(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-6-phenylhexan-3-one
Show/Hide
|
C22H28O3
|
1
|
| 1 |
IC50 = 35300 nM
|
|
|
|
CP0492611
|
US8796328, 12
Show/Hide
|
C18H20FN3O4S
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0521165
|
US8796328, 26
Show/Hide
|
C19H19F4N3O5S
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0551197
|
US8796328, 30
Show/Hide
|
C18H19F2N3O4S
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0442520
|
US8802711, 107
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0471212
|
US8802711, 53
Show/Hide
|
C19H20N4O3
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0490556
|
US8802711, 106
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0491524
|
US8802711, 109
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0516143
|
US8802711, 77
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0516164
|
US8802711, 110
Show/Hide
|
C22H24FN3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0530400
|
US8802711, 136
Show/Hide
|
C21H20ClN3O
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0530401
|
US8802711, 144
Show/Hide
|
C25H32N4O3
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0553812
|
US8802711, 19
Show/Hide
|
C21H23N3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0556835
|
US8802711, 118
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0556836
|
US8802711, 139
Show/Hide
|
C25H28FN3O
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0559775
|
US8802711, 146
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0567294
|
US8802711, 141
Show/Hide
|
C22H24N4O
|
1
|
| 1 |
IC50 > 37500 nM
|
|
|
|
CP0443870
|
US8969325, 121
Show/Hide
|
C19H16F3N3O4
|
1
|
| 1 |
IC50 > 38000 nM
|
|
|
|
CP0484811
|
US8969325, 169
Show/Hide
|
C20H19F3N4O4
|
1
|
| 1 |
IC50 > 38000 nM
|
|
|
|
CP0521232
|
US8969325, 118
Show/Hide
|
C18H16FN3O4
|
1
|
| 1 |
IC50 > 38000 nM
|
|
|
|
CP0529240
|
US8969325, 123
Show/Hide
|
C20H20FN3O4
|
1
|
| 1 |
IC50 > 38000 nM
|
|
|
|
CP0550499
|
US8969325, 115
Show/Hide
|
C19H16F3N3O5
|
1
|
| 1 |
IC50 > 38000 nM
|
|
|
|
CP0555108
|
US8969325, 122
Show/Hide
|
C21H20FN3O4
|
1
|
| 1 |
IC50 > 38000 nM
|
|
|
|
CP0420446
|
bis[(1S)-1-(4-chlorophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]methanone
Show/Hide
|
C35H34Cl2N2O5
|
1
|
| 1 |
IC50 = 49700 nM
|
|
|
|
CP0385454
|
5-hydroxy-1,6-diphenylhexan-3-one
Show/Hide
|
C18H20O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0391884
|
1-(1,3-benzodioxol-5-yl)-5-hydroxy-6-phenylhexan-3-one
Show/Hide
|
C19H20O4
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0392636
|
5-hydroxy-1-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-6-phenylhexan-3-one
Show/Hide
|
C24H32O3
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0392637
|
5-hydroxy-1-[4-hydroxy-3,5-di(propan-2-yl)phenyl]decan-3-one
Show/Hide
|
C22H36O3
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0392640
|
5-hydroxy-1-phenyldecan-3-one
Show/Hide
|
C16H24O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0390991
|
2-methyl-2-[4-methyl-4-(4-methylphenyl)pentyl]-7-pentyl-3,4-dihydrochromen-5-ol
Show/Hide
|
C28H40O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0420471
|
bis[(1S)-6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone
Show/Hide
|
C35H36N2O5
|
1
|
| 1 |
IC50 = 53000 nM
|
|
|
|
CP0420447
|
bis[(1S)-1-(4-fluorophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]methanone
Show/Hide
|
C35H34F2N2O5
|
1
|
| 1 |
IC50 = 68500 nM
|
|
|
|
CP0423849
|
(3Z,6R,11aS)-7,8,10-trimethoxy-9-methyl-6-phenyl-3-[(2,4,5-trimethoxy-3-methylphenyl)methylidene]-11,11a-dihydro-6H-pyrazino[1,2-b]isoquinoline-1,4-dione
Show/Hide
|
C33H36N2O8
|
1
|
| 1 |
IC50 = 68900 nM
|
|
|
|
CP0375145
|
N,N-dimethyl-5-[[4-(3-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
IC50 = 78900 nM
|
|
|
|
CP0399472
|
5-[[4-(3-carbamoylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
Show/Hide
|
C18H18N6O2
|
1
|
| 1 |
IC50 = 91800 nM
|
|
|
|
CP0431295
|
1-(1,3-benzodioxol-5-yl)-5-hydroxydecan-3-one
Show/Hide
|
C17H24O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0130454
|
N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380509
|
5-[[4-[3-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380511
|
5-[[4-(2-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380776
|
5-[[4-(4-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380777
|
methyl 3-[4-[[1-(dimethylcarbamoyl)tetrazol-5-yl]methyl]phenyl]benzoate
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380778
|
N,N-dimethyl-5-[[4-(2-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380780
|
5-[[4-(2-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380789
|
5-[[4-(3-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380790
|
N,N-dimethyl-5-[[4-(3-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0381258
|
5-[[4-(4-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0399470
|
5-[[4-(3-acetylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
Show/Hide
|
C19H19N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0407562
|
5-[[4-[4-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0433845
|
5-[[4-[3-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0433847
|
5-[[4-[4-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0433848
|
methyl 3-[4-[[2-(dimethylcarbamoyl)tetrazol-5-yl]methyl]phenyl]benzoate
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0433849
|
5-[[4-(3-acetylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
Show/Hide
|
C19H19N5O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0456753
|
N,N-dimethyl-5-[[4-(2-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide
Show/Hide
|
C18H19N5O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0040448
|
CHEBI:17447
Show/Hide
|
C10H18O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0114919
|
CHEBI:50462
Show/Hide
|
C10H20O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0375315
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 3-methylbenzoate
Show/Hide
|
C18H24O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0375316
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 2-(4-methoxyphenyl)acetate
Show/Hide
|
C19H26O3
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0375317
|
3,7-dimethyloct-6-enyl 2-(4-chlorophenyl)acetate
Show/Hide
|
C18H25ClO2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0375318
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 3-methylbenzoate
Show/Hide
|
C18H24O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0375343
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 4-cyanobenzoate
Show/Hide
|
C18H21NO2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0379931
|
3,7-dimethyloct-6-enyl 3-phenylpropanoate
Show/Hide
|
C19H28O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0379937
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 4-methylbenzoate
Show/Hide
|
C18H24O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380912
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 2-(4-methylphenyl)acetate
Show/Hide
|
C19H26O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380913
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 2-(4-chlorophenyl)acetate
Show/Hide
|
C18H23ClO2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380914
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 3-phenylpropanoate
Show/Hide
|
C19H26O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380915
|
CHEBI:70478
Show/Hide
|
C12H22O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380916
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 2-(4-methylphenyl)acetate
Show/Hide
|
C19H26O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0380921
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 4-cyanobenzoate
Show/Hide
|
C18H21NO2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0381510
|
NERYL ACETATE
Show/Hide
|
C12H20O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0386347
|
3,7-dimethyloct-6-enyl 4-methylbenzoate
Show/Hide
|
C18H26O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0396990
|
[(2E)-3,7-dimethylocta-2,6-dienyl] 3,5-bis(trifluoromethyl)benzoate
Show/Hide
|
C19H20F6O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0400237
|
CHEBI:29452
Show/Hide
|
C10H18O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0406624
|
N-[(2Z)-3,7-dimethylocta-2,6-dienyl]-3-phenylpropanamide
Show/Hide
|
C19H27NO
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0410528
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 2-(4-chlorophenyl)acetate
Show/Hide
|
C18H23ClO2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0410529
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 2-(3-iodophenyl)acetate
Show/Hide
|
C18H23IO2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0424276
|
CHEBI:5331
Show/Hide
|
C12H20O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0425991
|
[(2Z)-3,7-dimethylocta-2,6-dienyl] 2-naphthalen-2-ylacetate
Show/Hide
|
C22H26O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0474290
|
3,7-dimethyloct-6-enyl 2-(4-methylphenyl)acetate
Show/Hide
|
C19H28O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0411458
|
[(Z,7R)-18-[5-(4-hydroxy-3-methoxyphenyl)tetrazol-2-yl]octadec-9-en-7-yl] 2-phenylacetate
Show/Hide
|
C34H48N4O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0390989
|
(7R,8aR,10aR)-7-iodo-8,8,10a-trimethyl-3-pentyl-6,7,8a,9-tetrahydro-5H-xanthen-1-ol
Show/Hide
|
C21H31IO2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0396601
|
(8aR,10aR)-8,8,10a-trimethyl-3-pentyl-6,7,8a,9-tetrahydro-5H-xanthen-1-ol
Show/Hide
|
C21H32O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0412906
|
1-(6-chloro-1-(cyanomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
Show/Hide
|
C22H19ClN4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0485364
|
1-(isoquinolin-5-yl)-3-(6-methoxy-1-(pyridin-3-ylmethyl)-1,2,3,4-tetrahydronaphthalen-2-yl)urea
Show/Hide
|
C27H26N4O2
|
2
|
| 1 |
IC50 > 1000 nM
|
|
|
| 2 |
Ki = 1540 nM
|
|
|
|
CP0419424
|
US9422293, 85
Show/Hide
|
C24H24F3N5O2
|
1
|
| 1 |
IC50 > 2200 nM
|
|
|
|
CP0479328
|
US9422293, 101B
Show/Hide
|
C24H23F6N5O2S
|
1
|
| 1 |
IC50 > 2200 nM
|
|
|
|
CP0372298
|
2-N,7-N-bis[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11F6N5S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0372299
|
7-N-[4-(trifluoromethyl)phenyl]-2-N-[3-(trifluoromethyl)pyridin-2-yl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10F6N6S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0372300
|
2-N-(2,6-dichlorophenyl)-4-N-[4-(trifluoromethyl)phenyl]-1,3-benzothiazole-2,4-diamine
Show/Hide
|
C20H12Cl2F3N3S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0378976
|
(4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)phenyl)(pyrrolidin-1-yl)methanone
Show/Hide
|
C22H18Cl2N6OS
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0388331
|
2-N-(2,6-dichlorophenyl)-7-N-methyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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C19H12Cl2F3N5S
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1
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| 1 |
IC50 > 5000 nM
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CP0399261
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4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)benzamide
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C18H12Cl2N6OS
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1
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| 1 |
IC50 > 5000 nM
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CP0399935
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3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)benzoic acid
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C19H10Cl2F3N5O2S
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1
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| 1 |
IC50 > 5000 nM
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CP0399936
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N-(2,6-dichlorophenyl)-7-[4-(trifluoromethyl)phenyl]sulfanyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
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C18H9Cl2F3N4S2
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1
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| 1 |
IC50 > 5000 nM
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CP0460311
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2-N-(2,6-dichlorophenyl)-7-N-[2-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
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C18H10Cl2F3N5S
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1
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| 1 |
IC50 > 5000 nM
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CP0460313
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4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)benzoic acid
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C18H11Cl2N5O2S
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1
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| 1 |
IC50 > 5000 nM
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CP0460315
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4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)benzenesulfonamide
Show/Hide
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C17H12Cl2N6O2S2
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1
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| 1 |
IC50 > 5000 nM
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CP0464263
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2-N-phenyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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C18H12F3N5S
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1
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| 1 |
IC50 > 5000 nM
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CP0474070
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7-(4-tert-butylphenoxy)-N-(2,6-dichlorophenyl)thiazolo[5,4-d]pyrimidin-2-amine
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C21H18Cl2N4OS
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1
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| 1 |
IC50 > 5000 nM
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CP0480321
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2-N-[3-(trifluoromethyl)phenyl]-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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C19H11F6N5S
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1
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| 1 |
IC50 > 5000 nM
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CP0377759
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2-N-methyl-2-N-(1-methylpiperidin-3-yl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
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C28H31F6N7
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1
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| 1 |
IC50 > 5000 nM
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CP0533170
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2-N-piperidin-3-yl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
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C26H27F6N7
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1
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| 1 |
IC50 > 5000 nM
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CP0413281
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US9422293, 232
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C24H23Cl2F3N6
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1
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| 1 |
IC50 > 6670 nM
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CP0413301
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US9422293, 309
Show/Hide
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C30H33F6N5O
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1
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| 1 |
IC50 > 6670 nM
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CP0451453
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US9422293, 299
Show/Hide
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C28H32F3N7O2S
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1
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| 1 |
IC50 > 6670 nM
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CP0465800
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US9422293, 209
Show/Hide
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C23H21F6N5O2S
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1
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| 1 |
IC50 > 6670 nM
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CP0480857
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US9422293, 287
Show/Hide
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C24H22ClF6N5
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1
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| 1 |
IC50 > 6670 nM
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CP0486281
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US9422293, 251
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C26H27Cl2F3N6
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1
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| 1 |
IC50 > 6670 nM
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CP0488361
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US9422293, 304
Show/Hide
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C22H22F3N5O2S2
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1
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| 1 |
IC50 > 6670 nM
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CP0488626
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US9422293, 364
Show/Hide
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C29H25F6N5S
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1
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| 1 |
IC50 > 6670 nM
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CP0490934
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US9422293, 351
Show/Hide
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C28H23F6N5S
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1
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| 1 |
IC50 > 6670 nM
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CP0492922
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US9422293, 280
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C28H24F6N6
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1
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| 1 |
IC50 > 6670 nM
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CP0495319
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US9422293, 286
Show/Hide
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C26H31BrClN5
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1
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| 1 |
IC50 > 6670 nM
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CP0515419
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N-[6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-2-piperidin-1-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine
Show/Hide
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C26H27F6N7O
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1
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| 1 |
IC50 > 6670 nM
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CP0516747
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US9422293, 131
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C29H28F3N5
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1
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| 1 |
IC50 > 6670 nM
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CP0516766
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US9422293, 285
Show/Hide
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C27H31ClF3N5
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1
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| 1 |
IC50 > 6670 nM
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CP0519506
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US9422293, 256
Show/Hide
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C26H28Cl2F3N7
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1
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| 1 |
IC50 > 6670 nM
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CP0535998
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US9422293, 115
Show/Hide
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C25H24ClF6N5
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1
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| 1 |
IC50 > 6670 nM
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CP0561179
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US9422293, 134
Show/Hide
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C27H31F3N6O
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1
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| 1 |
IC50 > 6670 nM
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CP0561263
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US9422293, 132
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C29H34F3N5
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1
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| 1 |
IC50 > 6670 nM
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CP0413272
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US9422293, 18
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C23H19F3N6
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1
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| 1 |
IC50 > 6700 nM
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CP0413293
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US9422293, 98
Show/Hide
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C22H20Cl2F3N5S
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1
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| 1 |
IC50 > 6700 nM
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CP0494947
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US9422293, 25
Show/Hide
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C29H28F3N5O
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1
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| 1 |
IC50 > 6700 nM
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CP0515196
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US9422293, 89
Show/Hide
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C25H28F3N5O2S
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1
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| 1 |
IC50 > 6700 nM
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CP0517231
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US9422293, 28
Show/Hide
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C19H17F3N6
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1
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| 1 |
IC50 > 6700 nM
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CP0526062
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US9422293, 64
Show/Hide
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C24H24F6N6O
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1
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| 1 |
IC50 > 6700 nM
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CP0526196
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US9422293, 74B
Show/Hide
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C21H18F6N6S
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1
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| 1 |
IC50 > 6700 nM
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CP0550661
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US9422293, 26
Show/Hide
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C20H16F6N6
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1
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| 1 |
IC50 > 6700 nM
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CP0497011
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1-(2,4-Dichloro-benzyl)-3-(7-hydroxy-naphthalen-1-yl)-urea
Show/Hide
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C18H14Cl2N2O2
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1
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| 1 |
Ki = 2.8 nM
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CP0485361
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1-(isoquinolin-5-yl)-3-(3-phenyl-2-(4-(trifluoromethyl)phenyl)propyl)urea
Show/Hide
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C26H22F3N3O
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1
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| 1 |
Ki = 4 nM
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CP0509974
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1-(7-Hydroxy-naphthalen-1-yl)-3-[1-(4-trifluoromethyl-phenyl)-ethyl]-urea
Show/Hide
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C20H17F3N2O2
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1
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| 1 |
Ki = 4 nM
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CP0502062
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1-(3,4-Difluoro-benzyl)-3-(7-hydroxy-naphthalen-1-yl)-urea
Show/Hide
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C18H14F2N2O2
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1
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| 1 |
Ki = 7 nM
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CP0440610
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1-(2,3-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C22H25N3O3
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1
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| 1 |
Ki = 28 nM
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CP0463258
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N-(3-oxo-4H-1,4-benzoxazin-6-yl)-1-(3,4,5-trifluorophenyl)piperidine-4-carboxamide
Show/Hide
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C20H18F3N3O3
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1
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| 1 |
Ki = 49 nM
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CP0467340
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1-(7-Hydroxy-naphthalen-1-yl)-3-phenethyl-urea
Show/Hide
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C19H18N2O2
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1
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| 1 |
Ki = 53 nM
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CP0481443
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1-(3,4-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H19F2N3O3
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1
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| 1 |
Ki = 56 nM
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CP0554532
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1-(2-methylphenyl)-N-(3-oxo-4H-1,4-benzoxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C21H23N3O3
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1
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| 1 |
Ki = 61 nM
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CP0422863
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N-(3-oxo-4H-1,4-benzoxazin-6-yl)-1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide
Show/Hide
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C21H20F3N3O3
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1
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| 1 |
Ki = 65 nM
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CP0463260
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N-(3-oxo-4H-1,4-benzoxazin-6-yl)-1-[2-(trifluoromethyl)phenyl]piperidine-4-carboxamide
Show/Hide
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C21H20F3N3O3
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1
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| 1 |
Ki = 68 nM
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CP0554534
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1-(2-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H20BrN3O3
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1
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| 1 |
Ki = 71 nM
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CP0422864
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1-(2-isopropylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C23H27N3O3
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1
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| 1 |
Ki = 78 nM
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CP0481444
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1-(2-bromo-3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H19BrFN3O3
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1
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| 1 |
Ki = 81 nM
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CP0422866
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1-(3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H20FN3O3
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1
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| 1 |
Ki = 84 nM
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CP0527000
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1-(2-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H20ClN3O3
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1
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| 1 |
Ki = 93 nM
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CP0481445
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1-(3-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H20ClN3O3
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1
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| 1 |
Ki = 97 nM
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CP0463259
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1-(3-chloro-2-methylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C21H22ClN3O3
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1
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| 1 |
Ki = 100 nM
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CP0525982
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1-(2-ethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C22H25N3O3
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1
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| 1 |
Ki = 125 nM
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CP0397030
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1-(3,5-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H19F2N3O3
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1
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| 1 |
Ki = 137 nM
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CP0492709
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1-(4-tert-butylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C24H29N3O3
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1
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| 1 |
Ki = 142 nM
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CP0525983
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1-(3-methylphenyl)-N-(3-oxo-4H-1,4-benzoxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C21H23N3O3
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1
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| 1 |
Ki = 225 nM
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CP0526999
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1-(3,4-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C22H25N3O3
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1
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| 1 |
Ki = 314 nM
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CP0401347
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1-(3,4-Dichloro-benzyl)-3-(7-hydroxy-naphthalen-1-yl)-1-methyl-urea
Show/Hide
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C19H16Cl2N2O2
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1
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| 1 |
Ki = 581 nM
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CP0422865
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1-(2-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)piperidine-4-carboxamide
Show/Hide
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C20H20FN3O3
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1
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| 1 |
Ki = 1470 nM
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