General Information of the Compound
Compound ID
CP0551310
Compound Name
US8969325, 56
    Show/Hide
Structure
Formula
C23H25FN4O4
Molecular Weight
440.475
Canonical SMILES
OCCN1Cc2ccc(NC(=O)N[C@H]3CC4(CCC4)Oc4ccc(F)cc34)cc2NC1=O
    Show/Hide
InChI
InChI=1S/C23H25FN4O4/c24-15-3-5-20-17(10-15)19(12-23(32-20)6-1-7-23)26-21(30)25-16-4-2-14-13-28(8-9-29)22(31)27-18(14)11-16/h2-5,10-11,19,29H,1,6-9,12-13H2,(H,27,31)(H2,25,26,30)/t19-/m0/s1
    Show/Hide
InChIKey
MNPWXYBPXGQLIC-IBGZPJMESA-N
Physicochemical Property
logP
3.7335
Rotatable Bonds
4
Heavy Atom Count
32
Polar Areas
102.93
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 89649404
ChEMBL ID
CHEMBL3677354
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS