General Information of the Compound
Compound ID
CP0754428
Compound Name
2-(5-methyl-4-(1-(piperidine-1-carbonyl)-6-azaspiro[2.5]octane-6-carbonyl)-1H-pyrazol-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one
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Structure
Formula
C25H32N6O3
Molecular Weight
464.57
Canonical SMILES
Cc1c(C(=O)N2CCC3(CC2)CC3C(=O)N2CCCCC2)cnn1-c1nc2c(c(=O)[nH]1)CCC2
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InChI
InChI=1S/C25H32N6O3/c1-16-18(15-26-31(16)24-27-20-7-5-6-17(20)21(32)28-24)22(33)30-12-8-25(9-13-30)14-19(25)23(34)29-10-3-2-4-11-29/h15,19H,2-14H2,1H3,(H,27,28,32)
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InChIKey
KGURPZXOHXAFHK-UHFFFAOYSA-N
Physicochemical Property
logP
2.00752
Rotatable Bonds
3
Heavy Atom Count
34
Polar Areas
104.19
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137049471
ChEMBL ID
CHEMBL4536319
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03734, Sepiapterin reductase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000151 SK-N-BE(2) Homo sapiens (Human)  1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2 nM