| Compound ID |
Compound Name |
Compound Formula |
|
CP0377333
|
N-(dicyclopropylmethyl)-N-propyl-4-(2,4,6-trimethoxyphenyl)pyrimidin-2-amine
Show/Hide
|
C23H31N3O3
|
2
|
| 1 |
EC50 = 990 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0459293
|
4-(2-chloro-4,6-dimethoxyphenyl)-N-(dicyclopropylmethyl)-N-propylpyrimidin-2-amine
Show/Hide
|
C22H28ClN3O2
|
2
|
| 1 |
EC50 = 1600 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0464894
|
4-(2-heptan-4-yl-10-methyl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraen-7-yl)-3-methylbenzonitrile
Show/Hide
|
C25H30N4
|
1
|
| 1 |
IC50 = 3.981 nM
|
|
|
|
CP0051241
|
4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-pentan-3-ylbenzimidazole
Show/Hide
|
C20H21Cl3N2O
|
4
|
| 1 |
IC50 = 4.1 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
| 3 |
IC50 = 32 nM
|
|
|
| 4 |
IC50 = 44 nM
|
|
|
|
CP0520770
|
9-chloro-1-(2,4-dichlorophenyl)-N,N-diethyl-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazol-6-amine
Show/Hide
|
C20H21Cl3N4
|
2
|
| 1 |
IC50 = 4.4 nM
|
|
|
| 2 |
IC50 = 7.1 nM
|
|
|
|
CP0451552
|
4-chloro-N-(4-chloro-2-methoxy-6-methylphenyl)-7-heptan-4-yl-1-methylbenzimidazol-2-amine
Show/Hide
|
C23H29Cl2N3O
|
1
|
| 1 |
IC50 = 7.4 nM
|
|
|
|
CP0510070
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N,4-N-diethyl-3,7-dimethylbenzimidazole-2,4-diamine
Show/Hide
|
C21H27ClN4O
|
1
|
| 1 |
IC50 = 7.6 nM
|
|
|
|
CP0378527
|
4-chloro-N-(2,4-dichloro-6-methylphenyl)-1-methyl-7-pentan-3-ylbenzimidazol-2-amine
Show/Hide
|
C20H22Cl3N3
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0116903
|
3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H32N6
|
8
|
| 1 |
IC50 = 8.5 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
| 3 |
IC50 = 28.18 nM
|
|
|
| 4 |
IC50 = 50 nM
|
|
|
| 5 |
IC50 = 67 nM
|
|
|
| 6 |
Kd = 0.303 nM
|
|
|
| 7 |
Ki = 3.5 nM
|
|
|
| 8 |
Ki = 12 nM
|
|
|
|
CP0562719
|
3-chloro-4-(4-chloro-1-methyl-7-pentan-3-ylbenzimidazol-2-yl)oxy-5-methylbenzonitrile
Show/Hide
|
C21H21Cl2N3O
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0871596
|
Trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyclohexyl}-5-(trifluoromethyl)benzamid
Show/Hide
|
C25H23ClF4N2O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0401685
|
7-chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine
Show/Hide
|
C22H28Cl2N4O
|
2
|
| 1 |
IC50 = 9.5 nM
|
|
|
| 2 |
IC50 = 88 nM
|
|
|
|
CP0436414
|
7-chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N,4-N-diethyl-3-methylbenzimidazole-2,4-diamine
Show/Hide
|
C20H24Cl2N4O
|
2
|
| 1 |
IC50 = 9.5 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
|
CP0255382
|
Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-ethyl-amine
Show/Hide
|
C23H32N4
|
3
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 15.85 nM
|
|
|
| 3 |
Ki = 56 nM
|
|
|
|
CP0509239
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-4-N-ethyl-3-methyl-4-N-propan-2-ylbenzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C21H28BrClN4O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0529213
|
1-(2,4-dichlorophenyl)-N,N-diethyl-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazol-6-amine
Show/Hide
|
C20H22Cl2N4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0871523
|
Trans-5-chloro-N-[-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyclohexyl]-2-methylnicotinamide
Show/Hide
|
C24H25ClFN3O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0508798
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C22H30BrClN4O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0505051
|
7-(4-methoxy-2-methylphenyl)-10-methyl-2-pentan-3-yl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C23H29N3O
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0510668
|
3-methyl-4-(10-methyl-2-pentan-3-yl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraen-7-yl)benzonitrile
Show/Hide
|
C23H26N4
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0556072
|
US8614213, 19.26
Show/Hide
|
C21H22ClF4N3O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0431983
|
US8835444, 5.27
Show/Hide
|
C21H25ClF3N3O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0509238
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-4-N,4-N-diethyl-3-methylbenzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C20H26BrClN4O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0509240
|
2-(4-chloro-2-methoxy-6-methylanilino)-7-(diethylamino)-1-methylbenzimidazole-4-carbonitrile
Show/Hide
|
C21H24ClN5O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0549050
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N,4-N-diethyl-7-methoxy-3-methylbenzimidazole-2,4-diamine
Show/Hide
|
C21H27ClN4O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0490329
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N-phenyl-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C25H27ClN4O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0911855
|
Trans-5-Chloro-N-[4-(6-chloro-3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C24H27Cl2N3O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0420045
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine
Show/Hide
|
C22H29ClN4O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0483461
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-4-N,4-N-dibutyl-3-methylbenzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C24H34BrClN4O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0483464
|
2-(4-chloro-2-methoxy-6-methylanilino)-7-(dipropylamino)-1-methylbenzimidazole-4-carbonitrile
Show/Hide
|
C23H28ClN5O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0969642
|
US8614213, 19.80
Show/Hide
|
C24H23Cl2F3N4O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0391093
|
3-methyl-4-N,4-N-dipropyl-2-N-(2,4,6-trimethylphenyl)benzimidazole-2,4-diamine
Show/Hide
|
C23H32N4
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0441127
|
4-chloro-N-(4-chloro-2-methoxy-6-methylphenyl)-1-methyl-7-pentan-3-ylbenzimidazol-2-amine
Show/Hide
|
C21H25Cl2N3O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0464895
|
7-[2,4-bis(trifluoromethyl)phenyl]-2-heptan-4-yl-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C24H26F6N4
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0874372
|
Trans-2-Chloro-N-[4-((R)-3-fluoro-3-methyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C24H23ClF4N2O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0957641
|
US8614213, 19.63
Show/Hide
|
C22H21ClF4N4O
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0860100
|
Trans-5-Chloro-N-[4-(7-chloro-3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C24H27Cl2N3O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0850734
|
Trans-5-Chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C25H31ClN4O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0902358
|
Trans-2-Chloro-N-[4-(3-ethyl-2-oxo-2,3-dihydro-bcnzoimidazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C24H25ClF3N3O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0441126
|
7-bromo-2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N-ethyl-3-methyl-4-N-(3,3,3-trifluoropropyl)benzimidazole-2,4-diamine
Show/Hide
|
C21H23BrClF3N4O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0387567
|
2-N-(2,4-dichloro-6-methylphenyl)-4-N,4-N-diethyl-3-methylbenzimidazole-2,4-diamine
Show/Hide
|
C19H22Cl2N4
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0479391
|
US8614213, 19.73
Show/Hide
|
C21H22Cl2F3N3O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0519124
|
US8614213, 1.13
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0456084
|
9-chloro-1-(2,4-dichlorophenyl)-6-(1-methoxypropyl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C20H20Cl3N3O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0381750
|
US8835444, 5.1
Show/Hide
|
C22H27ClF3N3O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0424136
|
US8614213, 7
Show/Hide
|
C20H23ClF3N3O
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0531823
|
US8614213, 19.69
Show/Hide
|
C21H22Cl2F3N3O
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0573801
|
US8835444, 5.26
Show/Hide
|
C21H25ClF3N3O
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0505192
|
2-N-(4-chloro-2-methyl-6-propan-2-ylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C24H34Cl2N4
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0441128
|
3-chloro-4-(4-chloro-1-methyl-7-pentan-3-ylbenzimidazol-2-yl)oxy-5-methylbenzamide
Show/Hide
|
C21H23Cl2N3O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0424137
|
US8614213, 19.2
Show/Hide
|
C20H20ClF4N3O
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0540654
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N-(4-chlorophenyl)-3-methyl-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C25H26Cl2N4O
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0575531
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N-(6-methoxypyridin-3-yl)-3-methyl-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C25H28ClN5O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0493330
|
7-[2,4-bis(trifluoromethyl)phenyl]-10-methyl-2-pentan-3-yl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C22H22F6N4
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0577819
|
US8614213, 19.1
Show/Hide
|
C20H20ClF4N3O
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0549238
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N-(4-methoxyphenyl)-3-methyl-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C26H29ClN4O2
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 56 nM
|
|
|
|
CP0439676
|
2-[1-[1-[2,4-bis(trifluoromethyl)phenyl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C21H13F6N5S
|
1
|
| 1 |
IC50 = 27.54 nM
|
|
|
|
CP0449973
|
US8614213, 19.53
Show/Hide
|
C22H25ClF3N3O
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0902362
|
Trans-2-Chloro-N-[4-(5-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C25H25ClF4N2O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0144716
|
N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C21H24Cl2N4
|
3
|
| 1 |
IC50 = 29 nM
|
|
|
| 2 |
Ki = 1.6 nM
|
|
|
| 3 |
Ki = 3.2 nM
|
|
|
|
CP0556076
|
US8614213, 19.100
Show/Hide
|
C22H22ClF3N6O
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0578115
|
US8614213, 19.70
Show/Hide
|
C23H24ClF3N4O
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0449964
|
US8614213, 1.18
Show/Hide
|
C18H22Cl2N4OS
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0930219
|
US8614213, 19.49
Show/Hide
|
C22H26ClF3N4O
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0526498
|
2-(2,4-dichlorophenyl)-7-heptan-4-yl-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene
Show/Hide
|
C22H28Cl2N4
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0902269
|
US8614213, 19.68
Show/Hide
|
C23H24ClF3N4O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0492088
|
4-[6-methyl-4-[3-(2-oxoimidazolidin-1-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]-3-(trifluoromethyl)benzonitrile
Show/Hide
|
C22H18F3N7O
|
1
|
| 1 |
IC50 = 32.36 nM
|
|
|
|
CP0969643
|
US8614213, 19.114
Show/Hide
|
C19H21Cl2F3N4O
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0439681
|
2-[1-[1-[2-(difluoromethyl)-4-methoxyphenyl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C21H17F2N5OS
|
1
|
| 1 |
IC50 = 34.67 nM
|
|
|
|
CP0904714
|
US8835444, 1.8
Show/Hide
|
C26H27Cl2F3N4O2
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0442251
|
US8614213, 2.5
Show/Hide
|
C19H21ClF3N3OS
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0520771
|
4-(2,4-dichlorophenyl)-N,N-diethyl-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-9-amine
Show/Hide
|
C21H23Cl2N3
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0922780
|
US8614213, 19.79
Show/Hide
|
C25H26ClF3N4O
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0922781
|
US8614213, 19.103
Show/Hide
|
C23H23ClF3N5O
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0953257
|
Trans-2-Chloro-N-[4-(3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C23H23ClF3N3O2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0519123
|
US8614213, 1
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0577823
|
US8614213, 19.83
Show/Hide
|
C20H24Cl2N4O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0904389
|
Trans-5-Chloro-N-[4-(6-methoxy-3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C25H30ClN3O3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0563262
|
US8614213, 2.9
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0557996
|
1-(2,4-dichlorophenyl)-6-(diethylamino)-3,4-dihydropyrimido[1,2-a]benzimidazol-2-one
Show/Hide
|
C20H20Cl2N4O
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0113466
|
8-(2,4-dichlorophenyl)-N-(1,3-dimethoxypropan-2-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
Show/Hide
|
C18H21Cl2N5O2
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0445025
|
7-(3-fluoro-4-methoxyphenyl)-2-heptan-4-yl-10-methyl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C24H30FN3O
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0526495
|
4-[2-(1-methoxybutan-2-yl)-10-methyl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraen-7-yl]-3-methylbenzonitrile
Show/Hide
|
C23H26N4O
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0383851
|
2-[1-[1-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H15F3N6OS
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0480697
|
3-[6-(dimethylamino)-2,4-dimethylpyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C23H34N6
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
Ki = 5.2 nM
|
|
|
|
CP0461962
|
US8835444, 4.6
Show/Hide
|
C21H29ClN4O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0470322
|
US8614213, 10
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0922782
|
US8614213, 19.117
Show/Hide
|
C21H26ClF3N4O
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0862006
|
Trans-5-Chloro-N-[4-(-6-chloro-3-fluoro-3-methyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C23H24Cl2FN3O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0902360
|
Trans-5-Chloro-N-[4-(3-ethyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C23H27ClN4O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0520774
|
9-chloro-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(4,6-dimethoxy-2-methylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C20H19ClF5N5O3
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0961357
|
US8614213, 8
Show/Hide
|
C21H24ClF3N4O
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0862005
|
Trans-2-Chloro-N-[4-(6-fluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-bcnzamide
Show/Hide
|
C23H21ClF4N2O2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0911674
|
Trans-5-chloro-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl nicotinamide
Show/Hide
|
C24H28ClN3O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0454720
|
2-[[7-bromo-2-(4-chloro-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-ethylamino]ethanol
Show/Hide
|
C20H24BrClN4O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0520772
|
9-chloro-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(4-methoxy-2-methylphenyl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C21H19ClF5N3O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0557994
|
9-chloro-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(6-methoxy-2-methylpyridin-3-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C20H18ClF5N4O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0573766
|
US8835444, 5.29
Show/Hide
|
C21H24Cl2F3N3O
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0497118
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-6-fluoro-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H31FN6
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
Ki = 5.6 nM
|
|
|
|
CP0470275
|
US8614213, 9
Show/Hide
|
C21H21ClF4N2O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0577815
|
US8614213, 4.33
Show/Hide
|
C21H22ClF3N2O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0849230
|
Trans-2-Chloro-N-[4-(7-methoxy-3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C26H28ClF3N2O3
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0549022
|
9-chloro-1-(2,4-dichlorophenyl)-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C19H13Cl3F5N3O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0534899
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N-(4-chlorophenyl)-4-N-(2-methoxyethyl)-3-methylbenzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C25H27Cl3N4O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0445067
|
4-(2-heptan-4-yl-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraen-7-yl)-3-methylbenzonitrile
Show/Hide
|
C24H29N5
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0528217
|
7-(3-fluoro-4-methoxyphenyl)-10-methyl-2-pentan-3-yl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C22H26FN3O
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0423344
|
3-ethyl-4-[6-methyl-4-[3-(2-oxoimidazolidin-1-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C23H23N7O
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0449972
|
US8614213, 16b
Show/Hide
|
C22H24ClF3N2O
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0442252
|
US8614213, 19.98
Show/Hide
|
C21H22Cl2F3N3O2
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0540653
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-4-N-(3-methoxyphenyl)-3-methyl-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C26H29BrN4O2
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0957642
|
US8614213, 19.65
Show/Hide
|
C23H24ClF3N4O
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0447494
|
1-[[7-bromo-2-(4-chloro-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-ethylamino]propan-2-ol
Show/Hide
|
C21H26BrClN4O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0490328
|
3-[[2-(4-bromo-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-propan-2-ylamino]-N-methylbenzamide
Show/Hide
|
C27H30BrN5O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0439279
|
2-[1-[1-(4-methoxy-2-methylphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C21H19N5OS
|
1
|
| 1 |
IC50 = 53.7 nM
|
|
|
|
CP0957643
|
US8614213, 19.74
Show/Hide
|
C22H23ClF3N5O
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0456085
|
9-chloro-6-[(1R)-1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(2-methoxy-4,6-dimethylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C20H19ClF5N5O2
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
IC50 = 58 nM
|
|
|
|
CP0462399
|
1-[1-[1-[2-(difluoromethyl)-4-methoxyphenyl]-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
Show/Hide
|
C22H22F2N6O2
|
1
|
| 1 |
IC50 = 56.23 nM
|
|
|
|
CP0434754
|
2-[1-[1-(2-chloro-4-methoxyphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H16ClN5OS
|
1
|
| 1 |
IC50 = 56.23 nM
|
|
|
|
CP0920564
|
US8614213, 19.91
Show/Hide
|
C25H25Cl2F3N4O
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0849229
|
Trans-2-Chloro-5-trifluoromethyl-N-[4-(3,3,7-trimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-benzamide
Show/Hide
|
C26H28ClF3N2O2
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0439677
|
2-[1-[1-[4-nitro-2-(trifluoromethyl)phenyl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H13F3N6O2S
|
1
|
| 1 |
IC50 = 58.88 nM
|
|
|
|
CP0464483
|
US8614213, 19.116
Show/Hide
|
C25H25Cl2F3N4O
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0957644
|
US8614213, 19.94
Show/Hide
|
C24H24ClF3N4O
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0524276
|
US8835444, 4.2
Show/Hide
|
C26H25ClF3N3O3
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0554153
|
US8614213, 3
Show/Hide
|
C20H23ClF3N3OS
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0383849
|
2-[1-[1-(6-methoxy-2-methylpyridin-3-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H18N6OS
|
1
|
| 1 |
IC50 = 60.26 nM
|
|
|
|
CP0870802
|
US8614213, 4.15
Show/Hide
|
C21H26ClF3N4O
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0961356
|
US8614213, 4.11
Show/Hide
|
C24H23ClF4N4O
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0512237
|
US8614213, 19.54
Show/Hide
|
C20H24ClFN4O
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0969641
|
US8614213, 19.66
Show/Hide
|
C22H21Cl2F3N4O
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0860149
|
Trans-2-chloro-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-pyrrolo[2,3-b]pyridin-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C23H25ClFN3O2
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0470274
|
US8614213, 2.26
Show/Hide
|
C21H21Cl2F3N2O
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0886857
|
US8614213, 4.16
Show/Hide
|
C21H26ClF3N4O
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0490598
|
7-(4-methoxyphenyl)-10-methyl-2-pentan-3-yl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C22H27N3O
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0958501
|
Trans-2-Chloro-N-[4-(6-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C23H21Cl2F3N2O2
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0407462
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-4-N,4-N-bis(2-methoxyethyl)-3-methylbenzimidazole-2,4-diamine
Show/Hide
|
C22H29BrN4O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0577814
|
US8614213, 2.8
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0577816
|
US8614213, 5.14
Show/Hide
|
C19H25ClN4OS
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0387568
|
2-[9-chloro-1-(2,4-dichlorophenyl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazol-6-yl]butanenitrile
Show/Hide
|
C20H17Cl3N4
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0423485
|
EMICERFONT
Show/Hide
|
C22H24N6O2
|
2
|
| 1 |
IC50 = 66.07 nM
|
|
|
| 2 |
Kd = 72.44 nM
|
|
|
|
CP0382554
|
US8835444, 5.11
Show/Hide
|
C20H23ClF3N3O2
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0463858
|
1-[1-[6-methyl-1-[2-methyl-4-(trifluoromethoxy)phenyl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
Show/Hide
|
C22H21F3N6O2
|
1
|
| 1 |
IC50 = 67.61 nM
|
|
|
|
CP0467701
|
3-methyl-4-[6-methyl-4-[3-(2-oxoimidazolidin-1-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C22H21N7O
|
1
|
| 1 |
IC50 = 67.61 nM
|
|
|
|
CP0479393
|
US8614213, 19.101
Show/Hide
|
C25H26ClF3N4O
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0943172
|
US8614213, 19.93
Show/Hide
|
C21H21ClF3N5O
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0482441
|
3-[[2-(4-bromo-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-propan-2-ylamino]benzonitrile
Show/Hide
|
C26H26BrN5O
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0482442
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N-(5-methylpyridin-2-yl)-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C25H28ClN5O
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0470323
|
US8614213, 13
Show/Hide
|
C24H24F3N3O
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0525124
|
US8835444, 2.1
Show/Hide
|
C19H24Cl2N4O
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
IC50 = 256 nM
|
|
|
|
CP0556077
|
US8614213, 19.108
Show/Hide
|
C19H22ClFN4O
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0539673
|
3-[[2-(4-bromo-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-propan-2-ylamino]-N,N-dimethylbenzamide
Show/Hide
|
C28H32BrN5O2
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0279533
|
3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H30N4O3
|
2
|
| 1 |
IC50 = 76 nM
|
|
|
| 2 |
Ki = 3.4 nM
|
|
|
|
CP0470326
|
US8614213, 19.102
Show/Hide
|
C20H23ClF3N3O2
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0556069
|
US8614213, 4.21
Show/Hide
|
C20H21ClF3N3O
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0571354
|
7-N,7-N-dipropyl-2-N-(2,4,6-trimethylphenyl)-1,3-benzothiazole-2,7-diamine
Show/Hide
|
C22H29N3S
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0943171
|
US8614213, 19.76
Show/Hide
|
C21H25BrClF3N4O
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0445023
|
10-methyl-7-[2-methyl-4-(trifluoromethoxy)phenyl]-2-pentan-3-yl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C23H26F3N3O
|
1
|
| 1 |
IC50 = 79.43 nM
|
|
|
|
CP0542645
|
US8835444, 4.1
Show/Hide
|
C26H27ClF3N3O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0556074
|
US8614213, 19.56
Show/Hide
|
C22H25ClF3N3O2
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0570885
|
2-N-(2,4-dimethylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine;2,2,2-trifluoroacetic acid
Show/Hide
|
C24H31F3N4O2
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0577994
|
4-[[2-(4-bromo-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-propan-2-ylamino]benzonitrile
Show/Hide
|
C26H26BrN5O
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0902359
|
Trans-5-Chloro-2-methyl-N-[4-(3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-nicotinamide
Show/Hide
|
C22H25ClN4O2
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0943170
|
US8614213, 19.59
Show/Hide
|
C23H24ClF3N4O
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0439678
|
4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]-3-(trifluoromethyl)benzonitrile
Show/Hide
|
C21H13F3N6S
|
1
|
| 1 |
IC50 = 87.1 nM
|
|
|
|
CP0870803
|
US8614213, 19.57
Show/Hide
|
C21H21ClF3N5O
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0549021
|
N-[9-chloro-1-(2,4-dichlorophenyl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazol-6-yl]-N-ethylhydroxylamine
Show/Hide
|
C18H17Cl3N4O
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0502988
|
3-[1-[1-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1H-imidazol-2-one
Show/Hide
|
C22H16F6N6O
|
1
|
| 1 |
IC50 = 89.13 nM
|
|
|
|
CP0519152
|
US8614213, 6
Show/Hide
|
C21H23ClF3N5O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0922779
|
US8614213, 19.62
Show/Hide
|
C22H21ClF4N4O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0540652
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-3-methyl-4-N-(3-methylsulfonylphenyl)-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C26H29BrN4O3S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0963727
|
Trans-2-Chloro-N-[4-(2-oxo-2,3-dihydro-bcnzoimidazol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C22H21ClF3N3O2
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0311099
|
3,6-dimethyl-4-(pentan-3-yloxy)-2-(2,4,6-trimethylphenoxy)pyridine
Show/Hide
|
C21H29NO2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0532081
|
4-[4-(3-pyridin-2-ylpyrazol-1-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]-3-(trifluoromethyl)benzonitrile
Show/Hide
|
C23H15F3N6
|
1
|
| 1 |
IC50 = 93.33 nM
|
|
|
|
CP0416315
|
US8835444, 5.21
Show/Hide
|
C19H20Cl2F3N3O2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0954980
|
US8614213, 19.110
Show/Hide
|
C20H28ClN5O
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0553228
|
3-propan-2-yl-4-N,4-N-dipropyl-2-N-(2,4,6-trimethylphenyl)benzimidazole-2,4-diamine
Show/Hide
|
C25H36N4
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0526497
|
7-[2,4-bis(trifluoromethyl)phenyl]-2-heptan-4-yl-10-methyl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C25H27F6N3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0434921
|
3-methyl-4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C21H16N6S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0529158
|
9-chloro-1-(4,6-diethyl-2-methylpyrimidin-5-yl)-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C22H23ClF5N5O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0449971
|
US8614213, 15a
Show/Hide
|
C22H24ClF3N2O
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
|
CP0469294
|
3-[6-(dimethylamino)pyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C21H30N6
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
Ki = 4.2 nM
|
|
|
|
CP0441125
|
7-chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N-pentan-3-ylbenzimidazole-2,4-diamine
Show/Hide
|
C21H26Cl2N4O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0574083
|
N-[7-chloro-2-(4-chloro-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-N-propan-2-ylpropanamide
Show/Hide
|
C22H26Cl2N4O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0529216
|
9-chloro-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(2-methoxy-4,6-dimethylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C20H19ClF5N5O2
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 210 nM
|
|
|
|
CP0531825
|
US8614213, 21.8
Show/Hide
|
C20H22Cl2F3N3O
|
1
|
| 1 |
IC50 = 113 nM
|
|
|
|
CP0512238
|
US8614213, 21.1
Show/Hide
|
C22H21ClF3N3O
|
1
|
| 1 |
IC50 = 114 nM
|
|
|
|
CP0439683
|
3-chloro-4-[4-(3-pyrazol-1-ylpyrazol-1-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C20H14ClN7
|
1
|
| 1 |
IC50 = 114.82 nM
|
|
|
|
CP0900687
|
US8614213, 19.107
Show/Hide
|
C18H21ClF3N5O
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0946853
|
Trans-2,5-Dichloro-N-[4-(3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-benzamide trifluoroacetate
Show/Hide
|
C24H24Cl2F3N3O4
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0498790
|
2-(dipropylamino)-3,7-dimethyl-5-(2,4,6-trimethylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
Show/Hide
|
C23H32N4O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0530733
|
3-[[2-(4-bromo-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-propan-2-ylamino]benzamide
Show/Hide
|
C26H28BrN5O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0549237
|
2-[3-[[2-(4-bromo-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-propan-2-ylamino]phenyl]-2-methylpropanamide
Show/Hide
|
C29H34BrN5O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0454982
|
3-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1H-imidazol-2-one
Show/Hide
|
C22H22N6O2
|
1
|
| 1 |
IC50 = 120.23 nM
|
|
|
|
CP0467702
|
4-[6-methyl-4-[3-(2-oxoimidazolidin-1-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]-3-(trifluoromethoxy)benzonitrile
Show/Hide
|
C22H18F3N7O2
|
1
|
| 1 |
IC50 = 120.23 nM
|
|
|
|
CP0463856
|
1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]pyrrolidin-2-one
Show/Hide
|
C23H25N5O2
|
1
|
| 1 |
IC50 = 123.03 nM
|
|
|
|
CP0464893
|
2-heptan-4-yl-7-(4-methoxy-2-methylphenyl)-10-methyl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C25H33N3O
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0526496
|
7-[2,4-bis(trifluoromethyl)phenyl]-10-methyl-2-pentan-3-yl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C23H23F6N3
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0497921
|
3-ethyl-4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C22H18N6S
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0540781
|
US8835444, 5.8
Show/Hide
|
C20H23ClF3N3O2
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0902361
|
Trans-2,5-Dichloro-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-benzamide
Show/Hide
|
C24H26Cl2N2O2
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0511345
|
2-[1-[1-(2-methyl-4-pyrazol-1-ylphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C23H19N7S
|
1
|
| 1 |
IC50 = 128.82 nM
|
|
|
|
CP0456086
|
9-chloro-1-(2,4-dichlorophenyl)-6-(1-imidazol-1-ylpropyl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C22H20Cl3N5
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0425467
|
US8835444, 2.4
Show/Hide
|
C24H27ClN4O
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0434792
|
US8835444, 5.17
Show/Hide
|
C19H21ClF3N3O
|
1
|
| 1 |
IC50 = 132 nM
|
|
|
|
CP0879022
|
US8835444, 1.1
Show/Hide
|
C20H28ClN5O
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
|
CP0512235
|
US8614213, 12
Show/Hide
|
C20H23ClN2O
|
1
|
| 1 |
IC50 = 137 nM
|
|
|
|
CP0530789
|
2-(bis(cyclopropylmethyl)amino)-5-mesityl-3,7-dimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C25H32N4O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0521296
|
US8614213, 21.11
Show/Hide
|
C21H25ClF3N3O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0969797
|
US8614213, 19.71
Show/Hide
|
C25H26ClF3N4O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0414536
|
2-N-(2,6-dimethylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine;2,2,2-trifluoroacetic acid
Show/Hide
|
C24H31F3N4O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0378526
|
2-[[7-bromo-2-(4-chloro-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-ethylamino]acetamide
Show/Hide
|
C20H23BrClN5O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0429711
|
US8835444, 3.6
Show/Hide
|
C23H26ClN5O
|
1
|
| 1 |
IC50 = 142 nM
|
|
|
|
CP0957645
|
US8614213, 19.55
Show/Hide
|
C21H28ClN5O
|
1
|
| 1 |
IC50 = 143 nM
|
|
|
|
CP0517431
|
1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-diazinan-2-one
Show/Hide
|
C23H26N6O2
|
1
|
| 1 |
IC50 = 144.54 nM
|
|
|
|
CP0503090
|
4-[4-(3-pyrazol-1-ylpyrazol-1-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]-3-(trifluoromethyl)benzonitrile
Show/Hide
|
C21H14F3N7
|
1
|
| 1 |
IC50 = 144.54 nM
|
|
|
|
CP0948128
|
Trans-2-Chloro-N-[4-(1-methyl-2-oxo-1,2-dihydro-imidazo[4,5-b]pyridin-3-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C22H22ClF3N4O2
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0536469
|
US8835444, 2.16
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 147 nM
|
|
|
|
CP0904387
|
Trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C23H19Cl2F5N2O2
|
1
|
| 1 |
IC50 = 149 nM
|
|
|
|
CP0454721
|
2-[[7-bromo-2-(4-chloro-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-ethylamino]-N-methylacetamide
Show/Hide
|
C21H25BrClN5O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0531824
|
US8614213, 19.113
Show/Hide
|
C21H22Cl2F3N3O2
|
1
|
| 1 |
IC50 = 153 nM
|
|
|
|
CP0470327
|
US8614213, 21.5
Show/Hide
|
C22H25ClF3N5O2
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0858046
|
Trans-5-Chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C22H21Cl2F2N3O2
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0871599
|
Trans-5-Chloro-2-methyl-N-[4-(3,3,4-trimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-nicotinamide
Show/Hide
|
C25H30ClN3O2
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0428186
|
2-(1-methoxybutan-2-yl)-7-(4-methoxy-2-methylphenyl)-10-methyl-2,7,9-triazatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene
Show/Hide
|
C23H29N3O2
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0423345
|
3-[1-[1-(2,4-dichlorophenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1H-imidazol-2-one
Show/Hide
|
C20H16Cl2N6O
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0524334
|
4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]-3-(trifluoromethoxy)benzonitrile
Show/Hide
|
C21H13F3N6OS
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0295460
|
3-[5-(dimethylamino)-3-methylpyridin-2-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H32N6
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0407538
|
US8835444, 2.0
Show/Hide
|
C21H29ClN4O
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0559190
|
N-[2-(4-chloro-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-N-(4-chlorophenyl)acetamide;hydrochloride
Show/Hide
|
C24H23Cl3N4O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0503088
|
2-[1-[1-(4-fluoro-2-methylphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H16FN5S
|
1
|
| 1 |
IC50 = 162.18 nM
|
|
|
|
CP0862002
|
Trans-2-Chloro-N-[4-(5-methoxy-3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C26H28ClF3N2O3
|
1
|
| 1 |
IC50 = 166 nM
|
|
|
|
CP0527443
|
US8835444, 2.13
Show/Hide
|
C20H23ClF3N3O
|
1
|
| 1 |
IC50 = 167 nM
|
|
|
|
CP0544767
|
US8835444, 2.15
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0553229
|
5,7-dichloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine
Show/Hide
|
C22H27Cl3N4O
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0439679
|
2-[1-[1-(2,4-dimethoxyphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C21H19N5O2S
|
1
|
| 1 |
IC50 = 173.78 nM
|
|
|
|
CP0969792
|
US8614213, 11
Show/Hide
|
C25H28Cl2N4O
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0040853
|
2,5-dimethyl-3-(3-methyl-5-nitropyridin-2-yl)-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C20H26N6O2
|
2
|
| 1 |
IC50 = 180 nM
|
|
|
| 2 |
Ki = 9.1 nM
|
|
|
|
CP0441516
|
US8835444, 3.3
Show/Hide
|
C24H26ClFN4O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0557318
|
US8614213, 22.7
Show/Hide
|
C19H22ClF3N4O
|
1
|
| 1 |
IC50 = 187 nM
|
|
|
|
CP0486036
|
3-[6-(dimethylamino)-2-methylpyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H32N6
|
2
|
| 1 |
IC50 = 190 nM
|
|
|
| 2 |
Ki = 2.2 nM
|
|
|
|
CP0940920
|
US8614213, 1.35a
Show/Hide
|
C25H25ClF4N4O
|
1
|
| 1 |
IC50 = 199 nM
|
|
|
|
CP0969729
|
N2-(2,4-dichloro-6-methylphenyl)-1-methyl-N7,N7-dipropyl-1H-benzo[d]imidazole-2,7-diamine 2,2,2-trifluoroacetate
Show/Hide
|
C23H27Cl2F3N4O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0862004
|
Trans-2-Chloro-N-[4-((S)-3-fluoro-3-methyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C24H22Cl2F4N2O2
|
1
|
| 1 |
IC50 = 201 nM
|
|
|
|
CP0968878
|
Trans-2-Chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C23H21Cl2F3N2O2
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0387586
|
9-chloro-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(2-ethyl-4,6-dimethylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C21H21ClF5N5O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0578006
|
1-[9-chloro-1-(2,4-dichlorophenyl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazol-6-yl]propan-1-one
Show/Hide
|
C19H16Cl3N3O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0504690
|
2-[1-[1-(2,6-dimethoxypyridin-3-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H18N6O2S
|
1
|
| 1 |
IC50 = 213.8 nM
|
|
|
|
CP0458988
|
US8835444, 2.14
Show/Hide
|
C20H23ClF3N3O
|
1
|
| 1 |
IC50 = 214 nM
|
|
|
|
CP0519126
|
US8614213, 2.6
Show/Hide
|
C22H25ClF3N3O
|
1
|
| 1 |
IC50 = 215 nM
|
|
|
|
CP0539674
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N-(4-chlorophenyl)-3-methyl-4-N-(oxolan-3-ylmethyl)benzimidazole-2,4-diamine
Show/Hide
|
C27H28Cl2N4O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0500839
|
3-methyl-4-[4-(3-pyridin-2-ylpyrazol-1-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C23H18N6
|
1
|
| 1 |
IC50 = 223.87 nM
|
|
|
|
CP0434923
|
3-chloro-4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C20H13ClN6S
|
1
|
| 1 |
IC50 = 229.09 nM
|
|
|
|
CP0563857
|
US8614213, 22.3
Show/Hide
|
C24H23ClF3N3O
|
1
|
| 1 |
IC50 = 234 nM
|
|
|
|
CP0955707
|
Trans-5-chloro-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-pyrrolo[2,3-b]pyridin-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C23H27ClN4O2
|
1
|
| 1 |
IC50 = 242 nM
|
|
|
|
CP0439682
|
N,N,6-trimethyl-5-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]pyridin-2-amine
Show/Hide
|
C21H21N7S
|
1
|
| 1 |
IC50 = 257.04 nM
|
|
|
|
CP0501060
|
2-[1-[1-[2-methyl-4-(trifluoromethoxy)phenyl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C21H16F3N5OS
|
1
|
| 1 |
IC50 = 257.04 nM
|
|
|
|
CP0558681
|
2-[[7-bromo-2-(4-chloro-2-methoxy-6-methylanilino)-3-methylbenzimidazol-4-yl]-ethylamino]-N,N-dimethylacetamide
Show/Hide
|
C22H27BrClN5O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0573066
|
1-(2,4-dichlorophenyl)-N,N-diethyl-3,4-dihydro-1H-[1,4]oxazino[4,3-a]benzimidazol-6-amine
Show/Hide
|
C20H21Cl2N3O
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0967553
|
Trans-5-Chloro-N-[4-(3-ethyl-2-oxo-2,3-dihydro-imidazo[4,5-c]pyridin-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C22H26ClN5O2
|
1
|
| 1 |
IC50 = 275 nM
|
|
|
|
CP0563264
|
US8614213, 21.4
Show/Hide
|
C19H22ClF3N4O
|
1
|
| 1 |
IC50 = 299 nM
|
|
|
|
CP0463857
|
2-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,2,5-thiadiazolidine 1,1-dioxide
Show/Hide
|
C21H24N6O3S
|
1
|
| 1 |
IC50 = 309.03 nM
|
|
|
|
CP0519207
|
1-[1-[1-(4-ethoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
Show/Hide
|
C23H26N6O2
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0423798
|
3-methyl-4-[4-(3-pyrazol-1-ylpyrazol-1-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C21H17N7
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0456755
|
US8835444, 2.3
Show/Hide
|
C21H27ClN4O
|
1
|
| 1 |
IC50 = 318 nM
|
|
|
|
CP0520773
|
9-chloro-6-[1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(2,4,6-trimethylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C20H19ClF5N5O
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0563263
|
US8614213, 21.2
Show/Hide
|
C22H21ClF3N3O
|
1
|
| 1 |
IC50 = 338 nM
|
|
|
|
CP0035677
|
Pyrazolo[1,5-a]-1,3,5-triazine, 13-15
Show/Hide
|
C18H24N6O
|
2
|
| 1 |
IC50 = 340 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0512234
|
US8614213, 2.35
Show/Hide
|
C25H25ClF3N3O2
|
1
|
| 1 |
IC50 = 346 nM
|
|
|
|
CP0871525
|
Trans-2-Chloro-N-[4-(6-methoxy-3,3-dimethyl-2-oxo-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C25H27ClF3N3O3
|
1
|
| 1 |
IC50 = 347 nM
|
|
|
|
CP0403472
|
US8835444, 4.3
Show/Hide
|
C19H25ClN4O
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0529157
|
9-chloro-6-[(1S)-1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(2-methoxy-4,6-dimethylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
Show/Hide
|
C20H19ClF5N5O2
|
2
|
| 1 |
IC50 = 350 nM
|
|
|
| 2 |
IC50 = 1800 nM
|
|
|
|
CP0502277
|
3-[1-[1-(2-methoxy-4-pyrazol-1-ylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1H-imidazol-2-one
Show/Hide
|
C24H22N8O2
|
1
|
| 1 |
IC50 = 363.08 nM
|
|
|
|
CP0434755
|
3-chloro-4-[4-(3-pyridin-2-ylpyrazol-1-yl)-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C22H15ClN6
|
1
|
| 1 |
IC50 = 363.08 nM
|
|
|
|
CP0488152
|
1-[1-[6-methyl-1-(2-methyl-4-pyrazol-1-ylphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
Show/Hide
|
C24H24N8O
|
1
|
| 1 |
IC50 = 371.54 nM
|
|
|
|
CP0871598
|
Trans-5-Chloro-N-[4-(3,7-dimethyl-2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
Show/Hide
|
C22H26ClN5O2
|
1
|
| 1 |
IC50 = 416 nM
|
|
|
|
CP0434925
|
2-[1-[1-(4-methoxy-2-methylphenyl)-6-methylpyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C22H19N5OS
|
1
|
| 1 |
IC50 = 426.58 nM
|
|
|
|
CP0470325
|
US8614213, 18
Show/Hide
|
C20H27ClN4O
|
1
|
| 1 |
IC50 = 577 nM
|
|
|
|
CP0429980
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N-propan-2-yl-4-N-(3-propan-2-yloxyphenyl)benzimidazole-2,4-diamine
Show/Hide
|
C28H33ClN4O2
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0871595
|
Trans-N-[4-(3,3-Dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl-5-trifluoromethyl-nicotinamide
Show/Hide
|
C25H28F3N3O2
|
1
|
| 1 |
IC50 = 612 nM
|
|
|
|
CP0472524
|
US8835444, 3.17
Show/Hide
|
C20H25F3N4O
|
1
|
| 1 |
IC50 = 634 nM
|
|
|
|
CP0484565
|
US8835444, 4.5
Show/Hide
|
C19H25ClN4O2
|
1
|
| 1 |
IC50 = 665 nM
|
|
|
|
CP0500726
|
1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-3-methylimidazolidin-2-one
Show/Hide
|
C23H26N6O2
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0383848
|
2-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]-5-thiophen-2-ylbenzonitrile
Show/Hide
|
C24H16N6S2
|
1
|
| 1 |
IC50 = 851.14 nM
|
|
|
|
CP0860070
|
Trans-2-chloro-N-[4-(2-oxo-2,3-dihydro-pyrrolo[2,3-b]pyridin-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
Show/Hide
|
C22H21ClF3N3O2
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0550818
|
US8835444, 1.4
Show/Hide
|
C23H24ClF3N2O3
|
1
|
| 1 |
IC50 = 948 nM
|
|
|
|
CP0498792
|
2-(dibutylamino)-5-mesityl-3,7-dimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C25H36N4O
|
1
|
| 1 |
IC50 = 970 nM
|
|
|
|
CP0564925
|
7-N,7-N-dipropyl-2-N-(2,4,6-trimethylphenyl)-1,3-benzoxazole-2,7-diamine
Show/Hide
|
C22H29N3O
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0473982
|
2-(dipropylamino)-5-mesityl-3,6,7-trimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C24H34N4O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0539672
|
2-N-(4-bromo-2-methoxy-6-methylphenyl)-3-methyl-4-N-(4-methylsulfonylphenyl)-4-N-propan-2-ylbenzimidazole-2,4-diamine
Show/Hide
|
C26H29BrN4O3S
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0502987
|
1-[1-[6-methyl-1-(2-methyl-4-propan-2-yloxyphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
Show/Hide
|
C24H28N6O2
|
1
|
| 1 |
IC50 = 1230.27 nM
|
|
|
|
CP0578111
|
US8614213, 1.34
Show/Hide
|
C23H28ClF3N4O
|
1
|
| 1 |
IC50 = 1241 nM
|
|
|
|
CP0466095
|
5-(2,4-dimethylphenyl)-2-(dipropylamino)-3,7-dimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C22H30N4O
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0468895
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N-propan-2-yl-4-N-(4-propan-2-yloxyphenyl)benzimidazole-2,4-diamine
Show/Hide
|
C28H33ClN4O2
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0502985
|
3-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H23N5O3
|
1
|
| 1 |
IC50 = 1949.84 nM
|
|
|
|
CP0503089
|
3-fluoro-4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C20H13FN6S
|
1
|
| 1 |
IC50 = 2041.74 nM
|
|
|
|
CP0490497
|
3-phenyl-4-N,4-N-dipropyl-2-N-(2,4,6-trimethylphenyl)benzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C28H35ClN4
|
1
|
| 1 |
IC50 = 2200 nM
|
|
|
|
CP0556070
|
US8614213, 14.1
Show/Hide
|
C21H23ClF3N3O
|
1
|
| 1 |
IC50 = 2205 nM
|
|
|
|
CP0383906
|
2-[1-[1-(2-chloro-4-methylsulfonylphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H16ClN5O2S2
|
1
|
| 1 |
IC50 = 2344.23 nM
|
|
|
|
CP0483460
|
4-N,4-N-dipropyl-2-N-(2,4,6-trimethylphenyl)-1H-benzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C22H31ClN4
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0383852
|
3-methyl-4-[6-methyl-4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]pyrazolo[3,4-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C21H15N7S
|
1
|
| 1 |
IC50 = 2754.23 nM
|
|
|
|
CP0510163
|
5-(2,4-bis(trifluoromethyl)phenyl)-2-(dipropylamino)-3,7-dimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C22H24F6N4O
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0511364
|
5-(2,4-dimethoxyphenyl)-2-(dipropylamino)-3,7-dimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C22H30N4O3
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0509596
|
2-(dipropylamino)-3,7-dimethyl-5-(2,4,6-trimethoxyphenyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C23H32N4O4
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
|
CP0969794
|
US8614213, 14
Show/Hide
|
C24H23ClF4N4O
|
1
|
| 1 |
IC50 = 3225 nM
|
|
|
|
CP0502986
|
2-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,2-thiazolidine 1,1-dioxide
Show/Hide
|
C22H25N5O3S
|
1
|
| 1 |
IC50 = 3235.94 nM
|
|
|
|
CP0526852
|
5-(2,4-dimethylphenyl)-2-(dipropylamino)-3,6,7-trimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C23H32N4O
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
|
CP0423675
|
3-methyl-4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]phenol
Show/Hide
|
C20H17N5OS
|
1
|
| 1 |
IC50 = 3467.37 nM
|
|
|
|
CP0529871
|
5-mesityl-3,7-dimethyl-2-(piperidin-1-yl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C22H28N4O
|
1
|
| 1 |
IC50 = 3800 nM
|
|
|
|
CP0532080
|
2-[1-[1-[2,4-bis(methylsulfonyl)phenyl]-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C21H19N5O4S3
|
1
|
| 1 |
IC50 = 3890.45 nM
|
|
|
|
CP0577996
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N-(4-chlorophenyl)-4-N-(2,2-dimethylpropyl)-3-methylbenzimidazole-2,4-diamine;hydrochloride
Show/Hide
|
C27H31Cl3N4O
|
1
|
| 1 |
IC50 = 4400 nM
|
|
|
|
CP0519125
|
US8614213, 1.33
Show/Hide
|
C21H21ClF3N3O3
|
1
|
| 1 |
IC50 = 6425 nM
|
|
|
|
CP0474339
|
US8835444, 4.4
Show/Hide
|
C19H25ClN4O2
|
1
|
| 1 |
IC50 = 6956 nM
|
|
|
|
CP0423676
|
4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzene-1,3-dicarbonitrile
Show/Hide
|
C21H13N7S
|
1
|
| 1 |
IC50 = 7413.1 nM
|
|
|
|
CP0466094
|
2-(diethylamino)-5-mesityl-3,7-dimethyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
Show/Hide
|
C21H28N4O
|
1
|
| 1 |
IC50 = 7700 nM
|
|
|
|
CP0423678
|
3-[2,4-bis(trifluoromethyl)phenyl]-5-methyl-7-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-1H-imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C21H12F6N6OS
|
1
|
| 1 |
IC50 = 8317.64 nM
|
|
|
|
CP0524337
|
2-[1-[1-(4-methoxyphenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H17N5OS
|
1
|
| 1 |
IC50 = 8709.64 nM
|
|
|
|
CP0434924
|
3-nitro-4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]benzonitrile
Show/Hide
|
C20H13N7O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0434926
|
1-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-3H-[1,2]thiazolo[3,4-b]pyridine 2,2-dioxide
Show/Hide
|
C21H13F6N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0439280
|
3,5-dimethyl-4-[3-methyl-4-[4-[3-(1,3-thiazol-2-yl)pyrazol-1-yl]-2,3-dihydropyrrolo[2,3-b]pyridin-1-yl]phenyl]-1,2-oxazole
Show/Hide
|
C25H22N6OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0503077
|
2-[1-[3-[2,4-bis(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)imidazo[4,5-b]pyridin-7-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C22H11F9N6S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0503078
|
2-[1-[3-[2,4-bis(trifluoromethyl)phenyl]-2,5-dimethylimidazo[4,5-b]pyridin-7-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C22H14F6N6S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0508085
|
2-[1-[1-(4-fluoro-2-nitrophenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C19H13FN6O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0511235
|
2-[1-[2-(5-methoxy-2,3-dihydroindol-1-yl)-6-methylpyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C21H19N5OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0524335
|
2-[1-[1-(4-chloro-2-nitrophenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C19H13ClN6O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0524336
|
2-[1-[1-(4-methoxy-2-nitrophenyl)-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]-1,3-thiazole
Show/Hide
|
C20H16N6O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0436300
|
5-mesityl-4-methoxy-7-methyl-N,N-dipropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
Show/Hide
|
C23H32N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0441160
|
4-chloro-5-mesityl-7-methyl-N,N-dipropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
Show/Hide
|
C22H29ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0541318
|
2-(dipropylamino)-5-mesityl-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol
Show/Hide
|
C22H30N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0401686
|
2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N,4-N-diethyl-3-methyl-7-phenylbenzimidazole-2,4-diamine
Show/Hide
|
C26H29ClN4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0483463
|
5-chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamine
Show/Hide
|
C22H28Cl2N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0244594
|
(1-Ethyl-propyl)-[3-(4-methoxy-2-methyl-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-amine
Show/Hide
|
C21H28N4O
|
2
|
| 1 |
Kd = 0.279 nM
|
|
|
| 2 |
Ki = 1.5 nM
|
|
|
|
CP0504496
|
N-(dicyclopropylmethyl)-9-[4-(difluoromethoxy)-2-methoxyphenyl]-2,8-dimethylpurin-6-amine
Show/Hide
|
C22H25F2N5O2
|
2
|
| 1 |
Kd = 0.291 nM
|
|
|
| 2 |
Ki = 0.291 nM
|
|
|
|
CP0390146
|
9-[2-chloro-4-(difluoromethoxy)phenyl]-N-(dicyclopropylmethyl)-2,8-dimethylpurin-6-amine
Show/Hide
|
C21H22ClF2N5O
|
2
|
| 1 |
Kd = 0.373 nM
|
|
|
| 2 |
Ki = 0.373 nM
|
|
|
|
CP0452510
|
N-(dicyclopropylmethyl)-9-[4-(difluoromethoxy)phenyl]-2,8-dimethylpurin-6-amine
Show/Hide
|
C21H23F2N5O
|
2
|
| 1 |
Kd = 3 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0482121
|
N-(dicyclopropylmethyl)-9-(4-methoxyphenyl)-2,8-dimethylpurin-6-amine
Show/Hide
|
C21H25N5O
|
2
|
| 1 |
Kd = 12 nM
|
|
|
| 2 |
Ki = 19 nM
|
|
|
|
CP0390213
|
1-(4-methoxy-2-methylphenyl)-N-(2-methoxyethyl)-3,6-dimethyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C21H29N5O2
|
2
|
| 1 |
Kd = 14 nM
|
|
|
| 2 |
Ki = 13 nM
|
|
|
|
CP0534861
|
N-(cyclopropylmethyl)-8-(2,4-dichlorophenyl)-2-methyl-N-propylquinolin-4-amine
Show/Hide
|
C23H24Cl2N2
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0510311
|
8-(2,4-dichlorophenyl)-2-methyl-N,N-dipropylquinolin-4-amine
Show/Hide
|
C22H24Cl2N2
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0509745
|
(4-Chloro-benzyl)-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C25H29ClN6
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0490271
|
N-(cyclopropylmethyl)-2-methyl-N-propyl-8-(2,4,6-trimethylphenyl)quinolin-4-amine
Show/Hide
|
C26H32N2
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0408736
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-ethyl-2,5-dimethyl-N-[(4-methylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C26H32N6
|
1
|
| 1 |
Ki = 2.3 nM
|
|
|
|
CP0534906
|
Butyl-ethyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl]-amine
Show/Hide
|
C25H32N2
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0403581
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-ethyl-2,5-dimethyl-N-[(2-methylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C26H32N6
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0497707
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-ethyl-2,5-dimethyl-N-[(3-methylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C26H32N6
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0424154
|
N-(cyclopropylmethyl)-8-(2,4-dichlorophenyl)-2,7-dimethyl-N-propylquinolin-4-amine
Show/Hide
|
C24H26Cl2N2
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0499240
|
(3,4-Dichloro-benzyl)-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C25H28Cl2N6
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0514335
|
Butyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C22H32N6
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0515802
|
N-(cyclopropylmethyl)-3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C23H32N6
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0515803
|
Benzyl-butyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-amine
Show/Hide
|
C27H34N6
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0509446
|
Butyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl]-propyl-amine
Show/Hide
|
C26H34N2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0535531
|
2-methyl-N,N-dipropyl-8-(2,4,6-trimethylphenyl)quinolin-4-amine
Show/Hide
|
C25H32N2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0455500
|
Benzyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl]-propyl-amine
Show/Hide
|
C29H32N2
|
1
|
| 1 |
Ki = 3.2 nM
|
|
|
|
CP0509744
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-ethyl-N-[(2-fluorophenyl)methyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C25H29FN6
|
1
|
| 1 |
Ki = 3.4 nM
|
|
|
|
CP0534853
|
Benzyl-[8-(2,4-dichloro-phenyl)-2-methyl-quinolin-4-yl]-propyl-amine
Show/Hide
|
C26H24Cl2N2
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0499968
|
N,N-dibutyl-3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C24H36N6
|
1
|
| 1 |
Ki = 4.2 nM
|
|
|
|
CP0523962
|
8-(2,4-dichlorophenyl)-2,7-dimethyl-N,N-dipropylquinolin-4-amine
Show/Hide
|
C23H26Cl2N2
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0515801
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-heptan-4-yl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C23H34N6
|
1
|
| 1 |
Ki = 4.8 nM
|
|
|
|
CP0289537
|
Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C20H24Cl2N4
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0467574
|
4-Chloro-8-(2,4-dichloro-phenyl)-2-methyl-quinoline
Show/Hide
|
C16H10Cl3N
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0509747
|
Benzyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amine
Show/Hide
|
C26H32N6
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0465387
|
Butyl-[8-(2,4-dichloro-phenyl)-2-methyl-quinolin-4-yl]-ethyl-amine
Show/Hide
|
C22H24Cl2N2
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0523985
|
8-(2,4-dichlorophenyl)-N,N-bis(2-methoxyethyl)-2-methylquinolin-4-amine
Show/Hide
|
C22H24Cl2N2O2
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0535578
|
3-(2,4-Dichloro-phenyl)-2,5-dimethyl-7-(2-propyl-piperidin-1-yl)-pyrazolo[1,5-a]pyrimidine
Show/Hide
|
C22H26Cl2N4
|
1
|
| 1 |
Ki = 6.4 nM
|
|
|
|
CP0498258
|
Bis-(2-methoxy-ethyl)-[2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl]-amine
Show/Hide
|
C25H32N2O2
|
1
|
| 1 |
Ki = 6.5 nM
|
|
|
|
CP0495100
|
(1-Benzyl-2-methoxy-ethyl)-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-amine
Show/Hide
|
C26H32N6O
|
1
|
| 1 |
Ki = 6.5 nM
|
|
|
|
CP0390147
|
N-(dicyclopropylmethyl)-9-[4-(difluoromethoxy)-2-fluorophenyl]-2,8-dimethylpurin-6-amine
Show/Hide
|
C21H22F3N5O
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0497706
|
3-(4,6-dimethylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C21H29N5
|
1
|
| 1 |
Ki = 7.3 nM
|
|
|
|
CP0499957
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N-phenyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C25H30N6
|
1
|
| 1 |
Ki = 8.8 nM
|
|
|
|
CP0479744
|
8-(4-chlorophenyl)-2-methyl-N,N-dipropylquinolin-4-amine
Show/Hide
|
C22H25ClN2
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0210018
|
5-(2,4-dichlorophenyl)-N-(dicyclopropylmethyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C19H24Cl2N4
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0518324
|
8-(4-chlorophenyl)-7-methoxy-2-methyl-N,N-dipropylquinolin-4-amine
Show/Hide
|
C23H27ClN2O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0534488
|
N-butyl-N-ethyl-3,6-dimethyl-1-(2,4,6-trimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C22H31N5
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0452509
|
N-(dicyclopropylmethyl)-2,8-dimethyl-9-[4-(trifluoromethoxy)phenyl]purin-6-amine
Show/Hide
|
C21H22F3N5O
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0391232
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C21H30N6
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0512356
|
5-(4-bromo-2-methylphenyl)-N-(dicyclopropylmethyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C20H27BrN4
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0493539
|
3-(2,4-dichlorophenyl)-N-ethyl-N-(2-methoxyethyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C19H22Cl2N4O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0408651
|
Benzyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-isopropyl-amine
Show/Hide
|
C26H32N6
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0452508
|
9-(4-chlorophenyl)-N-(dicyclopropylmethyl)-2,8-dimethylpurin-6-amine
Show/Hide
|
C20H22ClN5
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0484983
|
9-(2-chloro-4-methoxyphenyl)-N-(dicyclopropylmethyl)-2,8-dimethylpurin-6-amine
Show/Hide
|
C21H24ClN5O
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0539621
|
8-(2,4-dichlorophenyl)-N,N-bis(2-methoxyethyl)-2,7-dimethylquinolin-4-amine
Show/Hide
|
C23H26Cl2N2O2
|
1
|
| 1 |
Ki = 12.1 nM
|
|
|
|
CP0445914
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N-(5-methylhexan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C23H34N6
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0525457
|
2-[5-(2,4-Dichloro-phenyl)-3-dipropylamino-[1,2,4]triazol-1-yl]-ethanol
Show/Hide
|
C16H22Cl2N4O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0452507
|
N-(dicyclopropylmethyl)-9-(4-methoxy-2-methylphenyl)-2,8-dimethylpurin-6-amine
Show/Hide
|
C22H27N5O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0506095
|
8-(2,4-dimethoxyphenyl)-2-methyl-N,N-dipropylquinolin-4-amine
Show/Hide
|
C24H30N2O2
|
1
|
| 1 |
Ki = 14.5 nM
|
|
|
|
CP0476047
|
Butyl-[3-(2-chloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C20H25ClN4
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0464134
|
5-(2,4-dichloro-5-fluorophenyl)-N-(dicyclopropylmethyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C19H23Cl2FN4
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0464642
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N-(naphthalen-2-ylmethyl)-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C30H34N6
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0487101
|
N-(dicyclopropylmethyl)-4-(2,4-dimethoxy-6-methylphenyl)-5-methyl-N-propylpyrimidin-2-amine
Show/Hide
|
C24H33N3O2
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0496138
|
8-(2,4-Dichloro-phenyl)-2-methyl-4-methylsulfanyl-quinoline
Show/Hide
|
C17H13Cl2NS
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0435722
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N-(3-methylbutan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C21H30N6
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0388299
|
1-(2,6-dimethoxypyridin-3-yl)-N-(2-methoxyethyl)-3,6-dimethyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H28N6O3
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0530361
|
N-(dicyclopropylmethyl)-4-(2,4-dimethoxyphenyl)-5-methyl-N-propylpyrimidin-2-amine
Show/Hide
|
C23H31N3O2
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0497034
|
3-[6-(dimethylamino)-2,4-dimethylpyridin-3-yl]-5-methyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H32N6
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0509347
|
N-(dicyclopropylmethyl)-9-(4-ethoxyphenyl)-2,8-dimethylpurin-6-amine
Show/Hide
|
C22H27N5O
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0497705
|
2,5-dimethyl-3-(6-methylpyridin-3-yl)-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C20H27N5
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0559427
|
5-(4-chloro-2-methylphenyl)-N-(dicyclopropylmethyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C20H27ClN4
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0499241
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-[(3-methoxyphenyl)methyl]-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C27H34N6O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0454292
|
5-(4-chloro-2-methoxyphenyl)-N-(dicyclopropylmethyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C20H27ClN4O
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0538645
|
N-heptan-4-yl-1-(4-methoxy-2-methylphenyl)-6-methylpyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C21H29N5O
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0528024
|
N-(dicyclopropylmethyl)-1-(4-methoxy-2-methylphenyl)-6-methylpyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C21H25N5O
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0538242
|
(2-Methyl-8-p-tolyl-quinolin-4-yl)-dipropyl-amine
Show/Hide
|
C23H28N2
|
1
|
| 1 |
Ki = 32.5 nM
|
|
|
|
CP0402789
|
5-(4-chlorophenyl)-N-(dicyclopropylmethyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C19H25ClN4
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0506481
|
N-heptan-4-yl-1-(4-methoxy-2-methylphenyl)-3,6-dimethylpyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C22H31N5O
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0497342
|
6-chloro-3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H31ClN6
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0501572
|
Butyl-[3-(2,4-dichloro-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C19H22Cl2N4
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0437481
|
3-(2,4-Dichloro-phenyl)-2,5-dimethyl-7-piperidin-1-yl-pyrazolo[1,5-a]pyrimidine
Show/Hide
|
C19H20Cl2N4
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0522089
|
1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-(pentan-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H27N5O
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0508270
|
1-(6-methoxy-2-methylpyridin-3-yl)-N-(2-methoxyethyl)-3,6-dimethyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H28N6O2
|
1
|
| 1 |
Ki = 43 nM
|
|
|
|
CP0452506
|
N-(dicyclopropylmethyl)-9-(4-methoxy-2-methylphenyl)-2-methylpurin-6-amine
Show/Hide
|
C21H25N5O
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0486116
|
4-(4-bromophenyl)-N-(dicyclopropylmethyl)-5-methyl-N-propylpyrimidin-2-amine
Show/Hide
|
C21H26BrN3
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0520304
|
8-(4-methoxyphenyl)-2-methyl-N,N-dipropylquinolin-4-amine
Show/Hide
|
C23H28N2O
|
1
|
| 1 |
Ki = 52 nM
|
|
|
|
CP0541216
|
4-[6-(dicyclopropylmethylamino)-2,8-dimethylpurin-9-yl]benzonitrile
Show/Hide
|
C21H22N6
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0501217
|
N-(dicyclopropylmethyl)-4-(2-fluoro-4,6-dimethoxyphenyl)-N-propylpyrimidin-2-amine
Show/Hide
|
C22H28FN3O2
|
1
|
| 1 |
Ki = 63 nM
|
|
|
|
CP0511274
|
4-(4-bromo-2-methylphenyl)-N-(dicyclopropylmethyl)-5-methyl-N-propylpyrimidin-2-amine
Show/Hide
|
C22H28BrN3
|
1
|
| 1 |
Ki = 63 nM
|
|
|
|
CP0373592
|
Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-amine
Show/Hide
|
C18H20Cl2N4
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0414888
|
N-(dicyclopropylmethyl)-5-(2,4-dimethylphenyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0490972
|
1-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-3,6-dimethyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C21H29N5O3
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0524023
|
(2R)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)pentan-1-ol
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
Ki = 76 nM
|
|
|
|
CP0537184
|
Butyl-[3-(4-chloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C20H25ClN4
|
1
|
| 1 |
Ki = 77 nM
|
|
|
|
CP0409128
|
5-(2,4-dichlorophenyl)-N-(dicyclopropylmethyl)-1-ethyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C20H26Cl2N4
|
1
|
| 1 |
Ki = 80 nM
|
|
|
|
CP0388310
|
N-[1-(4-methoxy-2-methylphenyl)-3,6-dimethylpyrazolo[3,4-d]pyrimidin-4-yl]-3-(propylaminomethyl)-1,2,4-oxadiazol-5-amine
Show/Hide
|
C21H26N8O2
|
1
|
| 1 |
Ki = 84 nM
|
|
|
|
CP0289681
|
3-(5-amino-3-methylpyridin-2-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C20H28N6
|
1
|
| 1 |
Ki = 85 nM
|
|
|
|
CP0534487
|
1-(4-methoxy-2-methylphenyl)-6-methyl-N-(pentan-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C19H25N5O
|
1
|
| 1 |
Ki = 85 nM
|
|
|
|
CP0494293
|
N-(dicyclopropylmethyl)-9-(4-fluorophenyl)-2,8-dimethylpurin-6-amine
Show/Hide
|
C20H22FN5
|
1
|
| 1 |
Ki = 91 nM
|
|
|
|
CP0373691
|
Butyl-[2,5-dimethyl-3-(2,4,6-trichloro-phenyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine
Show/Hide
|
C20H23Cl3N4
|
1
|
| 1 |
Ki = 93 nM
|
|
|
|
CP0449152
|
Allyl-dicyclopropylmethyl-[4-(2,4,6-trimethoxy-phenyl)-pyrimidin-2-yl]-amine
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0534493
|
4-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-methylbenzonitrile
Show/Hide
|
C21H26N6O
|
1
|
| 1 |
Ki = 101 nM
|
|
|
|
CP0397109
|
N-ethyl-N-(2-methoxyethyl)-1-(4-methoxy-2-methylphenyl)-3,6-dimethylpyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
Ki = 117 nM
|
|
|
|
CP0441914
|
N-(dicyclopropylmethyl)-1-methyl-N-propyl-5-(2,4,6-trimethylphenyl)-1,2,4-triazol-3-amine
Show/Hide
|
C22H32N4
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0535223
|
N-[1-(4-methoxy-2-methylphenyl)-3,6-dimethylpyrazolo[3,4-d]pyrimidin-4-yl]-5-(propylaminomethyl)-1,2,4-oxadiazol-3-amine
Show/Hide
|
C21H26N8O2
|
1
|
| 1 |
Ki = 124 nM
|
|
|
|
CP0535221
|
2-((1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)(propyl)amino)ethanol
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
Ki = 129 nM
|
|
|
|
CP0513968
|
1-(4-methoxy-2-methylphenyl)-N-(1-methoxyhexan-3-yl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C21H29N5O2
|
1
|
| 1 |
Ki = 132 nM
|
|
|
|
CP0459041
|
1-(4-methoxy-2-methylphenyl)-N-((S)-1-methoxybutan-2-yl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
Ki = 135 nM
|
|
|
|
CP0439051
|
8-(2,4-Dichloro-phenyl)-4-methoxy-2-methyl-quinoline
Show/Hide
|
C17H13Cl2NO
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0390145
|
N-(dicyclopropylmethyl)-2,8-dimethyl-9-(4-methylsulfonylphenyl)purin-6-amine
Show/Hide
|
C21H25N5O2S
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0390215
|
N-(dicyclopropylmethyl)-8-(methoxymethyl)-9-(4-methoxyphenyl)-2-methylpurin-6-amine
Show/Hide
|
C22H27N5O2
|
1
|
| 1 |
Ki = 157 nM
|
|
|
|
CP0524026
|
1-(6-(dimethylamino)-2,4-dimethylpyridin-3-yl)-N-(2-methoxyethyl)-3,6-dimethyl-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C21H31N7O
|
1
|
| 1 |
Ki = 183 nM
|
|
|
|
CP0535220
|
1-(4-methoxy-2-methylphenyl)-N,N-bis(2-methoxyethyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C21H29N5O3
|
1
|
| 1 |
Ki = 193 nM
|
|
|
|
CP0400428
|
1-(4-methoxy-2-methylphenyl)-N-((R)-1-methoxybutan-2-yl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
Ki = 210 nM
|
|
|
|
CP0384172
|
N-butyl-3-(2,4-dichlorophenyl)-N-methoxy-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C19H22Cl2N4O
|
1
|
| 1 |
Ki = 216 nM
|
|
|
|
CP0497343
|
6-bromo-3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C22H31BrN6
|
1
|
| 1 |
Ki = 240 nM
|
|
|
|
CP0478342
|
((R)-Cyclopropyl-phenyl-methyl)-propyl-[4-(2,4,6-trimethoxy-phenyl)-pyrimidin-2-yl]-amine
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
Ki = 240 nM
|
|
|
|
CP0501033
|
4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine
Show/Hide
|
C27H28ClFN2OS
|
1
|
| 1 |
Ki = 240 nM
|
|
|
|
CP0537582
|
N-propyl-N-(1-thiophen-2-ylcyclopropyl)-4-(2,4,6-trimethoxyphenyl)pyrimidin-2-amine
Show/Hide
|
C23H27N3O3S
|
1
|
| 1 |
Ki = 250 nM
|
|
|
|
CP0391222
|
3-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-(1-methoxybutan-2-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C21H30N6O
|
1
|
| 1 |
Ki = 260 nM
|
|
|
|
CP0528752
|
N-(dicyclopropylmethyl)-8-(3,3-difluorocyclobutyl)-9-(4-methoxyphenyl)-2-methylpurin-6-amine
Show/Hide
|
C24H27F2N5O
|
1
|
| 1 |
Ki = 261 nM
|
|
|
|
CP0417945
|
4-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-methylbenzamide
Show/Hide
|
C21H28N6O2
|
1
|
| 1 |
Ki = 275 nM
|
|
|
|
CP0505853
|
8-(cyclopropylmethyl)-N-(dicyclopropylmethyl)-9-(4-methoxyphenyl)-2-methylpurin-6-amine
Show/Hide
|
C24H29N5O
|
1
|
| 1 |
Ki = 308 nM
|
|
|
|
CP0437654
|
3-(2,4-Dichloro-phenyl)-2,5-dimethyl-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine
Show/Hide
|
C18H18Cl2N4O
|
1
|
| 1 |
Ki = 310 nM
|
|
|
|
CP0503169
|
N-(dicyclopropylmethyl)-1-ethyl-N-propyl-5-(2,4,6-trimethylphenyl)-1,2,4-triazol-3-amine
Show/Hide
|
C23H34N4
|
1
|
| 1 |
Ki = 310 nM
|
|
|
|
CP0535225
|
1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-(2-((propylamino)methyl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C22H28N8O
|
1
|
| 1 |
Ki = 400 nM
|
|
|
|
CP0437616
|
(2-Methyl-8-phenyl-quinolin-4-yl)-dipropyl-amine
Show/Hide
|
C22H26N2
|
1
|
| 1 |
Ki = 420 nM
|
|
|
|
CP0469449
|
8-(2,4-Dichloro-phenyl)-2,4-dimethyl-quinoline
Show/Hide
|
C17H13Cl2N
|
1
|
| 1 |
Ki = 460 nM
|
|
|
|
CP0551807
|
N-(dicyclopropylmethyl)-4-(2,4-dimethoxyphenyl)-N-propylpyrimidin-2-amine
Show/Hide
|
C22H29N3O2
|
1
|
| 1 |
Ki = 460 nM
|
|
|
|
CP0414863
|
Butyl-(2,5-dimethyl-3-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl)-ethyl-amine
Show/Hide
|
C20H26N4
|
1
|
| 1 |
Ki = 511 nM
|
|
|
|
CP0534486
|
(2S)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)pentan-1-ol
Show/Hide
|
C20H27N5O2
|
1
|
| 1 |
Ki = 574 nM
|
|
|
|
CP0524027
|
5-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-6-methylpicolinamide
Show/Hide
|
C20H27N7O2
|
1
|
| 1 |
Ki = 577 nM
|
|
|
|
CP0390218
|
N-(dicyclopropylmethyl)-9-(4-methoxyphenyl)-2-methyl-8-(2-methylpropyl)purin-6-amine
Show/Hide
|
C24H31N5O
|
1
|
| 1 |
Ki = 607 nM
|
|
|
|
CP0400430
|
(2S)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)butan-1-ol
Show/Hide
|
C19H25N5O2
|
1
|
| 1 |
Ki = 620 nM
|
|
|
|
CP0506496
|
4-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)isophthalonitrile
Show/Hide
|
C21H23N7O
|
1
|
| 1 |
Ki = 632 nM
|
|
|
|
CP0397260
|
(1-Furan-3-yl-cyclopropyl)-propyl-[4-(2,4,6-trimethoxy-phenyl)-pyrimidin-2-yl]-amine
Show/Hide
|
C23H27N3O4
|
1
|
| 1 |
Ki = 700 nM
|
|
|
|
CP0397823
|
N-(dicyclopropylmethyl)-4-(2,4-dimethoxyphenyl)-5-ethyl-N-propylpyrimidin-2-amine
Show/Hide
|
C24H33N3O2
|
1
|
| 1 |
Ki = 860 nM
|
|
|
|
CP0499119
|
N-(dicyclopropylmethyl)-9-(4-methoxyphenyl)-2-methyl-8-(oxolan-2-yl)purin-6-amine
Show/Hide
|
C24H29N5O2
|
1
|
| 1 |
Ki = 867 nM
|
|
|
|
CP0473887
|
N-[1-(4-methoxy-2-methylphenyl)-3,6-dimethylpyrazolo[3,4-d]pyrimidin-4-yl]-5-(propylaminomethyl)-1,3,4-oxadiazol-2-amine
Show/Hide
|
C21H26N8O2
|
1
|
| 1 |
Ki = 996 nM
|
|
|
|
CP0430981
|
(2R)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)butan-1-ol
Show/Hide
|
C19H25N5O2
|
1
|
| 1 |
Ki = 1130 nM
|
|
|
|
CP0514598
|
2-((1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)(propyl)amino)-N,N-dimethylacetamide
Show/Hide
|
C22H30N6O2
|
1
|
| 1 |
Ki = 1409 nM
|
|
|
|
CP0456775
|
N-(dicyclopropylmethyl)-N-propyl-1-(2,2,2-trifluoroethyl)-5-(2,4,6-trimethylphenyl)-1,2,4-triazol-3-amine
Show/Hide
|
C23H31F3N4
|
1
|
| 1 |
Ki = 1500 nM
|
|
|
|
CP0398218
|
N-propyl-N-(1-thiophen-3-ylcyclopropyl)-4-(2,4,6-trimethoxyphenyl)pyrimidin-2-amine
Show/Hide
|
C23H27N3O3S
|
1
|
| 1 |
Ki = 2000 nM
|
|
|
|
CP0492459
|
N-(dicyclopropylmethyl)-1-prop-2-enyl-N-propyl-5-(2,4,6-trimethylphenyl)-1,2,4-triazol-3-amine
Show/Hide
|
C24H34N4
|
1
|
| 1 |
Ki = 2200 nM
|
|
|
|
CP0538289
|
N-cyclopentyl-N-propyl-4-(2,4,6-trimethoxyphenyl)pyrimidin-2-amine
Show/Hide
|
C21H29N3O3
|
1
|
| 1 |
Ki = 2200 nM
|
|
|
|
CP0460061
|
5-(2,4-dichlorophenyl)-N-(dicyclopropylmethyl)-N-propyl-1H-1,2,4-triazol-3-amine
Show/Hide
|
C18H22Cl2N4
|
1
|
| 1 |
Ki = 2400 nM
|
|
|
|
CP0455298
|
1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-(5-((propylamino)methyl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
|
C22H28N8O
|
1
|
| 1 |
Ki = 2500 nM
|
|
|
|
CP0382885
|
5-(2,4-dichlorophenyl)-1-methyl-N,N-dipropyl-1,2,4-triazol-3-amine
Show/Hide
|
C15H20Cl2N4
|
1
|
| 1 |
Ki = 2600 nM
|
|
|
|
CP0425039
|
N-(dicyclopropylmethyl)-N-propyl-5-(2,4,6-trimethylphenyl)-1H-1,2,4-triazol-3-amine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
Ki = 3200 nM
|
|
|
|
CP0502981
|
5-(2,4-dichlorophenyl)-N-(2-methoxyphenyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C19H20Cl2N4O
|
1
|
| 1 |
Ki = 3400 nM
|
|
|
|
CP0456651
|
N-(cyclopropylmethyl)-5-(2,4-dichlorophenyl)-1-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C16H20Cl2N4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0500176
|
5-(2,4-dichlorophenyl)-N-(dicyclopropylmethyl)-2-methyl-N-propyl-1,2,4-triazol-3-amine
Show/Hide
|
C19H24Cl2N4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0447220
|
8-(2,4-Dichloro-phenyl)-2-methyl-quinolin-4-ol
Show/Hide
|
C16H11Cl2NO
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
