General Information of the Protein
Protein ID
PT03734
Protein Name
Sepiapterin reductase
Gene Name
SPR
Sequence
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
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Uniprot ID
Primary ID:
P35270

Secondarily ID:
A8K741
D6W5H2
Q53GI9
Q9UBB1
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Ensembl ID
ENSG00000116096
HGNC ID
HGNC:11257
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000752 , PBMC iPSC #1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0745149
 Compound Info 
3-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
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C25H21N9O2S
  1
1
IC50 = 11 nM
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CP0726235
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H25N5O2
  1
1
IC50 = 13 nM
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CP0909397
 Compound Info 
2-(4-(4-(1H-pyrrol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21N7O2
  1
1
IC50 = 13 nM
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CP0951452
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H25N7O2S
  1
1
IC50 = 13 nM
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CP0957703
 Compound Info 
3-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)oxazol-5-yl)benzonitrile
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C19H21N7O3
  1
1
IC50 = 13 nM
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CP0745147
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H25N7O2S
  1
1
IC50 = 14 nM
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CP0772462
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1
IC50 = 14 nM
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CP0823468
 Compound Info 
2-(5-methyl-4-(4-(4,4,4-trifluorobutanoyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O3
  1
1
IC50 = 14 nM
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CP0962073
 Compound Info 
tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate
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C23H29N7O4
  1
1
IC50 = 14 nM
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CP0951353
 Compound Info 
2-(4-(4-(2-chloropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O2
  1
1
IC50 = 15 nM
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CP0970224
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)oxazole-4-carbonitrile
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C20H18N8O3
  1
1
IC50 = 15 nM
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CP0738386
 Compound Info 
2-(5-methyl-4-(4-propionylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H25N5O3
  1
1
IC50 = 16 nM
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CP0823462
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-3-methoxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F3N6O3
  1
1
IC50 = 17 nM
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CP0823463
 Compound Info 
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F2N8O2
  1
1
IC50 = 17 nM
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CP0823466
 Compound Info 
2-(4-(4-acetyl-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H24N6O3
  1
1
IC50 = 17 nM
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CP0909350
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-3-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F3N6O3
  1
1
IC50 = 17 nM
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CP0909399
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H20F3N7O3
  1
1
IC50 = 17 nM
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CP0761063
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoroprop-1-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H22F3N5O2
  1
1
IC50 = 18 nM
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CP0829397
 Compound Info 
2-(5-methyl-4-(4-(5-(pyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H27N9O2S
  1
1
IC50 = 18 nM
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CP0947194
 Compound Info 
2-(4-(4-(6-fluoropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1
IC50 = 18 nM
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CP0951356
 Compound Info 
2-(5-methyl-4-(4-(1,1,1,4-tetrafluorobutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22F4N6O2
  1
1
IC50 = 19 nM
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CP0839342
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H22N8O2
  1
1
IC50 = 20 nM
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CP0909343
 Compound Info 
2-(4-(2-(3-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
  1
1
IC50 = 20 nM
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CP0909352
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H23N7O2
  1
1
IC50 = 20 nM
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CP0963567
 Compound Info 
2-(4-(4-(6-fluoropyridin-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1
IC50 = 20 nM
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CP0772463
 Compound Info 
2-(4-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H22N8O3
  1
1
IC50 = 21 nM
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CP0761015
 Compound Info 
2-(5-methyl-4-(7-oxo-3-azaspiro[5.5]undecane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H24N6O3
  1
1
IC50 = 22 nM
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CP0947195
 Compound Info 
2-(4-(3-(2-fluoropyridin-4-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 22 nM
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CP0951351
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17F3N8O3
  1
1
IC50 = 22 nM
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CP0969864
 Compound Info 
2-(5-methyl-4-(9-(2,2,2-trifluoroethylidene)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H21F3N6O2
  1
1
IC50 = 22 nM
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CP0964668
 Compound Info 
2-(4-(4-(2-chloro-1H-pyrrol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20ClN7O2
  1
1
IC50 = 23 nM
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CP0745028
 Compound Info 
2-(4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C15H15F3N8O2
  1
1
IC50 = 24 nM
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CP0761064
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
  1
1
IC50 = 24 nM
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CP0812551
 Compound Info 
7-fluoro-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H14F4N6O2
  1
1
IC50 = 24 nM
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CP0823457
 Compound Info 
2-(4-(3-cyclobutyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H25N7O2
  1
1
IC50 = 24 nM
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CP0951358
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-1H-pyrrole-3-carbonitrile
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C21H20N8O2
  1
1
IC50 = 24 nM
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CP0964693
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H26N6O2
  1
1
IC50 = 24 nM
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CP0713487
 Compound Info 
2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H21F2N5O2
  1
1
IC50 = 25 nM
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CP0745169
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O2
  1
1
IC50 = 25 nM
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CP0746926
 Compound Info 
2-(5-methyl-4-(4-(4-phenyloxazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H23N7O3
  1
1
IC50 = 25 nM
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CP0831450
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17F3N8O2S
  1
1
IC50 = 25 nM
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CP0962124
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19N7O2
  1
1
IC50 = 25 nM
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CP0713504
 Compound Info 
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H18F6N6O3
  1
1
IC50 = 26 nM
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CP0721044
 Compound Info 
2-(4-(4-(5-(6-fluoropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1
IC50 = 26 nM
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CP0962125
 Compound Info 
2-(4-(4-(3,3-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F2N8O2
  1
1
IC50 = 26 nM
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CP0738349
 Compound Info 
2-(5-methyl-4-(4-(1,1,1,3,3-pentafluoropropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F5N6O2
  1
1
IC50 = 27 nM
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CP0738374
 Compound Info 
2-(4-(3-hydroxy-3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H24N6O3
  1
1
IC50 = 27 nM
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CP0823454
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoroprop-1-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O2
  1
1
IC50 = 27 nM
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CP0838151
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F3N6O2
  1
1
IC50 = 27 nM
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CP0905462
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19F3N8O2
  1
1
IC50 = 27 nM
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CP0955450
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F2N6O2
  1
1
IC50 = 27 nM
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CP0913640
 Compound Info 
(S)-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H26N6O2
  1
1
IC50 = 28 nM
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CP0713542
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclobutanecarbonitrile
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C22H26N6O2
  1
1
IC50 = 29 nM
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CP0750097
 Compound Info 
2-(4-(4-butyrylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H24N6O3
  1
1
IC50 = 29 nM
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CP0823467
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F3N8O2
  1
1
IC50 = 29 nM
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CP0957699
 Compound Info 
2-(5-methyl-4-((1R,5S,9r)-9-(2,2,2-trifluoroethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H23F3N6O2
  1
1
IC50 = 29 nM
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CP0831445
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-2-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H25N7O2S
  1
1
IC50 = 31 nM
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CP0713482
 Compound Info 
2-(4-(2-(4-chlorophenyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17ClN6O2
  1
1
IC50 = 32 nM
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CP0713509
 Compound Info 
4-methyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H22N6O2
  1
1
IC50 = 32 nM
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CP0746915
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H20F3N5O2
  1
1
IC50 = 32 nM
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CP0823469
 Compound Info 
2-(4-(2-(6-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 32 nM
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CP0750095
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)azepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O2
  1
1
IC50 = 35 nM
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CP0823464
 Compound Info 
2-(4-(4-cyclopropyl-1,4-diazepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H23N7O2
  1
1
IC50 = 35 nM
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CP0844487
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)cyclopropyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F3N7O2
  1
1
IC50 = 35 nM
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CP0947192
 Compound Info 
2-(5-methyl-4-(4-(thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H22N6O2S
  1
1
IC50 = 35 nM
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CP0762707
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19F3N8O2
  1
1
IC50 = 36 nM
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CP0823470
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H20N8O2
  1
1
IC50 = 36 nM
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CP0909335
 Compound Info 
2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1
IC50 = 36 nM
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CP0909347
 Compound Info 
2-(5-methyl-4-((1R,5S)-9-(2,2,2-trifluoroethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H23F3N6O2
  1
1
IC50 = 36 nM
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CP0962081
 Compound Info 
2-(5-methyl-4-(2-(trifluoromethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H14F3N7O2S
  1
1
IC50 = 36 nM
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CP0738350
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O2S
  1
1
IC50 = 37 nM
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CP0761016
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H18N8O2
  1
1
IC50 = 37 nM
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CP0823421
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H21F3N6O2
  1
1
IC50 = 37 nM
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CP0823456
 Compound Info 
2-(5-methyl-4-(4-propionylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
  1
1
IC50 = 37 nM
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CP0966695
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
  1
1
IC50 = 37 nM
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CP0768978
 Compound Info 
2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H24F3N5O2
  1
1
IC50 = 38 nM
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CP0868872
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F3N6O3
  1
1
IC50 = 38 nM
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CP0909396
 Compound Info 
2-(4-(4-(5-chloropyridin-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19ClN8O2
  1
1
IC50 = 39 nM
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CP0951355
 Compound Info 
2-(4-(4-ethyl-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F3N6O2
  1
1
IC50 = 40 nM
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CP0966425
 Compound Info 
2-(5-methyl-4-(1-oxo-8-azaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N6O3
  1
1
IC50 = 40 nM
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CP0713488
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H24N6O2
  1
1
IC50 = 41 nM
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CP0909400
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
  1
1
IC50 = 41 nM
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CP0761068
 Compound Info 
2-allyl-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
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C24H27N7O2
  1
1
IC50 = 43 nM
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CP0839309
 Compound Info 
2-(4-(4-(2,2-difluorocyclopentyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F2N7O2
  1
1
IC50 = 43 nM
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CP0713493
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
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C19H21N7O2
  1
1
IC50 = 44 nM
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CP0829378
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C20H21N7O2
  1
1
IC50 = 44 nM
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CP0734272
 Compound Info 
2-(5-methyl-4-(7-(2,2,2-trifluoroethyl)-2,7-diazaspiro[3.5]nonane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22F3N7O2
  1
1
IC50 = 45 nM
 Bioactivity Info 
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CP0738377
 Compound Info 
tert-butyl 7-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
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C23H29N7O4
  1
1
IC50 = 45 nM
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CP0761002
 Compound Info 
2-(4-(4-(5-(4-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O3
  1
1
IC50 = 45 nM
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CP0838156
 Compound Info 
2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N6O2
  1
1
IC50 = 45 nM
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CP0902945
 Compound Info 
2-(5-methyl-4-(4-((tetrahydrofuran-2-yl)methyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H25N7O3
  1
1
IC50 = 45 nM
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CP0944287
 Compound Info 
2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F2N6O4S
  1
1
IC50 = 45 nM
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CP0969528
 Compound Info 
2-(4-(4-(5-fluoropyridin-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1
IC50 = 45 nM
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CP0761019
 Compound Info 
2-(4-(4-(2-fluorocyclopropyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20FN7O2
  1
1
IC50 = 46 nM
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CP0761067
 Compound Info 
2-(4-(9-hydroxy-9-(trifluoromethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O3
  1
1
IC50 = 46 nM
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CP0839343
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H18F3N7O2
  1
1
IC50 = 46 nM
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CP0745025
 Compound Info 
2-(4-(4-(4-(6-fluoropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1
IC50 = 47 nM
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CP0829380
 Compound Info 
4-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C18H19N7O2
  1
1
IC50 = 47 nM
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CP0944133
 Compound Info 
2-(5-methyl-4-(5-azaspiro[2.4]heptane-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18N6O2
  1
1
IC50 = 47 nM
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CP0964667
 Compound Info 
2-(4-(6-cyclopropyl-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21N7O2
  1
1
IC50 = 47 nM
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CP0754196
 Compound Info 
2-(5-methyl-4-(9-methylene-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N6O2
  1
1
IC50 = 48 nM
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CP0761071
 Compound Info 
2-(4-(3-(5-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 48 nM
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CP0829398
 Compound Info 
2-(4-(4-(5-(2-chloropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O2S
  1
1
IC50 = 48 nM
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CP0838157
 Compound Info 
(R)-tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
  1
1
IC50 = 48 nM
 Bioactivity Info 
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CP0966424
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O2S
  1
1
IC50 = 48 nM
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CP0750105
 Compound Info 
2-(4-((3aS,6aR)-4,4-difluorooctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F2N6O2
  1
1
IC50 = 49 nM
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CP0761066
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H18F3N7O2S
  1
1
IC50 = 50 nM
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CP0831448
 Compound Info 
2-(4-(3-(5-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 50 nM
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CP0954048
 Compound Info 
2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23N5O2
  1
1
IC50 = 50 nM
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CP0713494
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H23N7O2
  1
1
IC50 = 51 nM
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CP0772465
 Compound Info 
tert-butyl 7-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
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C24H32N6O4
  1
1
IC50 = 51 nM
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CP0909328
 Compound Info 
2-(4-(4-(2-fluoropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1
IC50 = 51 nM
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CP0951357
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
  1
1
IC50 = 51 nM
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CP0734273
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19F3N8O2
  1
1
IC50 = 52 nM
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CP0959089
 Compound Info 
2-(4-(4-(4-(2-fluoropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1
IC50 = 52 nM
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CP0738369
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C21H24N6O2
  1
1
IC50 = 53 nM
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CP0761023
 Compound Info 
2-(4-(2-(5-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 53 nM
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CP0761025
 Compound Info 
2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23N5O2
  1
1
IC50 = 54 nM
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CP0823417
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carbonyl)piperidine-4-carbonitrile
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C18H20N8O2
  1
1
IC50 = 55 nM
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CP0838149
 Compound Info 
2-(5-methyl-4-(4-(4-phenylthiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H26N6O2S
  1
1
IC50 = 55 nM
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CP0962080
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
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C22H26N6O2
  1
1
IC50 = 55 nM
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CP0963564
 Compound Info 
(R)-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H26N6O2
  1
1
IC50 = 55 nM
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CP0838153
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H15F2N7O2
  1
1
IC50 = 56 nM
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CP0844486
 Compound Info 
2-(4-(4-(2-chloro-1H-imidazol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19ClN8O2
  1
1
IC50 = 56 nM
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CP0823412
 Compound Info 
tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
  1
1
IC50 = 57 nM
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CP0831449
 Compound Info 
2-(5-methyl-4-(8-(trifluoromethyl)-3-azabicyclo[3.2.1]octane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O2
  1
1
IC50 = 57 nM
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CP0891290
 Compound Info 
2-(5-methyl-4-(9-(trifluoromethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1
IC50 = 57 nM
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CP0738385
 Compound Info 
2-(4-fluoro-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H25FN6O2
  1
1
IC50 = 58 nM
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CP0772464
 Compound Info 
N-cyclopropyl-N-methyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carboxamide
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C23H27N7O3
  1
1
IC50 = 58 nM
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CP0891289
 Compound Info 
2-(5-methyl-4-(3-(thiazol-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20N8O2S
  1
1
IC50 = 58 nM
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CP0909345
 Compound Info 
2-(4-(6-cyclobutyl-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23N7O2
  1
1
IC50 = 58 nM
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CP0947196
 Compound Info 
2-(4-(4-(5-(6-chloropyridin-3-yl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H19ClN10O3
  1
1
IC50 = 59 nM
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CP0954047
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
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C21H23N7O2
  1
1
IC50 = 59 nM
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CP0761065
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-2-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
  1
1
IC50 = 60 nM
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CP0829395
 Compound Info 
2-(5-methyl-4-(6-(3,3,3-trifluoropropyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F3N7O2
  1
1
IC50 = 60 nM
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CP0838150
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23F3N6O2
  1
1
IC50 = 60 nM
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CP0909349
 Compound Info 
2-(4-(4-(cyclopropanecarbonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N6O3
  1
1
IC50 = 61 nM
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CP0909351
 Compound Info 
2-(4-(4-(5-(2-fluoropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1
IC50 = 62 nM
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CP0746927
 Compound Info 
2-(4-(4-(azetidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H22F3N7O3
  1
1
IC50 = 63 nM
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CP0823414
 Compound Info 
2-(4-(8-hydroxy-8-(trifluoromethyl)-3-azabicyclo[3.2.1]octane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O3
  1
1
IC50 = 63 nM
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CP0768922
 Compound Info 
2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
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C22H20N8O4S
  1
1
IC50 = 64 nM
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CP0947189
 Compound Info 
2-(5-methyl-4-(2-azaspiro[3.4]octane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
  1
1
IC50 = 65 nM
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CP0883864
 Compound Info 
2-(4-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C20H22FN7O2
  1
1
IC50 = 66 nM
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CP0955211
 Compound Info 
2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H29N7O3
  1
1
IC50 = 67 nM
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CP0962089
 Compound Info 
(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C22H30N6O4
  1
1
IC50 = 67 nM
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CP0761062
 Compound Info 
2-(5-methyl-4-(3-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1
IC50 = 68 nM
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CP0964666
 Compound Info 
2-(4-(4-(4-(2-chloropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O2S
  1
1
IC50 = 68 nM
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CP0761012
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H20N8O2
  1
1
IC50 = 69 nM
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CP0754201
 Compound Info 
tert-butyl 3-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-ylcarbamate
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C20H25N7O4
  1
1
IC50 = 70 nM
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CP0772456
 Compound Info 
2-(4-(3-(6-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 70 nM
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CP0772466
 Compound Info 
2-(4-(3-(6-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 70 nM
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CP0868876
 Compound Info 
2-(5-methyl-4-(4-(3-(trifluoromethylsulfonyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20F3N7O4S
  1
1
IC50 = 70 nM
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CP0957702
 Compound Info 
2-(5-methyl-4-(2-(pyridin-3-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H18N8O2S
  1
1
IC50 = 70 nM
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CP0772438
 Compound Info 
2-(4-(2,2-difluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F2N6O2
  1
1
IC50 = 72 nM
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CP0823415
 Compound Info 
2-(4-(4-cyclopropyl-4-hydroxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
  1
1
IC50 = 72 nM
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CP0909336
 Compound Info 
tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
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C23H29N7O4
  1
1
IC50 = 72 nM
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CP0745155
 Compound Info 
(Z)-2-(5-methyl-4-(4-(1,1,1-trifluorobut-2-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1
IC50 = 74 nM
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CP0761061
 Compound Info 
2-(5-methyl-4-(4-(4-phenyloxazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H26N6O3
  1
1
IC50 = 74 nM
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CP0768907
 Compound Info 
tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)carbamate
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C20H25N7O4
  1
1
IC50 = 74 nM
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CP0947190
 Compound Info 
2-(4-(3,3-difluoro-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F2N6O2
  1
1
IC50 = 74 nM
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CP0761006
 Compound Info 
N-(1-isopropyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-1H-pyrazol-5-yl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
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C20H21F3N8O3
  1
1
IC50 = 75 nM
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CP0909341
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F3N7O2
  1
1
IC50 = 75 nM
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CP0761069
 Compound Info 
2-(4-(4-(6-chloropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O2
  1
1
IC50 = 76 nM
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CP0962064
 Compound Info 
(R)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
  1
1
IC50 = 76 nM
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CP0905460
 Compound Info 
2-(4-(4-(3,3-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F2N7O2
  1
1
IC50 = 77 nM
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CP0721047
 Compound Info 
2-(5-methyl-4-(4-(propylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H23N7O4S
  1
1
IC50 = 79 nM
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CP0754197
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20F3N7O2
  1
1
IC50 = 79 nM
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CP0831452
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-1H-pyrrole-2-carbonitrile
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C21H20N8O2
  1
1
IC50 = 79 nM
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CP0823410
 Compound Info 
2-(4-(4-methoxy-4-methylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H22N6O3
  1
1
IC50 = 80 nM
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CP0894171
 Compound Info 
2-(4-(4-(2,4-difluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19F2N7O4S
  1
1
IC50 = 80 nM
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CP0705960
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C17H18F3N7O2
  1
1
IC50 = 81 nM
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CP0838155
 Compound Info 
2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
  1
1
IC50 = 81 nM
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CP0909344
 Compound Info 
2-(5-methyl-4-(2-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H18F3N7O2S
  1
1
IC50 = 81 nM
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CP0754424
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O3
  1
1
IC50 = 82 nM
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CP0746918
 Compound Info 
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(pyridin-2-yl)piperidine-4-carbonitrile
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C22H20N8O2
  1
1
IC50 = 83 nM
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CP0829374
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxybutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F3N6O3
  1
1
IC50 = 83 nM
 Bioactivity Info 
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CP0883863
 Compound Info 
2-(5-methyl-4-(4-(pyrrolidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H24F3N7O3
  1
1
IC50 = 83 nM
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CP0762706
 Compound Info 
5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazole-3-carboxamide
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C19H21F3N6O3
  1
1
IC50 = 84 nM
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CP0829396
 Compound Info 
4-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
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C25H21N9O2S
  1
1
IC50 = 84 nM
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CP0946656
 Compound Info 
2-(5-methyl-4-(4-(piperidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H26F3N7O3
  1
1
IC50 = 84 nM
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CP0947191
 Compound Info 
2-(4-(4-(isopropylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H24N6O4S
  1
1
IC50 = 86 nM
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CP0959282
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoropropylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O4S
  1
1
IC50 = 86 nM
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CP0768979
 Compound Info 
2-(4-(2-ethyl-2,7-diazaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H25N7O2
  1
1
IC50 = 87 nM
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CP0954729
 Compound Info 
2-(5-methyl-4-(4-(naphthalen-1-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H23N7O4S
  1
1
IC50 = 87 nM
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CP0970014
 Compound Info 
2-(4-(4-(2-chlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O4S
  1
1
IC50 = 91 nM
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CP0713489
 Compound Info 
2-(4-(2-fluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21FN6O2
  1
1
IC50 = 92 nM
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CP0720795
 Compound Info 
2-(4-(4-(benzo[c][1,2,5]thiadiazol-4-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19N9O4S2
  1
1
IC50 = 92 nM
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CP0864191
 Compound Info 
2-(4-(4-(isopropylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H23N7O4S
  1
1
IC50 = 92 nM
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CP0913639
 Compound Info 
(S)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
  1
1
IC50 = 92 nM
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CP0839340
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1
IC50 = 93 nM
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CP0768921
 Compound Info 
2-(4-(4-(mesitylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H27N7O4S
  1
1
IC50 = 94 nM
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CP0829379
 Compound Info 
2-(4-(6,6-difluoro-3-azabicyclo[3.2.0]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F2N6O2
  1
1
IC50 = 94 nM
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CP0734255
 Compound Info 
2-(4-(4-(cyclohexylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H27N7O4S
  1
1
IC50 = 95 nM
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CP0831444
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carbonitrile
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C20H18N8O2S
  1
1
IC50 = 95 nM
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CP0909342
 Compound Info 
2-(5-methyl-4-(4-(5-(pyridin-3-yl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O3
  1
1
IC50 = 95 nM
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CP0909398
 Compound Info 
4-fluoro-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C20H22FN7O2
  1
1
IC50 = 97 nM
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CP0951354
 Compound Info 
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F2N7O2
  1
1
IC50 = 97 nM
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CP0768924
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethoxy)phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F3N7O5S
  1
1
IC50 = 98 nM
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CP0838154
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1
IC50 = 98 nM
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CP0734281
 Compound Info 
2-(4-(3-cyclopropyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23N7O2
  1
1
IC50 = 99 nM
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CP0746914
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)-1H-imidazol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19F3N8O2
  1
1
IC50 = 100 nM
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CP0772457
 Compound Info 
2-(3-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F3N7O2
  1
1
IC50 = 100 nM
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CP0870568
 Compound Info 
2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
  1
1
IC50 = 100 nM
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CP0883883
 Compound Info 
2-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
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C16H15F3N6O2
  1
1
IC50 = 100 nM
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CP0897051
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)butanenitrile
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C21H24N6O2
  1
1
IC50 = 100 nM
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CP0913637
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
  1
1
IC50 = 100 nM
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CP0950444
 Compound Info 
2-(4-(4-(2-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O4S
  1
1
IC50 = 100 nM
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CP0964669
 Compound Info 
(S)-2-(4-(7,7-difluorooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F2N7O2
  1
1
IC50 = 100 nM
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CP0966139
 Compound Info 
2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19N7O2
  1
1
IC50 = 100 nM
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CP0745031
 Compound Info 
2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O4S
  1
1
IC50 = 110 nM
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CP0761008
 Compound Info 
2-(4-(2-(4-fluorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18FN7O2S
  1
1
IC50 = 110 nM
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CP0761010
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N8O2
  1
1
IC50 = 110 nM
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CP0768977
 Compound Info 
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(2,2,2-trifluoroethyl)piperidine-4-carbonitrile
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C19H18F3N7O2
  1
1
IC50 = 110 nM
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CP0823411
 Compound Info 
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H27N7O3
  1
1
IC50 = 110 nM
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CP0823453
 Compound Info 
2-(5-methyl-4-(4-(phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H21N7O4S
  1
1
IC50 = 110 nM
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CP0823460
 Compound Info 
2-(4-(4-(4-(6-chloropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O2S
  1
1
IC50 = 110 nM
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CP0829388
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carbonitrile
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C21H21N7O2S
  1
1
IC50 = 110 nM
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CP0829389
 Compound Info 
2-(4-(4-hydroxy-4-(trifluoromethyl)azepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O3
  1
1
IC50 = 110 nM
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CP0829392
 Compound Info 
2-(4-(4-(4-(3-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O2S
  1
1
IC50 = 110 nM
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CP0829394
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoropropyl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22F3N7O2
  1
1
IC50 = 110 nM
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CP0950446
 Compound Info 
methyl 3-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)thiophene-2-carboxylate
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C21H21N7O6S2
  1
1
IC50 = 110 nM
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CP0954733
 Compound Info 
2-(4-(4-(benzylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H23N7O4S
  1
1
IC50 = 110 nM
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CP0957873
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16F3N7O4S
  1
1
IC50 = 110 nM
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CP0959283
 Compound Info 
2-(4-(4-(3-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O4S
  1
1
IC50 = 110 nM
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CP0970015
 Compound Info 
2-(4-(4-(2-chloro-4-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19ClFN7O4S
  1
1
IC50 = 110 nM
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CP0713490
 Compound Info 
2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)acetonitrile
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C17H18N8O2
  1
1
IC50 = 120 nM
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CP0726224
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C20H24N6O2
  1
1
IC50 = 120 nM
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CP0754200
 Compound Info 
4-fluoro-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H25FN6O2
  1
1
IC50 = 120 nM
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CP0820605
 Compound Info 
2-(4-(4-(3-chlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O4S
  1
1
IC50 = 120 nM
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CP0829376
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H17F3N8O2
  1
1
IC50 = 120 nM
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CP0839257
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O3
  1
1
IC50 = 120 nM
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CP0897050
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)-1,3'-biazetidine-1'-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1
IC50 = 120 nM
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CP0713491
 Compound Info 
2-(5-methyl-4-(3-methyl-4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1
IC50 = 130 nM
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CP0713492
 Compound Info 
(S)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C21H27N7O4
  1
1
IC50 = 130 nM
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CP0713541
 Compound Info 
2-(5-methyl-4-(9-(2,2,2-trifluoroethyl)-3,9-diazabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H25F3N6O2
  1
1
IC50 = 130 nM
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CP0721045
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22F3N7O2
  1
1
IC50 = 130 nM
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CP0726213
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H21N7O2
  1
1
IC50 = 130 nM
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CP0734280
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carboxamide
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C21H23N7O3S
  1
1
IC50 = 130 nM
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CP0745032
 Compound Info 
2-(5-methyl-4-(4-(thiophen-2-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19N7O4S2
  1
1
IC50 = 130 nM
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CP0745158
 Compound Info 
2-(5-methyl-4-(2-thia-6-azaspiro[3.3]heptane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16N6O2S
  1
1
IC50 = 130 nM
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CP0762915
 Compound Info 
2-(5-methyl-4-(2-(pyridin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H18N8O2S
  1
1
IC50 = 130 nM
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CP0831454
 Compound Info 
2-(4-(4-(2,4-dimethylthiazol-5-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N8O4S2
  1
1
IC50 = 130 nM
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CP0870569
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F2N6O2
  1
1
IC50 = 130 nM
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CP0762916
 Compound Info 
2-(5-methyl-4-(4-(5-(2-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
  1
1
IC50 = 140 nM
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CP0831440
 Compound Info 
2-(4-(1,1-difluoro-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F2N6O2
  1
1
IC50 = 140 nM
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CP0713496
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
  1
1
IC50 = 150 nM
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CP0754428
 Compound Info 
2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H32N6O3
  1
1
IC50 = 150 nM
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CP0761017
 Compound Info 
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N8O2
  1
1
IC50 = 150 nM
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CP0768923
 Compound Info 
2-(5-methyl-4-(4-(pyridin-3-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20N8O4S
  1
1
IC50 = 150 nM
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CP0829401
 Compound Info 
2-(4-(4-(5-chlorothiophen-2-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H18ClN7O4S2
  1
1
IC50 = 150 nM
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CP0909310
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)acetonitrile
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C18H19N7O2
  1
1
IC50 = 150 nM
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CP0909348
 Compound Info 
2-(5-methyl-4-(5-(2,2,2-trifluoroethyl)-5,8-diazaspiro[3.5]nonane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22F3N7O2
  1
1
IC50 = 150 nM
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CP0746916
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O3
  1
1
IC50 = 160 nM
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CP0750096
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17F3N8O3
  1
1
IC50 = 160 nM
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CP0772458
 Compound Info 
2-(4-hydroxy-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C20H23N7O3
  1
1
IC50 = 160 nM
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CP0772461
 Compound Info 
2-(4-(3-(3,3-difluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F2N7O2
  1
1
IC50 = 160 nM
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CP0823461
 Compound Info 
2-(4-(4-(5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O3
  1
1
IC50 = 160 nM
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CP0838152
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)cyclopropanecarbonitrile
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C20H19N7O2
  1
1
IC50 = 160 nM
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CP0909346
 Compound Info 
tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
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C21H25N7O4
  1
1
IC50 = 160 nM
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CP0950445
 Compound Info 
2-(5-methyl-4-(4-(quinolin-8-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O4S
  1
1
IC50 = 160 nM
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CP0962072
 Compound Info 
2-(5-methyl-4-(4-(thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19N7O2S
  1
1
IC50 = 160 nM
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CP0963565
 Compound Info 
2-(5-methyl-4-(1-(morpholine-4-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H30N6O4
  1
1
IC50 = 160 nM
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CP0966426
 Compound Info 
4-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-5-yl)benzonitrile
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C25H21N9O2S
  1
1
IC50 = 160 nM
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CP0726180
 Compound Info 
N,N-dimethyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-sulfonamide
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C17H22N8O4S
  1
1
IC50 = 170 nM
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CP0762709
 Compound Info 
2-(5-methyl-4-(3-(phenylsulfonyl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H18N6O4S
  1
1
IC50 = 170 nM
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CP0834668
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H17N7O2
  1
1
IC50 = 170 nM
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CP0913638
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F2N6O2
  1
1
IC50 = 170 nM
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CP0959281
 Compound Info 
2-(4-(4-(ethylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H21N7O4S
  1
1
IC50 = 170 nM
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CP0969656
 Compound Info 
4-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
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C22H20N8O4S
  1
1
IC50 = 170 nM
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CP0721046
 Compound Info 
2-(4-(4-(5-(2-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O2S
  1
1
IC50 = 180 nM
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CP0762917
 Compound Info 
2-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
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C25H21N9O2S
  1
1
IC50 = 180 nM
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CP0812528
 Compound Info 
2-(4-(4,4-difluoro-1,4'-bipiperidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H25F2N7O2
  1
1
IC50 = 180 nM
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CP0905461
 Compound Info 
2-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)oxazol-5-yl)benzonitrile
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C25H21N9O3
  1
1
IC50 = 180 nM
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CP0966423
 Compound Info 
tert-butyl 4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C20H25N7O4
  1
1
IC50 = 180 nM
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CP0738370
 Compound Info 
(S)-2-(4-(7,7-difluorooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
  1
1
IC50 = 190 nM
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CP0745045
 Compound Info 
(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19N7O2
  1
1
IC50 = 190 nM
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CP0905459
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H16F3N9O3
  1
1
IC50 = 190 nM
 Bioactivity Info 
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CP0959088
 Compound Info 
2-(5-methyl-4-(2-(pyridin-4-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H18N8O2S
  1
1
IC50 = 190 nM
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CP0964687
 Compound Info 
2-(4-(4-(4-(2-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O2S
  1
1
IC50 = 190 nM
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CP0772460
 Compound Info 
(R)-2-(4-(4-(cyclobutylmethyl)-3-methylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H27N7O2
  1
1
IC50 = 200 nM
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CP0812525
 Compound Info 
2-(5-methyl-4-(1-(morpholine-4-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H27N7O4
  1
1
IC50 = 200 nM
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CP0761093
 Compound Info 
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H30N6O3
  1
1
IC50 = 210 nM
 Bioactivity Info 
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CP0823455
 Compound Info 
2-(4-(3-(3-fluoropropyl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21FN6O2
  1
1
IC50 = 210 nM
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CP0823458
 Compound Info 
2-(4-(4-(5-(2-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O3
  1
1
IC50 = 210 nM
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CP0887753
 Compound Info 
2-(4-(4-(3,5-dimethylisoxazol-4-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N8O5S
  1
1
IC50 = 210 nM
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CP0738364
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-ylidene)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1
IC50 = 220 nM
 Bioactivity Info 
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CP0761040
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoropropyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1
IC50 = 220 nM
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CP0746917
 Compound Info 
1-ethyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carbonitrile
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C21H23N7O2
  1
1
IC50 = 230 nM
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CP0761005
 Compound Info 
2-(4-(4-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O3
  1
1
IC50 = 230 nM
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CP0838158
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1
IC50 = 240 nM
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CP0891288
 Compound Info 
2-(4-(4-tert-butylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H25N7O2
  1
1
IC50 = 240 nM
 Bioactivity Info 
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CP0726179
 Compound Info 
3-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
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C22H20N8O4S
  1
1
IC50 = 250 nM
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CP0745033
 Compound Info 
2-(4-(4-(6-chloropyridin-3-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19ClN8O4S
  1
1
IC50 = 250 nM
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CP0823477
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F3N7O4S
  1
1
IC50 = 260 nM
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CP0829375
 Compound Info 
2-(4-((1S,4S)-5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H23N7O2
  1
1
IC50 = 260 nM
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CP0912321
 Compound Info 
v2-(4-(4-(2,5-dichlorothiophen-3-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17Cl2N7O4S2
  1
1
IC50 = 260 nM
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CP0947197
 Compound Info 
2-(4-(4-(5-(4-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O3
  1
1
IC50 = 260 nM
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CP0745150
 Compound Info 
2-(4-(2-(6-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 270 nM
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CP0772469
 Compound Info 
2-(4-(4-(2,6-dichlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19Cl2N7O4S
  1
1
IC50 = 270 nM
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CP0966693
 Compound Info 
2-(4-(4-(4-(3-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
  1
1
IC50 = 270 nM
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CP0761009
 Compound Info 
2-(4-(4-(5-(3-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O3
  1
1
IC50 = 280 nM
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CP0962079
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C17H16F3N5O2S
  1
1
IC50 = 280 nM
 Bioactivity Info 
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CP0745027
 Compound Info 
2-(4-(4-(5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O3
  1
1
IC50 = 290 nM
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CP0745167
 Compound Info 
2-(4-(1-(azetidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H25N7O3
  1
1
IC50 = 290 nM
 Bioactivity Info 
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CP0762918
 Compound Info 
2-(5-methyl-4-(4-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O2S
  1
1
IC50 = 290 nM
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CP0959284
 Compound Info 
2-(4-(3-(2-(difluoromethyl)pyridin-4-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17F2N7O2
  1
1
IC50 = 300 nM
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CP0745021
 Compound Info 
N-(1-isopropyl-4-(3,3,3-trifluoroprop-1-en-2-yl)-1H-pyrazol-5-yl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
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C20H19F3N8O2
  1
1
IC50 = 310 nM
 Bioactivity Info 
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CP0909333
 Compound Info 
2-(4-(4-(5-(2-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O3
  1
1
IC50 = 310 nM
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CP0966694
 Compound Info 
2-(5-methyl-4-(4-(5-(pyridin-4-yl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O3
  1
1
IC50 = 310 nM
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CP0768918
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4(3H)-one
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C17H19F3N6O3
  1
1
IC50 = 320 nM
 Bioactivity Info 
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CP0947193
 Compound Info 
1-(4-hydroxy-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C20H21N7O3
  1
1
IC50 = 330 nM
 Bioactivity Info 
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CP0964690
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C17H18F3N7O2
  1
1
IC50 = 330 nM
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CP0772459
 Compound Info 
2-(4-(3-fluoro-3-phenylazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17FN6O2
  1
1
IC50 = 340 nM
 Bioactivity Info 
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CP0734279
 Compound Info 
2-(4-(1-(azetidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H28N6O3
  1
1
IC50 = 350 nM
 Bioactivity Info 
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CP0839341
 Compound Info 
2-(4-(4-(5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O3
  1
1
IC50 = 350 nM
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CP0761003
 Compound Info 
2-(4-(4-(4-(4-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
  1
1
IC50 = 360 nM
 Bioactivity Info 
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CP0844489
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C17H16F2N6O2
  1
1
IC50 = 360 nM
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CP0761070
 Compound Info 
2-(4-(4,4-difluoroazepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N6O2
  1
1
IC50 = 370 nM
 Bioactivity Info 
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CP0762708
 Compound Info 
2-(5-methyl-4-(3-(2-(trifluoromethyl)pyridin-4-yl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H16F3N7O2
  1
1
IC50 = 370 nM
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CP0823471
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C17H16F2N6O2
  1
1
IC50 = 370 nM
 Bioactivity Info 
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CP0969142
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16F2N8O2
  1
1
IC50 = 370 nM
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CP0868883
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
  1
1
IC50 = 380 nM
 Bioactivity Info 
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CP0957695
 Compound Info 
2-(4-(2-(4-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
  1
1
IC50 = 380 nM
 Bioactivity Info 
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CP0957696
 Compound Info 
2-(4-(4-(4-(2-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
  1
1
IC50 = 380 nM
 Bioactivity Info 
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CP0745057
 Compound Info 
2-(5-methyl-4-(2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
  1
1
IC50 = 410 nM
 Bioactivity Info 
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CP0838166
 Compound Info 
2-(4-(azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C14H14N6O2
  1
1
IC50 = 410 nM
 Bioactivity Info 
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CP0844485
 Compound Info 
2-(4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H15F3N8O2
  1
1
IC50 = 410 nM
 Bioactivity Info 
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CP0959087
 Compound Info 
2-(5-methyl-4-(4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O2S
  1
1
IC50 = 420 nM
 Bioactivity Info 
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CP0868873
 Compound Info 
2-(4-(3,3-difluoroazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C14H12F2N6O2
  1
1
IC50 = 440 nM
 Bioactivity Info 
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CP0745023
 Compound Info 
2-(5-methyl-4-(4-(5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
  1
1
IC50 = 450 nM
 Bioactivity Info 
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CP0964724
 Compound Info 
(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
  1
1
IC50 = 450 nM
 Bioactivity Info 
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CP0823459
 Compound Info 
2-(4-(4-(5-(3-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C24H21FN8O3
  1
1
IC50 = 490 nM
 Bioactivity Info 
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CP0944132
 Compound Info 
2-(4-(2-(2-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
  1
1
IC50 = 520 nM
 Bioactivity Info 
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CP0745022
 Compound Info 
2-(5-methyl-4-(2-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H18F3N7O2S
  1
1
IC50 = 540 nM
 Bioactivity Info 
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CP0844488
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C18H19F2N7O2
  1
1
IC50 = 580 nM
 Bioactivity Info 
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CP0868875
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethylsulfonyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20F3N7O4S
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0947157
 Compound Info 
2-(5-methyl-4-(4-(5-(3-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0761007
 Compound Info 
2-(5-methyl-4-(4-(4-(2-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O2S
  1
1
IC50 = 630 nM
 Bioactivity Info 
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CP0947198
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C15H13F2N7O2
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0946655
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C20H18N6O2
  1
1
IC50 = 740 nM
 Bioactivity Info 
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CP0864190
 Compound Info 
2-(5-methyl-4-(4-(methylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H19N7O4S
  1
1
IC50 = 780 nM
 Bioactivity Info 
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CP0823472
 Compound Info 
2-(4-(2-(5-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1
IC50 = 820 nM
 Bioactivity Info 
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CP0762922
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C18H19F2N7O2
  1
1
IC50 = 870 nM
 Bioactivity Info 
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CP0964688
 Compound Info 
2-(4-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H27N7O3
  1
1
IC50 = 890 nM
 Bioactivity Info 
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CP0761014
 Compound Info 
2-(5-methyl-4-(1-oxo-7-azaspiro[3.5]nonane-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20N6O3
  1
1
IC50 = 920 nM
 Bioactivity Info 
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CP0823465
 Compound Info 
2-(5-methyl-4-(4-propionylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O3
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0954051
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C17H17F3N6O2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0894170
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C18H18F3N7O2
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0745024
 Compound Info 
N-(3,3-difluorocyclobutyl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
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C15H14F2N6O2
  1
1
IC50 = 1300 nM
 Bioactivity Info 
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CP0768933
 Compound Info 
2-[4-[4-(trifluoromethyL)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H,5H,7H-furo[3,4-d]pyrimidin-4-one
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C16H16F3N5O3
  1
1
IC50 = 1300 nM
 Bioactivity Info 
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CP0823404
 Compound Info 
3-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidine-3-carbonitrile
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C16H14FN7O2
  1
1
IC50 = 2100 nM
 Bioactivity Info 
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CP0909334
 Compound Info 
6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C19H19N5O2
  1
1
IC50 = 2200 nM
 Bioactivity Info 
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CP0768916
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C18H18F3N7O2
  1
1
IC50 = 2400 nM
 Bioactivity Info 
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CP0831451
 Compound Info 
2-(5-methyl-4-(4-(5-(5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H19F3N10O3
  1
1
IC50 = 2600 nM
 Bioactivity Info 
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CP0698027
 Compound Info 
2-(5-methyl-4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16N8O2
  1
1
IC50 = 2700 nM
 Bioactivity Info 
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Cell Line ID: CL000151 , SK-N-BE(2)
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0713489
 Compound Info 
2-(4-(2-fluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21FN6O2
  1
1 IC50 = 1 nM
CP0713491
 Compound Info 
2-(5-methyl-4-(3-methyl-4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1 IC50 = 1 nM
CP0713493
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
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C19H21N7O2
  1
1 IC50 = 1 nM
CP0713494
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H23N7O2
  1
1 IC50 = 1 nM
CP0713504
 Compound Info 
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H18F6N6O3
  1
1 IC50 = 1 nM
CP0721047
 Compound Info 
2-(5-methyl-4-(4-(propylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H23N7O4S
  1
1 IC50 = 1 nM
CP0726180
 Compound Info 
N,N-dimethyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-sulfonamide
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C17H22N8O4S
  1
1 IC50 = 1 nM
CP0734255
 Compound Info 
2-(4-(4-(cyclohexylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H27N7O4S
  1
1 IC50 = 1 nM
CP0734281
 Compound Info 
2-(4-(3-cyclopropyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23N7O2
  1
1 IC50 = 1 nM
CP0738349
 Compound Info 
2-(5-methyl-4-(4-(1,1,1,3,3-pentafluoropropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F5N6O2
  1
1 IC50 = 1 nM
CP0738350
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O2S
  1
1 IC50 = 1 nM
CP0738369
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C21H24N6O2
  1
1 IC50 = 1 nM
CP0738372
 Compound Info 
4-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)benzonitrile
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C22H20N8O2
  1
1 IC50 = 1 nM
CP0738374
 Compound Info 
2-(4-(3-hydroxy-3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H24N6O3
  1
1 IC50 = 1 nM
CP0738385
 Compound Info 
2-(4-fluoro-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H25FN6O2
  1
1 IC50 = 1 nM
CP0738386
 Compound Info 
2-(5-methyl-4-(4-propionylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H25N5O3
  1
1 IC50 = 1 nM
CP0745031
 Compound Info 
2-(4-(4-(4-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O4S
  1
1 IC50 = 1 nM
CP0745032
 Compound Info 
2-(5-methyl-4-(4-(thiophen-2-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19N7O4S2
  1
1 IC50 = 1 nM
CP0745042
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O2
  1
1 IC50 = 1 nM
CP0745044
 Compound Info 
2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F3N6O2
  1
1 IC50 = 1 nM
CP0745046
 Compound Info 
2-ethyl-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C23H30N6O2
  1
1 IC50 = 1 nM
CP0745151
 Compound Info 
4-methyl-6-[5-methyl-4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-1,2-dihydropyridin-2-one
   Show/Hide
C17H19F3N4O2
  1
1 IC50 = 1 nM
CP0745155
 Compound Info 
(Z)-2-(5-methyl-4-(4-(1,1,1-trifluorobut-2-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1 IC50 = 1 nM
CP0745169
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O2
  1
1 IC50 = 1 nM
CP0746917
 Compound Info 
1-ethyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carbonitrile
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C21H23N7O2
  1
1 IC50 = 1 nM
CP0746918
 Compound Info 
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(pyridin-2-yl)piperidine-4-carbonitrile
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C22H20N8O2
  1
1 IC50 = 1 nM
CP0746919
 Compound Info 
2-(5-methyl-4-(4-(pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20N8O2
  1
1 IC50 = 1 nM
CP0746921
 Compound Info 
tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,5-diazaspiro[3.4]octane-5-carboxylate
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C22H27N7O4
  1
1 IC50 = 1 nM
CP0746927
 Compound Info 
2-(4-(4-(azetidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C21H22F3N7O3
  1
1 IC50 = 1 nM
CP0750095
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)azepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O2
  1
1 IC50 = 1 nM
CP0750097
 Compound Info 
2-(4-(4-butyrylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H24N6O3
  1
1 IC50 = 1 nM
CP0750105
 Compound Info 
2-(4-((3aS,6aR)-4,4-difluorooctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F2N6O2
  1
1 IC50 = 1 nM
CP0754196
 Compound Info 
2-(5-methyl-4-(9-methylene-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C20H22N6O2
  1
1 IC50 = 1 nM
CP0754424
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C18H19F3N6O3
  1
1 IC50 = 1 nM
CP0761006
 Compound Info 
N-(1-isopropyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-1H-pyrazol-5-yl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
   Show/Hide
C20H21F3N8O3
  1
1 IC50 = 1 nM
CP0761010
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C17H18F2N8O2
  1
1 IC50 = 1 nM
CP0761012
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C17H20N8O2
  1
1 IC50 = 1 nM
CP0761014
 Compound Info 
2-(5-methyl-4-(1-oxo-7-azaspiro[3.5]nonane-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C19H20N6O3
  1
1 IC50 = 1 nM
CP0761015
 Compound Info 
2-(5-methyl-4-(7-oxo-3-azaspiro[5.5]undecane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C21H24N6O3
  1
1 IC50 = 1 nM
CP0761016
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C16H18N8O2
  1
1 IC50 = 1 nM
CP0761062
 Compound Info 
2-(5-methyl-4-(3-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1 IC50 = 1 nM
CP0761063
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoroprop-1-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H22F3N5O2
  1
1 IC50 = 1 nM
CP0761064
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
  1
1 IC50 = 1 nM
CP0761065
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-2-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
  1
1 IC50 = 1 nM
CP0761066
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H18F3N7O2S
  1
1 IC50 = 1 nM
CP0761067
 Compound Info 
2-(4-(9-hydroxy-9-(trifluoromethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O3
  1
1 IC50 = 1 nM
CP0761069
 Compound Info 
2-(4-(4-(6-chloropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O2
  1
1 IC50 = 1 nM
CP0761081
 Compound Info 
2-(4-(5,5-difluorooctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F2N6O2
  1
1 IC50 = 1 nM
CP0761088
 Compound Info 
methyl 5-cyclopropyl-1-(7-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxylate
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C14H12FN5O3
  1
1 IC50 = 1 nM
CP0762706
 Compound Info 
5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazole-3-carboxamide
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C19H21F3N6O3
  1
1 IC50 = 1 nM
CP0762707
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19F3N8O2
  1
1 IC50 = 1 nM
CP0768906
 Compound Info 
2-cyclopropyl-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)acetonitrile
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C21H23N7O2
  1
1 IC50 = 1 nM
CP0768907
 Compound Info 
tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)carbamate
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C20H25N7O4
  1
1 IC50 = 1 nM
CP0768910
 Compound Info 
2-(4-(4-(3-chlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O2
  1
1 IC50 = 1 nM
CP0768921
 Compound Info 
2-(4-(4-(mesitylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H27N7O4S
  1
1 IC50 = 1 nM
CP0768922
 Compound Info 
2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
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C22H20N8O4S
  1
1 IC50 = 1 nM
CP0768923
 Compound Info 
2-(5-methyl-4-(4-(pyridin-3-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20N8O4S
  1
1 IC50 = 1 nM
CP0768924
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethoxy)phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F3N7O5S
  1
1 IC50 = 1 nM
CP0768971
 Compound Info 
2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrrol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F3N5O2
  1
1 IC50 = 1 nM
CP0768973
 Compound Info 
2-(2-methyl-3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrrol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H21F3N4O2
  1
1 IC50 = 1 nM
CP0772437
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
  1
1 IC50 = 1 nM
CP0772456
 Compound Info 
2-(4-(3-(6-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1 IC50 = 1 nM
CP0772458
 Compound Info 
2-(4-hydroxy-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C20H23N7O3
  1
1 IC50 = 1 nM
CP0772462
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1 IC50 = 1 nM
CP0772463
 Compound Info 
2-(4-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H22N8O3
  1
1 IC50 = 1 nM
CP0772464
 Compound Info 
N-cyclopropyl-N-methyl-6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-6-azaspiro[2.5]octane-1-carboxamide
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C23H27N7O3
  1
1 IC50 = 1 nM
CP0772466
 Compound Info 
2-(4-(3-(6-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1 IC50 = 1 nM
CP0772469
 Compound Info 
2-(4-(4-(2,6-dichlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19Cl2N7O4S
  1
1 IC50 = 1 nM
CP0812551
 Compound Info 
7-fluoro-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H14F4N6O2
  1
1 IC50 = 1 nM
CP0820605
 Compound Info 
2-(4-(4-(3-chlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O4S
  1
1 IC50 = 1 nM
CP0823410
 Compound Info 
2-(4-(4-methoxy-4-methylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H22N6O3
  1
1 IC50 = 1 nM
CP0823412
 Compound Info 
tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
  1
1 IC50 = 1 nM
CP0823414
 Compound Info 
2-(4-(8-hydroxy-8-(trifluoromethyl)-3-azabicyclo[3.2.1]octane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O3
  1
1 IC50 = 1 nM
CP0823415
 Compound Info 
2-(4-(4-cyclopropyl-4-hydroxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
  1
1 IC50 = 1 nM
CP0823417
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carbonyl)piperidine-4-carbonitrile
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C18H20N8O2
  1
1 IC50 = 1 nM
CP0823419
 Compound Info 
2-(5-methyl-4-(4-methyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19N7O2
  1
1 IC50 = 1 nM
CP0823422
 Compound Info 
2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrrol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H19F3N4O2
  1
1 IC50 = 1 nM
CP0823453
 Compound Info 
2-(5-methyl-4-(4-(phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H21N7O4S
  1
1 IC50 = 1 nM
CP0823454
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoroprop-1-en-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O2
  1
1 IC50 = 1 nM
CP0823455
 Compound Info 
2-(4-(3-(3-fluoropropyl)pyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21FN6O2
  1
1 IC50 = 1 nM
CP0823456
 Compound Info 
2-(5-methyl-4-(4-propionylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
  1
1 IC50 = 1 nM
CP0823457
 Compound Info 
2-(4-(3-cyclobutyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H25N7O2
  1
1 IC50 = 1 nM
CP0823462
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-3-methoxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F3N6O3
  1
1 IC50 = 1 nM
CP0823463
 Compound Info 
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F2N8O2
  1
1 IC50 = 1 nM
CP0823466
 Compound Info 
2-(4-(4-acetyl-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H24N6O3
  1
1 IC50 = 1 nM
CP0823467
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F3N8O2
  1
1 IC50 = 1 nM
CP0823468
 Compound Info 
2-(5-methyl-4-(4-(4,4,4-trifluorobutanoyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O3
  1
1 IC50 = 1 nM
CP0823470
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H20N8O2
  1
1 IC50 = 1 nM
CP0823477
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)phenylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F3N7O4S
  1
1 IC50 = 1 nM
CP0829374
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxybutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F3N6O3
  1
1 IC50 = 1 nM
CP0829376
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H17F3N8O2
  1
1 IC50 = 1 nM
CP0829377
 Compound Info 
2-(5-methyl-4-(7-(trifluoromethyl)-3-azabicyclo[4.1.0]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H17F3N6O2
  1
1 IC50 = 1 nM
CP0829378
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C20H21N7O2
  1
1 IC50 = 1 nM
CP0829379
 Compound Info 
2-(4-(6,6-difluoro-3-azabicyclo[3.2.0]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F2N6O2
  1
1 IC50 = 1 nM
CP0829387
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C19H21N5O2S
  1
1 IC50 = 1 nM
CP0829389
 Compound Info 
2-(4-(4-hydroxy-4-(trifluoromethyl)azepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O3
  1
1 IC50 = 1 nM
CP0829401
 Compound Info 
2-(4-(4-(5-chlorothiophen-2-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H18ClN7O4S2
  1
1 IC50 = 1 nM
CP0831444
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carbonitrile
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C20H18N8O2S
  1
1 IC50 = 1 nM
CP0831445
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-2-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H25N7O2S
  1
1 IC50 = 1 nM
CP0831449
 Compound Info 
2-(5-methyl-4-(8-(trifluoromethyl)-3-azabicyclo[3.2.1]octane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19F3N6O2
  1
1 IC50 = 1 nM
CP0831452
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-1H-pyrrole-2-carbonitrile
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C21H20N8O2
  1
1 IC50 = 1 nM
CP0831454
 Compound Info 
2-(4-(4-(2,4-dimethylthiazol-5-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N8O4S2
  1
1 IC50 = 1 nM
CP0834668
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H17N7O2
  1
1 IC50 = 1 nM
CP0838150
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23F3N6O2
  1
1 IC50 = 1 nM
CP0838151
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F3N6O2
  1
1 IC50 = 1 nM
CP0838153
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H15F2N7O2
  1
1 IC50 = 1 nM
CP0838155
 Compound Info 
2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
  1
1 IC50 = 1 nM
CP0838156
 Compound Info 
2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N6O2
  1
1 IC50 = 1 nM
CP0838157
 Compound Info 
(R)-tert-butyl 2-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
  1
1 IC50 = 1 nM
CP0838161
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
   Show/Hide
C20H23N7O2
  1
1 IC50 = 1 nM
CP0838162
 Compound Info 
tert-butyl 8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-5,8-diazaspiro[3.5]nonane-5-carboxylate
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C23H29N7O4
  1
1 IC50 = 1 nM
CP0838163
 Compound Info 
2-(5-methyl-4-(5-azaspiro[2.5]octane-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
  1
1 IC50 = 1 nM
CP0838165
 Compound Info 
2-(4-(6,6-difluoro-3-azabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F2N6O2
  1
1 IC50 = 1 nM
CP0838167
 Compound Info 
2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C15H14F3N7O2
  1
1 IC50 = 1 nM
CP0838168
 Compound Info 
2-(4-(3-(3,4-difluorophenyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H16F2N6O2
  1
1 IC50 = 1 nM
CP0838173
 Compound Info 
2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
  1
1 IC50 = 1 nM
CP0839257
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F3N6O3
  1
1 IC50 = 1 nM
CP0839263
 Compound Info 
2-(5-(4-(trifluoromethyl)piperidine-1-carbonyl)thiophen-2-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H18F3N3O2S
  1
1 IC50 = 1 nM
CP0839309
 Compound Info 
2-(4-(4-(2,2-difluorocyclopentyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23F2N7O2
  1
1 IC50 = 1 nM
CP0839340
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1 IC50 = 1 nM
CP0839342
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H22N8O2
  1
1 IC50 = 1 nM
CP0839343
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H18F3N7O2
  1
1 IC50 = 1 nM
CP0844486
 Compound Info 
2-(4-(4-(2-chloro-1H-imidazol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19ClN8O2
  1
1 IC50 = 1 nM
CP0844487
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)cyclopropyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F3N7O2
  1
1 IC50 = 1 nM
CP0868871
 Compound Info 
(R)-tert-butyl methyl(1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C20H25N7O4
  1
1 IC50 = 1 nM
CP0868872
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F3N6O3
  1
1 IC50 = 1 nM
CP0868874
 Compound Info 
2-(5-methyl-4-(4-phenylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H21N7O2
  1
1 IC50 = 1 nM
CP0868901
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16F3N7O2
  1
1 IC50 = 1 nM
CP0883863
 Compound Info 
2-(5-methyl-4-(4-(pyrrolidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H24F3N7O3
  1
1 IC50 = 1 nM
CP0883864
 Compound Info 
2-(4-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C20H22FN7O2
  1
1 IC50 = 1 nM
CP0883887
 Compound Info 
2-methyl-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
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C20H23N7O2
  1
1 IC50 = 1 nM
CP0887753
 Compound Info 
2-(4-(4-(3,5-dimethylisoxazol-4-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N8O5S
  1
1 IC50 = 1 nM
CP0891289
 Compound Info 
2-(5-methyl-4-(3-(thiazol-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20N8O2S
  1
1 IC50 = 1 nM
CP0891290
 Compound Info 
2-(5-methyl-4-(9-(trifluoromethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1 IC50 = 1 nM
CP0891305
 Compound Info 
2-(4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18N6O2
  1
1 IC50 = 1 nM
CP0897051
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)butanenitrile
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C21H24N6O2
  1
1 IC50 = 1 nM
CP0902945
 Compound Info 
2-(5-methyl-4-(4-((tetrahydrofuran-2-yl)methyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H25N7O3
  1
1 IC50 = 1 nM
CP0905460
 Compound Info 
2-(4-(4-(3,3-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F2N7O2
  1
1 IC50 = 1 nM
CP0909309
 Compound Info 
ethyl 5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylate
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C12H12N6O3
  1
1 IC50 = 1 nM
CP0909328
 Compound Info 
2-(4-(4-(2-fluoropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1 IC50 = 1 nM
CP0909335
 Compound Info 
2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1 IC50 = 1 nM
CP0909336
 Compound Info 
tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
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C23H29N7O4
  1
1 IC50 = 1 nM
CP0909341
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F3N7O2
  1
1 IC50 = 1 nM
CP0909342
 Compound Info 
2-(5-methyl-4-(4-(5-(pyridin-3-yl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O3
  1
1 IC50 = 1 nM
CP0909346
 Compound Info 
tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
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C21H25N7O4
  1
1 IC50 = 1 nM
CP0909347
 Compound Info 
2-(5-methyl-4-((1R,5S)-9-(2,2,2-trifluoroethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H23F3N6O2
  1
1 IC50 = 1 nM
CP0909348
 Compound Info 
2-(5-methyl-4-(5-(2,2,2-trifluoroethyl)-5,8-diazaspiro[3.5]nonane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22F3N7O2
  1
1 IC50 = 1 nM
CP0909349
 Compound Info 
2-(4-(4-(cyclopropanecarbonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N6O3
  1
1 IC50 = 1 nM
CP0909350
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-3-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F3N6O3
  1
1 IC50 = 1 nM
CP0909397
 Compound Info 
2-(4-(4-(1H-pyrrol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21N7O2
  1
1 IC50 = 1 nM
CP0909398
 Compound Info 
4-fluoro-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C20H22FN7O2
  1
1 IC50 = 1 nM
CP0909400
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O2S
  1
1 IC50 = 1 nM
CP0912321
 Compound Info 
v2-(4-(4-(2,5-dichlorothiophen-3-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17Cl2N7O4S2
  1
1 IC50 = 1 nM
CP0913621
 Compound Info 
2-(5-methyl-4-(2-azaspiro[4.4]nonane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O2
  1
1 IC50 = 1 nM
CP0913622
 Compound Info 
2-(4-(4-(4-fluorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1 IC50 = 1 nM
CP0913638
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F2N6O2
  1
1 IC50 = 1 nM
CP0913640
 Compound Info 
(S)-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H26N6O2
  1
1 IC50 = 1 nM
CP0946656
 Compound Info 
2-(5-methyl-4-(4-(piperidine-1-carbonyl)-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H26F3N7O3
  1
1 IC50 = 1 nM
CP0947147
 Compound Info 
6-[5-methyl-4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-4-(trifluoromethyl)-1,2-dihydropyridin-2-one
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C17H16F6N4O2
  1
1 IC50 = 1 nM
CP0947189
 Compound Info 
2-(5-methyl-4-(2-azaspiro[3.4]octane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O2
  1
1 IC50 = 1 nM
CP0947191
 Compound Info 
2-(4-(4-(isopropylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H24N6O4S
  1
1 IC50 = 1 nM
CP0947192
 Compound Info 
2-(5-methyl-4-(4-(thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H22N6O2S
  1
1 IC50 = 1 nM
CP0947193
 Compound Info 
1-(4-hydroxy-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclopropanecarbonitrile
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C20H21N7O3
  1
1 IC50 = 1 nM
CP0947194
 Compound Info 
2-(4-(4-(6-fluoropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1 IC50 = 1 nM
CP0947205
 Compound Info 
4-ethyl-1-(1-(7-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-5-methyl-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H20FN7O2
  1
1 IC50 = 1 nM
CP0950444
 Compound Info 
2-(4-(4-(2-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O4S
  1
1 IC50 = 1 nM
CP0950445
 Compound Info 
2-(5-methyl-4-(4-(quinolin-8-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22N8O4S
  1
1 IC50 = 1 nM
CP0950446
 Compound Info 
methyl 3-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)thiophene-2-carboxylate
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C21H21N7O6S2
  1
1 IC50 = 1 nM
CP0951351
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17F3N8O3
  1
1 IC50 = 1 nM
CP0951353
 Compound Info 
2-(4-(4-(2-chloropyridin-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O2
  1
1 IC50 = 1 nM
CP0951354
 Compound Info 
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F2N7O2
  1
1 IC50 = 1 nM
CP0951355
 Compound Info 
2-(4-(4-ethyl-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F3N6O2
  1
1 IC50 = 1 nM
CP0951356
 Compound Info 
2-(5-methyl-4-(4-(1,1,1,4-tetrafluorobutan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22F4N6O2
  1
1 IC50 = 1 nM
CP0951358
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-1H-pyrrole-3-carbonitrile
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C21H20N8O2
  1
1 IC50 = 1 nM
CP0954047
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
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C21H23N7O2
  1
1 IC50 = 1 nM
CP0954048
 Compound Info 
2-(4-(6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23N5O2
  1
1 IC50 = 1 nM
CP0954729
 Compound Info 
2-(5-methyl-4-(4-(naphthalen-1-ylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H23N7O4S
  1
1 IC50 = 1 nM
CP0955211
 Compound Info 
2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H29N7O3
  1
1 IC50 = 1 nM
CP0957699
 Compound Info 
2-(5-methyl-4-((1R,5S,9r)-9-(2,2,2-trifluoroethyl)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H23F3N6O2
  1
1 IC50 = 1 nM
CP0957702
 Compound Info 
2-(5-methyl-4-(2-(pyridin-3-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H18N8O2S
  1
1 IC50 = 1 nM
CP0957703
 Compound Info 
3-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)oxazol-5-yl)benzonitrile
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C19H21N7O3
  1
1 IC50 = 1 nM
CP0959282
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoropropylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O4S
  1
1 IC50 = 1 nM
CP0959283
 Compound Info 
2-(4-(4-(3-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O4S
  1
1 IC50 = 1 nM
CP0962057
 Compound Info 
2-methyl-2-(1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
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C19H21N7O2
  1
1 IC50 = 1 nM
CP0962059
 Compound Info 
4-ethyl-1-(1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H22N6O2
  1
1 IC50 = 1 nM
CP0962060
 Compound Info 
1-(1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
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C23H22N6O2
  1
1 IC50 = 1 nM
CP0962072
 Compound Info 
2-(5-methyl-4-(4-(thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19N7O2S
  1
1 IC50 = 1 nM
CP0962073
 Compound Info 
tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate
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C23H29N7O4
  1
1 IC50 = 1 nM
CP0962124
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19N7O2
  1
1 IC50 = 1 nM
CP0962125
 Compound Info 
2-(4-(4-(3,3-difluorocyclobutyl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F2N8O2
  1
1 IC50 = 1 nM
CP0963567
 Compound Info 
2-(4-(4-(6-fluoropyridin-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1 IC50 = 1 nM
CP0964668
 Compound Info 
2-(4-(4-(2-chloro-1H-pyrrol-1-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H20ClN7O2
  1
1 IC50 = 1 nM
CP0966139
 Compound Info 
2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19N7O2
  1
1 IC50 = 1 nM
CP0966424
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O2S
  1
1 IC50 = 1 nM
CP0966425
 Compound Info 
2-(5-methyl-4-(1-oxo-8-azaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22N6O3
  1
1 IC50 = 1 nM
CP0967572
 Compound Info 
2-(5-cyclopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-7-fluoropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H18F4N6O2
  1
1 IC50 = 1 nM
CP0967574
 Compound Info 
2-(4-(4-hydroxy-4-(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F3N6O3
  1
1 IC50 = 1 nM
CP0969528
 Compound Info 
2-(4-(4-(5-fluoropyridin-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20FN7O2
  1
1 IC50 = 1 nM
CP0969656
 Compound Info 
4-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
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C22H20N8O4S
  1
1 IC50 = 1 nM
CP0969864
 Compound Info 
2-(5-methyl-4-(9-(2,2,2-trifluoroethylidene)-3-azabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H21F3N6O2
  1
1 IC50 = 1 nM
CP0970014
 Compound Info 
2-(4-(4-(2-chlorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O4S
  1
1 IC50 = 1 nM
CP0970015
 Compound Info 
2-(4-(4-(2-chloro-4-fluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19ClFN7O4S
  1
1 IC50 = 1 nM
CP0970224
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)oxazole-4-carbonitrile
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C20H18N8O3
  1
1 IC50 = 1 nM
CP0713487
 Compound Info 
2-(4-(4-(difluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H21F2N5O2
  1
1 IC50 = 2 nM
CP0713488
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H24N6O2
  1
1 IC50 = 2 nM
CP0713490
 Compound Info 
2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)acetonitrile
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C17H18N8O2
  1
1 IC50 = 2 nM
CP0713492
 Compound Info 
(S)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C21H27N7O4
  1
1 IC50 = 2 nM
CP0713517
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H21N5O2
  1
1 IC50 = 2 nM
CP0713541
 Compound Info 
2-(5-methyl-4-(9-(2,2,2-trifluoroethyl)-3,9-diazabicyclo[3.3.1]nonane-3-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H25F3N6O2
  1
1 IC50 = 2 nM
CP0713542
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)cyclobutanecarbonitrile
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C22H26N6O2
  1
1 IC50 = 2 nM
CP0720795
 Compound Info 
2-(4-(4-(benzo[c][1,2,5]thiadiazol-4-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19N9O4S2
  1
1 IC50 = 2 nM
CP0726170
 Compound Info 
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H16F6N6O3
  1
1 IC50 = 2 nM
CP0726171
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H24N6O2
  1
1 IC50 = 2 nM
CP0726174
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N7O2S
  1
1 IC50 = 2 nM
CP0726179
 Compound Info 
3-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-ylsulfonyl)benzonitrile
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C22H20N8O4S
  1
1 IC50 = 2 nM
CP0726207
 Compound Info 
7-fluoro-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F4N6O2
  1
1 IC50 = 2 nM
CP0726213
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H21N7O2
  1
1 IC50 = 2 nM
CP0726235
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H25N5O2
  1
1 IC50 = 2 nM
CP0726239
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C17H16F3N5O2S
  1
1 IC50 = 2 nM
CP0734272
 Compound Info 
2-(5-methyl-4-(7-(2,2,2-trifluoroethyl)-2,7-diazaspiro[3.5]nonane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H22F3N7O2
  1
1 IC50 = 2 nM
CP0734274
 Compound Info 
2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C16H14F3N5O2S
  1
1 IC50 = 2 nM
CP0734280
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carboxamide
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C21H23N7O3S
  1
1 IC50 = 2 nM
CP0738364
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluorobutan-2-ylidene)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H21F3N6O2
  1
1 IC50 = 2 nM
CP0738377
 Compound Info 
tert-butyl 7-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
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C23H29N7O4
  1
1 IC50 = 2 nM
CP0738383
 Compound Info 
2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H14F3N5O2S
  1
1 IC50 = 2 nM
CP0745025
 Compound Info 
2-(4-(4-(4-(6-fluoropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1 IC50 = 2 nM
CP0745033
 Compound Info 
2-(4-(4-(6-chloropyridin-3-ylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19ClN8O4S
  1
1 IC50 = 2 nM
CP0745040
 Compound Info 
2-(5-cyclopropyl-4-(4-methylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O2
  1
1 IC50 = 2 nM
CP0745147
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-4-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H25N7O2S
  1
1 IC50 = 2 nM
CP0745149
 Compound Info 
3-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
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C25H21N9O2S
  1
1 IC50 = 2 nM
CP0745158
 Compound Info 
2-(5-methyl-4-(2-thia-6-azaspiro[3.3]heptane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16N6O2S
  1
1 IC50 = 2 nM
CP0745162
 Compound Info 
2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H18F2N6O4S
  1
1 IC50 = 2 nM
CP0746914
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)-1H-imidazol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H19F3N8O2
  1
1 IC50 = 2 nM
CP0746915
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H20F3N5O2
  1
1 IC50 = 2 nM
CP0746916
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O3
  1
1 IC50 = 2 nM
CP0746923
 Compound Info 
6-fluoro-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C16H14F4N6O2
  1
1 IC50 = 2 nM
CP0746924
 Compound Info 
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C23H21N7O2
  1
1 IC50 = 2 nM
CP0746926
 Compound Info 
2-(5-methyl-4-(4-(4-phenyloxazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H23N7O3
  1
1 IC50 = 2 nM
CP0754197
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20F3N7O2
  1
1 IC50 = 2 nM
CP0754200
 Compound Info 
4-fluoro-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H25FN6O2
  1
1 IC50 = 2 nM
CP0754201
 Compound Info 
tert-butyl 3-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-ylcarbamate
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C20H25N7O4
  1
1 IC50 = 2 nM
CP0754428
 Compound Info 
2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C25H32N6O3
  1
1 IC50 = 2 nM
CP0760995
 Compound Info 
2-(5-methyl-4-(5-phenyloctahydropyrrolo[3,4-c]pyrrole-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C23H23N7O2
  1
1 IC50 = 2 nM
CP0760996
 Compound Info 
2-(4-(3-(4,4-difluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C19H21F2N7O2
  1
1 IC50 = 2 nM
CP0760999
 Compound Info 
tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[3.4]octane-6-carboxylate
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C22H27N7O4
  1
1 IC50 = 2 nM
CP0761017
 Compound Info 
2-(4-(4-(2,2-difluorocyclobutyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N8O2
  1
1 IC50 = 2 nM
CP0761019
 Compound Info 
2-(4-(4-(2-fluorocyclopropyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C18H20FN7O2
  1
1 IC50 = 2 nM
CP0761025
 Compound Info 
2-(5-methyl-4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C19H23N5O2
  1
1 IC50 = 2 nM
CP0761040
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoropropyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1 IC50 = 2 nM
CP0761068
 Compound Info 
2-allyl-2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
   Show/Hide
C24H27N7O2
  1
1 IC50 = 2 nM
CP0761070
 Compound Info 
2-(4-(4,4-difluoroazepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F2N6O2
  1
1 IC50 = 2 nM
CP0761071
 Compound Info 
2-(4-(3-(5-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1 IC50 = 2 nM
CP0761085
 Compound Info 
(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C21H27N7O4
  1
1 IC50 = 2 nM
CP0762708
 Compound Info 
2-(5-methyl-4-(3-(2-(trifluoromethyl)pyridin-4-yl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H16F3N7O2
  1
1 IC50 = 2 nM
CP0762709
 Compound Info 
2-(5-methyl-4-(3-(phenylsulfonyl)azetidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H18N6O4S
  1
1 IC50 = 2 nM
CP0762915
 Compound Info 
2-(5-methyl-4-(2-(pyridin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H18N8O2S
  1
1 IC50 = 2 nM
CP0768909
 Compound Info 
(1S,5S)-tert-butyl 6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-3-carboxylate
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C21H25N7O4
  1
1 IC50 = 2 nM
CP0768911
 Compound Info 
2-(4-(4-(4-chlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20ClN7O2
  1
1 IC50 = 2 nM
CP0768915
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C18H18F3N5O2S
  1
1 IC50 = 2 nM
CP0768970
 Compound Info 
7-fluoro-2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F4N6O2
  1
1 IC50 = 2 nM
CP0768972
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-7-fluoropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H22FN7O2
  1
1 IC50 = 2 nM
CP0768977
 Compound Info 
1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-(2,2,2-trifluoroethyl)piperidine-4-carbonitrile
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C19H18F3N7O2
  1
1 IC50 = 2 nM
CP0768978
 Compound Info 
2-(5-methyl-4-(4-(1-(trifluoromethyl)cyclopropyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H24F3N5O2
  1
1 IC50 = 2 nM
CP0768979
 Compound Info 
2-(4-(2-ethyl-2,7-diazaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H25N7O2
  1
1 IC50 = 2 nM
CP0772433
 Compound Info 
2-(5-methyl-4-(1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C19H21N7O3
  1
1 IC50 = 2 nM
CP0772434
 Compound Info 
2-(5-methyl-4-(4-(pyrazin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H19N9O2
  1
1 IC50 = 2 nM
CP0772435
 Compound Info 
tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-5,8-diazaspiro[3.5]nonane-8-carboxylate
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C23H29N7O4
  1
1 IC50 = 2 nM
CP0772438
 Compound Info 
2-(4-(2,2-difluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C19H20F2N6O2
  1
1 IC50 = 2 nM
CP0772459
 Compound Info 
2-(4-(3-fluoro-3-phenylazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17FN6O2
  1
1 IC50 = 2 nM
CP0772460
 Compound Info 
(R)-2-(4-(4-(cyclobutylmethyl)-3-methylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H27N7O2
  1
1 IC50 = 2 nM
CP0772465
 Compound Info 
tert-butyl 7-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate
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C24H32N6O4
  1
1 IC50 = 2 nM
CP0812525
 Compound Info 
2-(5-methyl-4-(1-(morpholine-4-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H27N7O4
  1
1 IC50 = 2 nM
CP0812528
 Compound Info 
2-(4-(4,4-difluoro-1,4'-bipiperidine-1'-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H25F2N7O2
  1
1 IC50 = 2 nM
CP0812537
 Compound Info 
2-(5-methyl-4-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C18H20N6O4
  1
1 IC50 = 2 nM
CP0823404
 Compound Info 
3-fluoro-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidine-3-carbonitrile
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C16H14FN7O2
  1
1 IC50 = 2 nM
CP0823411
 Compound Info 
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C23H27N7O3
  1
1 IC50 = 2 nM
CP0823423
 Compound Info 
2-(5-methyl-4-(4-methyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H22N6O2
  1
1 IC50 = 2 nM
CP0823427
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
   Show/Hide
C19H21N5O2S
  1
1 IC50 = 2 nM
CP0823460
 Compound Info 
2-(4-(4-(4-(6-chloropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O2S
  1
1 IC50 = 2 nM
CP0829380
 Compound Info 
4-methyl-1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
   Show/Hide
C18H19N7O2
  1
1 IC50 = 2 nM
CP0829386
 Compound Info 
tert-butyl 8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate
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C22H27N7O4
  1
1 IC50 = 2 nM
CP0829395
 Compound Info 
2-(5-methyl-4-(6-(3,3,3-trifluoropropyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H20F3N7O2
  1
1 IC50 = 2 nM
CP0829396
 Compound Info 
4-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
   Show/Hide
C25H21N9O2S
  1
1 IC50 = 2 nM
CP0831440
 Compound Info 
2-(4-(1,1-difluoro-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C18H18F2N6O2
  1
1 IC50 = 2 nM
CP0831448
 Compound Info 
2-(4-(3-(5-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C19H16FN7O2
  1
1 IC50 = 2 nM
CP0836860
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C19H23N5O2
  1
1 IC50 = 2 nM
CP0838152
 Compound Info 
1-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)cyclopropanecarbonitrile
   Show/Hide
C20H19N7O2
  1
1 IC50 = 2 nM
CP0838160
 Compound Info 
tert-butyl 1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3-(trifluoromethyl)pyrrolidin-3-ylcarbamate
   Show/Hide
C21H24F3N7O4
  1
1 IC50 = 2 nM
CP0838164
 Compound Info 
2-(4-(3-cyclopropyl-3-hydroxyazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18N6O3
  1
1 IC50 = 2 nM
CP0838169
 Compound Info 
2-(4-(4-ethoxypiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C18H23N5O3
  1
1 IC50 = 2 nM
CP0838171
 Compound Info 
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C21H19F2N7O2
  1
1 IC50 = 2 nM
CP0838172
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C18H19N5O2S
  1
1 IC50 = 2 nM
CP0838179
 Compound Info 
1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C23H20N6O2S
  1
1 IC50 = 2 nM
CP0864191
 Compound Info 
2-(4-(4-(isopropylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C18H23N7O4S
  1
1 IC50 = 2 nM
CP0868876
 Compound Info 
2-(5-methyl-4-(4-(3-(trifluoromethylsulfonyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C21H20F3N7O4S
  1
1 IC50 = 2 nM
CP0868883
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C20H17N5O2S
  1
1 IC50 = 2 nM
CP0868886
 Compound Info 
2-(5-methyl-4-((2S,4S)-2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
  1
1 IC50 = 2 nM
CP0883883
 Compound Info 
2-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
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C16H15F3N6O2
  1
1 IC50 = 2 nM
CP0891307
 Compound Info 
4-ethyl-1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carbonyl)piperidine-4-carbonitrile
   Show/Hide
C17H18N8O2
  1
1 IC50 = 2 nM
CP0891308
 Compound Info 
2-(4-(6,6-difluoro-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C16H14F2N6O2
  1
1 IC50 = 2 nM
CP0894171
 Compound Info 
2-(4-(4-(2,4-difluorophenylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19F2N7O4S
  1
1 IC50 = 2 nM
CP0905462
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C20H19F3N8O2
  1
1 IC50 = 2 nM
CP0909310
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)acetonitrile
   Show/Hide
C18H19N7O2
  1
1 IC50 = 2 nM
CP0909352
 Compound Info 
2-(4-(4-cyclobutylpiperazine-1-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C19H23N7O2
  1
1 IC50 = 2 nM
CP0909396
 Compound Info 
2-(4-(4-(5-chloropyridin-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C20H19ClN8O2
  1
1 IC50 = 2 nM
CP0909399
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C20H20F3N7O3
  1
1 IC50 = 2 nM
CP0913620
 Compound Info 
2-(4-(2-azabicyclo[2.1.1]hexane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C16H16N6O2
  1
1 IC50 = 2 nM
CP0913637
 Compound Info 
2-(4-(4-cyclopropylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C18H21N7O2
  1
1 IC50 = 2 nM
CP0913639
 Compound Info 
(S)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
   Show/Hide
C21H27N7O4
  1
1 IC50 = 2 nM
CP0913648
 Compound Info 
2-(5-methyl-4-(4-phenylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C22H24N6O2
  1
1 IC50 = 2 nM
CP0913655
 Compound Info 
2-(4-(2,2-difluoro-7-azaspiro[3.5]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C20H23F2N5O2
  1
1 IC50 = 2 nM
CP0944128
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C18H18F3N5O2S
  1
1 IC50 = 2 nM
CP0944133
 Compound Info 
2-(5-methyl-4-(5-azaspiro[2.4]heptane-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C17H18N6O2
  1
1 IC50 = 2 nM
CP0947153
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C17H17F3N6O2
  1
1 IC50 = 2 nM
CP0947190
 Compound Info 
2-(4-(3,3-difluoro-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C18H18F2N6O2
  1
1 IC50 = 2 nM
CP0947195
 Compound Info 
2-(4-(3-(2-fluoropyridin-4-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C19H16FN7O2
  1
1 IC50 = 2 nM
CP0947206
 Compound Info 
2-methyl-2-(1-(1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
   Show/Hide
C20H24N6O2
  1
1 IC50 = 2 nM
CP0947243
 Compound Info 
2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C17H16F3N5O2S
  1
1 IC50 = 2 nM
CP0951452
 Compound Info 
2-(5-methyl-4-(4-(4-(pyridin-3-yl)thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C25H25N7O2S
  1
1 IC50 = 2 nM
CP0951458
 Compound Info 
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
   Show/Hide
C19H19F6N5O3
  1
1 IC50 = 2 nM
CP0955450
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
   Show/Hide
C17H16F2N6O2
  1
1 IC50 = 2 nM
CP0957873
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16F3N7O4S
  1
1 IC50 = 2 nM
CP0959284
 Compound Info 
2-(4-(3-(2-(difluoromethyl)pyridin-4-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17F2N7O2
  1
1 IC50 = 2 nM
CP0962064
 Compound Info 
(R)-tert-butyl 3-methyl-4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H27N7O4
  1
1 IC50 = 2 nM
CP0962079
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C17H16F3N5O2S
  1
1 IC50 = 2 nM
CP0963564
 Compound Info 
(R)-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H26N6O2
  1
1 IC50 = 2 nM
CP0964666
 Compound Info 
2-(4-(4-(4-(2-chloropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O2S
  1
1 IC50 = 2 nM
CP0964667
 Compound Info 
2-(4-(6-cyclopropyl-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21N7O2
  1
1 IC50 = 2 nM
CP0964693
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)butanenitrile
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C21H26N6O2
  1
1 IC50 = 2 nM
CP0966390
 Compound Info 
2-(4-(6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H21N5O2
  1
1 IC50 = 2 nM
CP0966393
 Compound Info 
2-(4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F3N6O3
  1
1 IC50 = 2 nM
CP0966695
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
  1
1 IC50 = 2 nM
CP0698027
 Compound Info 
2-(5-methyl-4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16N8O2
  1
1 IC50 = 3 nM
CP0713496
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
  1
1 IC50 = 3 nM
CP0713509
 Compound Info 
4-methyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H22N6O2
  1
1 IC50 = 3 nM
CP0721044
 Compound Info 
2-(4-(4-(5-(6-fluoropyridin-3-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1 IC50 = 3 nM
CP0721045
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoropropan-2-yl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22F3N7O2
  1
1 IC50 = 3 nM
CP0726172
 Compound Info 
methyl 1-(7-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-5-methyl-1H-pyrazole-4-carboxylate
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C12H10FN5O3
  1
1 IC50 = 3 nM
CP0726214
 Compound Info 
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C22H22F2N6O2
  1
1 IC50 = 3 nM
CP0726221
 Compound Info 
6-fluoro-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F4N6O2
  1
1 IC50 = 3 nM
CP0726224
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C20H24N6O2
  1
1 IC50 = 3 nM
CP0726225
 Compound Info 
N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-(quinolin-6-ylmethyl)-1H-pyrazole-4-carboxamide
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C23H22N6O2
  1
1 IC50 = 3 nM
CP0726227
 Compound Info 
N-(2-cyanoethyl)-N-cyclohexyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C21H26N6O2
  1
1 IC50 = 3 nM
CP0726247
 Compound Info 
2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3H,4H-thieno[2,3-d]pyrimidin-4-one
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C20H17N5O2S
  1
1 IC50 = 3 nM
CP0726250
 Compound Info 
6-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C16H18F3N5O2
  1
1 IC50 = 3 nM
CP0734254
 Compound Info 
2-(4-(4-methoxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H23N5O3
  1
1 IC50 = 3 nM
CP0734279
 Compound Info 
2-(4-(1-(azetidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H28N6O3
  1
1 IC50 = 3 nM
CP0738370
 Compound Info 
(S)-2-(4-(7,7-difluorooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
  1
1 IC50 = 3 nM
CP0745021
 Compound Info 
N-(1-isopropyl-4-(3,3,3-trifluoroprop-1-en-2-yl)-1H-pyrazol-5-yl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
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C20H19F3N8O2
  1
1 IC50 = 3 nM
CP0745028
 Compound Info 
2-(4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C15H15F3N8O2
  1
1 IC50 = 3 nM
CP0745150
 Compound Info 
2-(4-(2-(6-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1 IC50 = 3 nM
CP0750096
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17F3N8O3
  1
1 IC50 = 3 nM
CP0754202
 Compound Info 
2-(5-methyl-4-(3-(5-(trifluoromethyl)pyridin-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21F3N8O2
  1
1 IC50 = 3 nM
CP0754413
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C24H22N6O2S
  1
1 IC50 = 3 nM
CP0760997
 Compound Info 
(1S)-tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-6-carboxylate
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C21H25N7O4
  1
1 IC50 = 3 nM
CP0761008
 Compound Info 
2-(4-(2-(4-fluorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18FN7O2S
  1
1 IC50 = 3 nM
CP0761021
 Compound Info 
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H20F2N6O2
  1
1 IC50 = 3 nM
CP0761033
 Compound Info 
(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H24N6O2
  1
1 IC50 = 3 nM
CP0761041
 Compound Info 
2-(5-methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H24F3N5O3
  1
1 IC50 = 3 nM
CP0761061
 Compound Info 
2-(5-methyl-4-(4-(4-phenyloxazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H26N6O3
  1
1 IC50 = 3 nM
CP0761091
 Compound Info 
2-(4-(4-methoxy-4-methylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H25N5O3
  1
1 IC50 = 3 nM
CP0761093
 Compound Info 
2-(5-methyl-4-(1-(pyrrolidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H30N6O3
  1
1 IC50 = 3 nM
CP0762917
 Compound Info 
2-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-4-yl)benzonitrile
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C25H21N9O2S
  1
1 IC50 = 3 nM
CP0768940
 Compound Info 
2-(5-methyl-4-(4-phenylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H25N5O2
  1
1 IC50 = 3 nM
CP0768943
 Compound Info 
2-(4-(4-tert-butylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H25N5O2S
  1
1 IC50 = 3 nM
CP0772461
 Compound Info 
2-(4-(3-(3,3-difluoropiperidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H21F2N7O2
  1
1 IC50 = 3 nM
CP0812538
 Compound Info 
2-(5-methyl-4-(2-oxa-7-azaspiro[3.5]nonane-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20N6O3
  1
1 IC50 = 3 nM
CP0812542
 Compound Info 
2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C22H19F2N5O4S2
  1
1 IC50 = 3 nM
CP0812550
 Compound Info 
2-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
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C17H18F3N5O2
  1
1 IC50 = 3 nM
CP0823431
 Compound Info 
5-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-6H,7H-thieno[2,3-c]pyridin-7-one
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C17H15F3N4O2S
  1
1 IC50 = 3 nM
CP0823436
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H18F3N5O2
  1
1 IC50 = 3 nM
CP0823437
 Compound Info 
2-(5-methyl-4-(2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H18F3N5O2S
  1
1 IC50 = 3 nM
CP0823464
 Compound Info 
2-(4-(4-cyclopropyl-1,4-diazepane-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H23N7O2
  1
1 IC50 = 3 nM
CP0829388
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)thiazole-4-carbonitrile
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C21H21N7O2S
  1
1 IC50 = 3 nM
CP0831441
 Compound Info 
2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H20F3N5O2
  1
1 IC50 = 3 nM
CP0831450
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H17F3N8O2S
  1
1 IC50 = 3 nM
CP0838149
 Compound Info 
2-(5-methyl-4-(4-(4-phenylthiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H26N6O2S
  1
1 IC50 = 3 nM
CP0838154
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H20F3N7O2
  1
1 IC50 = 3 nM
CP0838175
 Compound Info 
2-(4-(4-tert-butylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H29N5O2
  1
1 IC50 = 3 nM
CP0838182
 Compound Info 
1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C18H20N6O2
  1
1 IC50 = 3 nM
CP0839261
 Compound Info 
2-(5-methyl-4-(piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H18N6O2
  1
1 IC50 = 3 nM
CP0868887
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
  1
1 IC50 = 3 nM
CP0868890
 Compound Info 
2-(4-(4-(2-chlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C22H23ClN6O2
  1
1 IC50 = 3 nM
CP0870568
 Compound Info 
2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
  1
1 IC50 = 3 nM
CP0883885
 Compound Info 
2-(4-(4-(6-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H23FN6O2S
  1
1 IC50 = 3 nM
CP0897056
 Compound Info 
2-(4-(4-cyclopropylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C18H19N5O2S
  1
1 IC50 = 3 nM
CP0905459
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H16F3N9O3
  1
1 IC50 = 3 nM
CP0909340
 Compound Info 
2-(4-(4-(1H-indol-4-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H26N6O2
  1
1 IC50 = 3 nM
CP0909345
 Compound Info 
2-(4-(6-cyclobutyl-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H23N7O2
  1
1 IC50 = 3 nM
CP0909351
 Compound Info 
2-(4-(4-(5-(2-fluoropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1 IC50 = 3 nM
CP0913625
 Compound Info 
6-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)nicotinonitrile
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C21H19N9O2
  1
1 IC50 = 3 nM
CP0913645
 Compound Info 
5-chloro-6-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C16H17ClF3N5O2
  1
1 IC50 = 3 nM
CP0913652
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C24H22N6O2S
  1
1 IC50 = 3 nM
CP0944287
 Compound Info 
2-(4-(4-(3,4-difluorophenylsulfonyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F2N6O4S
  1
1 IC50 = 3 nM
CP0947142
 Compound Info 
2-(5-methyl-4-(4-(3-(trifluoromethyl)phenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F3N7O2
  1
1 IC50 = 3 nM
CP0947198
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C15H13F2N7O2
  1
1 IC50 = 3 nM
CP0951347
 Compound Info 
2-(4-(3-hydroxy-3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H27N5O3
  1
1 IC50 = 3 nM
CP0954733
 Compound Info 
2-(4-(4-(benzylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H23N7O4S
  1
1 IC50 = 3 nM
CP0955723
 Compound Info 
4-methyl-6-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-1,2-dihydropyridin-2-one
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C16H17F3N4O2
  1
1 IC50 = 3 nM
CP0959089
 Compound Info 
2-(4-(4-(4-(2-fluoropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O2S
  1
1 IC50 = 3 nM
CP0962058
 Compound Info 
tert-butyl 4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C21H28N6O4
  1
1 IC50 = 3 nM
CP0962062
 Compound Info 
(1R,5R)-tert-butyl 6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-3-carboxylate
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C21H25N7O4
  1
1 IC50 = 3 nM
CP0962080
 Compound Info 
2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)pent-4-enenitrile
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C22H26N6O2
  1
1 IC50 = 3 nM
CP0962086
 Compound Info 
1-(1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
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C22H19N7O2
  1
1 IC50 = 3 nM
CP0962089
 Compound Info 
(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C22H30N6O4
  1
1 IC50 = 3 nM
CP0964688
 Compound Info 
2-(4-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H27N7O3
  1
1 IC50 = 3 nM
CP0964724
 Compound Info 
(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
  1
1 IC50 = 3 nM
CP0966392
 Compound Info 
2-(4-(3-(3,4-difluorophenyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H19F2N5O2
  1
1 IC50 = 3 nM
CP0966423
 Compound Info 
tert-butyl 4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C20H25N7O4
  1
1 IC50 = 3 nM
CP0966694
 Compound Info 
2-(5-methyl-4-(4-(5-(pyridin-4-yl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N9O3
  1
1 IC50 = 3 nM
CP0713502
 Compound Info 
4-ethyl-1-(1-(6-fluoro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C18H18FN7O2
  1
1 IC50 = 4 nM
CP0713503
 Compound Info 
tert-butyl 8-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate
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C23H30N6O4
  1
1 IC50 = 4 nM
CP0726211
 Compound Info 
2-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H21F6N5O3
  1
1 IC50 = 4 nM
CP0726223
 Compound Info 
2-(4-(4-(phenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20N6O4S
  1
1 IC50 = 4 nM
CP0726226
 Compound Info 
2-(5-methyl-4-(4-(phenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H25N5O4S
  1
1 IC50 = 4 nM
CP0734277
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H20N6O2S
  1
1 IC50 = 4 nM
CP0734278
 Compound Info 
2-methyl-2-(1-(1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
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C19H20N6O2S
  1
1 IC50 = 4 nM
CP0745045
 Compound Info 
(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H19N7O2
  1
1 IC50 = 4 nM
CP0745048
 Compound Info 
(R)-tert-butyl methyl(1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl)carbamate
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C21H26N6O4S
  1
1 IC50 = 4 nM
CP0745161
 Compound Info 
2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C17H16F3N5O2S
  1
1 IC50 = 4 nM
CP0745167
 Compound Info 
2-(4-(1-(azetidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H25N7O3
  1
1 IC50 = 4 nM
CP0746920
 Compound Info 
2-(4-(4-(3,4-dichlorophenyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19Cl2N7O2
  1
1 IC50 = 4 nM
CP0761001
 Compound Info 
(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C17H18N6O2S
  1
1 IC50 = 4 nM
CP0768935
 Compound Info 
2-(5-methyl-4-((2R,4R)-2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
  1
1 IC50 = 4 nM
CP0812540
 Compound Info 
2-(5-methyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H19N7O2
  1
1 IC50 = 4 nM
CP0823430
 Compound Info 
2-(5-methyl-4-(4-(2-methyl-1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H28N6O2
  1
1 IC50 = 4 nM
CP0823440
 Compound Info 
2-(4-(2,4-dimethylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H21N5O2S
  1
1 IC50 = 4 nM
CP0823459
 Compound Info 
2-(4-(4-(5-(3-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O3
  1
1 IC50 = 4 nM
CP0829394
 Compound Info 
2-(5-methyl-4-(4-(3,3,3-trifluoropropyl)-1,4-diazepane-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22F3N7O2
  1
1 IC50 = 4 nM
CP0838158
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1 IC50 = 4 nM
CP0838159
 Compound Info 
(S)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
  1
1 IC50 = 4 nM
CP0838170
 Compound Info 
(R)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H22N6O2
  1
1 IC50 = 4 nM
CP0838178
 Compound Info 
1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
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C23H20N6O2S
  1
1 IC50 = 4 nM
CP0839332
 Compound Info 
2-[4-[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]-5-methyl-1H-pyrazol-1-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one
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C18H21N5O2S
  1
1 IC50 = 4 nM
CP0864190
 Compound Info 
2-(5-methyl-4-(4-(methylsulfonyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H19N7O4S
  1
1 IC50 = 4 nM
CP0870569
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F2N6O2
  1
1 IC50 = 4 nM
CP0897050
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)-1,3'-biazetidine-1'-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F3N7O2
  1
1 IC50 = 4 nM
CP0905478
 Compound Info 
2-(4-(4-(2,4-difluorophenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17F2N7O2
  1
1 IC50 = 4 nM
CP0905479
 Compound Info 
6-fluoro-2-(4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H16F4N6O2
  1
1 IC50 = 4 nM
CP0913647
 Compound Info 
2-(4-(4-(phenylsulfonyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C21H19N5O4S2
  1
1 IC50 = 4 nM
CP0913654
 Compound Info 
3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carbonitrile
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C23H25N7O3
  1
1 IC50 = 4 nM
CP0944129
 Compound Info 
2-(4-(6-hydroxy-6-(trifluoromethyl)-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H17F3N6O3
  1
1 IC50 = 4 nM
CP0947155
 Compound Info 
2-(5-methyl-4-(2-phenylaziridine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H19N5O2
  1
1 IC50 = 4 nM
CP0951467
 Compound Info 
tert-butyl 6-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[3.4]octane-2-carboxylate
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C22H27N7O4
  1
1 IC50 = 4 nM
CP0951509
 Compound Info 
2-(4-(4-hydroxy-2-methyl-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H27N5O3
  1
1 IC50 = 4 nM
CP0954055
 Compound Info 
2-(5-cyclopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H22F3N5O2
  1
1 IC50 = 4 nM
CP0959035
 Compound Info 
2-methyl-2-(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
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C21H26N6O2
  1
1 IC50 = 4 nM
CP0959088
 Compound Info 
2-(5-methyl-4-(2-(pyridin-4-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H18N8O2S
  1
1 IC50 = 4 nM
CP0959281
 Compound Info 
2-(4-(4-(ethylsulfonyl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H21N7O4S
  1
1 IC50 = 4 nM
CP0962083
 Compound Info 
2-(5-methyl-4-(2-(pyridin-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C22H24N6O2
  1
1 IC50 = 4 nM
CP0964669
 Compound Info 
(S)-2-(4-(7,7-difluorooctahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H17F2N7O2
  1
1 IC50 = 4 nM
CP0966146
 Compound Info 
2-(4-(4,4-difluoropiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H19F2N5O2
  1
1 IC50 = 4 nM
CP0966389
 Compound Info 
2-(5-methyl-4-(1-(5-phenyl-1,3,4-oxadiazol-2-yl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C27H27N7O3
  1
1 IC50 = 4 nM
CP0966391
 Compound Info 
2-(4-(4-(6-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H21FN6O2S
  1
1 IC50 = 4 nM
CP0967573
 Compound Info 
2-(5-methyl-4-(1-(5-phenyl-1,3,4-oxadiazol-2-yl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C26H24N8O3
  1
1 IC50 = 4 nM
CP0713506
 Compound Info 
4-ethyl-1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidine-4-carbonitrile
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C19H20N6O2S
  1
1 IC50 = 5 nM
CP0726210
 Compound Info 
2-(4-(1-benzyl-1,7-diazaspiro[4.4]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C25H26N6O2S
  1
1 IC50 = 5 nM
CP0726229
 Compound Info 
(S)-2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H20F3N5O2
  1
1 IC50 = 5 nM
CP0726231
 Compound Info 
2-(4-(3-methoxyazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C16H19N5O3
  1
1 IC50 = 5 nM
CP0734273
 Compound Info 
2-(5-methyl-4-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H19F3N8O2
  1
1 IC50 = 5 nM
CP0738381
 Compound Info 
2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H21FN6O2S
  1
1 IC50 = 5 nM
CP0745054
 Compound Info 
2-(5-methyl-4-(3-phenoxypyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C22H23N5O3
  1
1 IC50 = 5 nM
CP0745057
 Compound Info 
2-(5-methyl-4-(2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
  1
1 IC50 = 5 nM
CP0745164
 Compound Info 
(S)-6-methyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C19H19N5O2
  1
1 IC50 = 5 nM
CP0745168
 Compound Info 
2-(5-methyl-4-(4-phenylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C22H21N5O2S
  1
1 IC50 = 5 nM
CP0754410
 Compound Info 
tert-butyl 2-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[4.5]decane-6-carboxylate
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C24H30N6O4S
  1
1 IC50 = 5 nM
CP0761023
 Compound Info 
2-(4-(2-(5-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1 IC50 = 5 nM
CP0820593
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H20F3N5O2
  1
1 IC50 = 5 nM
CP0820597
 Compound Info 
2-(5-methyl-4-((4R)-2-methyl-4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
  1
1 IC50 = 5 nM
CP0820601
 Compound Info 
2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C16H21N5O2
  1
1 IC50 = 5 nM
CP0823421
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H21F3N6O2
  1
1 IC50 = 5 nM
CP0823458
 Compound Info 
2-(4-(4-(5-(2-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O3
  1
1 IC50 = 5 nM
CP0823469
 Compound Info 
2-(4-(2-(6-fluoropyridin-3-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1 IC50 = 5 nM
CP0829382
 Compound Info 
3-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-2,4-diazabicyclo[4.2.0]octa-1(6),2-dien-5-one
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C17H18F3N5O2
  1
1 IC50 = 5 nM
CP0829397
 Compound Info 
2-(5-methyl-4-(4-(5-(pyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H27N9O2S
  1
1 IC50 = 5 nM
CP0831446
 Compound Info 
2-(5-methyl-4-(piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H21N5O2
  1
1 IC50 = 5 nM
CP0838174
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-7-fluoropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN7O2S
  1
1 IC50 = 5 nM
CP0839331
 Compound Info 
2-(3,5-dimethyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H18F3N5O2S
  1
1 IC50 = 5 nM
CP0839341
 Compound Info 
2-(4-(4-(5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O3
  1
1 IC50 = 5 nM
CP0891288
 Compound Info 
2-(4-(4-tert-butylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H25N7O2
  1
1 IC50 = 5 nM
CP0909339
 Compound Info 
2-(5-methyl-4-(4-phenoxypiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H25N5O3
  1
1 IC50 = 5 nM
CP0909343
 Compound Info 
2-(4-(2-(3-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
  1
1 IC50 = 5 nM
CP0909401
 Compound Info 
6-methyl-2-(5-methyl-4-(4-(pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C19H21N7O2
  1
1 IC50 = 5 nM
CP0947197
 Compound Info 
2-(4-(4-(5-(4-fluorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O3
  1
1 IC50 = 5 nM
CP0955174
 Compound Info 
2-(5-methyl-4-(3-phenylpyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C22H23N5O2
  1
1 IC50 = 5 nM
CP0957695
 Compound Info 
2-(4-(2-(4-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
  1
1 IC50 = 5 nM
CP0962081
 Compound Info 
2-(5-methyl-4-(2-(trifluoromethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H14F3N7O2S
  1
1 IC50 = 5 nM
CP0963565
 Compound Info 
2-(5-methyl-4-(1-(morpholine-4-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H30N6O4
  1
1 IC50 = 5 nM
CP0964654
 Compound Info 
2-(5-methyl-4-(5-oxooctahydrocyclopenta[c]pyrrole-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18N6O3
  1
1 IC50 = 5 nM
CP0713482
 Compound Info 
2-(4-(2-(4-chlorophenyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C20H17ClN6O2
  1
1 IC50 = 6 nM
CP0713518
 Compound Info 
N-benzyl-N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C18H19N5O2
  1
1 IC50 = 6 nM
CP0726209
 Compound Info 
2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C23H19FN6O2S2
  1
1 IC50 = 6 nM
CP0726216
 Compound Info 
2-(4-(4-(6-fluoro-1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H25FN6O2
  1
1 IC50 = 6 nM
CP0726228
 Compound Info 
N-((5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)-N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C22H20ClN7O3
  1
1 IC50 = 6 nM
CP0726233
 Compound Info 
2-(3,5-dimethyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C21H19N5O2S
  1
1 IC50 = 6 nM
CP0738351
 Compound Info 
2-(4-(3-methoxypyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H21N5O3
  1
1 IC50 = 6 nM
CP0745027
 Compound Info 
2-(4-(4-(5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O3
  1
1 IC50 = 6 nM
CP0745060
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one
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C19H16F3N5O2
  1
1 IC50 = 6 nM
CP0745159
 Compound Info 
2-(4-(5-hydroxy-5-methyloctahydrocyclopenta[c]pyrrole-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H22N6O3
  1
1 IC50 = 6 nM
CP0754350
 Compound Info 
tert-butyl 5-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
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C22H27N7O4
  1
1 IC50 = 6 nM
CP0768933
 Compound Info 
2-[4-[4-(trifluoromethyL)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-3H,4H,5H,7H-furo[3,4-d]pyrimidin-4-one
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C16H16F3N5O3
  1
1 IC50 = 6 nM
CP0772457
 Compound Info 
2-(3-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H18F3N7O2
  1
1 IC50 = 6 nM
CP0812546
 Compound Info 
tert-butyl(1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)methylcarbamate
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C21H28N6O4
  1
1 IC50 = 6 nM
CP0823433
 Compound Info 
1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
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C24H24N6O2
  1
1 IC50 = 6 nM
CP0823465
 Compound Info 
2-(5-methyl-4-(4-propionylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O3
  1
1 IC50 = 6 nM
CP0829381
 Compound Info 
(1R,5S)-tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,6-diazabicyclo[3.2.0]heptane-6-carboxylate
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C21H25N7O4
  1
1 IC50 = 6 nM
CP0829392
 Compound Info 
2-(4-(4-(4-(3-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O2S
  1
1 IC50 = 6 nM
CP0829398
 Compound Info 
2-(4-(4-(5-(2-chloropyridin-4-yl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O2S
  1
1 IC50 = 6 nM
CP0839329
 Compound Info 
2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H25N5O3
  1
1 IC50 = 6 nM
CP0839330
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C23H20N6O2S2
  1
1 IC50 = 6 nM
CP0883884
 Compound Info 
2-(5-methyl-4-(3-phenylazetidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C21H21N5O2
  1
1 IC50 = 6 nM
CP0905461
 Compound Info 
2-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)oxazol-5-yl)benzonitrile
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C25H21N9O3
  1
1 IC50 = 6 nM
CP0913649
 Compound Info 
2-(4-(1-benzyl-1,7-diazaspiro[4.4]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H30N6O2
  1
1 IC50 = 6 nM
CP0951349
 Compound Info 
2-(1-(5-cyclopropyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)-2-methylpropanenitrile
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C23H28N6O2
  1
1 IC50 = 6 nM
CP0955727
 Compound Info 
2-(5-methyl-4-(2-oxopiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H19N5O3
  1
1 IC50 = 6 nM
CP0962061
 Compound Info 
2-(5-methyl-4-(4-(4-(trifluoromethyl)phenyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H20F3N7O2
  1
1 IC50 = 6 nM
CP0964687
 Compound Info 
2-(4-(4-(4-(2-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O2S
  1
1 IC50 = 6 nM
CP0966387
 Compound Info 
(R)-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
  1
1 IC50 = 6 nM
CP0966388
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H23N7O2
  1
1 IC50 = 6 nM
CP0966394
 Compound Info 
6-methyl-2-(5-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C20H21N5O2
  1
1 IC50 = 6 nM
CP0726232
 Compound Info 
2-(5-methyl-4-(3-phenoxypiperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H25N5O3
  1
1 IC50 = 7 nM
CP0745050
 Compound Info 
benzyl 1-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)pyrrolidine-2-carboxylate
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C24H25N5O4
  1
1 IC50 = 7 nM
CP0745055
 Compound Info 
2-(4-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H25N5O3
  1
1 IC50 = 7 nM
CP0761055
 Compound Info 
6-methyl-2-(5-methyl-4-(7-(morpholinosulfonyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C23H26N6O5S
  1
1 IC50 = 7 nM
CP0761057
 Compound Info 
6-methyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C19H19N5O2
  1
1 IC50 = 7 nM
CP0761083
 Compound Info 
(1R,6S)-tert-butyl 8-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate
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C22H27N7O4
  1
1 IC50 = 7 nM
CP0768926
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H21N7O2
  1
1 IC50 = 7 nM
CP0772442
 Compound Info 
(R)-2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H20F3N5O2
  1
1 IC50 = 7 nM
CP0812541
 Compound Info 
2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN7O2S
  1
1 IC50 = 7 nM
CP0823461
 Compound Info 
2-(4-(4-(5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20FN9O3
  1
1 IC50 = 7 nM
CP0844485
 Compound Info 
2-(4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H15F3N8O2
  1
1 IC50 = 7 nM
CP0868888
 Compound Info 
N-benzyl-N-ethyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C21H23N5O2
  1
1 IC50 = 7 nM
CP0909334
 Compound Info 
6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C19H19N5O2
  1
1 IC50 = 7 nM
CP0913646
 Compound Info 
2-(4-(4-methoxy-4-phenylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H27N5O3
  1
1 IC50 = 7 nM
CP0913650
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C23H20N6O2S2
  1
1 IC50 = 7 nM
CP0944132
 Compound Info 
2-(4-(2-(2-chlorophenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H18ClN7O2S
  1
1 IC50 = 7 nM
CP0947247
 Compound Info 
2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C17H19N5O2S
  1
1 IC50 = 7 nM
CP0962087
 Compound Info 
tert-butyl 2-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-2,6-diazaspiro[4.5]decane-6-carboxylate
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C25H34N6O4
  1
1 IC50 = 7 nM
CP0962088
 Compound Info 
(R)-2-(5-methyl-4-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H20N6O2S
  1
1 IC50 = 7 nM
CP0964691
 Compound Info 
(R)-6-methyl-2-(5-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C20H21N5O2
  1
1 IC50 = 7 nM
CP0726217
 Compound Info 
2-(5-methyl-4-(octahydro-2H-pyrano[3,2-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C19H21N5O3S
  1
1 IC50 = 8 nM
CP0745041
 Compound Info 
6-fluoro-2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H18F4N6O2
  1
1 IC50 = 8 nM
CP0745051
 Compound Info 
N-cyclohexyl-N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C19H25N5O2
  1
1 IC50 = 8 nM
CP0761005
 Compound Info 
2-(4-(4-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H20ClN9O3
  1
1 IC50 = 8 nM
CP0761007
 Compound Info 
2-(5-methyl-4-(4-(4-(2-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O2S
  1
1 IC50 = 8 nM
CP0768929
 Compound Info 
2-(4-(3-methoxypiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C18H23N5O3
  1
1 IC50 = 8 nM
CP0829375
 Compound Info 
2-(4-((1S,4S)-5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H23N7O2
  1
1 IC50 = 8 nM
CP0838176
 Compound Info 
2-(1-(5-cyclopropyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperidin-4-yl)propanenitrile
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C22H26N6O2
  1
1 IC50 = 8 nM
CP0868873
 Compound Info 
2-(4-(3,3-difluoroazetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C14H12F2N6O2
  1
1 IC50 = 8 nM
CP0868875
 Compound Info 
2-(5-methyl-4-(4-(2-(trifluoromethylsulfonyl)-1H-pyrrol-1-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C21H20F3N7O4S
  1
1 IC50 = 8 nM
CP0868881
 Compound Info 
N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-propyl-1H-pyrazole-4-carboxamide
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C14H19N5O2
  1
1 IC50 = 8 nM
CP0868885
 Compound Info 
5-chloro-6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C19H18ClN5O2
  1
1 IC50 = 8 nM
CP0909333
 Compound Info 
2-(4-(4-(5-(2-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O3
  1
1 IC50 = 8 nM
CP0944284
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethoxy)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O3
  1
1 IC50 = 8 nM
CP0951345
 Compound Info 
(S)-N-tert-butyl-2-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C26H30N6O3
  1
1 IC50 = 8 nM
CP0955175
 Compound Info 
ethyl 1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylate
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C11H10N6O3
  1
1 IC50 = 8 nM
CP0957696
 Compound Info 
2-(4-(4-(4-(2-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
  1
1 IC50 = 8 nM
CP0713538
 Compound Info 
2-(4-(isoindoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C18H17N5O2
  1
1 IC50 = 9 nM
CP0726220
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-cyclopropyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H26N6O2S
  1
1 IC50 = 9 nM
CP0745024
 Compound Info 
N-(3,3-difluorocyclobutyl)-5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxamide
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C15H14F2N6O2
  1
1 IC50 = 9 nM
CP0745052
 Compound Info 
2-(5-methyl-4-(4-methyl-2-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H22F3N5O2
  1
1 IC50 = 9 nM
CP0745058
 Compound Info 
2-(4-(2,2-dimethylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H21N5O2S
  1
1 IC50 = 9 nM
CP0761009
 Compound Info 
2-(4-(4-(5-(3-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O3
  1
1 IC50 = 9 nM
CP0761035
 Compound Info 
2-(5-methyl-4-(2-methyl-2-p-tolylmorpholine-4-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H27N5O3
  1
1 IC50 = 9 nM
CP0761050
 Compound Info 
N-(2,3-dihydro-1H-inden-1-yl)-N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C20H21N5O2
  1
1 IC50 = 9 nM
CP0761086
 Compound Info 
3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carboxamide
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C23H27N7O4
  1
1 IC50 = 9 nM
CP0768918
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4(3H)-one
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C17H19F3N6O3
  1
1 IC50 = 9 nM
CP0820594
 Compound Info 
4-methyl-6-[3-methyl-4-[4-(trifluoromethyL)piperidine-1-carbonyl]-1H-pyrazol-1-yl]-1,2-dihydropyridin-2-one
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C17H19F3N4O2
  1
1 IC50 = 9 nM
CP0823420
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C23H20N6O2S
  1
1 IC50 = 9 nM
CP0823438
 Compound Info 
2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-3,5-dimethyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H21N5O2S
  1
1 IC50 = 9 nM
CP0831439
 Compound Info 
2-(4-(7-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C20H21N5O3
  1
1 IC50 = 9 nM
CP0831451
 Compound Info 
2-(5-methyl-4-(4-(5-(5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C23H19F3N10O3
  1
1 IC50 = 9 nM
CP0909402
 Compound Info 
6-methyl-2-(5-methyl-4-(8-oxa-2-azaspiro[4.5]decane-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C18H23N5O3
  1
1 IC50 = 9 nM
CP0944130
 Compound Info 
2-(5-methyl-4-(4-o-tolylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C23H26N6O2
  1
1 IC50 = 9 nM
CP0944283
 Compound Info 
N-(2-(1H-indol-3-yl)ethyl)-N,5-dimethyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C23H24N6O2
  1
1 IC50 = 9 nM
CP0954051
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C17H17F3N6O2
  1
1 IC50 = 9 nM
CP0959027
 Compound Info 
3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid
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C23H26N6O5
  1
1 IC50 = 9 nM
CP0964670
 Compound Info 
(S)-6-methyl-2-(5-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C20H21N5O2
  1
1 IC50 = 9 nM
CP0964674
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H14F3N5O2S
  1
1 IC50 = 9 nM
CP0966147
 Compound Info 
6-methyl-2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C15H16F3N5O2
  1
1 IC50 = 9 nM
CP0969142
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H16F2N8O2
  1
1 IC50 = 9 nM
CP0713510
 Compound Info 
2-(5-methyl-4-(3-phenyl-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H27N5O2
  1
1 IC50 = 10 nM
CP0721046
 Compound Info 
2-(4-(4-(5-(2-fluorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21FN8O2S
  1
1 IC50 = 10 nM
CP0726173
 Compound Info 
2-(4-(1-hydroxy-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H19N5O3
  1
1 IC50 = 10 nM
CP0726242
 Compound Info 
2-(5-methyl-4-(8-azaspiro[4.5]decane-8-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H23N5O2S
  1
1 IC50 = 10 nM
CP0726243
 Compound Info 
5-chloro-2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C18H16ClN5O2
  1
1 IC50 = 10 nM
CP0726251
 Compound Info 
6-methyl-2-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C19H16F3N5O2
  1
1 IC50 = 10 nM
CP0738352
 Compound Info 
2-(5-methyl-4-(2,2,6,6-tetramethylmorpholine-4-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C19H23N5O3S
  1
1 IC50 = 10 nM
CP0745022
 Compound Info 
2-(5-methyl-4-(2-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H18F3N7O2S
  1
1 IC50 = 10 nM
CP0760998
 Compound Info 
(1S,6R)-tert-butyl 3-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate
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C22H27N7O4
  1
1 IC50 = 10 nM
CP0761002
 Compound Info 
2-(4-(4-(5-(4-chlorophenyl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O3
  1
1 IC50 = 10 nM
CP0761031
 Compound Info 
methyl 3-(4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carbonyl)bicyclo[1.1.1]pentane-1-carboxylate
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C24H28N6O5
  1
1 IC50 = 10 nM
CP0761034
 Compound Info 
2-[4-(cyclopentyloxy)-1H-pyrazol-1-yl]-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
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C15H18N4O2
  1
1 IC50 = 10 nM
CP0761046
 Compound Info 
2-(4-((4aR,8aR)-decahydroisoquinoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H23N5O2S
  1
1 IC50 = 10 nM
CP0761049
 Compound Info 
5,6-dimethyl-2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C20H21N5O2
  1
1 IC50 = 10 nM
CP0761052
 Compound Info 
(R)-6-methyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C19H19N5O2
  1
1 IC50 = 10 nM
CP0761054
 Compound Info 
2-(5-(difluoromethyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C19H17F2N5O2
  1
1 IC50 = 10 nM
CP0762916
 Compound Info 
2-(5-methyl-4-(4-(5-(2-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
  1
1 IC50 = 10 nM
CP0820600
 Compound Info 
N-ethyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-propyl-1H-pyrazole-4-carboxamide
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C15H21N5O2
  1
1 IC50 = 10 nM
CP0823434
 Compound Info 
2-(5-isopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C18H22F3N5O2
  1
1 IC50 = 10 nM
CP0823441
 Compound Info 
2-(4-(7-azabicyclo[2.2.1]heptane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C16H19N5O2
  1
1 IC50 = 10 nM
CP0823442
 Compound Info 
2-(5-isopropyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C21H23N5O2
  1
1 IC50 = 10 nM
CP0823472
 Compound Info 
2-(4-(2-(5-fluoropyridin-2-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C19H16FN7O2
  1
1 IC50 = 10 nM
CP0838166
 Compound Info 
2-(4-(azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C14H14N6O2
  1
1 IC50 = 10 nM
CP0839334
 Compound Info 
6-methyl-2-(5-methyl-4-(4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-6-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C16H17N7O2
  1
1 IC50 = 10 nM
CP0868882
 Compound Info 
5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N,N-dipropyl-1H-pyrazole-4-carboxamide
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C16H23N5O2
  1
1 IC50 = 10 nM
CP0883881
 Compound Info 
2-(5-isopropyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H24F3N5O2
  1
1 IC50 = 10 nM
CP0891300
 Compound Info 
2-(4-(3-oxa-7-azabicyclo[3.3.1]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H23N5O3
  1
1 IC50 = 10 nM
CP0909344
 Compound Info 
2-(5-methyl-4-(2-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H18F3N7O2S
  1
1 IC50 = 10 nM
CP0909403
 Compound Info 
N,N-diethyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C14H19N5O2
  1
1 IC50 = 10 nM
CP0947196
 Compound Info 
2-(4-(4-(5-(6-chloropyridin-3-yl)oxazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-1,2,3-triazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H19ClN10O3
  1
1 IC50 = 10 nM
CP0959033
 Compound Info 
6-methyl-2-(5-methyl-4-(3-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C16H18F3N5O2
  1
1 IC50 = 10 nM
CP0962054
 Compound Info 
(1R,5S)-3-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxamide
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C18H20N6O3
  1
1 IC50 = 10 nM
CP0962084
 Compound Info 
benzyl 2-methyl-4-(5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)piperazine-1-carboxylate
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C25H28N6O4
  1
1 IC50 = 10 nM
CP0962090
 Compound Info 
2-(4-(4-(5-fluorobenzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H23FN6O2S
  1
1 IC50 = 10 nM
CP0966144
 Compound Info 
6-methyl-2-(5-methyl-4-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C16H17N7O2
  1
1 IC50 = 10 nM
CP0966386
 Compound Info 
2-(4-((4aR,8aS)-decahydroisoquinoline-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H23N5O2S
  1
1 IC50 = 10 nM
CP0966426
 Compound Info 
4-(2-(4-(5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carbonyl)piperazin-1-yl)thiazol-5-yl)benzonitrile
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C25H21N9O2S
  1
1 IC50 = 10 nM
CP0966693
 Compound Info 
2-(4-(4-(4-(3-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
  1
1 IC50 = 10 nM
CP0713539
 Compound Info 
6-methyl-2-(5-methyl-4-(7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C20H18F3N5O2
  1
1 IC50 = 20 nM
CP0726218
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C25H21N5O2S
  1
1 IC50 = 20 nM
CP0738382
 Compound Info 
N-ethyl-N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C13H17N5O2
  1
1 IC50 = 20 nM
CP0738384
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H24N6O2S
  1
1 IC50 = 20 nM
CP0745023
 Compound Info 
2-(5-methyl-4-(4-(5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
  1
1 IC50 = 20 nM
CP0745047
 Compound Info 
2-(4-(3-oxa-7-azabicyclo[3.3.1]nonane-7-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H19N5O3S
  1
1 IC50 = 20 nM
CP0745163
 Compound Info 
2-(3-(3,3-dimethylpyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H17N5O2S
  1
1 IC50 = 20 nM
CP0745165
 Compound Info 
6-methyl-2-[3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C18H17N5O2
  1
1 IC50 = 20 nM
CP0761003
 Compound Info 
2-(4-(4-(4-(4-chlorophenyl)thiazol-2-yl)piperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C24H21ClN8O2S
  1
1 IC50 = 20 nM
CP0761048
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroquinoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
  1
1 IC50 = 20 nM
CP0761060
 Compound Info 
2-(4-(indoline-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C18H17N5O2
  1
1 IC50 = 20 nM
CP0761087
 Compound Info 
2-(4-(1-hydroxy-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H15N5O3S
  1
1 IC50 = 20 nM
CP0762918
 Compound Info 
2-(5-methyl-4-(4-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O2S
  1
1 IC50 = 20 nM
CP0768908
 Compound Info 
2-(5-methyl-4-(5-methyloctahydropyrrolo[3,4-c]pyrrole-2-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H21N7O2
  1
1 IC50 = 20 nM
CP0768937
 Compound Info 
5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-(2,2,2-trifluoroethyl)-N-(3,3,3-trifluoropropyl)-1H-pyrazole-4-carboxamide
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C17H17F6N5O2
  1
1 IC50 = 20 nM
CP0768975
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C25H26N6O2
  1
1 IC50 = 20 nM
CP0772436
 Compound Info 
2-(5-methyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H22N6O2
  1
1 IC50 = 20 nM
CP0772443
 Compound Info 
2-(4-(2,2-dimethylpyrrolidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C17H19N5O2S
  1
1 IC50 = 20 nM
CP0772444
 Compound Info 
2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H14F3N5O2S
  1
1 IC50 = 20 nM
CP0812548
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C24H19N5O2S2
  1
1 IC50 = 20 nM
CP0820602
 Compound Info 
N-cyclopentyl-5-isopropyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C17H23N5O2
  1
1 IC50 = 20 nM
CP0823429
 Compound Info 
2-(4-(1-hydroxy-3-azabicyclo[3.1.0]hexane-3-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one
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C16H15N5O3S
  1
1 IC50 = 20 nM
CP0823432
 Compound Info 
2-(4-(4-benzylpiperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C24H27N5O2
  1
1 IC50 = 20 nM
CP0838180
 Compound Info 
2-(5-methyl-4-(4-phenylpiperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C22H22N6O2
  1
1 IC50 = 20 nM
CP0839333
 Compound Info 
N-cyclopentyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-3-carboxamide
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C14H17N5O2
  1
1 IC50 = 20 nM
CP0868889
 Compound Info 
N-(2-morpholinophenyl)-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C21H22N6O3
  1
1 IC50 = 20 nM
CP0868891
 Compound Info 
2-(5-methyl-4-(4-(1-methyl-1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C26H28N6O2
  1
1 IC50 = 20 nM
CP0883878
 Compound Info 
2-(3,5-dimethyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C20H21N5O2
  1
1 IC50 = 20 nM
CP0905477
 Compound Info 
(R)-5,6-dimethyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C20H21N5O2
  1
1 IC50 = 20 nM
CP0909404
 Compound Info 
5-methyl-1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylic acid
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C10H8N6O3
  1
1 IC50 = 20 nM
CP0913626
 Compound Info 
2-(5-methyl-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C17H14F3N9O2
  1
1 IC50 = 20 nM
CP0944285
 Compound Info 
1-(1-[4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl]-1H-pyrazole-4-carbonyl)-4-phenylpiperidine-4-carbonitrile
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C22H18N6O2S
  1
1 IC50 = 20 nM
CP0947150
 Compound Info 
5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-phenethyl-N-(3,3,3-trifluoro-2-hydroxypropyl)-1H-pyrazole-4-carboxamide
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C23H24F3N5O3
  1
1 IC50 = 20 nM
CP0947157
 Compound Info 
2-(5-methyl-4-(4-(5-(3-(trifluoromethyl)phenyl)oxazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O3
  1
1 IC50 = 20 nM
CP0951357
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-3-methyl-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C18H19F2N7O2
  1
1 IC50 = 20 nM
CP0958058
 Compound Info 
6-methyl-2-[4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-1,2,3-triazol-1-yl]-3,4-dihydropyrimidin-4-one
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C17H16N6O2
  1
1 IC50 = 20 nM
CP0959032
 Compound Info 
5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-pyrazole-4-carboxamide
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C20H21N5O2
  1
1 IC50 = 20 nM
CP0959087
 Compound Info 
2-(5-methyl-4-(4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C25H21F3N8O2S
  1
1 IC50 = 20 nM
CP0962123
 Compound Info 
tert-butyl(1-(5-methyl-1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-1H-pyrazole-4-carbonyl)azetidin-3-yl)methylcarbamate
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C20H24N6O4S
  1
1 IC50 = 20 nM
CP0963555
 Compound Info 
6-methyl-2-[4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C18H17N5O2
  1
1 IC50 = 20 nM
CP0964672
 Compound Info 
N,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-pyrazole-4-carboxamide
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C21H23N5O2
  1
1 IC50 = 20 nM
CP0966395
 Compound Info 
6-methyl-2-(5-methyl-4-(morpholine-4-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C14H17N5O3
  1
1 IC50 = 20 nM
CP0705960
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C17H18F3N7O2
  1
1 IC50 = 30 nM
CP0713507
 Compound Info 
2-(5-(4-(trifluoromethyl)piperidine-1-carbonyl)thiazol-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H13F3N4O2S2
  1
1 IC50 = 30 nM
CP0734276
 Compound Info 
2-(3-(indoline-1-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C17H15N5O2
  1
1 IC50 = 30 nM
CP0745049
 Compound Info 
2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)pyridin-2-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C19H19F3N4O2
  1
1 IC50 = 30 nM
CP0745056
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one
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C19H22F3N5O2
  1
1 IC50 = 30 nM
CP0745156
 Compound Info 
2-(5-methyl-4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C16H15N9O2
  1
1 IC50 = 30 nM
CP0746922
 Compound Info 
2-(5-methyl-4-(piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C16H20N6O2
  1
1 IC50 = 30 nM
CP0761045
 Compound Info 
(S)-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C20H17N5O2S
  1
1 IC50 = 30 nM
CP0761056
 Compound Info 
2-Methyl-1-(3-methyl-5-oxo-cyclohexa-1,3-dienyl)-1H-pyrrole-3-carboxylic acid adamantan-1-ylamide
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C23H28N2O2
  1
1 IC50 = 30 nM
CP0768928
 Compound Info 
N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-N-isopropyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C24H27N5O4
  1
1 IC50 = 30 nM
CP0768930
 Compound Info 
5-methyl-1-[4-oxo-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-2-yl]-1H-pyrazole4-carboxylic acid
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C12H12N4O3
  1
1 IC50 = 30 nM
CP0883875
 Compound Info 
2-(4-(4-ethylpiperazine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-5,6-dimethylpyrimidin-4(3H)-one
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C17H24N6O2
  1
1 IC50 = 30 nM
CP0883879
 Compound Info 
5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-((1-phenylcyclopentyl)methyl)-1H-pyrazole-4-carboxamide
   Show/Hide
C22H25N5O2
  1
1 IC50 = 30 nM
CP0946655
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C20H18N6O2
  1
1 IC50 = 30 nM
CP0958059
 Compound Info 
N-(2,3-dihydro-1H-inden-1-yl)-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C19H19N5O2
  1
1 IC50 = 30 nM
CP0962085
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C23H20N6O2S
  1
1 IC50 = 30 nM
CP0963569
 Compound Info 
(S)-N-benzyl-5-methyl-1-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)-N-(1-phenylethyl)-1H-pyrazole-4-carboxamide
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C27H27N5O2
  1
1 IC50 = 30 nM
CP0964673
 Compound Info 
2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
   Show/Hide
C20H17N5O2S
  1
1 IC50 = 30 nM
CP0964690
 Compound Info 
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
   Show/Hide
C17H18F3N7O2
  1
1 IC50 = 30 nM
CP0966145
 Compound Info 
2-(5-(difluoromethyl)-4-(morpholine-4-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C14H15F2N5O3
  1
1 IC50 = 30 nM
CP0713519
 Compound Info 
6-methyl-2-[5-methyl-4-(1,2,3,4-tetrahydroisoquinolin-2-ylmethyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C19H21N5O
  1
1 IC50 = 40 nM
CP0746925
 Compound Info 
2-(5-methyl-4-(2,6-diazaspiro[4.5]decane-2-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H26N6O2
  1
1 IC50 = 40 nM
CP0768925
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
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C22H19N7O2S
  1
1 IC50 = 40 nM
CP0768939
 Compound Info 
6-methyl-2-(3-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C16H18F3N5O2
  1
1 IC50 = 40 nM
CP0909338
 Compound Info 
5,6-dimethyl-2-(5-methyl-4-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
   Show/Hide
C20H21N5O2
  1
1 IC50 = 40 nM
CP0947246
 Compound Info 
2-[4-[(1,1-dioxidothiomorpholin-4-yl)carbonyl]-5-methyl-1H-pyrazol-1-yl]-6-methylpyrimidin-4(3H)-one
   Show/Hide
C14H17N5O4S
  1
1 IC50 = 40 nM
CP0955177
 Compound Info 
6-methyl-2-(3-(2-methylindoline-1-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
   Show/Hide
C18H17N5O2
  1
1 IC50 = 40 nM
CP0966148
 Compound Info 
2-(4-(4-(trifluoromethyl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H15F3N4O2S
  1
1 IC50 = 40 nM
CP0713516
 Compound Info 
2-(4-(3,5-bis(trifluoromethyl)piperidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H15F6N5O2S
  1
1 IC50 = 50 nM
CP0761051
 Compound Info 
6-methyl-2-[5-methyl-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3,4-dihydropyrimidin-4-one
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C19H19N5O2
  1
1 IC50 = 50 nM
CP0820599
 Compound Info 
2-(5-isobutyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C22H25N5O2
  1
1 IC50 = 50 nM
CP0713540
 Compound Info 
N-cyclopentyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C15H19N5O2
  1
1 IC50 = 60 nM
CP0745166
 Compound Info 
2-(3,5-dimethyl-4-(3-oxo-3-(pyrrolidin-1-yl)propyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C17H23N5O2
  1
1 IC50 = 60 nM
CP0823443
 Compound Info 
N,N,5-trimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C12H15N5O2
  1
1 IC50 = 60 nM
CP0964694
 Compound Info 
2-(4-(3-(aminomethyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C16H20N6O2
  1
1 IC50 = 60 nM
CP0966688
 Compound Info 
methyl-5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxylate
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C11H12N4O3
  1
1 IC50 = 60 nM
CP0726249
 Compound Info 
2-(4-(3,3-dimethylpyrrolidine-1-carbonyl)-5-isobutyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C19H27N5O2
  1
1 IC50 = 70 nM
CP0812543
 Compound Info 
2-(5-methyl-4-(2,6-diazaspiro[4.5]decane-2-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C19H22N6O2S
  1
1 IC50 = 70 nM
CP0812544
 Compound Info 
(R)-2-(5-methyl-4-(3-(methylamino)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C17H22N6O2
  1
1 IC50 = 70 nM
CP0812549
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C22H18N6O2S2
  1
1 IC50 = 70 nM
CP0868880
 Compound Info 
5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(pyrazin-2-ylmethyl)-1H-pyrazole-4-carboxamide
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C15H15N7O2
  1
1 IC50 = 70 nM
CP0891293
 Compound Info 
5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(2,2,3,3,3-pentafluoropropyl)-1H-pyrazole-4-carboxamide
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C13H12F5N5O2
  1
1 IC50 = 70 nM
CP0891295
 Compound Info 
5-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N-(3,3,3-trifluoropropyl)-1H-pyrazole-4-carboxamide
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C13H14F3N5O2
  1
1 IC50 = 70 nM
CP0713513
 Compound Info 
methyl-6-[4-oxo-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-2-yl]pyridine-3-carboxylate
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C14H13N3O3
  1
1 IC50 = 80 nM
CP0909337
 Compound Info 
N-cyclopentyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
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C15H16F3N5O2
  1
1 IC50 = 80 nM
CP0959031
 Compound Info 
N-cyclopentyl-5-(difluoromethyl)-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C15H17F2N5O2
  1
1 IC50 = 80 nM
CP0726237
 Compound Info 
5-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thiazolo[5,4-d]pyrimidin-7(6H)-one
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C16H15F3N6O2S
  1
1 IC50 = 100 nM
CP0726238
 Compound Info 
7-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C18H19F3N6O2
  1
1 IC50 = 100 nM
CP0761032
 Compound Info 
2-(4-(3-(aminomethyl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C15H16N6O2S
  1
1 IC50 = 100 nM
CP0761053
 Compound Info 
2-(5-benzyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C25H23N5O2
  1
1 IC50 = 100 nM
CP0762922
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C18H19F2N7O2
  1
1 IC50 = 100 nM
CP0772445
 Compound Info 
2-[3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one
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C19H15N5O2S
  1
1 IC50 = 100 nM
CP0820598
 Compound Info 
5-benzyl-N-cyclopentyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazole-4-carboxamide
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C21H23N5O2
  1
1 IC50 = 100 nM
CP0823435
 Compound Info 
6-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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C16H16F3N7O2
  1
1 IC50 = 100 nM
CP0823471
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C17H16F2N6O2
  1
1 IC50 = 100 nM
CP0844488
 Compound Info 
2-(4-(3-(3,3-difluoropyrrolidin-1-yl)azetidine-1-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C18H19F2N7O2
  1
1 IC50 = 100 nM
CP0844489
 Compound Info 
2-(4-(6,6-difluoro-2-azaspiro[3.3]heptane-2-carbonyl)-5-methyl-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C17H16F2N6O2
  1
1 IC50 = 100 nM
CP0883880
 Compound Info 
2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)quinazolin-4(3H)-one
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C19H18F3N5O2
  1
1 IC50 = 100 nM
CP0894170
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
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C18H18F3N7O2
  1
1 IC50 = 100 nM
CP0954053
 Compound Info 
6-methyl-2-(3-(morpholine-4-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C13H15N5O3
  1
1 IC50 = 100 nM
CP0713505
 Compound Info 
2-(3-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)pyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C19H17F3N4O2S
  1
1 IC50 = 200 nM
CP0726208
 Compound Info 
2-(4-(4-(benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-3-methylpyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C25H21N5O2S2
  1
1 IC50 = 200 nM
CP0726212
 Compound Info 
2-(3-(4-(trifluoromethyl)piperidine-1-carbonyl)phenyl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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C20H20F3N3O2
  1
1 IC50 = 200 nM
CP0726230
 Compound Info 
2-[5-[4-(trifluoromethyl)piperidine-1-carbonyl]pyridin-2-yl]-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
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C19H19F3N4O2
  1
1 IC50 = 200 nM
CP0726240
 Compound Info 
6-methyl-2-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C18H18F3N5O2S
  1
1 IC50 = 200 nM
CP0768916
 Compound Info 
2-(5-methyl-4-(6-(2,2,2-trifluoroethyl)-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-1H-pyrazol-1-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
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C18H18F3N7O2
  1
1 IC50 = 200 nM
CP0772446
 Compound Info 
2-(5-benzyl-4-(4-(pyridin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
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C25H25N7O2
  1
1 IC50 = 200 nM
CP0812545
 Compound Info 
(R)-2-(5-methyl-4-(3-(methylamino)pyrrolidine-1-carbonyl)-1H-pyrazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C16H18N6O2S
  1
1 IC50 = 200 nM
CP0823418
 Compound Info 
1-(4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)-1H-1,2,3-triazole-4-carboxylic acid
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C9H6N6O3
  1
1 IC50 = 200 nM
CP0868884
 Compound Info 
5-(5-methyl-4-(4-(trifluoromethyl)piperidine-1-carbonyl)-1H-pyrazol-1-yl)thiazolo[4,5-d]pyrimidin-7(6H)-one
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C16H15F3N6O2S
  1
1 IC50 = 200 nM
CP0713508
 Compound Info 
2-(4-[[4-(trifluoromethyl)piperidin-1-yl]sulfonyl]pyridin-2-yl)-3H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-4-one
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C18H19F3N4O3S
  1
1 IC50 = 300 nM
CP0726252
 Compound Info 
2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)quinazolin-4(3H)-one
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C22H19N5O2
  1
1 IC50 = 300 nM
CP0772448
 Compound Info 
N-(4-chlorophenyl)-3-(3,5-dimethyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1H-pyrazol-4-yl)propanamide
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C19H20ClN5O2
  1
1 IC50 = 300 nM
CP0883886
 Compound Info 
2-(4-(4-(1H-indol-3-yl)piperidine-1-carbonyl)-3-methylpyridin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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C26H23N5O2S
  1
1 IC50 = 300 nM
CP0959034
 Compound Info 
6-tert-butyl-2-(5-methyl-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-pyrazol-1-yl)pyrimidin-4(3H)-one
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C22H25N5O2
  1
1 IC50 = 300 nM
CP0726219
 Compound Info 
2-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)isonicotinic acid
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C12H7N3O3S
  1
1 IC50 = 2300 nM
CP0812547
 Compound Info 
2-(4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)isonicotinic acid
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C13H11N3O3
  1
1 IC50 = 5000 nM
CP0838177
 Compound Info 
2-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)isonicotinic acid
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C12H7N3O3S
  1
1 IC50 = 5000 nM