| Compound ID |
Compound Name |
Compound Formula |
|
CP0726211
|
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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|
C20H21F6N5O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0726216
|
2-(4-(4-(6-fluoro-1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H25FN6O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0838178
|
1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
Show/Hide
|
C23H20N6O2S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0746924
|
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
Show/Hide
|
C23H21N7O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0754413
|
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C24H22N6O2S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0745046
|
2-ethyl-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C23H30N6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0883885
|
2-(4-(4-(6-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H23FN6O2S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0838149
|
2-(5-methyl-4-(4-(4-phenylthiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C26H26N6O2S
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0947155
|
2-(5-methyl-4-(2-phenylaziridine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C20H19N5O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0768978
|
2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C21H24F3N5O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0726235
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C20H25N5O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0768940
|
2-(5-methyl-4-(4-phenylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C23H25N5O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0812551
|
7-fluoro-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C16H14F4N6O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0909340
|
2-(4-(4-(1H-indol-4-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H26N6O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0726214
|
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C22H22F2N6O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0962090
|
2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H23FN6O2S
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0838175
|
2-(4-(4-tert-butylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C21H29N5O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0868890
|
2-(4-(4-(2-chlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C22H23ClN6O2
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0768943
|
2-(4-(4-tert-butylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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|
C20H25N5O2S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0761088
|
methyl 5-cyclopropyl-1-(7-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxylate
Show/Hide
|
C14H12FN5O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0772437
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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|
C18H20N6O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0812550
|
2-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
Show/Hide
|
C17H18F3N5O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0838150
|
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H23F3N6O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0909335
|
2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H21F3N6O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0823430
|
2-(5-methyl-4-(4-(2-methyl-1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C26H28N6O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0963569
|
(S)-N-benzyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-(1-phenylethyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C27H27N5O2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0768975
|
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H26N6O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0836860
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H23N5O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0726171
|
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H24N6O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0768972
|
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-7-fluoropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H22FN7O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0966388
|
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H23N7O2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0713504
|
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H18F6N6O3
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0913652
|
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
|
C24H22N6O2S
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0964693
|
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C21H26N6O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0823432
|
2-(4-(4-benzylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H27N5O2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0959035
|
2-methyl-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
|
C21H26N6O2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0913650
|
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C23H20N6O2S2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0962087
|
tert-butyl 2-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[4.5]decane-6-carboxylate
Show/Hide
|
C25H34N6O4
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0838162
|
tert-butyl 8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-5,8-diazaspiro[3.5]nonane-5-carboxylate
Show/Hide
|
C23H29N7O4
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0761046
|
2-(4-((4aR,8aR)-decahydroisoquinoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C20H23N5O2S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0768910
|
2-(4-(4-(3-chlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20ClN7O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0913648
|
2-(5-methyl-4-(4-phenylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C22H24N6O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0966390
|
2-(4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H21N5O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0738384
|
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H24N6O2S
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0829374
|
2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxybutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H23F3N6O3
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0868889
|
N-(2-morpholinophenyl)-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C21H22N6O3
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0909311
|
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pentanenitrile
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0962085
|
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C23H20N6O2S
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0913640
|
(S)-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C21H26N6O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0713510
|
2-(5-methyl-4-(3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0839330
|
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
|
C23H20N6O2S2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0951509
|
2-(4-(4-hydroxy-2-methyl-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H27N5O3
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0746915
|
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H20F3N5O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0746920
|
2-(4-(4-(3,4-dichlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H19Cl2N7O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0966392
|
2-(4-(3-(3,4-difluorophenyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C21H19F2N5O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0726207
|
7-fluoro-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16F4N6O2
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0745168
|
2-(5-methyl-4-(4-phenylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C22H21N5O2S
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0726224
|
4-ethyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C20H24N6O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0812542
|
2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C22H19F2N5O4S2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0823423
|
2-(5-methyl-4-(4-methyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C21H22N6O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0838151
|
2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H23F3N6O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0951345
|
(S)-N-tert-butyl-2-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C26H30N6O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0754200
|
4-fluoro-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C21H25FN6O2
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0726174
|
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H21N7O2S
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0868887
|
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H22F3N5O2
|
1
|
| 1 |
IC50 = 56 nM
|
|
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CP0883887
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2-methyl-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
IC50 = 57 nM
|
|
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|
CP0913646
|
2-(4-(4-methoxy-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H27N5O3
|
1
|
| 1 |
IC50 = 57 nM
|
|
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CP0726226
|
2-(5-methyl-4-(4-(phenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C23H25N5O4S
|
1
|
| 1 |
IC50 = 58 nM
|
|
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CP0745155
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(Z)-2-(5-methyl-4-(4-(1,1,1-trifluorobut-2-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H21F3N6O2
|
1
|
| 1 |
IC50 = 58 nM
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|
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CP0768973
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2-(2-methyl-3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrrol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H21F3N4O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
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CP0772463
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2-(4-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H22N8O3
|
1
|
| 1 |
IC50 = 58 nM
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|
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CP0768926
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2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H21N7O2
|
1
|
| 1 |
IC50 = 59 nM
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|
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CP0868886
|
2-(5-methyl-4-((2S,4S)-2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H22F3N5O2
|
1
|
| 1 |
IC50 = 59 nM
|
|
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CP0947147
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6-[5-methyl-4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-4-(trifluoromethyl)-1,2-dihydropyridin-2-one
Show/Hide
|
C17H16F6N4O2
|
1
|
| 1 |
IC50 = 59 nM
|
|
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|
CP0713517
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2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C21H21N5O2
|
1
|
| 1 |
IC50 = 61 nM
|
|
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|
CP0734278
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2-methyl-2-(1-(1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
|
C19H20N6O2S
|
1
|
| 1 |
IC50 = 62 nM
|
|
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CP0944130
|
2-(5-methyl-4-(4-o-tolylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C23H26N6O2
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0768911
|
2-(4-(4-(4-chlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20ClN7O2
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0962073
|
tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate
Show/Hide
|
C23H29N7O4
|
1
|
| 1 |
IC50 = 65 nM
|
|
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|
CP0913622
|
2-(4-(4-(4-fluorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20FN7O2
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0868874
|
2-(5-methyl-4-(4-phenylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H21N7O2
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0951347
|
2-(4-(3-hydroxy-3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0944420
|
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopentanecarbonitrile
Show/Hide
|
C22H25N7O2
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0947153
|
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H17F3N6O2
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0909330
|
2-(5-methyl-4-(9-(3,3,3-trifluoropropyl)-3,9-diazabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H24F3N7O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0829387
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C19H21N5O2S
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0909331
|
2-(4-(3-(4-chlorophenyl)-3-fluoro-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H22ClFN6O2
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0713487
|
2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H21F2N5O2
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0726242
|
2-(5-methyl-4-(8-azaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C20H23N5O2S
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0812541
|
2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H20FN7O2S
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0962089
|
(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
Show/Hide
|
C22H30N6O4
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0962060
|
1-(1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
Show/Hide
|
C23H22N6O2
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0966386
|
2-(4-((4aR,8aS)-decahydroisoquinoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C20H23N5O2S
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0868891
|
2-(5-methyl-4-(4-(1-methyl-1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C26H28N6O2
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0947144
|
2-(5-methyl-4-(3-phenyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H23N7O2
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0761041
|
2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C20H24F3N5O3
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0947205
|
4-ethyl-1-(1-(7-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-5-methyl-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C19H20FN7O2
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0738372
|
4-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)benzonitrile
Show/Hide
|
C22H20N8O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0745042
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H22N6O2
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0954047
|
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
Show/Hide
|
C21H23N7O2
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0883883
|
2-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
Show/Hide
|
C16H15F3N6O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0951458
|
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H19F6N5O3
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0913633
|
2-(5-methyl-4-(4-(4-phenylthiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C25H23N7O2S
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0726220
|
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-cyclopropyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C26H26N6O2S
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0839263
|
2-(5-(4-(trifluoromethyl)piperidine-1-carbonyl)thiophen-2-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H18F3N3O2S
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0962079
|
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C17H16F3N5O2S
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0772462
|
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H20F3N7O2
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0838172
|
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C18H19N5O2S
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0838174
|
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-7-fluoropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H20FN7O2S
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0868903
|
2-(4-(3-(4-fluorophenyl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0968732
|
2-(4-(3-(3-fluorophenyl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0768970
|
7-fluoro-2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16F4N6O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0745054
|
2-(5-methyl-4-(3-phenoxypyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C22H23N5O3
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0913655
|
2-(4-(2,2-difluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C20H23F2N5O2
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0823433
|
1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
Show/Hide
|
C24H24N6O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0754428
|
2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C25H32N6O3
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0909339
|
2-(5-methyl-4-(4-phenoxypiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C23H25N5O3
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0761021
|
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C21H20F2N6O2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0745055
|
2-(4-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C23H25N5O3
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0745151
|
4-methyl-6-[5-methyl-4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-1,2-dihydropyridin-2-one
Show/Hide
|
C17H19F3N4O2
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0768928
|
N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-N-isopropyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H27N5O4
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0838171
|
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H19F2N7O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0891305
|
2-(4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H18N6O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0713488
|
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H24N6O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0713494
|
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H23N7O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0726209
|
2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C23H19FN6O2S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0726210
|
2-(4-(1-benzyl-1,7-diazaspiro[4.4]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H26N6O2S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0726228
|
N-((5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C22H20ClN7O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0726247
|
2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3H,4H-thieno[2,3-d]pyrimidin-4-one
Show/Hide
|
C20H17N5O2S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0738369
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1-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C21H24N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0738374
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2-(4-(3-hydroxy-3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H24N6O3
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1
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| 1 |
IC50 = 100 nM
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CP0738383
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2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H14F3N5O2S
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1
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| 1 |
IC50 = 100 nM
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CP0745057
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2-(5-methyl-4-(2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
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1
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| 1 |
IC50 = 100 nM
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CP0746916
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2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O3
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1
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| 1 |
IC50 = 100 nM
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CP0746923
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6-fluoro-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H14F4N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0754410
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tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[4.5]decane-6-carboxylate
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C24H30N6O4S
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1
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| 1 |
IC50 = 100 nM
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CP0761025
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2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23N5O2
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1
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| 1 |
IC50 = 100 nM
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CP0761034
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2-[4-(cyclopentyloxy)-1H-pyrazol-1-yl]-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
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C15H18N4O2
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1
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| 1 |
IC50 = 100 nM
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CP0768906
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2-cyclopropyl-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)acetonitrile
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C21H23N7O2
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1
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| 1 |
IC50 = 100 nM
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CP0768971
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2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrrol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F3N5O2
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1
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| 1 |
IC50 = 100 nM
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CP0823415
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2-(4-(4-cyclopropyl-4-hydroxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
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1
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| 1 |
IC50 = 100 nM
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CP0823420
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2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C23H20N6O2S
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1
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| 1 |
IC50 = 100 nM
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CP0823422
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2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrrol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H19F3N4O2
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1
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| 1 |
IC50 = 100 nM
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CP0823427
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2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C19H21N5O2S
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1
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| 1 |
IC50 = 100 nM
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CP0831441
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2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H20F3N5O2
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1
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| 1 |
IC50 = 100 nM
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CP0838161
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2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C20H23N7O2
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1
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| 1 |
IC50 = 100 nM
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CP0838179
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1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
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C23H20N6O2S
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1
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| 1 |
IC50 = 100 nM
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CP0839329
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2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H25N5O3
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1
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| 1 |
IC50 = 100 nM
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CP0868872
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2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F3N6O3
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1
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| 1 |
IC50 = 100 nM
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CP0868883
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2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
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1
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| 1 |
IC50 = 100 nM
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CP0868888
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N-benzyl-N-ethyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C21H23N5O2
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1
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| 1 |
IC50 = 100 nM
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CP0883863
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2-(5-methyl-4-(4-(pyrrolidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H24F3N7O3
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1
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| 1 |
IC50 = 100 nM
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CP0883884
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2-(5-methyl-4-(3-phenylazetidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H21N5O2
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1
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| 1 |
IC50 = 100 nM
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CP0897049
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2-[4-(9-azatricyclo[6.2.2.0(2,7)]dodeca-2,4,6-trien-9-ylcarbonyl)-5-methyl-1H-pyrazol-1-yl]pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
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C22H20N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0909314
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4-(8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)benzonitrile
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C24H22N8O2
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1
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| 1 |
IC50 = 100 nM
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CP0909328
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2-(4-(4-(2-fluoropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
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1
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| 1 |
IC50 = 100 nM
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CP0909396
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2-(4-(4-(5-chloropyridin-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H19ClN8O2
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1
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| 1 |
IC50 = 100 nM
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CP0909398
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4-fluoro-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
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C20H22FN7O2
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1
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| 1 |
IC50 = 100 nM
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CP0944284
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2-(5-methyl-4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H22F3N5O3
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1
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| 1 |
IC50 = 100 nM
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CP0944285
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1-(1-[4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl]-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
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C22H18N6O2S
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1
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| 1 |
IC50 = 100 nM
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CP0944287
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2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H20F2N6O4S
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1
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| 1 |
IC50 = 100 nM
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CP0946653
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2-(4-(3-(4-chlorophenyl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H22ClN7O2
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1
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| 1 |
IC50 = 100 nM
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CP0947143
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tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
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C23H29N7O4
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1
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| 1 |
IC50 = 100 nM
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CP0947146
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2-(5-methyl-4-(5-(trifluoromethyl)octahydrocyclopenta[c]pyrrole-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H19F3N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0947189
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2-(5-methyl-4-(2-azaspiro[3.4]octane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0951508
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2-(5-methyl-4-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-ylcarbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H22N6O3
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1
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| 1 |
IC50 = 100 nM
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CP0955174
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2-(5-methyl-4-(3-phenylpyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C22H23N5O2
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1
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| 1 |
IC50 = 100 nM
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CP0955211
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2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C24H29N7O3
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1
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| 1 |
IC50 = 100 nM
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CP0958064
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2-(4-(4-cyclopropyl-4-methoxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H24N6O3
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1
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| 1 |
IC50 = 100 nM
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CP0962059
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4-ethyl-1-(1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C19H22N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0962077
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2-(5-methyl-4-(9-(2,2,2-trifluoroethyl)-3,9-diazabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H22F3N7O2
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1
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| 1 |
IC50 = 100 nM
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CP0962078
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tert-butyl 3-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate
Show/Hide
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C24H32N6O4
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1
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| 1 |
IC50 = 100 nM
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CP0962083
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2-(5-methyl-4-(2-(pyridin-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C22H24N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0962086
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1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
Show/Hide
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C22H19N7O2
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1
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| 1 |
IC50 = 100 nM
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CP0963561
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2-(5-methyl-4-(3-(p-tolyloxy)-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H26N6O3
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1
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| 1 |
IC50 = 100 nM
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CP0966137
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2-(3-chloro-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H14ClF3N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0967572
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2-(5-cyclopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-7-fluoropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H18F4N6O2
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1
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| 1 |
IC50 = 100 nM
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CP0713503
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tert-butyl 8-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate
Show/Hide
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C23H30N6O4
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1
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| 1 |
IC50 = 200 nM
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CP0726170
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2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H16F6N6O3
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1
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| 1 |
IC50 = 200 nM
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CP0726213
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4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C19H21N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0726225
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N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-(quinolin-6-ylmethyl)-1H-pyrazole-4-carboxamide
Show/Hide
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C23H22N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0726232
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2-(5-methyl-4-(3-phenoxypiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C23H25N5O3
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1
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| 1 |
IC50 = 200 nM
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CP0726239
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2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
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C17H16F3N5O2S
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1
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| 1 |
IC50 = 200 nM
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CP0734274
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2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
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C16H14F3N5O2S
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1
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| 1 |
IC50 = 200 nM
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CP0734277
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4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C19H20N6O2S
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1
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| 1 |
IC50 = 200 nM
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CP0738364
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2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-ylidene)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H21F3N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0738377
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tert-butyl 7-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
Show/Hide
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C23H29N7O4
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1
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| 1 |
IC50 = 200 nM
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CP0745040
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2-(5-cyclopropyl-4-(4-methylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0745044
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2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H17F3N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0745051
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N-cyclohexyl-N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C19H25N5O2
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1
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| 1 |
IC50 = 200 nM
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CP0746917
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1-ethyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carbonitrile
Show/Hide
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C21H23N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0746919
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2-(5-methyl-4-(4-(pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H20N8O2
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1
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| 1 |
IC50 = 200 nM
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CP0746921
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tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,5-diazaspiro[3.4]octane-5-carboxylate
Show/Hide
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C22H27N7O4
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1
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| 1 |
IC50 = 200 nM
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CP0754202
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2-(5-methyl-4-(3-(5-(trifluoromethyl)pyridin-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21F3N8O2
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1
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| 1 |
IC50 = 200 nM
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CP0760995
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2-(5-methyl-4-(5-phenyloctahydropyrrolo[3,4-c]pyrrole-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H23N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0760999
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tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[3.4]octane-6-carboxylate
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C22H27N7O4
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1
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| 1 |
IC50 = 200 nM
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CP0761033
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(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H24N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0761035
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2-(5-methyl-4-(2-methyl-2-p-tolylmorpholine-4-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C24H27N5O3
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1
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| 1 |
IC50 = 200 nM
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CP0761040
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2-(5-methyl-4-(4-(3,3,3-trifluoropropyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0761081
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2-(4-(5,5-difluorooctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H18F2N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0761085
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(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 200 nM
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CP0761091
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2-(4-(4-methoxy-4-methylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H25N5O3
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1
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| 1 |
IC50 = 200 nM
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CP0768915
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
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C18H18F3N5O2S
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1
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| 1 |
IC50 = 200 nM
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CP0768925
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2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H19N7O2S
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1
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| 1 |
IC50 = 200 nM
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CP0768935
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2-(5-methyl-4-((2R,4R)-2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
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1
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| 1 |
IC50 = 200 nM
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CP0772438
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2-(4-(2,2-difluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F2N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0772465
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tert-butyl 7-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
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C24H32N6O4
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1
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| 1 |
IC50 = 200 nM
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CP0812546
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tert-butyl(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)methylcarbamate
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C21H28N6O4
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1
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| 1 |
IC50 = 200 nM
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CP0820597
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2-(5-methyl-4-((4R)-2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
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1
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| 1 |
IC50 = 200 nM
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CP0823412
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tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 200 nM
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CP0823414
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2-(4-(8-hydroxy-8-(trifluoromethyl)-3-azabicyclo[3.2.1]octane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O3
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1
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| 1 |
IC50 = 200 nM
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CP0823419
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2-(5-methyl-4-(4-methyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H19N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0823421
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C18H21F3N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0823437
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2-(5-methyl-4-(2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C18H18F3N5O2S
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1
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| 1 |
IC50 = 200 nM
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CP0823440
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2-(4-(2,4-dimethylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H21N5O2S
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1
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| 1 |
IC50 = 200 nM
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CP0829377
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2-(5-methyl-4-(7-(trifluoromethyl)-3-azabicyclo[4.1.0]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H17F3N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0829378
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1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
Show/Hide
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C20H21N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0831440
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2-(4-(1,1-difluoro-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H18F2N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0838152
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1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)cyclopropanecarbonitrile
Show/Hide
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C20H19N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0838155
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2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0838156
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2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H18F2N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0838163
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2-(5-methyl-4-(5-azaspiro[2.5]octane-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0838167
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2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C15H14F3N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0838168
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2-(4-(3-(3,4-difluorophenyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H16F2N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0838169
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2-(4-(4-ethoxypiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H23N5O3
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1
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| 1 |
IC50 = 200 nM
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CP0838173
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2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0868871
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(R)-tert-butyl methyl(1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
Show/Hide
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C20H25N7O4
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1
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| 1 |
IC50 = 200 nM
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CP0868901
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2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H16F3N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0883864
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2-(4-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
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C20H22FN7O2
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1
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| 1 |
IC50 = 200 nM
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CP0897056
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2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
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C18H19N5O2S
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1
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| 1 |
IC50 = 200 nM
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CP0905473
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2-(5-methyl-4-(2-azaspiro[3.4]octane-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H23N5O2
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1
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| 1 |
IC50 = 200 nM
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CP0909309
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ethyl 5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylate
Show/Hide
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C12H12N6O3
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1
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| 1 |
IC50 = 200 nM
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CP0909317
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2-(4-(4-(benzo[d]thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H20N8O2S
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1
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| 1 |
IC50 = 200 nM
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CP0909336
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tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
Show/Hide
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C23H29N7O4
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1
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| 1 |
IC50 = 200 nM
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CP0913621
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2-(5-methyl-4-(2-azaspiro[4.4]nonane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0944128
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C18H18F3N5O2S
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1
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| 1 |
IC50 = 200 nM
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CP0944282
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2-(4-(3-ethyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H23N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0944421
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2-(4-(4-(4-chlorophenyl)-4-fluoropiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H20ClFN6O2
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1
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| 1 |
IC50 = 200 nM
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CP0947142
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2-(5-methyl-4-(4-(3-(trifluoromethyl)phenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H20F3N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0947149
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tert-butyl 2-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
Show/Hide
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C24H32N6O4
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1
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| 1 |
IC50 = 200 nM
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CP0947206
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2-methyl-2-(1-(1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
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C20H24N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0947249
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2-(5-methyl-4-(3-(pyridin-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H22N8O2
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1
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| 1 |
IC50 = 200 nM
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CP0951349
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2-(1-(5-cyclopropyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-2-methylpropanenitrile
Show/Hide
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C23H28N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0954048
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2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H23N5O2
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1
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| 1 |
IC50 = 200 nM
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CP0958063
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2-(4-(4-(bicyclo[2.2.1]heptan-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H27N7O2
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1
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| 1 |
IC50 = 200 nM
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CP0962058
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tert-butyl 4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C21H28N6O4
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1
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| 1 |
IC50 = 200 nM
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CP0962061
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2-(5-methyl-4-(4-(4-(trifluoromethyl)phenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H20F3N7O2
|
1
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| 1 |
IC50 = 200 nM
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CP0962069
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2-(5-methyl-4-(9-(trifluoromethyl)-6-azaspiro[3.5]nonane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H21F3N6O2
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1
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| 1 |
IC50 = 200 nM
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CP0962072
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2-(5-methyl-4-(4-(thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H19N7O2S
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1
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| 1 |
IC50 = 200 nM
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CP0962084
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benzyl 2-methyl-4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C25H28N6O4
|
1
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| 1 |
IC50 = 200 nM
|
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CP0964658
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1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclobutanecarbonitrile
Show/Hide
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C21H23N7O2
|
1
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| 1 |
IC50 = 200 nM
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CP0966389
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2-(5-methyl-4-(1-(5-phenyl-1,3,4-oxadiazol-2-yl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C27H27N7O3
|
1
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| 1 |
IC50 = 200 nM
|
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CP0966391
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2-(4-(4-(6-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C23H21FN6O2S
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1
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| 1 |
IC50 = 200 nM
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CP0966396
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2-(4-(2,2-dimethyl-4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22F3N7O2
|
1
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| 1 |
IC50 = 200 nM
|
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CP0967574
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2-(4-(4-hydroxy-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H17F3N6O3
|
1
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| 1 |
IC50 = 200 nM
|
|
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CP0969861
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6-(8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)nicotinonitrile
Show/Hide
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C23H21N9O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
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CP0713489
|
2-(4-(2-fluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21FN6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0713491
|
2-(5-methyl-4-(3-methyl-4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H20F3N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0713493
|
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
|
C19H21N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0713506
|
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C19H20N6O2S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0726172
|
methyl 1-(7-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-5-methyl-1H-pyrazole-4-carboxylate
Show/Hide
|
C12H10FN5O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0726229
|
(S)-2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H20F3N5O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0734273
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2-(5-methyl-4-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H19F3N8O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0738381
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2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C23H21FN6O2S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0745052
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2-(5-methyl-4-(4-methyl-2-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H22F3N5O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0745164
|
(S)-6-methyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
|
C19H19N5O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0746918
|
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(pyridin-2-yl)piperidine-4-carbonitrile
Show/Hide
|
C22H20N8O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0750105
|
2-(4-((3aS,6aR)-4,4-difluorooctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H18F2N6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0754424
|
2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H19F3N6O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0768907
|
tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)carbamate
Show/Hide
|
C20H25N7O4
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0772435
|
tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-5,8-diazaspiro[3.5]nonane-8-carboxylate
Show/Hide
|
C23H29N7O4
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0772459
|
2-(4-(3-fluoro-3-phenylazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H17FN6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0772460
|
(R)-2-(4-(4-(cyclobutylmethyl)-3-methylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H27N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0772464
|
N-cyclopropyl-N-methyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carboxamide
Show/Hide
|
C23H27N7O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0820593
|
2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H20F3N5O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0823417
|
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C18H20N8O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0823431
|
5-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-6H,7H-thieno[2,3-c]pyridin-7-one
Show/Hide
|
C17H15F3N4O2S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0829379
|
2-(4-(6,6-difluoro-3-azabicyclo[3.2.0]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16F2N6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0829382
|
3-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-2,4-diazabicyclo[4.2.0]octa-1(6),2-dien-5-one
Show/Hide
|
C17H18F3N5O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0829386
|
tert-butyl 8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate
Show/Hide
|
C22H27N7O4
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0838153
|
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C16H15F2N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0838157
|
(R)-tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
|
C21H27N7O4
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0838165
|
2-(4-(6,6-difluoro-3-azabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16F2N6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0838182
|
1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
|
C18H20N6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0839257
|
2-(5-methyl-4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H19F3N6O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0891300
|
2-(4-(3-oxa-7-azabicyclo[3.3.1]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C19H23N5O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0905478
|
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H17F2N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0909397
|
2-(4-(4-(1H-pyrrol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H21N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0913635
|
2-(5-methyl-4-(4-methylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H20N6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0913637
|
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H21N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0947243
|
2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C17H16F3N5O2S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0951350
|
2-(4-(3-fluoro-4-methylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H19FN6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0954042
|
2-(5-methyl-4-(3-(4-(trifluoromethyl)phenyl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C24H22F3N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0954055
|
2-(5-cyclopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C20H22F3N5O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0955171
|
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
|
C19H22N8O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0955727
|
2-(5-methyl-4-(2-oxopiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C17H19N5O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0962057
|
2-methyl-2-(1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
|
C19H21N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0962066
|
2-(4-(3-azabicyclo[3.3.1]nonane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H22N6O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0962070
|
2-(4-(4-fluoro-4-(pyridin-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20FN7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0966139
|
2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H19N7O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0966140
|
N-(4-fluoro-2-(2-hydroxypropan-2-yl)phenyl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C20H19FN6O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0966387
|
(R)-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C20H17N5O2S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0966393
|
2-(4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H17F3N6O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0969862
|
2-(4-(4-(4-fluorobenzyloxy)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H23FN6O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0726221
|
6-fluoro-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16F4N6O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0726223
|
2-(4-(4-(phenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H20N6O4S
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0726233
|
2-(3,5-dimethyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C21H19N5O2S
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0734254
|
2-(4-(4-methoxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C18H23N5O3
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0734272
|
2-(5-methyl-4-(7-(2,2,2-trifluoroethyl)-2,7-diazaspiro[3.5]nonane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H22F3N7O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0745048
|
(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
Show/Hide
|
C21H26N6O4S
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0745050
|
benzyl 1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidine-2-carboxylate
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0745158
|
2-(5-methyl-4-(2-thia-6-azaspiro[3.3]heptane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C16H16N6O2S
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0745162
|
2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C21H18F2N6O4S
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0754201
|
tert-butyl 3-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-ylcarbamate
Show/Hide
|
C20H25N7O4
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0761093
|
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C24H30N6O3
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0772434
|
2-(5-methyl-4-(4-(pyrazin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H19N9O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0823411
|
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H27N7O3
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0829375
|
2-(4-((1S,4S)-5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C23H23N7O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0831446
|
2-(5-methyl-4-(piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C17H21N5O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0838164
|
2-(4-(3-cyclopropyl-3-hydroxyazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18N6O3
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1
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| 1 |
IC50 = 400 nM
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CP0838170
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(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H22N6O2
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1
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| 1 |
IC50 = 400 nM
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CP0891288
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2-(4-(4-tert-butylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H25N7O2
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1
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| 1 |
IC50 = 400 nM
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CP0891308
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2-(4-(6,6-difluoro-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H14F2N6O2
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1
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| 1 |
IC50 = 400 nM
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CP0905479
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6-fluoro-2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F4N6O2
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1
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| 1 |
IC50 = 400 nM
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CP0909310
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2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)acetonitrile
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C18H19N7O2
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1
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| 1 |
IC50 = 400 nM
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CP0909341
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H18F3N7O2
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1
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| 1 |
IC50 = 400 nM
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CP0913625
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6-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)nicotinonitrile
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C21H19N9O2
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1
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| 1 |
IC50 = 400 nM
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CP0913627
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tert-butyl methyl((1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)methyl)carbamate
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C21H27N7O4
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1
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| 1 |
IC50 = 400 nM
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CP0943130
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tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 400 nM
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CP0944133
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2-(5-methyl-4-(5-azaspiro[2.4]heptane-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18N6O2
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1
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| 1 |
IC50 = 400 nM
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CP0944283
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N-(2-(1H-indol-3-yl)ethyl)-N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C23H24N6O2
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1
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| 1 |
IC50 = 400 nM
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CP0947150
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5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-phenethyl-N-(3,3,3-trifluoro-2-hydroxypropyl)-1H-pyrazole-4-carboxamide
Show/Hide
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C23H24F3N5O3
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1
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| 1 |
IC50 = 400 nM
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CP0962064
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(R)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 400 nM
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CP0962071
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(3S,5R)-tert-butyl 3,5-dimethyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C22H29N7O4
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1
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| 1 |
IC50 = 400 nM
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CP0962076
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2-(5-methyl-4-(3-(trifluoromethyl)-1,4'-bipiperidine-1'-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H26F3N7O2
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1
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| 1 |
IC50 = 400 nM
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CP0963562
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2-(5-methyl-4-(4-(5-(trifluoromethyl)-1H-pyrazol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19F3N8O2
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1
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| 1 |
IC50 = 400 nM
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CP0964269
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N-methyl-N-(8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)benzamide
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C26H27N7O3
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1
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| 1 |
IC50 = 400 nM
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CP0964655
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2-(5-methyl-4-(4-(thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18N8O2S
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1
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| 1 |
IC50 = 400 nM
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CP0964673
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2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
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1
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| 1 |
IC50 = 400 nM
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CP0966689
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(R)-2-(5-methyl-4-(4-(2-(trifluoromethyl)pyrrolidin-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H24F3N7O2
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1
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| 1 |
IC50 = 400 nM
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CP0967573
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2-(5-methyl-4-(1-(5-phenyl-1,3,4-oxadiazol-2-yl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C26H24N8O3
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1
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| 1 |
IC50 = 400 nM
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CP0713492
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(S)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 500 nM
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CP0713509
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4-methyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C19H22N6O2
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1
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| 1 |
IC50 = 500 nM
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CP0745058
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2-(4-(2,2-dimethylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H21N5O2S
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1
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| 1 |
IC50 = 500 nM
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CP0745161
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2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
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C17H16F3N5O2S
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1
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| 1 |
IC50 = 500 nM
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CP0761001
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(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
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C17H18N6O2S
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1
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| 1 |
IC50 = 500 nM
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CP0761048
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2-(5-methyl-4-(1,2,3,4-tetrahydroquinoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C20H17N5O2S
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1
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| 1 |
IC50 = 500 nM
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CP0768979
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2-(4-(2-ethyl-2,7-diazaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H25N7O2
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1
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| 1 |
IC50 = 500 nM
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CP0812537
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2-(5-methyl-4-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O4
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1
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| 1 |
IC50 = 500 nM
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CP0823436
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2-(5-methyl-4-(3-(trifluoromethyl)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C17H18F3N5O2
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1
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| 1 |
IC50 = 500 nM
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CP0829376
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H17F3N8O2
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1
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| 1 |
IC50 = 500 nM
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CP0868885
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5-chloro-6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
Show/Hide
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C19H18ClN5O2
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1
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| 1 |
IC50 = 500 nM
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CP0913639
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(S)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C21H27N7O4
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1
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| 1 |
IC50 = 500 nM
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CP0913649
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2-(4-(1-benzyl-1,7-diazaspiro[4.4]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C26H30N6O2
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1
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| 1 |
IC50 = 500 nM
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CP0943131
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2-(4-(4-(ethyl(methyl)amino)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H25N7O2
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1
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| 1 |
IC50 = 500 nM
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CP0947190
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2-(4-(3,3-difluoro-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H18F2N6O2
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1
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| 1 |
IC50 = 500 nM
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CP0947191
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2-(4-(4-(isopropylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H24N6O4S
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1
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| 1 |
IC50 = 500 nM
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CP0947250
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(3aR,6aR)-tert-butyl 1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
Show/Hide
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C22H27N7O4
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1
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| 1 |
IC50 = 500 nM
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CP0958062
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2-(5-methyl-4-(2-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H17F3N6O2
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1
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| 1 |
IC50 = 500 nM
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CP0966423
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tert-butyl 4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
Show/Hide
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C20H25N7O4
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1
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| 1 |
IC50 = 500 nM
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CP0713490
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2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)acetonitrile
Show/Hide
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C17H18N8O2
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1
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| 1 |
IC50 = 600 nM
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CP0713502
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4-ethyl-1-(1-(6-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C18H18FN7O2
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1
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| 1 |
IC50 = 600 nM
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CP0726217
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2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C19H21N5O3S
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1
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| 1 |
IC50 = 600 nM
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CP0726227
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N-(2-cyanoethyl)-N-cyclohexyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C21H26N6O2
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1
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| 1 |
IC50 = 600 nM
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CP0745045
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(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H19N7O2
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1
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| 1 |
IC50 = 600 nM
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CP0761052
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(R)-6-methyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C19H19N5O2
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1
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| 1 |
IC50 = 600 nM
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CP0772442
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(R)-2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C18H20F3N5O2
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1
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| 1 |
IC50 = 600 nM
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CP0812528
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2-(4-(4,4-difluoro-1,4'-bipiperidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H25F2N7O2
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1
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| 1 |
IC50 = 600 nM
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CP0829380
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4-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C18H19N7O2
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1
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| 1 |
IC50 = 600 nM
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CP0913620
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2-(4-(2-azabicyclo[2.1.1]hexane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H16N6O2
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1
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| 1 |
IC50 = 600 nM
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CP0913638
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2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H16F2N6O2
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1
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| 1 |
IC50 = 600 nM
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CP0947248
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2-(4-(azetidine-1-carbonyl)-5-cyclopropyl-1H-pyrazol-1-yl)-7-fluoropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H15FN6O2
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1
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| 1 |
IC50 = 600 nM
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CP0947251
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2-(4-(1-(5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl)-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C26H23FN8O3
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1
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| 1 |
IC50 = 600 nM
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CP0955723
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4-methyl-6-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-1,2-dihydropyridin-2-one
Show/Hide
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C16H17F3N4O2
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1
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| 1 |
IC50 = 600 nM
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CP0962088
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(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C18H20N6O2S
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1
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| 1 |
IC50 = 600 nM
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CP0964656
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tert-butyl 1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
Show/Hide
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C22H27N7O4
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1
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| 1 |
IC50 = 600 nM
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CP0726218
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2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C25H21N5O2S
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1
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| 1 |
IC50 = 700 nM
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CP0768909
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(1S,5S)-tert-butyl 6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-3-carboxylate
Show/Hide
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C21H25N7O4
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1
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| 1 |
IC50 = 700 nM
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CP0768977
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1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(2,2,2-trifluoroethyl)piperidine-4-carbonitrile
Show/Hide
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C19H18F3N7O2
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1
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| 1 |
IC50 = 700 nM
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CP0772458
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2-(4-hydroxy-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
Show/Hide
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C20H23N7O3
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1
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| 1 |
IC50 = 700 nM
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CP0823410
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2-(4-(4-methoxy-4-methylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H22N6O3
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1
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| 1 |
IC50 = 700 nM
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CP0838176
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2-(1-(5-cyclopropyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
Show/Hide
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C22H26N6O2
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1
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| 1 |
IC50 = 700 nM
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CP0839261
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2-(5-methyl-4-(piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H18N6O2
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1
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| 1 |
IC50 = 700 nM
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CP0839331
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2-(3,5-dimethyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H18F3N5O2S
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1
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| 1 |
IC50 = 700 nM
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CP0870568
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2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
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1
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| 1 |
IC50 = 700 nM
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CP0913645
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5-chloro-6-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C16H17ClF3N5O2
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1
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| 1 |
IC50 = 700 nM
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CP0944131
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tert-butyl 3,3-dimethyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C22H29N7O4
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1
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| 1 |
IC50 = 700 nM
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CP0946654
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2-(5-methyl-4-(1-(5-(pyridin-3-yl)-1,2,4-oxadiazol-3-yl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H23N9O3
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1
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| 1 |
IC50 = 700 nM
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CP0954045
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2-(4-((1R,5S)-6-(fluoromethyl)-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17FN6O2
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1
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| 1 |
IC50 = 700 nM
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CP0963563
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2-(5-methyl-4-(2-(3,3,3-trifluoropropyl)-2,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H26F3N7O2
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1
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| 1 |
IC50 = 700 nM
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CP0964663
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2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H19F2N5O2
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1
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| 1 |
IC50 = 700 nM
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CP0738370
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(S)-2-(4-(7,7-difluorooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
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1
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| 1 |
IC50 = 800 nM
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CP0745041
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6-fluoro-2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F4N6O2
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1
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| 1 |
IC50 = 800 nM
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CP0745060
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2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one
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C19H16F3N5O2
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1
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| 1 |
IC50 = 800 nM
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CP0812540
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2-(5-methyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H19N7O2
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1
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| 1 |
IC50 = 800 nM
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CP0812549
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2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C22H18N6O2S2
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1
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| 1 |
IC50 = 800 nM
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CP0838154
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2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
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1
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| 1 |
IC50 = 800 nM
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CP0838160
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tert-butyl 1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3-(trifluoromethyl)pyrrolidin-3-ylcarbamate
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C21H24F3N7O4
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1
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| 1 |
IC50 = 800 nM
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CP0870569
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2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F2N6O2
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1
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| 1 |
IC50 = 800 nM
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CP0909318
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2-(5-methyl-4-(3-(4-(trifluoromethyl)benzyl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H19F3N6O2
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1
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| 1 |
IC50 = 800 nM
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CP0962062
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(1R,5R)-tert-butyl 6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-3-carboxylate
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C21H25N7O4
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1
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| 1 |
IC50 = 800 nM
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CP0962063
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tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate
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C22H27N7O4
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1
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| 1 |
IC50 = 800 nM
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CP0964660
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(R)-2-(4-(3-((2-chlorothiazol-5-yl)methoxy)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H18ClN7O3S
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1
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| 1 |
IC50 = 800 nM
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CP0964724
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(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
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1
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| 1 |
IC50 = 800 nM
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CP0754350
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tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
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C22H27N7O4
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1
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| 1 |
IC50 = 900 nM
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CP0760996
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2-(4-(3-(4,4-difluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F2N7O2
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1
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| 1 |
IC50 = 900 nM
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CP0761057
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6-methyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C19H19N5O2
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1
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| 1 |
IC50 = 900 nM
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CP0838158
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2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
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1
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| 1 |
IC50 = 900 nM
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CP0839332
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2-[4-[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]-5-methyl-1H-pyrazol-1-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one
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C18H21N5O2S
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1
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| 1 |
IC50 = 900 nM
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CP0883881
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2-(5-isopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H24F3N5O2
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1
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| 1 |
IC50 = 900 nM
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CP0909327
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2-(4-(3-(3,4-difluorobenzyloxy)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H18F2N6O3
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1
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| 1 |
IC50 = 900 nM
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CP0947148
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tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)octahydro-1,5-naphthyridine-1(2H)-carboxylate
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C24H31N7O4
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1
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| 1 |
IC50 = 900 nM
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CP0951467
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tert-butyl 6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[3.4]octane-2-carboxylate
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C22H27N7O4
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1
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| 1 |
IC50 = 900 nM
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CP0969527
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2-(4-(3-benzyl-3,9-diazabicyclo[3.3.1]nonane-9-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H27N7O2
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1
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| 1 |
IC50 = 900 nM
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CP0713496
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2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
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1
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| 1 |
IC50 = 1000 nM
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CP0726231
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2-(4-(3-methoxyazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C16H19N5O3
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1
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| 1 |
IC50 = 1000 nM
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CP0768929
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2-(4-(3-methoxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C18H23N5O3
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1
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| 1 |
IC50 = 1000 nM
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CP0812538
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2-(5-methyl-4-(2-oxa-7-azaspiro[3.5]nonane-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O3
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1
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| 1 |
IC50 = 1000 nM
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CP0870571
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2-(5-methyl-4-(3-(2,2,2-trifluoroethyl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H15F3N6O2
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1
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| 1 |
IC50 = 1000 nM
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CP0891307
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4-ethyl-1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C17H18N8O2
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1
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| 1 |
IC50 = 1000 nM
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CP0909313
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(1R,4R)-tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
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C21H25N7O4
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1
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| 1 |
IC50 = 1000 nM
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CP0909334
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6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C19H19N5O2
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1
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| 1 |
IC50 = 1000 nM
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CP0943132
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2-(4-(6-(2,2-difluoroethyl)-2,6-diazaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19F2N7O2
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1
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| 1 |
IC50 = 1000 nM
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CP0947156
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(S)-2-(5-methyl-4-(4-(2-(trifluoromethyl)pyrrolidin-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H24F3N7O2
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1
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| 1 |
IC50 = 1000 nM
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CP0954044
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4-(methoxymethyl)-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
Show/Hide
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C19H21N7O3
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1
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| 1 |
IC50 = 1000 nM
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CP0955168
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(S)-2-(4-(3-((2-chlorothiazol-5-yl)methoxy)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H18ClN7O3S
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1
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| 1 |
IC50 = 1000 nM
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CP0962068
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2-(4-(2,2-dimethyl-3-(trifluoromethyl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O2
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1
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| 1 |
IC50 = 1000 nM
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CP0962123
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tert-butyl(1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)methylcarbamate
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C20H24N6O4S
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1
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| 1 |
IC50 = 1000 nM
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CP0963559
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2-(5-methyl-4-(2-oxa-7-azaspiro[4.4]nonane-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20N6O3
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1
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| 1 |
IC50 = 1000 nM
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CP0964662
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2-(4-(3-(4-fluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22FN7O2
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1
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| 1 |
IC50 = 1000 nM
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CP0966141
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2-(4-(3-fluoro-3-(trifluoromethyl)-1,3'-biazetidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H17F4N7O2
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1
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| 1 |
IC50 = 1000 nM
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CP0966142
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(S)-2-(5-methyl-4-(3-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19F3N6O3
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1
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| 1 |
IC50 = 1000 nM
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CP0726250
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6-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C16H18F3N5O2
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1
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| 1 |
IC50 = 1100 nM
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CP0772461
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2-(4-(3-(3,3-difluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21F2N7O2
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1
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| 1 |
IC50 = 1100 nM
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CP0838159
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(S)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H21N7O2
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1
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| 1 |
IC50 = 1100 nM
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CP0868902
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2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)octahydrocyclopenta[c]pyrrole-5-carbonitrile
Show/Hide
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C19H19N7O2
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1
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| 1 |
IC50 = 1100 nM
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CP0891286
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2-(4-(3-(4-fluorobenzyl)-3-hydroxypyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C22H21FN6O3
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1
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| 1 |
IC50 = 1100 nM
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CP0905474
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2-(5-methyl-4-(2-methyl-1-pivaloyloctahydropyrrolo[2,3-c]pyrrole-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C23H29N7O3
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1
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| 1 |
IC50 = 1100 nM
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CP0909321
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2-(4-(4-methoxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H20N6O3
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1
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| 1 |
IC50 = 1100 nM
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CP0913634
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2-(5-methyl-4-(3-(2,2,2-trifluoroethoxy)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H15F3N6O3
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1
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| 1 |
IC50 = 1100 nM
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CP0913647
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2-(4-(4-(phenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C21H19N5O4S2
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1
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| 1 |
IC50 = 1100 nM
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CP0964674
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2-(5-methyl-4-(3-(trifluoromethyl)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C16H14F3N5O2S
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1
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| 1 |
IC50 = 1100 nM
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CP0964691
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(R)-6-methyl-2-(5-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C20H21N5O2
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1
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| 1 |
IC50 = 1100 nM
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CP0966146
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2-(4-(4,4-difluoropiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C17H19F2N5O2
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1
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| 1 |
IC50 = 1100 nM
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CP0713538
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2-(4-(isoindoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C18H17N5O2
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1
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| 1 |
IC50 = 1200 nM
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CP0745047
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2-(4-(3-oxa-7-azabicyclo[3.3.1]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H19N5O3S
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1
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| 1 |
IC50 = 1200 nM
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CP0760997
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(1S)-tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-6-carboxylate
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C21H25N7O4
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1
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| 1 |
IC50 = 1200 nM
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CP0761045
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(S)-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
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1
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| 1 |
IC50 = 1200 nM
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CP0761050
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N-(2,3-dihydro-1H-inden-1-yl)-N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C20H21N5O2
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1
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| 1 |
IC50 = 1200 nM
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CP0768937
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5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-(2,2,2-trifluoroethyl)-N-(3,3,3-trifluoropropyl)-1H-pyrazole-4-carboxamide
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C17H17F6N5O2
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1
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| 1 |
IC50 = 1200 nM
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CP0838180
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2-(5-methyl-4-(4-phenylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C22H22N6O2
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1
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| 1 |
IC50 = 1200 nM
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CP0904666
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(S)-2-(4-(3-(3-fluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22FN7O2
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1
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| 1 |
IC50 = 1200 nM
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CP0909401
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6-methyl-2-(5-methyl-4-(4-(pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C19H21N7O2
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1
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| 1 |
IC50 = 1200 nM
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CP0823404
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3-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidine-3-carbonitrile
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C16H14FN7O2
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1
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| 1 |
IC50 = 1300 nM
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CP0955178
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2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H16F3N9O2S
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1
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| 1 |
IC50 = 1300 nM
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CP0958061
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1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C17H17N7O2
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1
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| 1 |
IC50 = 1300 nM
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CP0963560
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3-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-3-carbonitrile
Show/Hide
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C18H19N7O2
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1
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| 1 |
IC50 = 1300 nM
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CP0964271
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2-(5-methyl-4-(3-oxo-4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H16F3N7O3
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1
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| 1 |
IC50 = 1300 nM
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CP0964657
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2-(5-methyl-4-(3-(2,2,2-trifluoroethyl)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F3N6O2
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1
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| 1 |
IC50 = 1300 nM
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CP0969863
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2-(4-(4-(2-(2-fluorophenyl)acetyl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H21FN8O3
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1
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| 1 |
IC50 = 1300 nM
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CP0738351
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2-(4-(3-methoxypyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C17H21N5O3
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1
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| 1 |
IC50 = 1400 nM
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CP0761083
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(1R,6S)-tert-butyl 8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate
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C22H27N7O4
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1
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| 1 |
IC50 = 1400 nM
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CP0820594
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4-methyl-6-[3-methyl-4-[4-(trifluoromethyL)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-1,2-dihydropyridin-2-one
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C17H19F3N4O2
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1
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| 1 |
IC50 = 1400 nM
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CP0891285
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2-(4-(3-(2,2-difluoroethoxy)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16F2N6O3
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1
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| 1 |
IC50 = 1400 nM
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CP0909322
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2-(4-(3-fluoro-1,3'-biazetidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18FN7O2
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1
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| 1 |
IC50 = 1400 nM
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CP0913636
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(R)-2-(4-(3-((4-chloropyrimidin-2-yloxy)methyl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19ClN8O3
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1
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| 1 |
IC50 = 1400 nM
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CP0944286
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2-(4-(3,3-difluoropyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C15H14F2N6O2
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1
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| 1 |
IC50 = 1400 nM
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CP0944422
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(R)-2-(5-methyl-4-(3-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O3
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1
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| 1 |
IC50 = 1400 nM
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CP0962065
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3-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)propanenitrile
Show/Hide
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C18H20N8O2
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1
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| 1 |
IC50 = 1400 nM
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CP0962075
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2-(4-(3-methoxy-3-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19F3N6O3
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1
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| 1 |
IC50 = 1400 nM
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CP0713539
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6-methyl-2-(5-methyl-4-(7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C20H18F3N5O2
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1
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| 1 |
IC50 = 1500 nM
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CP0738352
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2-(5-methyl-4-(2,2,6,6-tetramethylmorpholine-4-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C19H23N5O3S
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1
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| 1 |
IC50 = 1500 nM
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CP0955175
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ethyl 1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylate
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C11H10N6O3
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1
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| 1 |
IC50 = 1500 nM
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CP0958066
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2-(4-(3-chloro-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H14ClN7O2
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1
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| 1 |
IC50 = 1500 nM
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CP0964670
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(S)-6-methyl-2-(5-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C20H21N5O2
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1
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| 1 |
IC50 = 1500 nM
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CP0964672
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N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C21H23N5O2
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1
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| 1 |
IC50 = 1500 nM
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CP0966394
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6-methyl-2-(5-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C20H21N5O2
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1
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| 1 |
IC50 = 1500 nM
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CP0726173
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2-(4-(1-hydroxy-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C17H19N5O3
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1
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| 1 |
IC50 = 1600 nM
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CP0768933
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2-[4-[4-(trifluoromethyL)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H,5H,7H-furo[3,4-d]pyrimidin-4-one
Show/Hide
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C16H16F3N5O3
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1
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| 1 |
IC50 = 1600 nM
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CP0951346
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2-(5-methyl-4-(4-(2-oxopyrrolidin-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H23N7O3
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1
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| 1 |
IC50 = 1600 nM
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CP0829381
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(1R,5S)-tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-6-carboxylate
Show/Hide
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C21H25N7O4
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1
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| 1 |
IC50 = 1700 nM
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CP0913631
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2-(4-(4-(1H-1,2,4-triazol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19N9O2
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1
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| 1 |
IC50 = 1700 nM
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CP0964694
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2-(4-(3-(aminomethyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C16H20N6O2
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1
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| 1 |
IC50 = 1700 nM
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CP0966690
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2-(4-(3-((S)-3-fluoropiperidin-1-yl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H24FN7O2
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1
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| 1 |
IC50 = 1700 nM
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CP0713507
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2-(5-(4-(trifluoromethyl)piperidine-1-carbonyl)thiazol-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C16H13F3N4O2S2
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1
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| 1 |
IC50 = 1800 nM
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CP0820601
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2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C16H21N5O2
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1
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| 1 |
IC50 = 1800 nM
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CP0964654
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2-(5-methyl-4-(5-oxooctahydrocyclopenta[c]pyrrole-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H18N6O3
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1
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| 1 |
IC50 = 1800 nM
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CP0966138
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(5S)-2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2-azabicyclo[2.2.1]heptane-5-carbonitrile
Show/Hide
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C18H17N7O2
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1
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| 1 |
IC50 = 1800 nM
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CP0909325
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2-(4-(3-fluoro-3-(4-fluorophenyl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H18F2N6O2
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1
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| 1 |
IC50 = 1900 nM
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CP0943133
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2-(4-(3,5-bis(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H16F6N6O2
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1
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| 1 |
IC50 = 1900 nM
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CP0713516
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2-(4-(3,5-bis(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C18H15F6N5O2S
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1
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| 1 |
IC50 = 2000 nM
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CP0745049
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2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)pyridin-2-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C19H19F3N4O2
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1
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| 1 |
IC50 = 2000 nM
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CP0745165
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6-methyl-2-[3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
Show/Hide
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C18H17N5O2
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1
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| 1 |
IC50 = 2000 nM
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CP0913632
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(1R,6S)-tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate
Show/Hide
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C22H27N7O4
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1
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| 1 |
IC50 = 2000 nM
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CP0947154
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(R)-2-(4-(3-(3-fluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20FN7O2
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1
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| 1 |
IC50 = 2000 nM
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CP0713518
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N-benzyl-N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C18H19N5O2
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1
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| 1 |
IC50 = 2100 nM
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CP0745056
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2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one
Show/Hide
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C19H22F3N5O2
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1
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| 1 |
IC50 = 2100 nM
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CP0745159
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2-(4-(5-hydroxy-5-methyloctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22N6O3
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1
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| 1 |
IC50 = 2100 nM
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CP0746925
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2-(5-methyl-4-(2,6-diazaspiro[4.5]decane-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C20H26N6O2
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1
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| 1 |
IC50 = 2100 nM
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CP0761049
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5,6-dimethyl-2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C20H21N5O2
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1
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| 1 |
IC50 = 2100 nM
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CP0812548
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2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C24H19N5O2S2
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1
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| 1 |
IC50 = 2100 nM
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CP0823442
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2-(5-isopropyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C21H23N5O2
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1
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| 1 |
IC50 = 2200 nM
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CP0772443
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2-(4-(2,2-dimethylpyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C17H19N5O2S
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1
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| 1 |
IC50 = 2300 nM
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CP0883861
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(S)-2-(4-(3-(3-fluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H20FN7O2
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1
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| 1 |
IC50 = 2300 nM
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CP0909315
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(S)-2-(5-methyl-4-(8a-methyloctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H23N7O2
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1
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| 1 |
IC50 = 2300 nM
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CP0944129
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2-(4-(6-hydroxy-6-(trifluoromethyl)-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H17F3N6O3
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1
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| 1 |
IC50 = 2300 nM
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CP0970223
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2-(4-(6,6-difluoro-1-azaspiro[3.3]heptane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H16F2N6O2
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1
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| 1 |
IC50 = 2300 nM
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CP0726251
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6-methyl-2-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C19H16F3N5O2
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1
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| 1 |
IC50 = 2400 nM
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CP0955170
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2-(4-(3-((R)-3-fluoropiperidin-1-yl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H24FN7O2
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1
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| 1 |
IC50 = 2400 nM
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CP0761054
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2-(5-(difluoromethyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C19H17F2N5O2
|
1
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| 1 |
IC50 = 2500 nM
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CP0868873
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2-(4-(3,3-difluoroazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C14H12F2N6O2
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1
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| 1 |
IC50 = 2500 nM
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CP0883878
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2-(3,5-dimethyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C20H21N5O2
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1
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| 1 |
IC50 = 2500 nM
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CP0761031
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methyl 3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carboxylate
Show/Hide
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C24H28N6O5
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1
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| 1 |
IC50 = 2600 nM
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CP0761060
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2-(4-(indoline-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C18H17N5O2
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1
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| 1 |
IC50 = 2700 nM
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CP0823434
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2-(5-isopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C18H22F3N5O2
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1
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| 1 |
IC50 = 2700 nM
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CP0823438
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2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-3,5-dimethyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C18H21N5O2S
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1
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| 1 |
IC50 = 2700 nM
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CP0947247
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2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C17H19N5O2S
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1
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| 1 |
IC50 = 2700 nM
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CP0905477
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(R)-5,6-dimethyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C20H21N5O2
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1
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| 1 |
IC50 = 2800 nM
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CP0959032
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5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C20H21N5O2
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1
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| 1 |
IC50 = 2900 nM
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CP0959033
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6-methyl-2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C16H18F3N5O2
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1
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| 1 |
IC50 = 2900 nM
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CP0823429
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2-(4-(1-hydroxy-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
Show/Hide
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C16H15N5O3S
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1
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| 1 |
IC50 = 3000 nM
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CP0955167
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2-(4-(3,3-difluoro-1,3'-bipyrrolidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21F2N7O2
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1
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| 1 |
IC50 = 3000 nM
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CP0951348
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2-(5-methyl-4-(3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H14F3N7O2
|
1
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| 1 |
IC50 = 3100 nM
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CP0954051
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2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
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C17H17F3N6O2
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1
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| 1 |
IC50 = 3100 nM
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CP0964664
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2-(4-((3S)-3-fluoro-1,3'-bipyrrolidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H22FN7O2
|
1
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| 1 |
IC50 = 3100 nM
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CP0966691
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2-(4-(3-(4-fluoropiperidin-1-yl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C20H24FN7O2
|
1
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| 1 |
IC50 = 3100 nM
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CP0772436
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2-(5-methyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
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C17H22N6O2
|
1
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| 1 |
IC50 = 3300 nM
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CP0868907
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(5R)-2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2-azabicyclo[2.2.1]heptane-5-carbonitrile
Show/Hide
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C18H17N7O2
|
1
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| 1 |
IC50 = 3400 nM
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CP0823441
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2-(4-(7-azabicyclo[2.2.1]heptane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
|
C16H19N5O2
|
1
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| 1 |
IC50 = 3500 nM
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CP0838166
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2-(4-(azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C14H14N6O2
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1
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| 1 |
IC50 = 3500 nM
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CP0760998
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(1S,6R)-tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate
Show/Hide
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C22H27N7O4
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1
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| 1 |
IC50 = 3600 nM
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CP0883886
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2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-3-methylpyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C26H23N5O2S
|
1
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| 1 |
IC50 = 3600 nM
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CP0726243
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5-chloro-2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
|
C18H16ClN5O2
|
1
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| 1 |
IC50 = 3700 nM
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CP0761032
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2-(4-(3-(aminomethyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C15H16N6O2S
|
1
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| 1 |
IC50 = 3700 nM
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CP0883879
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5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-((1-phenylcyclopentyl)methyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C22H25N5O2
|
1
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| 1 |
IC50 = 3800 nM
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CP0966147
|
6-methyl-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
|
C15H16F3N5O2
|
1
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| 1 |
IC50 = 3900 nM
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CP0713505
|
2-(3-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C19H17F3N4O2S
|
1
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| 1 |
IC50 = 4000 nM
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CP0909319
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2-(4-fluorophenyl)-2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)acetonitrile
Show/Hide
|
C23H21FN8O2
|
1
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| 1 |
IC50 = 4000 nM
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CP0913629
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2-(5-methyl-4-(2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H15F3N8O2
|
1
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| 1 |
IC50 = 4000 nM
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CP0955169
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2-(4-((3R)-3-fluoro-1,3'-bipyrrolidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H22FN7O2
|
1
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| 1 |
IC50 = 4000 nM
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CP0946655
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2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
Show/Hide
|
C20H18N6O2
|
1
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| 1 |
IC50 = 4100 nM
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CP0831439
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2-(4-(7-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
|
C20H21N5O3
|
1
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| 1 |
IC50 = 4200 nM
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CP0909338
|
5,6-dimethyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
|
C20H21N5O2
|
1
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| 1 |
IC50 = 4300 nM
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CP0812543
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2-(5-methyl-4-(2,6-diazaspiro[4.5]decane-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C19H22N6O2S
|
1
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| 1 |
IC50 = 4400 nM
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CP0883875
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2-(4-(4-ethylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-5,6-dimethylpyrimidin-4(3H)-one
Show/Hide
|
C17H24N6O2
|
1
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| 1 |
IC50 = 4400 nM
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CP0761056
|
2-Methyl-1-(3-methyl-5-oxo-cyclohexa-1,3-dienyl)-1H-pyrrole-3-carboxylic acid adamantan-1-ylamide
Show/Hide
|
C23H28N2O2
|
1
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| 1 |
IC50 = 4600 nM
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CP0868882
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5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N,N-dipropyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C16H23N5O2
|
1
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| 1 |
IC50 = 4600 nM
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CP0812544
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(R)-2-(5-methyl-4-(3-(methylamino)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C17H22N6O2
|
1
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| 1 |
IC50 = 4700 nM
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CP0909402
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6-methyl-2-(5-methyl-4-(8-oxa-2-azaspiro[4.5]decane-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
|
C18H23N5O3
|
1
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| 1 |
IC50 = 5000 nM
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CP0761087
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2-(4-(1-hydroxy-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C16H15N5O3S
|
1
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| 1 |
IC50 = 5200 nM
|
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CP0868881
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N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-propyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C14H19N5O2
|
1
|
| 1 |
IC50 = 5300 nM
|
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CP0966148
|
2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C18H15F3N4O2S
|
1
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| 1 |
IC50 = 5300 nM
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CP0955176
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2-(5-methyl-4-(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C20H25N7O2
|
1
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| 1 |
IC50 = 5400 nM
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CP0745163
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2-(3-(3,3-dimethylpyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C16H17N5O2S
|
1
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| 1 |
IC50 = 5600 nM
|
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CP0958059
|
N-(2,3-dihydro-1H-inden-1-yl)-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C19H19N5O2
|
1
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| 1 |
IC50 = 5800 nM
|
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CP0963555
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6-methyl-2-[4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
Show/Hide
|
C18H17N5O2
|
1
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| 1 |
IC50 = 5800 nM
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CP0820602
|
N-cyclopentyl-5-isopropyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C17H23N5O2
|
1
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| 1 |
IC50 = 6100 nM
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CP0958065
|
2-(5-methyl-4-(3-morpholinopyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H23N7O3
|
1
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| 1 |
IC50 = 6200 nM
|
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CP0955177
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6-methyl-2-(3-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
|
C18H17N5O2
|
1
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| 1 |
IC50 = 6300 nM
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CP0909403
|
N,N-diethyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C14H19N5O2
|
1
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| 1 |
IC50 = 6400 nM
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CP0768939
|
6-methyl-2-(3-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
|
C16H18F3N5O2
|
1
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| 1 |
IC50 = 6500 nM
|
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CP0969526
|
2-(5-methyl-4-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H16N8O2
|
1
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| 1 |
IC50 = 6700 nM
|
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CP0909320
|
2-(4-[[(3aS,6aS)-1,1-dioxidohexahydro-5H-thieno[2,3-c]pyrrol-5-yl]carbonyl]-5-methyl-1H-pyrazol-1-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H18N6O4S
|
1
|
| 1 |
IC50 = 7200 nM
|
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CP0913654
|
3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carbonitrile
Show/Hide
|
C23H25N7O3
|
1
|
| 1 |
IC50 = 7300 nM
|
|
|
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CP0726212
|
2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)phenyl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C20H20F3N3O2
|
1
|
| 1 |
IC50 = 7400 nM
|
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CP0820600
|
N-ethyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-propyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C15H21N5O2
|
1
|
| 1 |
IC50 = 7500 nM
|
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CP0746922
|
2-(5-methyl-4-(piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
Show/Hide
|
C16H20N6O2
|
1
|
| 1 |
IC50 = 8100 nM
|
|
|
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CP0734276
|
2-(3-(indoline-1-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
|
C17H15N5O2
|
1
|
| 1 |
IC50 = 8200 nM
|
|
|
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CP0913626
|
2-(5-methyl-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H14F3N9O2
|
1
|
| 1 |
IC50 = 8300 nM
|
|
|
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CP0768908
|
2-(5-methyl-4-(5-methyloctahydropyrrolo[3,4-c]pyrrole-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C18H21N7O2
|
1
|
| 1 |
IC50 = 8800 nM
|
|
|
|
CP0954046
|
2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)-2-(thiophen-2-yl)acetonitrile
Show/Hide
|
C21H20N8O2S
|
1
|
| 1 |
IC50 = 8900 nM
|
|
|
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CP0745166
|
2-(3,5-dimethyl-4-(3-oxo-3-(pyrrolidin-1-yl)propyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
|
C17H23N5O2
|
1
|
| 1 |
IC50 = 9000 nM
|
|
|
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CP0954043
|
1-cyclopropyl-7-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)octahydro-1,7-naphthyridin-2(1H)-one
Show/Hide
|
C22H25N7O3
|
1
|
| 1 |
IC50 = 9000 nM
|
|
|
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CP0962067
|
2-(4-(4-(1H-imidazol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C19H20N8O2
|
1
|
| 1 |
IC50 = 9100 nM
|
|
|
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CP0962074
|
2-(4-(1,3'-biazetidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
|
C17H19N7O2
|
1
|
| 1 |
IC50 = 9200 nM
|
|
|
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CP0713508
|
2-(4-[[4-(trifluoromethyl)piperidin-1-yl]sulfonyl]pyridin-2-yl)-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
Show/Hide
|
C18H19F3N4O3S
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0726208
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2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-3-methylpyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C25H21N5O2S2
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1
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| 1 |
IC50 = 10000 nM
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CP0726219
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2-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)isonicotinic acid
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C12H7N3O3S
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1
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| 1 |
IC50 = 10000 nM
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CP0745156
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2-(5-methyl-4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C16H15N9O2
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1
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| 1 |
IC50 = 10000 nM
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CP0761086
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3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carboxamide
Show/Hide
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C23H27N7O4
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1
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| 1 |
IC50 = 10000 nM
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CP0772433
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2-(5-methyl-4-(1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H21N7O3
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1
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| 1 |
IC50 = 10000 nM
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CP0812545
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(R)-2-(5-methyl-4-(3-(methylamino)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C16H18N6O2S
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1
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| 1 |
IC50 = 10000 nM
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CP0812547
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2-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)isonicotinic acid
Show/Hide
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C13H11N3O3
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1
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| 1 |
IC50 = 10000 nM
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CP0823418
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1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylic acid
Show/Hide
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C9H6N6O3
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1
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| 1 |
IC50 = 10000 nM
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CP0838177
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2-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)isonicotinic acid
Show/Hide
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C12H7N3O3S
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1
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| 1 |
IC50 = 10000 nM
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CP0868906
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2-(4-(3-(5-cyclopropyl-1H-1,2,4-triazol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H23N9O2
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1
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| 1 |
IC50 = 10000 nM
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CP0883862
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2-(4-(3-hydroxy-3-(trifluoromethyl)-1,3'-biazetidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H18F3N7O3
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1
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| 1 |
IC50 = 10000 nM
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CP0905472
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(S)-2-(5-methyl-4-(6-oxooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19N7O3
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1
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| 1 |
IC50 = 10000 nM
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CP0909324
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2-(4-(4-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H23N9O2
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1
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| 1 |
IC50 = 10000 nM
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CP0909404
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5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylic acid
Show/Hide
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C10H8N6O3
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1
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| 1 |
IC50 = 10000 nM
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CP0913628
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2-(4-(3-cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C19H19N9O2
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1
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| 1 |
IC50 = 10000 nM
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CP0913630
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2-(5-methyl-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C17H16N8O2
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1
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| 1 |
IC50 = 10000 nM
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CP0944419
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3-methyl-2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)butanenitrile
Show/Hide
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C20H24N8O2
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1
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| 1 |
IC50 = 10000 nM
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CP0947152
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2-(4-(4-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C21H23N9O2
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1
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| 1 |
IC50 = 10000 nM
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CP0947209
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(R)-2-(5-methyl-4-(6-oxooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H19N7O3
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1
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| 1 |
IC50 = 10000 nM
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CP0958058
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6-methyl-2-[4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-1,2,3-triazol-1-yl]-3,4-dihydropyrimidin-4-one
Show/Hide
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C17H16N6O2
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1
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| 1 |
IC50 = 10000 nM
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CP0959027
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3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid
Show/Hide
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C23H26N6O5
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1
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| 1 |
IC50 = 10000 nM
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CP0962054
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(1R,5S)-3-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxamide
Show/Hide
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C18H20N6O3
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1
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| 1 |
IC50 = 10000 nM
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CP0964268
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2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)octahydrocyclopenta[c]pyrrole-5-carboxamide
Show/Hide
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C19H21N7O3
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1
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| 1 |
IC50 = 10000 nM
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CP0966136
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2-(5-methyl-4-(4-(2-(methylsulfonyl)ethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
Show/Hide
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C18H23N7O4S
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1
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| 1 |
IC50 = 10000 nM
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CP0713519
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6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinolin-2-ylmethyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
Show/Hide
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C19H21N5O
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1
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| 1 |
IC50 = 11000 nM
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CP0738382
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N-ethyl-N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C13H17N5O2
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1
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| 1 |
IC50 = 11000 nM
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CP0891295
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5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(3,3,3-trifluoropropyl)-1H-pyrazole-4-carboxamide
Show/Hide
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C13H14F3N5O2
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1
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| 1 |
IC50 = 11000 nM
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CP0761051
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6-methyl-2-[5-methyl-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
Show/Hide
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C19H19N5O2
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1
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| 1 |
IC50 = 12000 nM
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CP0761055
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6-methyl-2-(5-methyl-4-(7-(morpholinosulfonyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C23H26N6O5S
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1
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| 1 |
IC50 = 12000 nM
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CP0772444
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2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C16H14F3N5O2S
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1
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| 1 |
IC50 = 12000 nM
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CP0839333
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N-cyclopentyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-3-carboxamide
Show/Hide
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C14H17N5O2
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1
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| 1 |
IC50 = 12000 nM
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CP0966688
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methyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxylate
Show/Hide
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C11H12N4O3
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1
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| 1 |
IC50 = 12000 nM
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CP0966395
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6-methyl-2-(5-methyl-4-(morpholine-4-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C14H17N5O3
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1
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| 1 |
IC50 = 13000 nM
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CP0726249
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2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-5-isobutyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C19H27N5O2
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1
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| 1 |
IC50 = 14000 nM
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CP0820599
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2-(5-isobutyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C22H25N5O2
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1
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| 1 |
IC50 = 15000 nM
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CP0959031
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N-cyclopentyl-5-(difluoromethyl)-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C15H17F2N5O2
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1
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| 1 |
IC50 = 15000 nM
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CP0713513
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methyl-6-[4-oxo-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-2-yl]pyridine-3-carboxylate
Show/Hide
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C14H13N3O3
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1
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| 1 |
IC50 = 16000 nM
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CP0713540
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N-cyclopentyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C15H19N5O2
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1
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| 1 |
IC50 = 16000 nM
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CP0726238
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7-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
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C18H19F3N6O2
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1
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| 1 |
IC50 = 16000 nM
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CP0891293
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5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2,2,3,3,3-pentafluoropropyl)-1H-pyrazole-4-carboxamide
Show/Hide
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C13H12F5N5O2
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1
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| 1 |
IC50 = 16000 nM
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CP0726230
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2-[5-[4-(trifluoromethyl)piperidine-1-carbonyl]pyridin-2-yl]-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
Show/Hide
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C19H19F3N4O2
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1
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| 1 |
IC50 = 17000 nM
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CP0823443
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N,N,5-trimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C12H15N5O2
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1
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| 1 |
IC50 = 20000 nM
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CP0761053
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2-(5-benzyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C25H23N5O2
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1
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| 1 |
IC50 = 22000 nM
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CP0772448
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N-(4-chlorophenyl)-3-(3,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazol-4-yl)propanamide
Show/Hide
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C19H20ClN5O2
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1
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| 1 |
IC50 = 22000 nM
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CP0820598
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5-benzyl-N-cyclopentyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C21H23N5O2
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1
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| 1 |
IC50 = 22000 nM
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CP0868880
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5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(pyrazin-2-ylmethyl)-1H-pyrazole-4-carboxamide
Show/Hide
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C15H15N7O2
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1
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| 1 |
IC50 = 23000 nM
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CP0726240
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6-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
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C18H18F3N5O2S
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1
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| 1 |
IC50 = 25000 nM
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CP0772446
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2-(5-benzyl-4-(4-(pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C25H25N7O2
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1
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| 1 |
IC50 = 28000 nM
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CP0726237
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5-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thiazolo[5,4-d]pyrimidin-7(6H)-one
Show/Hide
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C16H15F3N6O2S
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1
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| 1 |
IC50 = 31000 nM
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CP0726252
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2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)quinazolin-4(3H)-one
Show/Hide
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C22H19N5O2
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1
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| 1 |
IC50 = 35000 nM
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CP0823435
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6-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
Show/Hide
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C16H16F3N7O2
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1
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| 1 |
IC50 = 35000 nM
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CP0772445
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2-[3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one
Show/Hide
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C19H15N5O2S
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1
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| 1 |
IC50 = 36000 nM
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CP0954053
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6-methyl-2-(3-(morpholine-4-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C13H15N5O3
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1
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| 1 |
IC50 = 40000 nM
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CP0883880
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2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)quinazolin-4(3H)-one
Show/Hide
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C19H18F3N5O2
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1
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| 1 |
IC50 = 49000 nM
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CP0909337
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N-cyclopentyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
Show/Hide
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C15H16F3N5O2
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1
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| 1 |
IC50 = 49000 nM
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CP0839334
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6-methyl-2-(5-methyl-4-(4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C16H17N7O2
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1
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| 1 |
IC50 = 53000 nM
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CP0966145
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2-(5-(difluoromethyl)-4-(morpholine-4-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
Show/Hide
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C14H15F2N5O3
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1
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| 1 |
IC50 = 57000 nM
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CP0868884
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5-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thiazolo[4,5-d]pyrimidin-7(6H)-one
Show/Hide
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C16H15F3N6O2S
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1
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| 1 |
IC50 = 58000 nM
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CP0947246
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2-[4-[(1,1-dioxidothiomorpholin-4-yl)carbonyl]-5-methyl-1H-pyrazol-1-yl]-6-methylpyrimidin-4(3H)-one
Show/Hide
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C14H17N5O4S
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1
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| 1 |
IC50 = 67000 nM
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CP0959034
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6-tert-butyl-2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C22H25N5O2
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1
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| 1 |
IC50 = 69000 nM
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CP0966144
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6-methyl-2-(5-methyl-4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
Show/Hide
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C16H17N7O2
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1
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| 1 |
IC50 = 78000 nM
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CP0768930
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5-methyl-1-[4-oxo-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-2-yl]-1H-pyrazole4-carboxylic acid
Show/Hide
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C12H12N4O3
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1
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| 1 |
IC50 = 95000 nM
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