General Information of the Compound
Compound ID
CP0485363
Compound Name
1-(1-allyl-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea
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Structure
Formula
C23H22FN3O
Molecular Weight
375.447
Canonical SMILES
Fc1ccc2C(CC=C)C(CCc2c1)NC(=O)Nc1cccc2cnccc12
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InChI
InChI=1S/C23H22FN3O/c1-2-4-20-18-9-8-17(24)13-15(18)7-10-22(20)27-23(28)26-21-6-3-5-16-14-25-12-11-19(16)21/h2-3,5-6,8-9,11-14,20,22H,1,4,7,10H2,(H2,26,27,28)
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InChIKey
GIZOKURWNNMZGN-UHFFFAOYSA-N
Physicochemical Property
logP
5.1701
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
54.02
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44444396
ChEMBL ID
CHEMBL251182
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
2
Ki = 2 nM
   TI
   LI
   LO
   TS