Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
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 PubChem ID
CID: 137129903
Canonical SMILES
O=C(c1cnn(-c2nn3cccc3c(=O)[nH]2)c1)N1CCC(C(F)(F)F)CC1
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Compound Formula C16H15F3N6O2
Compound Structure
Protein Name
 Protein Info 
Sepiapterin reductase
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
P35270
Gene Name
SPR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CL000151 SK-N-BE(2)
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2 nM