General Information of the Compound
Compound ID
CP0450286
Compound Name
US8969325, 323
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Structure
Formula
C20H18ClF2N3O4
Molecular Weight
437.83
Canonical SMILES
FCC1(CF)C[C@@H](NC(=O)Nc2cccc3NC(=O)COc23)c2ccc(Cl)cc2O1
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InChI
InChI=1S/C20H18ClF2N3O4/c21-11-4-5-12-15(7-20(9-22,10-23)30-16(12)6-11)26-19(28)25-14-3-1-2-13-18(14)29-8-17(27)24-13/h1-6,15H,7-10H2,(H,24,27)(H2,25,26,28)/t15-/m1/s1
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InChIKey
LQKZENZHXLQYCB-OAHLLOKOSA-N
Physicochemical Property
logP
3.994
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
88.69
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89649166
ChEMBL ID
CHEMBL3682410
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4.5 nM
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