General Information of the Compound
Compound ID
CP0424764
Compound Name
1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)-3-(pyridin-3-yl)propyl)urea
    Show/Hide
Structure
Formula
C25H24N4O2
Molecular Weight
412.493
Canonical SMILES
COc1ccc(cc1)C(CNC(=O)Nc1cccc2cnccc12)Cc1cccnc1
    Show/Hide
InChI
InChI=1S/C25H24N4O2/c1-31-22-9-7-19(8-10-22)21(14-18-4-3-12-26-15-18)17-28-25(30)29-24-6-2-5-20-16-27-13-11-23(20)24/h2-13,15-16,21H,14,17H2,1H3,(H2,28,29,30)
    Show/Hide
InChIKey
TYNWYOMSZOLTRN-UHFFFAOYSA-N
Physicochemical Property
logP
4.7864
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
76.14
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44444349
ChEMBL ID
CHEMBL250169
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 184 nM
   TI
   LI
   LO
   TS
2
Ki = 578 nM
   TI
   LI
   LO
   TS