General Information of the Compound
Compound ID
CP0768918
Compound Name
2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4(3H)-one
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Structure
Formula
C17H19F3N6O3
Molecular Weight
412.372
Canonical SMILES
Cc1c(C(=O)N2CCN(CC(F)(F)F)CC2)cnn1-c1nc2c(c(=O)[nH]1)COC2
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InChI
InChI=1S/C17H19F3N6O3/c1-10-11(15(28)25-4-2-24(3-5-25)9-17(18,19)20)6-21-26(10)16-22-13-8-29-7-12(13)14(27)23-16/h6H,2-5,7-9H2,1H3,(H,22,23,27)
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InChIKey
IPXOGQLVXYOOHU-UHFFFAOYSA-N
Physicochemical Property
logP
0.61432
Rotatable Bonds
3
Heavy Atom Count
29
Polar Areas
96.35
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137049699
ChEMBL ID
CHEMBL4593821
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03734, Sepiapterin reductase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 9 nM