General Information of the Compound
Compound ID
CP0371747
Compound Name
1-(1-(4-cyanobenzyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
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Structure
Formula
C29H26N4O2
Molecular Weight
462.553
Canonical SMILES
COc1ccc2C(Cc3ccc(cc3)C#N)C(CCc2c1)NC(=O)Nc1cccc2cnccc12
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InChI
InChI=1S/C29H26N4O2/c1-35-23-10-11-24-21(16-23)9-12-28(26(24)15-19-5-7-20(17-30)8-6-19)33-29(34)32-27-4-2-3-22-18-31-14-13-25(22)27/h2-8,10-11,13-14,16,18,26,28H,9,12,15H2,1H3,(H2,32,33,34)
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InChIKey
HVIMFCCKQDZURG-UHFFFAOYSA-N
Physicochemical Property
logP
5.57788
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
87.04
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44444399
ChEMBL ID
CHEMBL399277
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
2
Ki = 17 nM
   TI
   LI
   LO
   TS