Brief Information of the Compound and Protein
Compound Name
 Compound Info 
9-chloro-6-[(1R)-1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(2-methoxy-4,6-dimethylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
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 PubChem ID
CID: 145969226
Canonical SMILES
COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c32)c(C)n1
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Compound Formula C20H19ClF5N5O2
Compound Structure
Protein Name
 Protein Info 
Corticotropin-releasing factor receptor 1
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
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Peptide receptor (family B GPCR)
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Corticotropin releasing factor receptor
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Corticotropin releasing factor receptor
Uniprot ID
P34998
Gene Name
CRHR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
2
IC50 = 58 nM
   TI
   LI
   LO
   TS