General Information of the Compound
Compound ID
CP0554199
Compound Name
US8969325, 303
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Structure
Formula
C26H31FN4O4
Molecular Weight
482.556
Canonical SMILES
CC1(C)C[C@@H](NC(=O)Nc2ccc3CC(N4CCCOCC4)C(=O)Nc3c2)c2ccc(F)cc2O1
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InChI
InChI=1S/C26H31FN4O4/c1-26(2)15-21(19-7-5-17(27)13-23(19)35-26)30-25(33)28-18-6-4-16-12-22(24(32)29-20(16)14-18)31-8-3-10-34-11-9-31/h4-7,13-14,21-22H,3,8-12,15H2,1-2H3,(H,29,32)(H2,28,30,33)/t21-,22?/m1/s1
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InChIKey
IMLPTBIWFWTZCY-ZMFCMNQTSA-N
Physicochemical Property
logP
3.8351
Rotatable Bonds
3
Heavy Atom Count
35
Polar Areas
91.93
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89649285
ChEMBL ID
CHEMBL3682390
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 610 nM
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