General Information of the Compound
Compound ID
CP0421865
Compound Name
5-tert-butyl-2-(4-(1,1,2,2-tetrafluoroethoxy)phenyl)-1H-benzo[d]imidazole
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Structure
Formula
C19H18F4N2O
Molecular Weight
366.358
Canonical SMILES
CC(C)(C)c1ccc2nc([nH]c2c1)-c1ccc(OC(F)(F)C(F)F)cc1
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InChI
InChI=1S/C19H18F4N2O/c1-18(2,3)12-6-9-14-15(10-12)25-16(24-14)11-4-7-13(8-5-11)26-19(22,23)17(20)21/h4-10,17H,1-3H3,(H,24,25)
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InChIKey
HHHJUTSVZVJDHK-UHFFFAOYSA-N
Physicochemical Property
logP
5.7641
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
37.91
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44447628
ChEMBL ID
CHEMBL254462
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 477 nM
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