Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide

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PubChem ID

CID: 9929425

SID: 14902055

Canonical SMILES	CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show/Hide
Compound Formula	C20H25ClN4O

Compound Structure

Protein Name

Protein Info

Transient receptor potential cation channel subfamily V member 1

Protein Classification

Ion channel

Voltage-gated ion channel

Transient receptor potential channel

Uniprot ID

Q8NER1

Gene Name

TRPV1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000094	1321N1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 5 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	IC50 = 1.83 nM	TI LI LO TS
2	Ki = 4.32 nM	TI LI LO TS
3	Ki = 10.5 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 19 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 0.15 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 6.7 nM	TI LI LO TS
2	IC50 = 7 nM	TI LI LO TS
3	IC50 = 16 nM	TI LI LO TS
4	IC50 = 29.8 nM	TI LI LO TS
5	IC50 = 34 nM	TI LI LO TS
6	Ki = 2.5 nM	TI LI LO TS
CL000058	T-REx-293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 0.18 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 24 nM
2	IC50 = 34.9 nM