General Information of the Compound
Compound ID
CP0461671
Compound Name
N-[(6-hydroxy-9-methyl-1,2,3,4-tetrahydrocarbazol-4-yl)methyl]-4-(trifluoromethoxy)benzamide
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Structure
Formula
C22H21F3N2O3
Molecular Weight
418.415
Canonical SMILES
Cn1c2CCCC(CNC(=O)c3ccc(OC(F)(F)F)cc3)c2c2cc(O)ccc12
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InChI
InChI=1S/C22H21F3N2O3/c1-27-18-10-7-15(28)11-17(18)20-14(3-2-4-19(20)27)12-26-21(29)13-5-8-16(9-6-13)30-22(23,24)25/h5-11,14,28H,2-4,12H2,1H3,(H,26,29)
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InChIKey
UMHVOYZISKMPIT-UHFFFAOYSA-N
Physicochemical Property
logP
4.6324
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
63.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24882612
SID: 50138354
ChEMBL ID
CHEMBL438345
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02183, Transient receptor potential cation channel subfamily V member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 23 nM
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