| Compound ID |
Compound Name |
Compound Formula |
|
CP0200314
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4,4-difluorocyclohexyl)methanone
Show/Hide
|
C18H18ClF2N3O2
|
3
|
| 1 |
Activity = 3800 nM
|
|
|
| 2 |
EC50 = 180 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0488159
|
(4R,5R)-5-(3,4-difluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H14F2N2O2
|
3
|
| 1 |
EC50 = 0.2 nM
|
|
|
| 2 |
EC50 = 50 nM
|
|
|
| 3 |
Ki = 2.8 nM
|
|
|
|
CP0462040
|
(4R,5R)-5-(4-fluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
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|
C22H15FN2O2
|
3
|
| 1 |
EC50 = 0.4 nM
|
|
|
| 2 |
EC50 = 504 nM
|
|
|
| 3 |
Ki = 1.7 nM
|
|
|
|
CP0488162
|
(4R,5R)-5-(4-chlorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H15ClN2O2
|
3
|
| 1 |
EC50 = 0.6 nM
|
|
|
| 2 |
EC50 = 333 nM
|
|
|
| 3 |
Ki = 2.2 nM
|
|
|
|
CP0459051
|
(4R,5R)-5-phenyl-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H16N2O2
|
3
|
| 1 |
EC50 = 0.7 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 1.4 nM
|
|
|
|
CP0678727
|
(4R,5R)-5-(3-Fluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one
Show/Hide
|
C22H15FN2O2
|
6
|
| 1 |
EC50 = 0.8 nM
|
|
|
| 2 |
EC50 = 0.83 nM
|
|
|
| 3 |
EC50 = 1.1 nM
|
|
|
| 4 |
EC50 > 30000 nM
|
|
|
| 5 |
EC50 > 3000 nM
|
|
|
| 6 |
Ki = 1.5 nM
|
|
|
|
CP0488160
|
(4R,5R)-5-(3-chlorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H15ClN2O2
|
3
|
| 1 |
EC50 = 0.9 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 1.8 nM
|
|
|
|
CP0459048
|
(4R,5R)-5-(2,4-difluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H14F2N2O2
|
3
|
| 1 |
EC50 = 1.2 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 1.4 nM
|
|
|
|
CP0390670
|
(4R,5R)-5-(2-fluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H15FN2O2
|
3
|
| 1 |
EC50 = 1.5 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 1.9 nM
|
|
|
|
CP0530752
|
(4R,5R)-5-phenyl-4-[2-(2-phenylethynyl)pyridin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H16N2O2
|
2
|
| 1 |
EC50 = 1.5 nM
|
|
|
| 2 |
Ki = 2.1 nM
|
|
|
|
CP0107868
|
5-methyl-2-(2-phenylethynyl)-6,7-dihydro-[1,3]thiazolo[5,4-c]pyridin-4-one
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|
C15H12N2OS
|
3
|
| 1 |
EC50 = 2.4 nM
|
|
|
| 2 |
EC50 = 193 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0378988
|
5-cyclopentyl-2-(2-phenylethynyl)-4H-pyrrolo[3,4-d][1,3]thiazol-6-one
Show/Hide
|
C18H16N2OS
|
2
|
| 1 |
EC50 = 2.5 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0397083
|
(3,3-difluorocyclobutyl)-[2-[2-(3-fluorophenyl)ethynyl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H15F3N2OS
|
2
|
| 1 |
EC50 = 2.5 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0653288
|
(4R,5R)-5-(2,5-Difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one
Show/Hide
|
C22H14F2N2O2
|
5
|
| 1 |
EC50 = 2.6 nM
|
|
|
| 2 |
EC50 > 30000 nM
|
|
|
| 3 |
EC50 > 3000 nM
|
|
|
| 4 |
IC50 = 3 nM
|
|
|
| 5 |
Ki = 1.6 nM
|
|
|
|
CP0462043
|
(4R,5R)-5-(4-fluorophenyl)-4-[5-(2-pyridin-3-ylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C21H14FN3O2
|
3
|
| 1 |
EC50 = 3.3 nM
|
|
|
| 2 |
EC50 = 273 nM
|
|
|
| 3 |
Ki = 32 nM
|
|
|
|
CP0433421
|
[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]-spiro[2.3]hexan-2-ylmethanone
Show/Hide
|
C21H20N2OS
|
2
|
| 1 |
EC50 = 3.9 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0488161
|
(4R,5R)-5-(2,3-difluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H14F2N2O2
|
3
|
| 1 |
EC50 = 4.2 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 1.8 nM
|
|
|
|
CP0459050
|
(4R,5R)-5-(4-fluorophenyl)-4-[5-[2-(2-fluoropyridin-4-yl)ethynyl]pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C21H13F2N3O2
|
3
|
| 1 |
EC50 = 4.8 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 15 nM
|
|
|
|
CP0410823
|
(4R,5R)-5-(3,5-difluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H14F2N2O2
|
3
|
| 1 |
EC50 = 5.5 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 1.4 nM
|
|
|
|
CP0425857
|
6-cyclopentyl-2-(phenylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C21H20N2O
|
2
|
| 1 |
EC50 = 5.9 nM
|
|
|
| 2 |
Ki = 890 nM
|
|
|
|
CP0885392
|
(4R,5R)-5-(4-Fluorophenyl)-4-(5-((5-fluoropyridin-3-yl)ethynyl)pyridin-3-yl)oxazolidin-2-one
Show/Hide
|
C21H13F2N3O2
|
3
|
| 1 |
EC50 = 6 nM
|
|
|
| 2 |
EC50 = 315 nM
|
|
|
| 3 |
Ki = 25 nM
|
|
|
|
CP0494911
|
US9315498, 124
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|
C18H16F2N4O
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0555375
|
US9315498, 5
Show/Hide
|
C18H16N2O2
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0494354
|
6-cyclopentyl-2-(m-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C22H22N2O
|
2
|
| 1 |
EC50 = 7.5 nM
|
|
|
| 2 |
Ki = 670 nM
|
|
|
|
CP0503945
|
US9688669, Example 89
Show/Hide
|
C20H17FN2O2
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0446543
|
(3-chlorophenyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H15ClN2OS
|
2
|
| 1 |
EC50 = 8.7 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0413549
|
US9315498, 6
Show/Hide
|
C18H15FN2O2
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0381125
|
(2-methylcyclopropyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H18N2OS
|
2
|
| 1 |
EC50 = 9.4 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0415457
|
(4R,5R)-5-phenyl-4-[6-(2-phenylethynyl)pyridin-2-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H16N2O2
|
2
|
| 1 |
EC50 = 9.4 nM
|
|
|
| 2 |
Ki = 44 nM
|
|
|
|
CP0187023
|
[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]-pyrrolidin-1-ylmethanone
Show/Hide
|
C19H19N3OS
|
2
|
| 1 |
EC50 = 9.8 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0466183
|
US9221802, Ref. Ex. 72
Show/Hide
|
C19H18N2O2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0410897
|
(4R,5R)-5-(4-fluorophenyl)-4-[5-[2-(3-fluoropyridin-2-yl)ethynyl]pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C21H13F2N3O2
|
3
|
| 1 |
EC50 = 10 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 14 nM
|
|
|
|
CP0449736
|
[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]-[3-(trifluoromethyl)phenyl]methanone
Show/Hide
|
C22H15F3N2OS
|
2
|
| 1 |
EC50 = 11 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0413558
|
US9315498, 84
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|
C21H21N3O
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0539884
|
US9315498, 34
Show/Hide
|
C18H14F2N2O2
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0547470
|
US9315498, 119
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|
C18H16ClN3O
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0575879
|
US9315498, 122
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0504355
|
6-cyclopentyl-2-(thiophen-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C19H18N2OS
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
Ki = 2840 nM
|
|
|
|
CP0413557
|
US9315498, 77
Show/Hide
|
C19H17ClN2O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0512591
|
US9221802, Ref. Ex. 81
Show/Hide
|
C19H16F2N2O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0516736
|
US9315498, 23
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0517373
|
US9315498, 43
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|
C20H19FN2O
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0518493
|
US9315498, 62
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|
C20H20N2O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0564863
|
US9315498, 174
Show/Hide
|
C19H17FN4O
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0570545
|
US9315498, 87
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0377841
|
6-cyclohexyl-2-(thiophen-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C20H20N2OS
|
2
|
| 1 |
EC50 = 13 nM
|
|
|
| 2 |
Ki = 720 nM
|
|
|
|
CP0447450
|
US9688669, Example 98
Show/Hide
|
C20H16F2N2O2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0512590
|
US9221802, Ref. Ex. 76
Show/Hide
|
C19H17FN2O2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0515879
|
US9315498, 125
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0564070
|
US9315498, 169
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|
C20H19FN2O3
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0564862
|
US9315498, 170
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|
C19H18N4O
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0569382
|
US9315498, 118
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|
C18H16FN3O
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0570751
|
US9315498, 115
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|
C18H17N3O
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0507552
|
US9315498, 153
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|
C18H17N3O2
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0516738
|
US9315498, 48
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0539883
|
US9315498, 22
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|
C19H16N2O2
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0415456
|
(4R,5R)-5-(4-fluorophenyl)-4-[5-(2-pyridin-4-ylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C21H14FN3O2
|
3
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 16 nM
|
|
|
|
CP0090288
|
(4R,5R)-5-(3-fluorophenyl)-4-[3-(2-phenylethynyl)phenyl]-1,3-oxazolidin-2-one
Show/Hide
|
C23H16FNO2
|
2
|
| 1 |
EC50 = 15 nM
|
|
|
| 2 |
EC50 > 30000 nM
|
|
|
|
CP0413556
|
US9315498, 67
Show/Hide
|
C20H21N3O
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0451617
|
US9315498, 152
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|
C17H15N3O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0518497
|
US9315498, 168
Show/Hide
|
C18H17N3O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0554173
|
US9315498, 27
Show/Hide
|
C19H18N2O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0560707
|
US9315498, 9
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|
C18H14N2O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0564060
|
US9315498, 29
Show/Hide
|
C17H14FN3O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0570542
|
US9315498, 40
Show/Hide
|
C19H17FN2O
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0466182
|
US9315498, 59
Show/Hide
|
C21H20N2O
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0494860
|
US9315498, 42
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0407069
|
[2-[2-(3-fluorophenyl)ethynyl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]-(3-methylcyclobutyl)methanone
Show/Hide
|
C20H19FN2OS
|
2
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0554171
|
US9315498, 8
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0561577
|
US9315498, 71
Show/Hide
|
C20H18FN3O
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0052128
|
(3,3-difluorocyclobutyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H16F2N2OS
|
2
|
| 1 |
EC50 = 18 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0397079
|
[(2S)-2-bicyclo[2.2.1]heptanyl]-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C22H22N2OS
|
2
|
| 1 |
EC50 = 18 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0504417
|
US9688669, Example 121
Show/Hide
|
C20H15ClF2N2O2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0490076
|
US9315498, 123
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0494910
|
US9315498, 99
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|
C22H23N3O
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0518770
|
US11059766, WO2011128279 Ex. 109
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|
C20H18FN3O
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0560889
|
US9315498, 129
Show/Hide
|
C19H19N3O2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0572433
|
US9315498, 3
Show/Hide
|
C18H16N2O3
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0262183
|
N-cyclopentyl-6-(2-phenylethynyl)pyridine-3-carboxamide
Show/Hide
|
C19H18N2O
|
2
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
Ki = 3300 nM
|
|
|
|
CP0397067
|
cyclopentyl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C20H20N2OS
|
2
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0559938
|
US9315498, 88
Show/Hide
|
C20H19FN2O
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0562380
|
US9315498, 151
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0570540
|
US9315498, 32
Show/Hide
|
C18H15FN2O2
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0466186
|
US9315498, 132
Show/Hide
|
C19H18FN3O2
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0563400
|
US9315498, 150
Show/Hide
|
C18H17N3O
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0494862
|
US9221802, Ref. Ex. 79
Show/Hide
|
C19H17FN2O2
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0515878
|
US9315498, 114
Show/Hide
|
C20H20N2O3
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0564065
|
US9315498, 37
Show/Hide
|
C18H16FN3O
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0547471
|
US9315498, 126
Show/Hide
|
C18H16F2N4O
|
1
|
| 1 |
EC50 = 23 nM
|
|
|
|
CP0499896
|
US9212171, 28
Show/Hide
|
C21H20N2O
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0545947
|
US9315498, 78
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0562381
|
US9315498, 156
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0380039
|
US9688669, Example 86
Show/Hide
|
C21H19FN2O2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0531447
|
US9212171, 31
Show/Hide
|
C21H19FN2O
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0516968
|
US9315498, 147
Show/Hide
|
C18H16N4O
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0539886
|
US9315498, 89
Show/Hide
|
C20H19ClN2O
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0570539
|
US9315498, 10
Show/Hide
|
C19H16N2O2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0459049
|
(4R,5R)-5-(4-fluorophenyl)-4-[5-(2-pyridin-2-ylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C21H14FN3O2
|
3
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
EC50 > 3000 nM
|
|
|
| 3 |
Ki = 23 nM
|
|
|
|
CP0464018
|
(3,3-difluoroazetidin-1-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C18H15F2N3OS
|
2
|
| 1 |
EC50 = 26 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0413554
|
US9315498, 31
Show/Hide
|
C16H16N4O2
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0516737
|
US9315498, 46
Show/Hide
|
C19H16N2O
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0557427
|
US9315498, 167
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0507477
|
US9221802, Ref. Ex. 20
Show/Hide
|
C19H18N2O2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0512589
|
US9315498, 75
Show/Hide
|
C18H16ClN3O2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0519497
|
US9315498, 50
Show/Hide
|
C17H19N5O
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0547466
|
US9221802, Ref. Ex. 103
Show/Hide
|
C20H18N2O2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0557421
|
US9315498, 19
Show/Hide
|
C21H22N2O2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0574021
|
US9315498, 85
Show/Hide
|
C20H20N4O
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0572446
|
US9315498, 140
Show/Hide
|
C20H22N4O
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
|
CP0575880
|
US9315498, 141
Show/Hide
|
C20H21FN4O
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
|
CP0407068
|
(3-methoxyphenyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C22H18N2O2S
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0121820
|
(4R,5R)-5-(3-methoxyphenyl)-4-[3-(2-phenylethynyl)phenyl]-1,3-oxazolidin-2-one
Show/Hide
|
C24H19NO3
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
EC50 > 30000 nM
|
|
|
|
CP0419543
|
US9315498, 160
Show/Hide
|
C18H16FN3O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0477805
|
US9315498, 44
Show/Hide
|
C21H21N3O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0490083
|
US9315498, 173
Show/Hide
|
C17H14N2O3S
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0507553
|
US9315498, 161
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0519499
|
US9315498, 51
Show/Hide
|
C18H17ClN4O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0545945
|
US9315498, 53
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0557428
|
US9315498, 172
Show/Hide
|
C19H18N2O2
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0563396
|
US9315498, 127
Show/Hide
|
C19H19N3O2
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0449737
|
(3-fluorophenyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H15FN2OS
|
2
|
| 1 |
EC50 = 30 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0517336
|
US9315498, 21
Show/Hide
|
C19H17FN2O
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0561580
|
US11059766, WO2011128279 Ex. 106
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0562375
|
US9315498, 1
Show/Hide
|
C18H15FN2O2
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0503944
|
US9688669, Example 97
Show/Hide
|
C20H15F3N2O2
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0419539
|
US9315498, 144
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0490079
|
US9315498, 136
Show/Hide
|
C19H17F2N3O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0494863
|
US9315498, 92
Show/Hide
|
C20H18F2N2O
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0494909
|
US9315498, 54
Show/Hide
|
C19H18ClN3O
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0562376
|
US9315498, 86
Show/Hide
|
C20H19FN4O
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0562400
|
US9315498, 33
Show/Hide
|
C18H14F2N2O2
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0572444
|
US9315498, 111
Show/Hide
|
C19H17F2N3O
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0502621
|
2-((3-chlorophenyl)ethynyl)-6-cyclopentyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C21H19ClN2O
|
2
|
| 1 |
EC50 = 33 nM
|
|
|
| 2 |
Ki = 5230 nM
|
|
|
|
CP0379852
|
2-(2-phenylethynyl)-5,6-dihydro-4H-1,3-benzothiazol-7-one
Show/Hide
|
C15H11NOS
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0402708
|
US9315498, 7
Show/Hide
|
C17H15N3O2
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0419524
|
US9315498, 26
Show/Hide
|
C20H21N3O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0537484
|
US9315498, 38
Show/Hide
|
C18H17N3O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0557423
|
US9315498, 58
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0214911
|
5-methyl-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
|
C15H14N2S
|
2
|
| 1 |
EC50 = 34 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0441563
|
US9212171, 9
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0494929
|
US9315498, 52
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0406366
|
US9688669, Example 115
Show/Hide
|
C20H15F3N2O2
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0522617
|
US9212171, 25
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0413551
|
US9315498, 16
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0494912
|
US9315498, 135
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0519500
|
US9315498, 60
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0537483
|
US9315498, 24
Show/Hide
|
C18H14FN3O2
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0539889
|
US9315498, 131
Show/Hide
|
C19H18FN3O2
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0556014
|
US9315498, 57
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0562984
|
US9315498, 96
Show/Hide
|
C19H17N3O
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0425855
|
6-cyclohexyl-2-(m-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C23H24N2O
|
2
|
| 1 |
EC50 = 36 nM
|
|
|
| 2 |
Ki = 3210 nM
|
|
|
|
CP0490074
|
US9315498, 97
Show/Hide
|
C18H16N2O
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0490082
|
US9315498, 165
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0539885
|
US9315498, 47
Show/Hide
|
C20H18N2O2
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0563375
|
US9315498, 93
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0491628
|
US9315498, 80
Show/Hide
|
C19H16F2N2O2
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0516739
|
US9315498, 49
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0529256
|
US9315498, 13
Show/Hide
|
C19H18N2O
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0402623
|
US9212171, 3
Show/Hide
|
C20H19ClN2O
|
1
|
| 1 |
EC50 = 38 nM
|
|
|
|
CP0563399
|
US9315498, 145
Show/Hide
|
C19H19N3O2
|
1
|
| 1 |
EC50 = 38 nM
|
|
|
|
CP0462038
|
(4R,5R)-5-phenyl-4-[3-(2-phenylethynyl)phenyl]-1,3-oxazolidin-2-one
Show/Hide
|
C23H17NO2
|
2
|
| 1 |
EC50 = 38 nM
|
|
|
| 2 |
Ki = 8.9 nM
|
|
|
|
CP0549981
|
US9212171, 24
Show/Hide
|
C20H19FN2O
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0451616
|
US9315498, 148
Show/Hide
|
C19H18FN3O2
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0512587
|
US9315498, 11
Show/Hide
|
C20H18N2O2
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0529258
|
US9315498, 18
Show/Hide
|
C21H23N3O
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0562378
|
US9315498, 101
Show/Hide
|
C23H25N3O
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0563395
|
US9315498, 98
Show/Hide
|
C18H15N3O
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0460701
|
6-cyclohexyl-2-(phenylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C22H22N2O
|
2
|
| 1 |
EC50 = 40 nM
|
|
|
| 2 |
Ki = 12430 nM
|
|
|
|
CP0539888
|
US9315498, 121
Show/Hide
|
C18H15F2N3O
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0556015
|
US9315498, 68
Show/Hide
|
C20H19F2N3O
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0572445
|
US9315498, 116
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0479355
|
US9315498, 134
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
|
CP0569630
|
US9315498, 104
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
|
CP0507478
|
US9315498, 65
Show/Hide
|
C20H19FN2O2
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
|
CP0564068
|
US9315498, 102
Show/Hide
|
C20H18N2O2
|
1
|
| 1 |
EC50 = 43 nM
|
|
|
|
CP0560887
|
US9315498, 117
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
EC50 = 44 nM
|
|
|
|
CP0419542
|
US9315498, 158
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
EC50 = 46 nM
|
|
|
|
CP0484868
|
azepan-1-yl-[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C18H21ClN4O2
|
2
|
| 1 |
EC50 = 47 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0499895
|
US9212171, 27
Show/Hide
|
C21H20N2O
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0477958
|
US9315498, 143
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0556010
|
US9315498, 2
Show/Hide
|
C18H16N2O3
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0574022
|
US9315498, 95
Show/Hide
|
C19H18N2O3
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0557422
|
US9315498, 28
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0570541
|
US9315498, 39
Show/Hide
|
C18H16ClN3O
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0380030
|
US9688669, Example 83
Show/Hide
|
C22H21FN2O2
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0517374
|
US9315498, 69
Show/Hide
|
C20H20FN3O
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0575881
|
US9315498, 159
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0375652
|
2-(2-pyridin-3-ylethynyl)-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C13H9N3OS
|
2
|
| 1 |
EC50 = 51 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0575852
|
US9315498, 113
Show/Hide
|
C19H16FN3O
|
1
|
| 1 |
EC50 = 51 nM
|
|
|
|
CP0493280
|
US9212171, 33
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
|
CP0449735
|
(3,3-difluoropyrrolidin-1-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H17F2N3OS
|
2
|
| 1 |
EC50 = 53 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0507479
|
US9315498, 83
Show/Hide
|
C20H19N3O
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0413555
|
US9315498, 55
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0494859
|
US9315498, 35
Show/Hide
|
C17H14FN3O2
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0575597
|
US9212171, 42
Show/Hide
|
C22H21FN2O
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0512588
|
US9315498, 45
Show/Hide
|
C22H23N3O
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0555386
|
US9315498, 139
Show/Hide
|
C19H18F2N4O
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0563397
|
US9315498, 133
Show/Hide
|
C19H17F2N3O2
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0569628
|
US9315498, 82
Show/Hide
|
C19H16N2O2
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0495528
|
US9212171, 11
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0556013
|
US9315498, 41
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0564061
|
US9315498, 36
Show/Hide
|
C17H13N3O2
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0423889
|
US9212171, 22
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0494861
|
US9315498, 74
Show/Hide
|
C18H16FN3O2
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0556017
|
US9315498, 73
Show/Hide
|
C18H17N3O2
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0559939
|
US9315498, 107
Show/Hide
|
C21H23N3O
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0518134
|
US9688669, Example 123
Show/Hide
|
C20H14ClF3N2O2
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0443818
|
US9212171, 1
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0537006
|
US9315498, 138
Show/Hide
|
C19H19FN4O
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0563394
|
US9315498, 94
Show/Hide
|
C19H16N2O3
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0402624
|
US9212171, 4
Show/Hide
|
C20H19FN2O
|
1
|
| 1 |
EC50 = 61 nM
|
|
|
|
CP0451611
|
US9315498, 154
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
EC50 = 61 nM
|
|
|
|
CP0483444
|
6-(2-phenylethynyl)-N-propan-2-ylpyridine-3-carboxamide
Show/Hide
|
C17H16N2O
|
2
|
| 1 |
EC50 = 62 nM
|
|
|
| 2 |
Ki = 7100 nM
|
|
|
|
CP0488845
|
US9212171, 45
Show/Hide
|
C19H18ClN3O
|
1
|
| 1 |
EC50 = 65 nM
|
|
|
|
CP0406318
|
US9688669, Example 108
Show/Hide
|
C20H15ClF2N2O2
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0490072
|
US9315498, 17
Show/Hide
|
C20H21N3O
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0494913
|
US9315498, 137
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0570546
|
US9315498, 90
Show/Hide
|
C19H18ClN3O
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0563388
|
US9315498, 12
Show/Hide
|
C21H20N2O2
|
1
|
| 1 |
EC50 = 67 nM
|
|
|
|
CP0569629
|
US9315498, 91
Show/Hide
|
C20H19FN2O
|
1
|
| 1 |
EC50 = 67 nM
|
|
|
|
CP0412264
|
US9212171, 41
Show/Hide
|
C22H21FN2O
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0507483
|
US9315498, 105
Show/Hide
|
C19H18N2O3
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0451983
|
US9688669, Example 120
Show/Hide
|
C20H14F4N2O2
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0516969
|
US9315498, 163
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0517337
|
US9315498, 25
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0562377
|
US9315498, 100
Show/Hide
|
C21H22N4O
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0562379
|
US9315498, 146
Show/Hide
|
C19H17F2N3O2
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0160087
|
N-[(2R)-3,3-dimethylbutan-2-yl]-6-[(3-fluorophenyl)methoxy]pyridine-3-carboxamide
Show/Hide
|
C19H23FN2O2
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0378987
|
(4,4-difluorocyclohexyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H20F2N2OS
|
2
|
| 1 |
EC50 = 70 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0402712
|
US9315498, 63
Show/Hide
|
C19H18ClN3O2
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0407779
|
3-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carbonyl]benzonitrile
Show/Hide
|
C22H15N3OS
|
2
|
| 1 |
EC50 = 71 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0488584
|
[(2S)-2-bicyclo[2.2.1]heptanyl]-[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H20FN3O2
|
1
|
| 1 |
EC50 = 72 nM
|
|
|
|
CP0469463
|
(4,4-difluoropiperidin-1-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C20H19F2N3OS
|
2
|
| 1 |
EC50 = 72 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0419540
|
US9315498, 155
Show/Hide
|
C18H17ClN4O
|
1
|
| 1 |
EC50 = 73 nM
|
|
|
|
CP0488585
|
[(2S)-2-bicyclo[2.2.1]heptanyl]-[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H20ClN3O2
|
1
|
| 1 |
EC50 = 74 nM
|
|
|
|
CP0375476
|
(4-fluoropiperidin-1-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C20H20FN3OS
|
2
|
| 1 |
EC50 = 74 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0556016
|
US9315498, 70
Show/Hide
|
C19H18N4O
|
1
|
| 1 |
EC50 = 74 nM
|
|
|
|
CP0375608
|
[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]-piperidin-1-ylmethanone
Show/Hide
|
C20H21N3OS
|
2
|
| 1 |
EC50 = 75 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0516741
|
US9315498, 66
Show/Hide
|
C20H19FN2O2
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0564062
|
US9315498, 61
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0380038
|
US9688669, Example 93
Show/Hide
|
C21H19FN2O3
|
1
|
| 1 |
EC50 = 77 nM
|
|
|
|
CP0478756
|
US9212171, 29
Show/Hide
|
C21H19FN2O
|
1
|
| 1 |
EC50 = 78 nM
|
|
|
|
CP0563398
|
US9315498, 142
Show/Hide
|
C20H21FN4O
|
1
|
| 1 |
EC50 = 78 nM
|
|
|
|
CP0491607
|
US9255103, 5
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 79.6 nM
|
|
|
|
CP0413553
|
US9315498, 30
Show/Hide
|
C16H14N4O2
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0547469
|
US9315498, 112
Show/Hide
|
C19H16FN3O
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0397068
|
(3-methylcyclobutyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C20H20N2OS
|
2
|
| 1 |
EC50 = 81 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0539148
|
US9255103, 26
Show/Hide
|
C21H17FN4O2
|
1
|
| 1 |
EC50 = 83 nM
|
|
|
|
CP0522619
|
US9212171, 37
Show/Hide
|
C22H22N2O
|
1
|
| 1 |
EC50 = 84 nM
|
|
|
|
CP0449734
|
(3-fluorocyclobutyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H17FN2OS
|
2
|
| 1 |
EC50 = 85 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0516740
|
US9315498, 64
Show/Hide
|
C21H22N2O2
|
1
|
| 1 |
EC50 = 87 nM
|
|
|
|
CP0545946
|
US9315498, 56
Show/Hide
|
C20H21N3O
|
1
|
| 1 |
EC50 = 87 nM
|
|
|
|
CP0522621
|
US9212171, 44
Show/Hide
|
C19H18ClN3O
|
1
|
| 1 |
EC50 = 88 nM
|
|
|
|
CP0564071
|
US9315498, 171
Show/Hide
|
C18H16N2O2
|
1
|
| 1 |
EC50 = 88 nM
|
|
|
|
CP0442290
|
US9688669, Example 88
Show/Hide
|
C19H15FN2O2
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0488844
|
US9212171, 23
Show/Hide
|
C20H19FN2O
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0575596
|
US9212171, 20
Show/Hide
|
C21H22N2O
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0413559
|
US9315498, 120
Show/Hide
|
C18H16FN3O
|
1
|
| 1 |
EC50 = 92 nM
|
|
|
|
CP0531405
|
US9212171, 19
Show/Hide
|
C21H22N2O2
|
1
|
| 1 |
EC50 = 96 nM
|
|
|
|
CP0547468
|
US9315498, 110
Show/Hide
|
C19H17F2N3O
|
1
|
| 1 |
EC50 = 96 nM
|
|
|
|
CP0446038
|
[(2R)-2-bicyclo[2.2.1]heptanyl]-[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H20ClN3O2
|
1
|
| 1 |
EC50 = 98 nM
|
|
|
|
CP0478304
|
US9212171, 13
Show/Hide
|
C21H21FN2O
|
1
|
| 1 |
EC50 = 98 nM
|
|
|
|
CP0378912
|
(3-methylphenyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C22H18N2OS
|
2
|
| 1 |
EC50 = 99 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0557865
|
[(2R)-2-bicyclo[2.2.1]heptanyl]-[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H20FN3O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0375472
|
5-(3-methylbutyl)-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
|
C19H22N2S
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0407615
|
(3-methylcyclohexyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C22H24N2OS
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0420585
|
5-(2,4-difluorophenyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
Show/Hide
|
C19H15F2N3O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0544908
|
2-[(3-fluorophenoxy)methyl]-5-(4-fluorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
Show/Hide
|
C19H15F2N3O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0522618
|
US9212171, 35
Show/Hide
|
C22H22N2O
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0539887
|
US9315498, 108
Show/Hide
|
C20H20FN3O
|
1
|
| 1 |
EC50 = 102 nM
|
|
|
|
CP0531448
|
US9212171, 46
Show/Hide
|
C19H18ClN3O
|
1
|
| 1 |
EC50 = 103 nM
|
|
|
|
CP0433420
|
5-butyl-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
|
C18H20N2S
|
2
|
| 1 |
EC50 = 110 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0379855
|
2-(2-phenylethynyl)-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C14H10N2OS
|
3
|
| 1 |
EC50 = 112 nM
|
|
|
| 2 |
EC50 = 123 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0549868
|
US9212171, 12
Show/Hide
|
C21H22N2O
|
1
|
| 1 |
EC50 = 113 nM
|
|
|
|
CP0490081
|
US9315498, 149
Show/Hide
|
C19H18FN3O2
|
1
|
| 1 |
EC50 = 114 nM
|
|
|
|
CP0403774
|
5-(2-methoxyethyl)-2-(2-phenylethynyl)-6,7-dihydro-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C17H16N2O2S
|
1
|
| 1 |
EC50 = 119 nM
|
|
|
|
CP0531843
|
[(2S)-2-bicyclo[2.2.1]heptanyl]-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)azetidin-1-yl]methanone
Show/Hide
|
C19H21N3O2
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0397096
|
4-oxochroman-7-yl benzoate
Show/Hide
|
C16H12O4
|
1
|
| 1 |
EC50 = 128 nM
|
|
|
|
CP0484157
|
oxolan-3-yl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H18N2O2S
|
2
|
| 1 |
EC50 = 130 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0380040
|
US9688669, Example 124
Show/Hide
|
C20H14Cl2F2N2O2
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0490796
|
US9212171, 6
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0554172
|
US9315498, 15
Show/Hide
|
C18H17N3O
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0515572
|
US9212171, 17
Show/Hide
|
C20H20FN3O
|
1
|
| 1 |
EC50 = 132 nM
|
|
|
|
CP0490797
|
US9212171, 7
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 137 nM
|
|
|
|
CP0518226
|
US9255103, 42
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
EC50 = 138 nM
|
|
|
|
CP0507554
|
US9315498, 166
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0418125
|
US9212171, 39
Show/Hide
|
C22H21FN2O
|
1
|
| 1 |
EC50 = 141 nM
|
|
|
|
CP0522620
|
US9212171, 43
Show/Hide
|
C22H21FN2O
|
1
|
| 1 |
EC50 = 146 nM
|
|
|
|
CP0404862
|
(3,3-difluorocyclobutyl)-[2-[2-(4-fluorophenyl)ethynyl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H15F3N2OS
|
2
|
| 1 |
EC50 = 150 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0446544
|
5-cyclohexylsulfonyl-2-(2-phenylethynyl)-4,6-dihydropyrrolo[3,4-d][1,3]thiazole
Show/Hide
|
C19H20N2O2S2
|
2
|
| 1 |
EC50 = 150 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0379856
|
(S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-[1,2,4]oxadiazol-5-yl)piperidine
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 157 nM
|
|
|
|
CP0404864
|
(6-methylpyridin-2-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H17N3OS
|
2
|
| 1 |
EC50 = 160 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0561297
|
US9255103, 1
Show/Hide
|
C20H18FN3O2
|
1
|
| 1 |
EC50 = 161 nM
|
|
|
|
CP0407032
|
cyclohexyl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H22N2OS
|
2
|
| 1 |
EC50 = 167 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0491604
|
US9255103, 3
Show/Hide
|
C20H18FN3O2
|
1
|
| 1 |
EC50 = 169 nM
|
|
|
|
CP0573293
|
US9255103, 31
Show/Hide
|
C21H16F2N4O2
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0421993
|
2-((3-chlorophenyl)ethynyl)-6-cyclohexyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C22H21ClN2O
|
2
|
| 1 |
EC50 = 171 nM
|
|
|
| 2 |
Ki = 12020 nM
|
|
|
|
CP0402508
|
US9212171, 15
Show/Hide
|
C20H21N3O
|
1
|
| 1 |
EC50 = 179 nM
|
|
|
|
CP0398075
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C18H19Cl2N3O2
|
1
|
| 1 |
EC50 = 180 nM
|
|
|
|
CP0413633
|
N-[(2R)-3,3-dimethylbutan-2-yl]-4-[(3-fluorophenyl)methoxy]benzamide
Show/Hide
|
C20H24FNO2
|
1
|
| 1 |
EC50 = 180 nM
|
|
|
|
CP0484013
|
US9212171, 21
Show/Hide
|
C20H18F2N2O
|
1
|
| 1 |
EC50 = 188 nM
|
|
|
|
CP0381592
|
(4-methylcyclohexyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C22H24N2OS
|
2
|
| 1 |
EC50 = 190 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0456909
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(3-fluoropiperidin-1-yl)methanone
Show/Hide
|
C17H18ClFN4O2
|
2
|
| 1 |
EC50 = 200 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0539146
|
US9255103, 2
Show/Hide
|
C20H18FN3O2
|
1
|
| 1 |
EC50 = 201 nM
|
|
|
|
CP0537007
|
US9315498, 157
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
EC50 = 206 nM
|
|
|
|
CP0564349
|
US9255103, 8
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 208 nM
|
|
|
|
CP0413453
|
US9255103, 39
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 209 nM
|
|
|
|
CP0505446
|
5-((2-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-oxoethoxy)methyl)thiophene-2-carbonitrile
Show/Hide
|
C18H17Cl2N3O2S
|
1
|
| 1 |
EC50 = 210 nM
|
|
|
|
CP0406787
|
US9212171, 14
Show/Hide
|
C21H21FN2O
|
1
|
| 1 |
EC50 = 212 nM
|
|
|
|
CP0397727
|
(2-methyl-1,3-thiazol-4-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H15N3OS2
|
2
|
| 1 |
EC50 = 220 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0380041
|
US9688669, Example 95
Show/Hide
|
C20H17FN2O3
|
1
|
| 1 |
EC50 = 237 nM
|
|
|
|
CP0483446
|
6-cyclopentyl-2-(o-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C22H22N2O
|
2
|
| 1 |
EC50 = 239 nM
|
|
|
| 2 |
Ki = 18790 nM
|
|
|
|
CP0505445
|
1-(4-(4-chloro-2-methylphenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C19H22ClN3O2
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0490798
|
US9212171, 10
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 247 nM
|
|
|
|
CP0479592
|
2-(2-phenylethynyl)-5-piperidin-1-ylsulfonyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazole
Show/Hide
|
C18H19N3O2S2
|
2
|
| 1 |
EC50 = 250 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0388393
|
US9688669, Example 103
Show/Hide
|
C20H17FN2O3
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0540949
|
US9255103, 18
Show/Hide
|
C22H22FN3O2
|
1
|
| 1 |
EC50 = 256 nM
|
|
|
|
CP0540945
|
US9255103, 9
Show/Hide
|
C20H18FN3O2
|
1
|
| 1 |
EC50 = 257 nM
|
|
|
|
CP0478755
|
US9212171, 26
Show/Hide
|
C20H20N2O
|
1
|
| 1 |
EC50 = 265 nM
|
|
|
|
CP0549883
|
US9255103, 10
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 269 nM
|
|
|
|
CP0406897
|
2-(benzyloxy)-1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H20ClFN2O2
|
1
|
| 1 |
EC50 = 270 nM
|
|
|
|
CP0564350
|
US9255103, 11
Show/Hide
|
C20H16F3N3O2
|
1
|
| 1 |
EC50 = 273 nM
|
|
|
|
CP0574013
|
US9315498, 4
Show/Hide
|
C18H16N2O3
|
1
|
| 1 |
EC50 = 278 nM
|
|
|
|
CP0406898
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazol-4-ylmethoxy)ethanone
Show/Hide
|
C16H17Cl2N3O2S
|
1
|
| 1 |
EC50 = 290 nM
|
|
|
|
CP0375609
|
2-[2-(3-fluorophenyl)ethynyl]-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C14H9FN2OS
|
2
|
| 1 |
EC50 = 290 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0404523
|
oxan-4-yl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C20H20N2O2S
|
2
|
| 1 |
EC50 = 290 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0413451
|
US9255103, 6
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 292 nM
|
|
|
|
CP0540958
|
US9255103, 38
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 295 nM
|
|
|
|
CP0479133
|
2-(benzyloxy)-1-(4-(2,4-difluorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H20F2N2O2
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0388389
|
US9688669, Example 105
Show/Hide
|
C21H19FN2O3
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0506316
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyridin-2-ylmethoxy)ethanone
Show/Hide
|
C18H19Cl2N3O2
|
1
|
| 1 |
EC50 = 310 nM
|
|
|
|
CP0397217
|
oxan-2-yl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C20H20N2O2S
|
2
|
| 1 |
EC50 = 320 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0515045
|
US9255103, 12
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 322 nM
|
|
|
|
CP0512594
|
US9315498, 164
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
EC50 = 329 nM
|
|
|
|
CP0451449
|
US9688669, Example 106
Show/Hide
|
C21H19FN2O3
|
1
|
| 1 |
EC50 = 330 nM
|
|
|
|
CP0540954
|
US9255103, 30
Show/Hide
|
C21H17FN4O2
|
1
|
| 1 |
EC50 = 331 nM
|
|
|
|
CP0425808
|
2-(benzyloxy)-1-(4-(4-chlorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H21ClN2O2
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0425809
|
1-(4-(2-chloro-4-fluorophenyl)piperidin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C19H20ClFN2O2
|
1
|
| 1 |
EC50 = 370 nM
|
|
|
|
CP0435773
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-piperidin-1-ylmethanone
Show/Hide
|
C17H19ClN4O2
|
2
|
| 1 |
EC50 = 370 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0377840
|
6-Cyclohexyl-2-pyridin-3-ylethynyl-7,8-dihydro-6H-1,6-naphthyridin-5-one
Show/Hide
|
C21H21N3O
|
2
|
| 1 |
EC50 = 387 nM
|
|
|
| 2 |
Ki = 15610 nM
|
|
|
|
CP0529257
|
US9315498, 14
Show/Hide
|
C19H18N2O2
|
1
|
| 1 |
EC50 = 388 nM
|
|
|
|
CP0505448
|
1-(4-(2,4-dichlorophenyl)piperidin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C19H20Cl2N2O2
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0508920
|
US9212171, 8
Show/Hide
|
C19H18FN3O
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0460695
|
2-((2-chlorophenyl)ethynyl)-6-cyclopentyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C21H19ClN2O
|
2
|
| 1 |
EC50 = 393 nM
|
|
|
| 2 |
Ki > 32000 nM
|
|
|
|
CP0513233
|
[(2R)-2-bicyclo[2.2.1]heptanyl]-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)azetidin-1-yl]methanone
Show/Hide
|
C19H21N3O2
|
1
|
| 1 |
EC50 = 400 nM
|
|
|
|
CP0521492
|
US9255103, 7
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 406 nM
|
|
|
|
CP0376731
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(3-methylcyclohexyl)methanone
Show/Hide
|
C19H22ClN3O2
|
2
|
| 1 |
EC50 = 410 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0412263
|
US9212171, 18
Show/Hide
|
C20H20N2O2
|
1
|
| 1 |
EC50 = 414 nM
|
|
|
|
CP0491605
|
US9255103, 4
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 414 nM
|
|
|
|
CP0540952
|
US9255103, 25
Show/Hide
|
C21H18N4O2
|
1
|
| 1 |
EC50 = 457 nM
|
|
|
|
CP0377842
|
6-cyclopentyl-2-((3-methoxyphenyl)ethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C22H22N2O2
|
2
|
| 1 |
EC50 = 462 nM
|
|
|
| 2 |
Ki > 32000 nM
|
|
|
|
CP0422043
|
6-cyclohexyl-2-(o-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C23H24N2O
|
2
|
| 1 |
EC50 = 466 nM
|
|
|
| 2 |
Ki > 32000 nM
|
|
|
|
CP0381590
|
2-(oxan-4-yl)-1-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]ethanone
Show/Hide
|
C21H22N2O2S
|
2
|
| 1 |
EC50 = 470 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0381280
|
(3-methylcyclohexyl)-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C20H25N3O2
|
2
|
| 1 |
EC50 = 500 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0442967
|
[4,4-dimethyl-2-(phenoxymethyl)-6,7-dihydro-[1,3]oxazolo[5,4-c]pyridin-5-yl]-(4-fluorophenyl)methanone
Show/Hide
|
C22H21FN2O3
|
1
|
| 1 |
EC50 = 510 nM
|
|
|
|
CP0381287
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-cyclohexylmethanone
Show/Hide
|
C18H20ClN3O2
|
2
|
| 1 |
EC50 = 520 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0453884
|
(4,4-difluorocyclohexyl)-[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C18H18F3N3O2
|
2
|
| 1 |
EC50 = 520 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0504590
|
(4-fluorophenyl)-[6-methyl-2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H19FN2O3
|
1
|
| 1 |
EC50 = 520 nM
|
|
|
|
CP0476968
|
US9212171, 5
Show/Hide
|
C27H25N3O3
|
1
|
| 1 |
EC50 = 528 nM
|
|
|
|
CP0200315
|
[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(2-methylcyclohexyl)methanone
Show/Hide
|
C19H22FN3O2
|
2
|
| 1 |
EC50 = 540 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0088839
|
1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C18H19ClFN3O2
|
1
|
| 1 |
EC50 = 550 nM
|
|
|
|
CP0516192
|
US9255103, 56
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 550 nM
|
|
|
|
CP0540959
|
US9255103, 43
Show/Hide
|
C22H20N4O2
|
1
|
| 1 |
EC50 = 562 nM
|
|
|
|
CP0504666
|
2-(benzyloxy)-1-(4-(4-chloropyridin-2-yl)piperazin-1-yl)ethanone
Show/Hide
|
C18H20ClN3O2
|
1
|
| 1 |
EC50 = 570 nM
|
|
|
|
CP0508932
|
US9212171, 16
Show/Hide
|
C20H20FN3O
|
1
|
| 1 |
EC50 = 573 nM
|
|
|
|
CP0573291
|
US9255103, 13
Show/Hide
|
C20H16F3N3O2
|
1
|
| 1 |
EC50 = 587 nM
|
|
|
|
CP0484863
|
(4,4-difluorocyclohexyl)-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H21F2N3O2
|
2
|
| 1 |
EC50 = 590 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0506317
|
1-(4-(4-chloro-2-fluorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C18H19ClFN3O2
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0433436
|
(3-methoxycyclobutyl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C20H20N2O2S
|
2
|
| 1 |
EC50 = 640 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0533448
|
1-(4-(4-chlorophenyl)piperidin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C19H21ClN2O2
|
1
|
| 1 |
EC50 = 680 nM
|
|
|
|
CP0376728
|
[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-[4-(trifluoromethyl)cyclohexyl]methanone
Show/Hide
|
C19H19F4N3O2
|
2
|
| 1 |
EC50 = 680 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0564861
|
US9315498, 162
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
EC50 = 681 nM
|
|
|
|
CP0437333
|
7-(phenylethynyl)chroman-4-one
Show/Hide
|
C17H12O2
|
1
|
| 1 |
EC50 = 682 nM
|
|
|
|
CP0540960
|
US9255103, 44
Show/Hide
|
C22H19FN4O2
|
1
|
| 1 |
EC50 = 692 nM
|
|
|
|
CP0483449
|
6-cyclopentyl-2-(pyridin-3-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C20H19N3O
|
2
|
| 1 |
EC50 = 748 nM
|
|
|
| 2 |
Ki > 32000 nM
|
|
|
|
CP0385654
|
(4-fluorophenyl)-[4-methyl-2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H19FN2O3
|
1
|
| 1 |
EC50 = 750 nM
|
|
|
|
CP0409822
|
1-[2-(phenoxymethyl)-7,8-dihydro-6H-imidazo[1,2-b]pyridazin-5-yl]ethanone
Show/Hide
|
C15H17N3O2
|
1
|
| 1 |
EC50 = 780 nM
|
|
|
|
CP0407052
|
oxolan-2-yl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H18N2O2S
|
2
|
| 1 |
EC50 = 790 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0409823
|
1-[5-methyl-2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C16H19N3O2
|
1
|
| 1 |
EC50 = 794 nM
|
|
|
|
CP0398076
|
1-(4-(4-chlorophenyl)-4-fluoropiperidin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C19H20ClFN2O2
|
1
|
| 1 |
EC50 = 800 nM
|
|
|
|
CP0455244
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4-methylpiperidin-1-yl)methanone
Show/Hide
|
C18H21ClN4O2
|
2
|
| 1 |
EC50 = 865 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0402994
|
1-[2-(phenoxymethyl)-6,7-dihydro-5H-[1,3]thiazolo[5,4-b]pyridin-4-yl]ethanone
Show/Hide
|
C15H16N2O2S
|
1
|
| 1 |
EC50 = 888 nM
|
|
|
|
CP0460697
|
2-((2-chlorophenyl)ethynyl)-6-cyclohexyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C22H21ClN2O
|
2
|
| 1 |
EC50 = 924 nM
|
|
|
| 2 |
Ki > 32000 nM
|
|
|
|
CP0486593
|
cyclohexyl-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H23N3O2
|
2
|
| 1 |
EC50 = 950 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0133913
|
7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one
Show/Hide
|
C16H14O3
|
1
|
| 1 |
EC50 = 950 nM
|
|
|
|
CP0456971
|
(4-methylcyclohexyl)-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C20H25N3O2
|
2
|
| 1 |
EC50 = 970 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0425858
|
2-((4-chlorophenyl)ethynyl)-6-cyclopentyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C21H19ClN2O
|
2
|
| 1 |
EC50 = 979 nM
|
|
|
| 2 |
Ki > 32000 nM
|
|
|
|
CP0490795
|
US9212171, 2
Show/Hide
|
C19H19N3O
|
1
|
| 1 |
EC50 = 981 nM
|
|
|
|
CP0488583
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4-fluoropiperidin-1-yl)methanone
Show/Hide
|
C17H18ClFN4O2
|
2
|
| 1 |
EC50 = 990 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0523800
|
2-(benzyloxy)-1-(4-(2,4-dichlorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H20Cl2N2O2
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0484867
|
cyclohexyl-[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C18H20FN3O2
|
2
|
| 1 |
EC50 = 1000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0486589
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-[4-(trifluoromethyl)cyclohexyl]methanone
Show/Hide
|
C19H19ClF3N3O2
|
2
|
| 1 |
EC50 = 1000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0491249
|
[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-[4-(trifluoromethyl)cyclohexyl]methanone
Show/Hide
|
C20H22F3N3O2
|
2
|
| 1 |
EC50 = 1000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0483448
|
6-isopropyl-2-(p-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C20H20N2O
|
2
|
| 1 |
EC50 = 1012 nM
|
|
|
| 2 |
Ki = 20180 nM
|
|
|
|
CP0411995
|
US9255103, 33
Show/Hide
|
C21H16F2N4O2
|
1
|
| 1 |
EC50 = 1047 nM
|
|
|
|
CP0521493
|
US9255103, 19
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
EC50 = 1067 nM
|
|
|
|
CP0425810
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyridin-3-ylmethoxy)ethanone
Show/Hide
|
C18H19Cl2N3O2
|
1
|
| 1 |
EC50 = 1090 nM
|
|
|
|
CP0425811
|
2-(benzyloxy)-1-(4-(2-chlorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H21ClN2O2
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0505449
|
2-(benzyloxy)-1-(4-(4-fluorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H21FN2O2
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0456908
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-spiro[3.5]nonan-7-ylmethanone
Show/Hide
|
C21H24ClN3O2
|
2
|
| 1 |
EC50 = 1100 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0531751
|
2-(4-fluorophenyl)-1-[(2S)-2-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]ethanone
Show/Hide
|
C19H15F2N3O2
|
2
|
| 1 |
EC50 = 1200 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0375477
|
(1-methylpiperidin-4-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C21H23N3OS
|
2
|
| 1 |
EC50 = 1200 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0398077
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazol-5-ylmethoxy)ethanone
Show/Hide
|
C16H17Cl2N3O2S
|
1
|
| 1 |
EC50 = 1280 nM
|
|
|
|
CP0561298
|
US9255103, 21
Show/Hide
|
C19H15F3N4O2
|
1
|
| 1 |
EC50 = 1281 nM
|
|
|
|
CP0398078
|
1-(4-(4-chlorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C18H20ClN3O2
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0508787
|
1-[2-(phenoxymethyl)-6,7-dihydro-5H-[1,3]oxazolo[5,4-b]pyridin-4-yl]ethanone
Show/Hide
|
C15H16N2O3
|
1
|
| 1 |
EC50 = 1345 nM
|
|
|
|
CP0411993
|
US9255103, 23
Show/Hide
|
C19H16F2N4O2
|
1
|
| 1 |
EC50 = 1372 nM
|
|
|
|
CP0456907
|
(4-fluorophenyl)-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H16FN3O2
|
2
|
| 1 |
EC50 = 1400 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0436802
|
(3,4-difluorophenyl)-[(2S)-2-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H15F2N3O2
|
2
|
| 1 |
EC50 = 1500 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0486590
|
[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4-methylcyclohexyl)methanone
Show/Hide
|
C19H22ClN3O2
|
2
|
| 1 |
EC50 = 1500 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0397070
|
2-[2-(2-fluorophenyl)ethynyl]-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C14H9FN2OS
|
2
|
| 1 |
EC50 = 1500 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0455966
|
(5-methyl-1,2-oxazol-3-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H15N3O2S
|
2
|
| 1 |
EC50 = 1600 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0515046
|
US9255103, 28
Show/Hide
|
C21H17FN4O2
|
1
|
| 1 |
EC50 = 1660 nM
|
|
|
|
CP0518224
|
US9255103, 32
Show/Hide
|
C21H16F2N4O2
|
1
|
| 1 |
EC50 = 1778 nM
|
|
|
|
CP0529941
|
US9255103, 59
Show/Hide
|
C21H20FN3O3
|
1
|
| 1 |
EC50 = 1820 nM
|
|
|
|
CP0488580
|
2-(4-fluorophenyl)-1-[(2S)-2-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]ethanone
Show/Hide
|
C20H18FN3O2
|
2
|
| 1 |
EC50 = 1900 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0523801
|
1-(4-(4-chlorophenyl)-4-methylpiperidin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C20H23ClN2O2
|
1
|
| 1 |
EC50 = 2100 nM
|
|
|
|
CP0379848
|
7-(phenoxymethyl)chroman-4-one
Show/Hide
|
C16H14O3
|
1
|
| 1 |
EC50 = 2140 nM
|
|
|
|
CP0488586
|
[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4-methylcyclohexyl)methanone
Show/Hide
|
C19H22FN3O2
|
2
|
| 1 |
EC50 = 2200 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0376727
|
(4-fluorophenyl)-[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C18H13F2N3O2
|
2
|
| 1 |
EC50 = 2400 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0523567
|
2-(3-fluorophenyl)-1-[(2S)-2-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]ethanone
Show/Hide
|
C19H15F2N3O2
|
2
|
| 1 |
EC50 = 2400 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0381278
|
(4-chlorophenyl)-[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C18H13ClFN3O2
|
2
|
| 1 |
EC50 = 2500 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0397076
|
2-[2-(3-chlorophenyl)ethynyl]-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C14H9ClN2OS
|
2
|
| 1 |
EC50 = 2500 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0570655
|
US9255103, 53
Show/Hide
|
C21H17F4N3O2
|
1
|
| 1 |
EC50 = 2630 nM
|
|
|
|
CP0425812
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrimidin-4-ylmethoxy)ethanone
Show/Hide
|
C17H18Cl2N4O2
|
1
|
| 1 |
EC50 = 2800 nM
|
|
|
|
CP0540951
|
US9255103, 22
Show/Hide
|
C20H19FN4O2
|
1
|
| 1 |
EC50 = 2907 nM
|
|
|
|
CP0425501
|
US9255103, 20
Show/Hide
|
C19H16F2N4O2
|
1
|
| 1 |
EC50 = 2950 nM
|
|
|
|
CP0517836
|
US9255103, 55
Show/Hide
|
C20H17ClFN3O2
|
1
|
| 1 |
EC50 = 2951 nM
|
|
|
|
CP0413452
|
US9255103, 34
Show/Hide
|
C18H16FN5O2
|
1
|
| 1 |
EC50 = 3020 nM
|
|
|
|
CP0516193
|
US9255103, 57
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
EC50 = 3020 nM
|
|
|
|
CP0491608
|
US9255103, 24
Show/Hide
|
C20H19FN4O2
|
1
|
| 1 |
EC50 = 3026 nM
|
|
|
|
CP0507174
|
(3,4-difluorophenyl)-[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C18H12F3N3O2
|
2
|
| 1 |
EC50 = 3200 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0459032
|
1-[3-fluoro-2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C15H16FN3O2
|
1
|
| 1 |
EC50 = 3236 nM
|
|
|
|
CP0531345
|
1-[2-(phenoxymethyl)-6,7-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C14H16N4O2
|
1
|
| 1 |
EC50 = 3400 nM
|
|
|
|
CP0406899
|
1-(4-(4-chloropyridin-2-yl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C17H19ClN4O2
|
1
|
| 1 |
EC50 = 4200 nM
|
|
|
|
CP0054278
|
2-[2-chloro-N-methylsulfonyl-5-(trifluoromethyl)anilino]-N-(cyclopropylmethyl)acetamide
Show/Hide
|
C14H16ClF3N2O3S
|
1
|
| 1 |
EC50 = 4500 nM
|
|
|
|
CP0517837
|
US9255103, 58
Show/Hide
|
C20H19FN4O2
|
1
|
| 1 |
EC50 = 4571 nM
|
|
|
|
CP0398083
|
1-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C18H19F2N3O2
|
1
|
| 1 |
EC50 = 4600 nM
|
|
|
|
CP0002355
|
(2S)-2-aminopentanedioic acid
Show/Hide
|
C5H9NO4
|
2
|
| 1 |
EC50 = 4700 nM
|
|
|
| 2 |
Ki = 4677.35 nM
|
|
|
|
CP0395182
|
6-cyclopentyl-2-(p-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C22H22N2O
|
2
|
| 1 |
EC50 = 4816 nM
|
|
|
| 2 |
Ki > 32000 nM
|
|
|
|
CP0502949
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrazin-2-ylmethoxy)ethanone
Show/Hide
|
C17H18Cl2N4O2
|
1
|
| 1 |
EC50 = 5200 nM
|
|
|
|
CP0397069
|
2-[2-(4-fluorophenyl)ethynyl]-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C14H9FN2OS
|
2
|
| 1 |
EC50 = 5200 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0533450
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-4-(pyridin-4-yl)butan-1-one
Show/Hide
|
C19H21Cl2N3O
|
1
|
| 1 |
EC50 = 5300 nM
|
|
|
|
CP0390298
|
1-[2-(phenoxymethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C21H21N3O2
|
1
|
| 1 |
EC50 = 5370 nM
|
|
|
|
CP0522140
|
1-(4-(2,4-dichlorophenyl)-4-fluoropiperidin-1-yl)-2-(pyridin-4-ylmethoxy)ethanone
Show/Hide
|
C19H19Cl2FN2O2
|
1
|
| 1 |
EC50 = 6600 nM
|
|
|
|
CP0508066
|
2-(benzyloxy)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H21ClN2O2
|
1
|
| 1 |
EC50 = 6700 nM
|
|
|
|
CP0488577
|
[3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4-methylphenyl)methanone
Show/Hide
|
C19H16FN3O2
|
2
|
| 1 |
EC50 = 6800 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0505451
|
2-(benzyloxy)-1-(4-phenylpiperazin-1-yl)ethanone
Show/Hide
|
C19H22N2O2
|
1
|
| 1 |
EC50 = 7100 nM
|
|
|
|
CP0533451
|
2-(benzylthio)-1-(4-(2,4-dichlorophenyl)piperazin-1-yl)ethanone
Show/Hide
|
C19H20Cl2N2OS
|
1
|
| 1 |
EC50 = 7100 nM
|
|
|
|
CP0381277
|
(4-chlorophenyl)-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
|
C19H16ClN3O2
|
2
|
| 1 |
EC50 = 7100 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0387089
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyridin-4-ylmethylamino)ethanone
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C18H20Cl2N4O
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1
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| 1 |
EC50 = 8500 nM
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CP0395181
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N-cyclopentyl-6-(2-pyridin-3-ylethynyl)pyridine-3-carboxamide
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C18H17N3O
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
Ki > 32000 nM
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CP0376724
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4-methoxypiperidin-1-yl)methanone
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C18H21ClN4O3
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 > 10000 nM
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CP0376726
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(3-methoxypiperidin-1-yl)methanone
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C18H21ClN4O3
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1830 nM
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CP0381279
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5-[1-(4-fluorophenyl)sulfonylazetidin-3-yl]-3-(3-methylphenyl)-1,2,4-oxadiazole
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C18H16FN3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 950 nM
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CP0381281
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(3-methylpiperidin-1-yl)methanone
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C18H21ClN4O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 3400 nM
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CP0381282
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(3-methylpyrrolidin-1-yl)methanone
Show/Hide
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C17H19ClN4O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 > 10000 nM
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CP0381283
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(2-fluorophenyl)-[(2S)-2-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
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C18H13F2N3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 920 nM
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CP0381285
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(2-fluorophenyl)-[(2S)-2-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
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C19H16FN3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1800 nM
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CP0381286
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4-[(2S)-2-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidine-1-carbonyl]benzonitrile
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C20H16N4O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1400 nM
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CP0381288
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(oxolan-2-yl)methanone
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C16H16ClN3O3
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 890 nM
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CP0396498
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3-(3-methylphenyl)-5-[1-(3-methylphenyl)sulfonylazetidin-3-yl]-1,2,4-oxadiazole
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C19H19N3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 650 nM
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CP0435751
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(3-fluorophenyl)methanone
Show/Hide
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C18H13ClFN3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 780 nM
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CP0436803
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(4-fluorophenyl)methanone
Show/Hide
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C18H13ClFN3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 4000 nM
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CP0436804
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[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(oxolan-3-yl)methanone
Show/Hide
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C17H19N3O3
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1300 nM
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CP0436805
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[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(oxolan-2-yl)methanone
Show/Hide
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C17H19N3O3
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1900 nM
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CP0436806
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-cyclobutylmethanone
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C16H16ClN3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1500 nM
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CP0446826
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(2-fluorophenyl)-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
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C19H16FN3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1400 nM
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CP0446827
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3-(3-methylphenyl)-5-[1-(4-methylphenyl)sulfonylazetidin-3-yl]-1,2,4-oxadiazole
Show/Hide
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C19H19N3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 670 nM
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CP0446828
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5-[1-(4-chlorophenyl)sulfonylazetidin-3-yl]-3-(3-methylphenyl)-1,2,4-oxadiazole
Show/Hide
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C18H16ClN3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1100 nM
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CP0453883
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[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(oxan-4-yl)methanone
Show/Hide
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C18H21N3O3
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1800 nM
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CP0455226
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cyclopentyl-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
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C18H21N3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 2500 nM
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CP0456905
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3-(3-chlorophenyl)-5-[1-(4-chlorophenyl)sulfonylazetidin-3-yl]-1,2,4-oxadiazole
Show/Hide
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C17H13Cl2N3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 170 nM
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CP0484866
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3-(3-chlorophenyl)-5-[1-(3-methylphenyl)sulfonylazetidin-3-yl]-1,2,4-oxadiazole
Show/Hide
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C18H16ClN3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 390 nM
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CP0486592
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(2,6-dimethylmorpholin-4-yl)methanone
Show/Hide
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C18H21ClN4O3
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 990 nM
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CP0488581
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(3-fluorophenyl)-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
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C19H16FN3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 2100 nM
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CP0488582
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3-(3-chlorophenyl)-5-[1-(4-methylphenyl)sulfonylazetidin-3-yl]-1,2,4-oxadiazole
Show/Hide
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C18H16ClN3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 920 nM
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CP0513111
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[3-[3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-(2-fluorophenyl)methanone
Show/Hide
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C18H13ClFN3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 670 nM
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CP0513234
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3-(3-chlorophenyl)-5-[1-(4-fluorophenyl)sulfonylazetidin-3-yl]-1,2,4-oxadiazole
Show/Hide
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C17H13ClFN3O3S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 130 nM
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CP0523566
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cyclobutyl-[3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone
Show/Hide
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C17H19N3O2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1000 nM
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CP0379956
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2-(2-chloro-N-methylsulfonylanilino)-N-(2-fluoropyridin-3-yl)acetamide
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C14H13ClFN3O3S
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1
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| 1 |
EC50 > 10000 nM
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CP0379958
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2-(2-chloro-N-methylsulfonylanilino)-N-(6-fluoropyridin-3-yl)acetamide
Show/Hide
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C14H13ClFN3O3S
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1
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| 1 |
EC50 > 10000 nM
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CP0392496
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3-(4-fluorophenyl)-5-[(3S)-1-(4-fluorophenyl)sulfonylpiperidin-3-yl]-1,2,4-oxadiazole
Show/Hide
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C19H17F2N3O3S
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1
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| 1 |
EC50 > 10000 nM
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CP0375475
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5-cyclopentyl-2-[2-(3-fluorophenyl)ethynyl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C19H19FN2S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 640 nM
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CP0375604
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2-(2-phenylethynyl)-5-pyrrolidin-1-ylsulfonyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C18H19N3O2S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 36 nM
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CP0375605
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2-[2-(3-methylphenyl)ethynyl]-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
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C15H12N2OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 > 10000 nM
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CP0375651
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2-(2-phenylethynyl)-5-propan-2-ylsulfonyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazole
Show/Hide
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C16H16N2O2S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 140 nM
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CP0376474
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1-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]propan-1-one
Show/Hide
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C17H16N2OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 38 nM
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CP0376475
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1-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]ethanone
Show/Hide
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C16H14N2OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 90 nM
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CP0381040
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5-cyclobutyl-2-[2-(3-fluorophenyl)ethynyl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C18H17FN2S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 200 nM
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CP0381083
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2-[2-(3-fluorophenyl)ethynyl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C15H13FN2S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 > 10000 nM
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CP0381102
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2-(2-phenylethynyl)-5-propan-2-ylsulfonyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C17H18N2O2S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 11 nM
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CP0396241
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5-cyclopropyl-2-(2-phenylethynyl)-4H-pyrrolo[3,4-d][1,3]thiazol-6-one
Show/Hide
|
C16H12N2OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 23 nM
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CP0397071
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(3-fluoroazetidin-1-yl)-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C18H16FN3OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 > 10000 nM
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CP0397072
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4-[[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]sulfonyl]morpholine
Show/Hide
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C18H19N3O3S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 13 nM
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CP0397074
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2-[2-(3-fluorophenyl)ethynyl]-5-(oxolan-3-yl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C18H17FN2OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 400 nM
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CP0397075
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2-[2-(2-methoxyphenyl)ethynyl]-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
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C15H12N2O2S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 > 10000 nM
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CP0397082
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cyclobutyl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H18N2OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 370 nM
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CP0433422
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N,N-dimethyl-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-sulfonamide
Show/Hide
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C16H17N3O2S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 5.7 nM
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CP0433423
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5-cyclohexylsulfonyl-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C20H22N2O2S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 480 nM
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CP0449866
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5-cyclohexyl-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C20H22N2S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 > 10000 nM
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CP0464017
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5-ethyl-2-[2-(3-fluorophenyl)ethynyl]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C16H15FN2S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 72 nM
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CP0464068
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5-(2-methylpropyl)-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
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C18H20N2S
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 650 nM
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CP0466846
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5-cyclopropylsulfonyl-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
|
C17H16N2O2S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 34 nM
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CP0468587
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5-ethyl-2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
|
C16H16N2S
|
2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 1200 nM
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CP0487625
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cyclopropyl-[2-(2-phenylethynyl)-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C18H16N2OS
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 290 nM
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CP0501340
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2-(2-phenylethynyl)-5-piperidin-1-ylsulfonyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
Show/Hide
|
C19H21N3O2S2
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2
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| 1 |
EC50 > 10000 nM
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| 2 |
IC50 = 780 nM
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CP0086086
|
Benzoic acid
Show/Hide
|
C7H6O2
|
1
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| 1 |
EC50 > 10000 nM
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CP0526567
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6-hydroxy-3,4-dihydrochromen-2-one
Show/Hide
|
C9H8O3
|
1
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| 1 |
EC50 > 10000 nM
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CP0385650
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1H-indol-2-yl-[2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
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C22H19N3O3
|
1
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| 1 |
EC50 > 10000 nM
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CP0409530
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[2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]-(1H-pyrazolo[4,3-b]pyridin-3-yl)methanone
Show/Hide
|
C20H17N5O3
|
1
|
| 1 |
EC50 > 10000 nM
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CP0428487
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(4-fluorophenyl)-[2-(pyridin-3-yloxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone
Show/Hide
|
C19H16FN3O3
|
1
|
| 1 |
EC50 > 10000 nM
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CP0389360
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1-[2-(3,4-dihydro-2H-quinolin-1-ylmethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C18H22N4O
|
1
|
| 1 |
EC50 > 10000 nM
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CP0390391
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[2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]-pyridin-4-ylmethanone
Show/Hide
|
C19H18N4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
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CP0390405
|
1-[2-(anilinomethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C15H18N4O
|
1
|
| 1 |
EC50 > 10000 nM
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CP0402985
|
3-[(4-acetyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-2-yl)methoxy]-5-fluorobenzonitrile
Show/Hide
|
C16H15FN4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
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CP0402989
|
[2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]-pyridin-2-ylmethanone
Show/Hide
|
C19H18N4O2
|
1
|
| 1 |
EC50 > 10000 nM
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|
|
CP0459029
|
1-[2-[(4-fluorophenoxy)methyl]-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C15H16FN3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0540946
|
US9255103, 14
Show/Hide
|
C20H19FN4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0570653
|
US9255103, 36
Show/Hide
|
C18H16FN5O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0572412
|
US9255103, 29
Show/Hide
|
C19H17ClN4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0522063
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazol-2-ylmethoxy)ethanone
Show/Hide
|
C16H17Cl2N3O2S
|
1
|
| 1 |
EC50 = 10300 nM
|
|
|
|
CP0493849
|
1-(4-(4-fluoro-2-chlorophenyl)piperidin-1-yl)-2-(pyridin-4-ylmethoxy)ethanethione
Show/Hide
|
C19H20ClFN2OS
|
1
|
| 1 |
EC50 > 10600 nM
|
|
|
|
CP0387087
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrimidin-2-ylmethoxy)ethanone
Show/Hide
|
C17H18Cl2N4O2
|
1
|
| 1 |
EC50 = 18000 nM
|
|
|
|
CP0876173
|
Cis-1-Amino-2-carboxymethyl-cyclopropanecarboxylic acid
Show/Hide
|
C6H9NO4
|
2
|
| 1 |
EC50 = 19000 nM
|
|
|
| 2 |
Ki = 19054.61 nM
|
|
|
|
CP0398084
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(phenylthio)ethanone
Show/Hide
|
C18H18Cl2N2OS
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0398085
|
(R)-1-(4-(4-chloro-2-fluorophenyl)piperidin-1-yl)-2-(pyridin-4-ylmethoxy)propan-1-one
Show/Hide
|
C20H22ClFN2O2
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0400059
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(methyl(pyridin-4-ylmethyl)amino)ethanone
Show/Hide
|
C19H22Cl2N4O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0508068
|
2-(benzyloxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
Show/Hide
|
C18H21N3O2
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0533449
|
1-(2-(benzyloxy)ethyl)-4-(2,4-dichlorophenyl)piperazine
Show/Hide
|
C19H22Cl2N2O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0531591
|
US9255103, 37
Show/Hide
|
C19H18FN5O2
|
1
|
| 1 |
EC50 > 30200 nM
|
|
|
|
CP0540947
|
US9255103, 15
Show/Hide
|
C20H19FN4O2
|
1
|
| 1 |
EC50 > 30200 nM
|
|
|
|
CP0540957
|
US9255103, 35
Show/Hide
|
C19H18FN5O2
|
1
|
| 1 |
EC50 > 30200 nM
|
|
|
|
CP0540962
|
US9255103, 54
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
EC50 > 30200 nM
|
|
|
|
CP0573292
|
US9255103, 27
Show/Hide
|
C21H17FN4O2
|
1
|
| 1 |
EC50 > 30200 nM
|
|
|
|
CP0390299
|
1-[2-(benzenesulfonylmethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C15H17N3O3S
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
|
CP0390394
|
1-[2-(benzenesulfinylmethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C15H17N3O2S
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
|
CP0402988
|
1-[2-(2,3-dihydroindol-1-ylmethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C17H20N4O
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
|
CP0402990
|
furan-2-yl-[2-(phenoxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]methanone
Show/Hide
|
C18H17N3O3
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
|
CP0414113
|
1-[2-[[2-bicyclo[1.1.1]pentanyl(methyl)amino]methyl]-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C15H22N4O
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
|
CP0458999
|
1-[2-(pyridin-3-yloxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C14H16N4O2
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
|
CP0524291
|
1-[2-(pyridin-4-yloxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-4-yl]ethanone
Show/Hide
|
C14H16N4O2
|
1
|
| 1 |
EC50 > 31622.78 nM
|
|
|
|
CP0505447
|
1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiophen-2-ylmethoxy)ethanone
Show/Hide
|
C17H18Cl2N2O2S
|
1
|
| 1 |
EC50 > 310 nM
|
|
|
|
CP0442291
|
US9688669, Example 101
Show/Hide
|
C22H21FN2O4
|
1
|
| 1 |
EC50 > 1600 nM
|
|
|
|
CP0442293
|
US9688669, Example 104
Show/Hide
|
C20H17FN2O3
|
1
|
| 1 |
EC50 > 1600 nM
|
|
|
|
CP0883848
|
(4R,5R)-5-Phenyl-4-(4-(phenylethynyl)pyridin-2-yl)oxazolidin-2-one
Show/Hide
|
C22H16N2O2
|
2
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0530766
|
(4R,5R)-5-(2-chlorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H15ClN2O2
|
2
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0533025
|
(4R,5R)-5-(2,6-difluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H14F2N2O2
|
3
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
| 3 |
Ki = 2.7 nM
|
|
|
|
CP0380029
|
US9688669, Example 96
Show/Hide
|
C19H15FN2O3
|
1
|
| 1 |
EC50 > 3200 nM
|
|
|
|
CP0388391
|
US9688669, Example 94
Show/Hide
|
C20H17FN2O3
|
1
|
| 1 |
EC50 > 3200 nM
|
|
|
|
CP0442292
|
US9688669, Example 102
Show/Hide
|
C20H15FN2O3
|
1
|
| 1 |
EC50 > 3200 nM
|
|
|
|
CP0442294
|
US9688669, Example 110
Show/Hide
|
C21H18F2N2O3
|
1
|
| 1 |
EC50 > 3200 nM
|
|
|
|
CP0451987
|
US9688669, Example 117
Show/Hide
|
C20H14F4N2O2
|
1
|
| 1 |
EC50 > 3200 nM
|
|
|
|
CP0454684
|
US9688669, Example 109
Show/Hide
|
C20H14F4N2O2
|
1
|
| 1 |
EC50 > 3200 nM
|
|
|
|
CP0518135
|
US9688669, Example 99
Show/Hide
|
C20H16F2N2O2
|
1
|
| 1 |
EC50 > 3200 nM
|
|
|
|
CP0488300
|
US8921370, 126
Show/Hide
|
C21H24N4O2
|
1
|
| 1 |
IC50 = 0.32 nM
|
|
|
|
CP0443629
|
3-chloro-4-fluoro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C16H7ClF2N4
|
2
|
| 1 |
IC50 = 0.3981 nM
|
|
|
| 2 |
Ki = 0.7943 nM
|
|
|
|
CP0066697
|
3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C16H8ClFN4
|
2
|
| 1 |
IC50 = 0.631 nM
|
|
|
| 2 |
Ki = 0.5012 nM
|
|
|
|
CP0443627
|
6-[6-(3-chloro-5-cyanophenyl)pyrimidin-4-yl]pyridine-3-carbonitrile
Show/Hide
|
C17H8ClN5
|
2
|
| 1 |
IC50 = 0.631 nM
|
|
|
| 2 |
Ki = 0.631 nM
|
|
|
|
CP0438411
|
5-(4-fluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0426305
|
US9212165, 3
Show/Hide
|
C21H20FN3O
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0385751
|
3-chloro-4-fluoro-5-(6-pyridin-2-ylpyrimidin-4-yl)benzonitrile
Show/Hide
|
C16H8ClFN4
|
2
|
| 1 |
IC50 = 1.585 nM
|
|
|
| 2 |
Ki = 1.259 nM
|
|
|
|
CP0412258
|
US9212165, 16
Show/Hide
|
C21H21N3O
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0426646
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H18ClN3OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0191235
|
2-Methyl-6-(phenylethynyl)pyridine
Show/Hide
|
C14H11N
|
4
|
| 1 |
IC50 = 2.3 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
| 3 |
Kd = 8.6 nM
|
|
|
| 4 |
Ki = 3.4 nM
|
|
|
|
CP0553420
|
5-(3,4-dichlorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H16Cl2N4O
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0498903
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]but-3-enyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C19H18ClN5OS
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0392590
|
3-chloro-4-fluoro-5-(6-pyrazol-1-ylpyrimidin-4-yl)benzonitrile
Show/Hide
|
C14H7ClFN5
|
2
|
| 1 |
IC50 = 2.512 nM
|
|
|
| 2 |
Ki = 0.5012 nM
|
|
|
|
CP0420543
|
3-chloro-5-(6-pyridin-2-ylpyrimidin-4-yl)benzonitrile
Show/Hide
|
C16H9ClN4
|
2
|
| 1 |
IC50 = 2.512 nM
|
|
|
| 2 |
Ki = 3.162 nM
|
|
|
|
CP0420547
|
5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzene-1,3-dicarbonitrile
Show/Hide
|
C17H8FN5
|
2
|
| 1 |
IC50 = 2.512 nM
|
|
|
| 2 |
Ki = 1.585 nM
|
|
|
|
CP0460694
|
6-methyl-2-(m-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C18H16N2O
|
2
|
| 1 |
IC50 = 2.9 nM
|
|
|
| 2 |
Ki = 820 nM
|
|
|
|
CP0477472
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(5-methyl-1,2-oxazol-3-yl)methanone
Show/Hide
|
C21H20ClN3O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0443628
|
3-chloro-5-[6-(5-chloropyridin-2-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C16H8Cl2N4
|
2
|
| 1 |
IC50 = 3.162 nM
|
|
|
| 2 |
Ki = 1.585 nM
|
|
|
|
CP0527752
|
5-(2,4-difluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H16F2N4O
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0506854
|
US8921370, 2
Show/Hide
|
C22H24ClN3O2
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0438410
|
5-(4-chlorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H17ClN4O
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0414266
|
US9212165, 58
Show/Hide
|
C23H24N4O
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0537023
|
US8921370, 160
Show/Hide
|
C21H23FN4O2
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0513225
|
5-(3,4-difluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H16F2N4O
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0205916
|
1,4-dimethyl-N-(6-methylpyridin-2-yl)-5-phenylpyrazole-3-carboxamide
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0438409
|
5-(3-chlorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H17ClN4O
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0506855
|
US8921370, 171
Show/Hide
|
C20H24N4O2S
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0460699
|
6-isopropyl-2-(m-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C20H20N2O
|
2
|
| 1 |
IC50 = 4.8 nM
|
|
|
| 2 |
Ki = 510 nM
|
|
|
|
CP0468834
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C19H16ClN3OS
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0361501
|
3-chloro-5-(6-pyrazol-1-ylpyrimidin-4-yl)benzonitrile
Show/Hide
|
C14H8ClN5
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
Ki = 3.981 nM
|
|
|
|
CP0504460
|
3-chloro-5-[6-(5-methylpyridin-2-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C17H11ClN4
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
Ki = 2.512 nM
|
|
|
|
CP0438408
|
1,4-dimethyl-5-(4-methylphenyl)-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0483784
|
5-(3,5-difluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H16F2N4O
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0477223
|
US9212165, 37
Show/Hide
|
C22H23N3O
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0460700
|
2-((3-chlorophenyl)ethynyl)-6-isopropyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C19H17ClN2O
|
2
|
| 1 |
IC50 = 5.7 nM
|
|
|
| 2 |
Ki = 100 nM
|
|
|
|
CP0487895
|
1-(3,4-dichlorophenyl)-2,5-dimethyl-N-(6-methylpyridin-2-yl)imidazole-4-carboxamide
Show/Hide
|
C18H16Cl2N4O
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
|
CP0418122
|
US9212165, 26
Show/Hide
|
C21H21N3O
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0477222
|
US9212165, 17
Show/Hide
|
C20H20N4O
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0283393
|
Basimglurant
Show/Hide
|
C18H13ClFN3
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
Ki = 36 nM
|
|
|
|
CP0573557
|
N-(2-chloropyrimidin-4-yl)-5-(4-fluorophenyl)-1,4-dimethylpyrazole-3-carboxamide
Show/Hide
|
C16H13ClFN5O
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0544129
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-2-methylpropyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C19H20ClN5OS
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
|
|
CP0182750
|
3-fluoro-5-[3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl]benzonitrile
Show/Hide
|
C14H6F2N4O
|
2
|
| 1 |
IC50 = 7.6 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0428272
|
[2-[6-(3-chlorophenyl)-4-methoxypyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H18ClN3O2S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0468828
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-thiophen-2-ylmethanone
Show/Hide
|
C20H17ClN2OS
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0477470
|
[2-[6-(3-chlorophenyl)-4-methoxypyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C21H23ClN2O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0418233
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C19H20ClN5OS
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0418236
|
N-[(E,1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]pent-3-enyl]-1,3-thiazole-2-carboxamide
Show/Hide
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C20H20ClN5OS
|
1
|
| 1 |
IC50 = 8.8 nM
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CP0468826
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[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
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C19H16ClN3OS
|
1
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| 1 |
IC50 = 9 nM
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CP0441264
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3-[2-(2-methylpyridin-4-yl)ethynyl]-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
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C18H13N3O
|
2
|
| 1 |
IC50 = 9 nM
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| 2 |
Ki = 18 nM
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CP0551029
|
US8921370, 6
Show/Hide
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C21H23FN4O2
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1
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| 1 |
IC50 = 9 nM
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CP0418235
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N-[(R)-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-cyclobutylmethyl]-1,3-thiazole-2-carboxamide
Show/Hide
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C20H20ClN5OS
|
1
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| 1 |
IC50 = 9.3 nM
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CP0522615
|
US9212165, 41
Show/Hide
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C20H19FN4O
|
1
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| 1 |
IC50 = 9.3 nM
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CP0544130
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N-[(R)-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-cyclopropylmethyl]-1,3-thiazole-2-carboxamide
Show/Hide
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C19H18ClN5OS
|
1
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| 1 |
IC50 = 9.7 nM
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CP0425122
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[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
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C21H19ClN4O
|
1
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| 1 |
IC50 = 10 nM
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CP0088860
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2-chloro-4-[2-[2,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazol-4-yl]ethynyl]pyridine
Show/Hide
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C19H13ClF3N3O
|
2
|
| 1 |
IC50 = 10 nM
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| 2 |
Ki = 20 nM
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CP0530518
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N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]-4-methyl-1,3-thiazole-2-carboxamide
Show/Hide
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C20H22ClN5OS
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1
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| 1 |
IC50 = 10 nM
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CP0394974
|
AFQ056
Show/Hide
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C19H23NO3
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2
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| 1 |
IC50 = 10 nM
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| 2 |
Ki = 10 nM
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CP0573558
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5-(4-fluorophenyl)-N-(5-fluoropyridin-2-yl)-1,4-dimethylpyrazole-3-carboxamide
Show/Hide
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C17H14F2N4O
|
1
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| 1 |
IC50 = 10.3 nM
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CP0524933
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[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
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C21H23ClN2O
|
1
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| 1 |
IC50 = 11 nM
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CP0557201
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1-methyl-3-(2-phenylethynyl)-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
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C19H14N2O
|
2
|
| 1 |
IC50 = 11 nM
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| 2 |
Ki = 29 nM
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CP0493295
|
US9212165, 23
Show/Hide
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C21H20FN3O
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1
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| 1 |
IC50 = 11 nM
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CP0098719
|
2-methyl-4-(pyridin-3-ylethynyl)thiazole
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C11H8N2S
|
1
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| 1 |
IC50 = 12 nM
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CP0455312
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4-methyl-2-(2-pyridin-3-ylethynyl)-1,3-thiazole
Show/Hide
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C11H8N2S
|
1
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| 1 |
IC50 = 12 nM
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CP0499761
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4-[2-[1-(3-fluorophenyl)-2-methylimidazol-4-yl]ethynyl]-2-methylpyridine
Show/Hide
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C18H14FN3
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2
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| 1 |
IC50 = 12 nM
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| 2 |
Ki = 17 nM
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CP0484133
|
US9212165, 46
Show/Hide
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C19H20N4OS
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1
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| 1 |
IC50 = 12 nM
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CP0385761
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3-methyl-5-(6-pyrazol-1-ylpyrimidin-4-yl)benzonitrile
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C15H11N5
|
2
|
| 1 |
IC50 = 12.59 nM
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| 2 |
Ki = 3.981 nM
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CP0484533
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N-[(1R)-1-[5-chloro-6-[(6-fluoropyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C18H17ClFN5OS
|
1
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| 1 |
IC50 = 12.8 nM
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CP0499184
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1-(4-fluorophenyl)-2,5-dimethyl-N-(6-methylpyridin-2-yl)imidazole-4-carboxamide
Show/Hide
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C18H17FN4O
|
1
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| 1 |
IC50 = 13 nM
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CP0499762
|
2-methyl-4-[2-(2-methyl-1-phenylimidazol-4-yl)ethynyl]pyridine
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C18H15N3
|
2
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| 1 |
IC50 = 13 nM
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| 2 |
Ki = 28 nM
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CP0418237
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N-[(1R)-1-[5-chloro-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
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C19H20ClN5O2S
|
1
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| 1 |
IC50 = 13.3 nM
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CP0182748
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6-[5-(3-cyano-5-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyridine-3-carbonitrile
Show/Hide
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C15H6FN5O
|
4
|
| 1 |
IC50 = 13.4 nM
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| 2 |
IC50 = 51 nM
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| 3 |
Ki = 17.9 nM
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| 4 |
Ki = 28 nM
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CP0917299
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rac-(2-(6-(3-chlorophenyl)-4-methylpyridin-3-yl)pyrrolidin-1-yl)(thiazol-2-yl)methanone
Show/Hide
|
C20H18ClN3OS
|
1
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| 1 |
IC50 = 14 nM
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CP0481099
|
1-(3-chloro-4-fluorophenyl)-2,5-dimethyl-N-(6-methylpyridin-2-yl)imidazole-4-carboxamide
Show/Hide
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C18H16ClFN4O
|
1
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| 1 |
IC50 = 14.5 nM
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CP0516717
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N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]propyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C18H18ClN5OS
|
1
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| 1 |
IC50 = 15.4 nM
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CP0279567
|
2-chloro-4-[2-[1-(2,4-difluorophenyl)-2,5-dimethylimidazol-4-yl]ethynyl]pyridine
Show/Hide
|
C18H12ClF2N3
|
2
|
| 1 |
IC50 = 16 nM
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| 2 |
Ki = 33 nM
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CP0481100
|
5-(4-fluorophenyl)-1,4-dimethyl-N-(4-methyl-1,3-thiazol-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C16H15FN4OS
|
1
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| 1 |
IC50 = 16.4 nM
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CP0565956
|
N-(6-chloropyridin-2-yl)-5-(4-fluorophenyl)-1,4-dimethylpyrazole-3-carboxamide
Show/Hide
|
C17H14ClFN4O
|
1
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| 1 |
IC50 = 16.4 nM
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CP0380524
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N-[(R)-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-cyclopentylmethyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C21H22ClN5OS
|
1
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| 1 |
IC50 = 16.6 nM
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CP0457396
|
[(2R)-2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C20H18ClN3OS
|
1
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| 1 |
IC50 = 17 nM
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CP0483782
|
5-(4-methoxyphenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C19H20N4O2
|
1
|
| 1 |
IC50 = 17 nM
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CP0493296
|
US9212165, 32
Show/Hide
|
C20H22N4O
|
1
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| 1 |
IC50 = 17 nM
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CP0448887
|
1-(4-chlorophenyl)-2,5-dimethyl-N-(6-methylpyridin-2-yl)imidazole-4-carboxamide
Show/Hide
|
C18H17ClN4O
|
1
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| 1 |
IC50 = 17.1 nM
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CP0385750
|
3-methyl-5-(2-pyrazol-1-ylpyridin-4-yl)benzonitrile
Show/Hide
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C16H12N4
|
2
|
| 1 |
IC50 = 19.95 nM
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| 2 |
Ki = 19.95 nM
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CP0514128
|
ADX48621
Show/Hide
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C16H12FN3
|
1
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| 1 |
IC50 = 20 nM
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CP0395183
|
2-((3-chlorophenyl)ethynyl)-6-methyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C17H13ClN2O
|
2
|
| 1 |
IC50 = 22 nM
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| 2 |
Ki = 250 nM
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CP0515625
|
3-fluoro-5-(4-pyridin-2-yl-1,3-oxazol-2-yl)benzonitrile
Show/Hide
|
C15H8FN3O
|
1
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| 1 |
IC50 = 22 nM
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CP0494546
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C20H21ClN2O
|
1
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| 1 |
IC50 = 23 nM
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CP0525476
|
3-fluoro-5-(5-pyridin-2-yl-1,2,4-oxadiazol-3-yl)benzonitrile
Show/Hide
|
C14H7FN4O
|
1
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| 1 |
IC50 = 23 nM
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CP0396034
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N-[(5R,7S)-2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]-6-methylpyridine-2-carboxamide
Show/Hide
|
C21H22ClN3O2
|
1
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| 1 |
IC50 = 23 nM
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CP0498904
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-oxazole-4-carboxamide
Show/Hide
|
C19H20ClN5O2
|
1
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| 1 |
IC50 = 23.3 nM
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CP0573553
|
1-(4-fluorophenyl)-N-(6-fluoropyridin-2-yl)-2,5-dimethylimidazole-4-carboxamide
Show/Hide
|
C17H14F2N4O
|
1
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| 1 |
IC50 = 24.2 nM
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CP0319448
|
3-fluoro-5-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)benzonitrile
Show/Hide
|
C14H7FN4O
|
1
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| 1 |
IC50 = 25 nM
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CP0480167
|
5-cyclohexyl-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H24N4O
|
1
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| 1 |
IC50 = 25 nM
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CP0487066
|
3-[2-(3-methylphenyl)ethynyl]-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
|
C19H14N2O
|
2
|
| 1 |
IC50 = 26 nM
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| 2 |
Ki = 72 nM
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CP0537022
|
US8921370, 15
Show/Hide
|
C20H22ClN3O2S
|
1
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| 1 |
IC50 = 26 nM
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CP0483445
|
6-isopropyl-2-(pyridin-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C18H17N3O
|
2
|
| 1 |
IC50 = 27 nM
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| 2 |
Ki = 2740 nM
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CP0480144
|
1-methyl-N-(6-methylpyridin-2-yl)-4,5,6,7-tetrahydroindazole-3-carboxamide
Show/Hide
|
C15H18N4O
|
1
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| 1 |
IC50 = 27 nM
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CP0520351
|
4-ethyl-1-methyl-N-(6-methylpyridin-2-yl)-5-phenylpyrazole-3-carboxamide
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 = 27 nM
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CP0547549
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]pyridine-2-carboxamide
Show/Hide
|
C21H22ClN5O
|
1
|
| 1 |
IC50 = 27.8 nM
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CP0481103
|
N-(5-fluoro-6-methylpyridin-2-yl)-5-(4-fluorophenyl)-1,4-dimethylpyrazole-3-carboxamide
Show/Hide
|
C18H16F2N4O
|
1
|
| 1 |
IC50 = 28 nM
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CP0088859
|
4-[2-[1-(4-fluorophenyl)-2-methylimidazol-4-yl]ethynyl]-2-methylpyridine
Show/Hide
|
C18H14FN3
|
2
|
| 1 |
IC50 = 28 nM
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| 2 |
Ki = 22 nM
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CP0398132
|
3-[2-methyl-4-[2-(2-methylpyridin-4-yl)ethynyl]imidazol-1-yl]benzonitrile
Show/Hide
|
C19H14N4
|
2
|
| 1 |
IC50 = 28 nM
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| 2 |
Ki = 90 nM
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CP0547551
|
N-[1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C19H20ClN5OS
|
1
|
| 1 |
IC50 = 28.7 nM
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CP0395188
|
6-Methyl-2-phenylethynyl-7,8-dihydro-6H-1,6-naphthyridin-5-one
Show/Hide
|
C17H14N2O
|
2
|
| 1 |
IC50 = 30 nM
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| 2 |
Ki = 760 nM
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CP0375556
|
[2-[6-(3-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H18FN3OS
|
1
|
| 1 |
IC50 = 30 nM
|
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CP0493297
|
US9212165, 62
Show/Hide
|
C22H21FN4O
|
1
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| 1 |
IC50 = 30 nM
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CP0418234
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]pentyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C20H22ClN5OS
|
1
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| 1 |
IC50 = 30.9 nM
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CP0530517
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N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-2,2-dimethylpropyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C20H22ClN5OS
|
1
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| 1 |
IC50 = 30.9 nM
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CP0547550
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-4-carboxamide
Show/Hide
|
C19H20ClN5OS
|
1
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| 1 |
IC50 = 31.2 nM
|
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CP0385762
|
3-(6-pyrimidin-4-ylpyrimidin-4-yl)benzonitrile
Show/Hide
|
C15H9N5
|
2
|
| 1 |
IC50 = 31.62 nM
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| 2 |
Ki = 5.012 nM
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CP0513561
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[2-(5-chloropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone
Show/Hide
|
C18H14ClN3O2
|
1
|
| 1 |
IC50 = 32 nM
|
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CP0488301
|
US8921370, 176
Show/Hide
|
C22H24ClN3O2
|
1
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| 1 |
IC50 = 33 nM
|
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CP0551021
|
US9029360, 4
Show/Hide
|
C16H16BrN5OS
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
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CP0512931
|
US8921370, 36
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 = 35 nM
|
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CP0544132
|
N-[(R)-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-cyclohexylmethyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C22H24ClN5OS
|
1
|
| 1 |
IC50 = 37.8 nM
|
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CP0483783
|
1,4-dimethyl-N-(6-methylpyridin-2-yl)-5-[4-(trifluoromethyl)phenyl]pyrazole-3-carboxamide
Show/Hide
|
C19H17F3N4O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
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CP0509031
|
US8921370, 178
Show/Hide
|
C21H25N5O2
|
1
|
| 1 |
IC50 = 38 nM
|
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CP0520175
|
(3-chloro-5-fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Show/Hide
|
C18H12ClF2N3O2
|
1
|
| 1 |
IC50 = 38 nM
|
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CP0444271
|
3-methyl-5-(4-pyrazol-1-ylpyridin-2-yl)benzonitrile
Show/Hide
|
C16H12N4
|
2
|
| 1 |
IC50 = 39.81 nM
|
|
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| 2 |
Ki = 25.12 nM
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CP0205900
|
N-(2-chloropyrimidin-4-yl)-1-(4-fluorophenyl)-2,5-dimethylimidazole-4-carboxamide
Show/Hide
|
C16H13ClFN5O
|
1
|
| 1 |
IC50 = 40.4 nM
|
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|
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CP0498852
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(5-methyl-1,2-oxazol-3-yl)methanone
Show/Hide
|
C20H18ClN3O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
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CP0481101
|
5-(4-fluorophenyl)-N-(2-fluoropyridin-4-yl)-1,4-dimethylpyrazole-3-carboxamide
Show/Hide
|
C17H14F2N4O
|
1
|
| 1 |
IC50 = 41.6 nM
|
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CP0444632
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-oxazole-2-carboxamide
Show/Hide
|
C19H20ClN5O2
|
1
|
| 1 |
IC50 = 42.2 nM
|
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|
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CP0000961
|
3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-benzonitrile
Show/Hide
|
C14H8N4O
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0956933
|
US9029360, 6
Show/Hide
|
C15H14BrN5OS
|
1
|
| 1 |
IC50 = 43 nM
|
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|
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CP0544133
|
N-[(1R)-1-[5-chloro-6-[(2-methylpyrimidin-5-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C18H19ClN6OS
|
1
|
| 1 |
IC50 = 43.9 nM
|
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|
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CP0422002
|
6-isopropyl-2-(thiophen-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C17H16N2OS
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
Ki = 1930 nM
|
|
|
|
CP0396054
|
(3-chloro-5-methylphenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Show/Hide
|
C19H15ClFN3O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0573555
|
2,5-dimethyl-N-(6-methylpyridin-2-yl)-1-[4-(trifluoromethyl)phenyl]imidazole-4-carboxamide
Show/Hide
|
C19H17F3N4O
|
1
|
| 1 |
IC50 = 46.2 nM
|
|
|
|
CP0175365
|
3-fluoro-N-(4-methyl-1,3-thiazol-2-yl)-5-pyrimidin-5-yloxybenzamide
Show/Hide
|
C15H11FN4O2S
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0568926
|
(3-chlorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Show/Hide
|
C18H13ClFN3O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0226107
|
[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone
Show/Hide
|
C18H14FN3O2
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0516719
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-2-phenylethyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C23H20ClN5OS
|
1
|
| 1 |
IC50 = 55.5 nM
|
|
|
|
CP0516720
|
N-[(1R)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-2-methoxyethyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C18H18ClN5O2S
|
1
|
| 1 |
IC50 = 55.9 nM
|
|
|
|
CP0499185
|
N-(2-chloropyridin-4-yl)-5-(4-fluorophenyl)-1,4-dimethylpyrazole-3-carboxamide
Show/Hide
|
C17H14ClFN4O
|
1
|
| 1 |
IC50 = 56.3 nM
|
|
|
|
CP0859828
|
Fenobam
Show/Hide
|
C11H11ClN4O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0408181
|
(2-fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Show/Hide
|
C18H13F2N3O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0447528
|
N-[(1R,3R)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-3-fluorobenzamide
Show/Hide
|
C20H20ClFN2O2
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
Ki = 211 nM
|
|
|
|
CP0554842
|
US9029360, 10
Show/Hide
|
C14H12ClN5OS
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0452964
|
N-[(1R)-1-[5-chloro-6-[(2-methyl-1,3-thiazol-5-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C17H18ClN5OS2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0521034
|
3-fluoro-5-(5-pyridin-2-ylfuran-2-yl)benzonitrile
Show/Hide
|
C16H9FN2O
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0450228
|
N-[(1R,3R)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C19H20ClN3O2
|
2
|
| 1 |
IC50 = 62 nM
|
|
|
| 2 |
Ki = 205 nM
|
|
|
|
CP0540434
|
N-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)-2,5-dimethylimidazole-4-carboxamide
Show/Hide
|
C17H14ClFN4O
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0480172
|
N-(3-chlorophenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide
Show/Hide
|
C13H11ClN2O2
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0554843
|
US9029360, 13
Show/Hide
|
C15H14ClN5OS
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0393630
|
(3-fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Show/Hide
|
C18H13F2N3O2
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0574810
|
US9029360, 11
Show/Hide
|
C14H12BrN5O2S
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0455531
|
3-(3-chlorophenyl)-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile
Show/Hide
|
C22H15ClN4
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0426104
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyridin-4-ylmethanone
Show/Hide
|
C22H20ClN3O
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0557189
|
4-[2-methyl-4-[2-(2-methylpyridin-4-yl)ethynyl]imidazol-1-yl]benzonitrile
Show/Hide
|
C19H14N4
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
Ki = 83 nM
|
|
|
|
CP0565958
|
1,4-dimethyl-N-(6-methylpyridin-2-yl)-5-pyridin-4-ylpyrazole-3-carboxamide
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0443014
|
N-[(1R)-1-[5-chloro-6-(pyridin-3-ylamino)pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C18H18ClN5OS
|
1
|
| 1 |
IC50 = 71.4 nM
|
|
|
|
CP0425120
|
[2-[6-(3-chloro-5-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H17ClFN3OS
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0527377
|
[2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C20H17ClN4O
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0232636
|
(3-chloro-5-fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone
Show/Hide
|
C18H13ClF2N4O
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0520352
|
N-(6-cyanopyridin-2-yl)-1-(4-fluorophenyl)-2,5-dimethylimidazole-4-carboxamide
Show/Hide
|
C18H14FN5O
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0419290
|
3-(4-chloro-3-methoxyphenyl)-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile
Show/Hide
|
C23H17ClN4O
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0069025
|
3-chloro-5-[6-(4-fluoropyrazol-1-yl)pyrimidin-4-yl]benzonitrile
Show/Hide
|
C14H7ClFN5
|
2
|
| 1 |
IC50 = 79.43 nM
|
|
|
| 2 |
Ki = 19.95 nM
|
|
|
|
CP0505323
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-hydroxypyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C20H18ClN3O2S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0438407
|
5-(4-fluorophenyl)-1,4-dimethyl-N-(4-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
IC50 = 82.3 nM
|
|
|
|
CP0484156
|
US9212165, 51
Show/Hide
|
C19H20N4OS
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0426180
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrimidin-4-ylmethanone
Show/Hide
|
C21H19ClN4O
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0898409
|
trans-rac-3-chloro-N-(3-(3-fluorobenzamido)cyclohexyl)benzamide
Show/Hide
|
C20H20ClFN2O2
|
2
|
| 1 |
IC50 = 86 nM
|
|
|
| 2 |
Ki = 320 nM
|
|
|
|
CP0431884
|
3-(3-chlorophenyl)-4-(3,3-difluorocyclobutyl)-6-(3-fluorophenyl)-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile
Show/Hide
|
C23H14ClF3N4
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0573550
|
1-(4-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2,5-dimethylimidazole-4-carboxamide
Show/Hide
|
C17H14F2N4O
|
1
|
| 1 |
IC50 = 88.3 nM
|
|
|
|
CP0520173
|
(4-fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Show/Hide
|
C18H13F2N3O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0487717
|
5-(4-fluorophenyl)-1,4-dimethyl-N-(5-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
IC50 = 90.8 nM
|
|
|
|
CP0527751
|
5-cyclohexyloxy-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H24N4O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0426181
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-fluoropyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H17ClFN3OS
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0451202
|
5-(4-fluorophenyl)-1,4-dimethyl-N-(2-methylpyridin-4-yl)pyrazole-3-carboxamide
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
IC50 = 94.5 nM
|
|
|
|
CP0571604
|
1-methyl-N-(6-methylpyridin-2-yl)-5-phenylpyrazole-3-carboxamide
Show/Hide
|
C17H16N4O
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0398054
|
4-[2-[1-(2,4-difluorophenyl)-2-methylimidazol-4-yl]ethynyl]-2-methylpyridine
Show/Hide
|
C18H13F2N3
|
2
|
| 1 |
IC50 = 97 nM
|
|
|
| 2 |
Ki = 32 nM
|
|
|
|
CP0444199
|
2-methyl-4-[2-[2-methyl-1-(3-methylsulfonylphenyl)imidazol-4-yl]ethynyl]pyridine
Show/Hide
|
C19H17N3O2S
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
Ki = 252 nM
|
|
|
|
CP0374977
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrimidin-5-ylmethanone
Show/Hide
|
C21H19ClN4O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0575554
|
US9029360, 5
Show/Hide
|
C14H12BrN5OS
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0377847
|
6-isopropyl-2-((3-methoxyphenyl)ethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C20H20N2O2
|
2
|
| 1 |
IC50 = 111 nM
|
|
|
| 2 |
Ki = 2950 nM
|
|
|
|
CP0396032
|
N-[(5R,7S)-2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]pyridine-2-carboxamide
Show/Hide
|
C20H20ClN3O2
|
2
|
| 1 |
IC50 = 115 nM
|
|
|
| 2 |
Ki = 178 nM
|
|
|
|
CP0194425
|
2-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyridine
Show/Hide
|
C13H8ClN3O
|
1
|
| 1 |
IC50 = 116 nM
|
|
|
|
CP0453574
|
5-(3-bromophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
|
C13H8BrN3O
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0425121
|
[2-[6-(3-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H19FN4O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0468830
|
[2-[4-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H20N4OS
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0498812
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-fluoropyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H18ClFN4O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0397925
|
3-[2-(6-methylpyridin-2-yl)ethynyl]-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
|
C18H13N3O
|
2
|
| 1 |
IC50 = 124 nM
|
|
|
| 2 |
Ki = 213 nM
|
|
|
|
CP0473155
|
phenyl-(2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
Show/Hide
|
C19H17N3O
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0521163
|
US9029360, 19
Show/Hide
|
C14H12ClN5O2S
|
1
|
| 1 |
IC50 = 128 nM
|
|
|
|
CP0507812
|
5-(4-fluorophenyl)-1,4-dimethyl-N-[6-(trifluoromethyl)pyridin-2-yl]pyrazole-3-carboxamide
Show/Hide
|
C18H14F4N4O
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0519677
|
US8921370, 161
Show/Hide
|
C21H23FN4O2
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
|
CP0531393
|
3-chloro-N-[3-[(3-chlorobenzoyl)amino]cyclohexyl]benzamide
Show/Hide
|
C20H20Cl2N2O2
|
1
|
| 1 |
IC50 = 139 nM
|
|
|
|
CP0573551
|
N-(5-fluoro-6-methylpyridin-2-yl)-1-(4-fluorophenyl)-2,5-dimethylimidazole-4-carboxamide
Show/Hide
|
C18H16F2N4O
|
1
|
| 1 |
IC50 = 139 nM
|
|
|
|
CP0375104
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyridin-3-ylmethanone
Show/Hide
|
C22H20ClN3O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0468825
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyridin-2-ylmethanone
Show/Hide
|
C22H20ClN3O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0498811
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-fluoropyrrolidin-1-yl]-cyclobutylmethanone
Show/Hide
|
C21H22ClFN2O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0444201
|
2-methyl-4-[2-[2-methyl-1-(4-methylsulfonylphenyl)imidazol-4-yl]ethynyl]pyridine
Show/Hide
|
C19H17N3O2S
|
2
|
| 1 |
IC50 = 141 nM
|
|
|
| 2 |
Ki = 567 nM
|
|
|
|
CP0486604
|
5-(3,5-dichlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
|
C13H7Cl2N3O
|
1
|
| 1 |
IC50 = 142 nM
|
|
|
|
CP0529261
|
US9029360, 1
Show/Hide
|
C16H13BrClN5O
|
1
|
| 1 |
IC50 = 146 nM
|
|
|
|
CP0481098
|
1-(4-methoxyphenyl)-2,5-dimethyl-N-(6-methylpyridin-2-yl)imidazole-4-carboxamide
Show/Hide
|
C19H20N4O2
|
1
|
| 1 |
IC50 = 147 nM
|
|
|
|
CP0509037
|
US9029360, 12
Show/Hide
|
C17H18BrN5OS
|
1
|
| 1 |
IC50 = 148 nM
|
|
|
|
CP0537667
|
[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-(3-methylphenyl)methanone
Show/Hide
|
C19H17FN4O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0537668
|
(3-chlorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone
Show/Hide
|
C18H14ClFN4O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0480904
|
5-(3,5-difluorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
|
C13H7F2N3O
|
1
|
| 1 |
IC50 = 154 nM
|
|
|
|
CP0520174
|
[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-(3-methoxyphenyl)methanone
Show/Hide
|
C19H16FN3O3
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0170977
|
3-(2-phenylethynyl)-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
|
C18H12N2O
|
2
|
| 1 |
IC50 = 161 nM
|
|
|
| 2 |
Ki = 69 nM
|
|
|
|
CP0537670
|
[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-phenylmethanone
Show/Hide
|
C18H15FN4O
|
1
|
| 1 |
IC50 = 164 nM
|
|
|
|
CP0573552
|
1-(4-fluorophenyl)-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-2-yl]imidazole-4-carboxamide
Show/Hide
|
C18H14F4N4O
|
1
|
| 1 |
IC50 = 173 nM
|
|
|
|
CP0393629
|
[2-(5-bromopyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone
Show/Hide
|
C18H14BrN3O2
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0386273
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-2-fluorobenzamide
Show/Hide
|
C20H20ClFN2O2
|
2
|
| 1 |
IC50 = 175 nM
|
|
|
| 2 |
Ki = 760 nM
|
|
|
|
CP0545189
|
5-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)benzene-1,3-dicarbonitrile
Show/Hide
|
C15H7N5O
|
1
|
| 1 |
IC50 = 176 nM
|
|
|
|
CP0530140
|
(3-chlorophenyl)-(2-pyridin-2-yl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
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C18H15ClN4O
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1
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| 1 |
IC50 = 176 nM
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CP0393628
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[2-(5-methylpyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone
Show/Hide
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C19H17N3O2
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1
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| 1 |
IC50 = 177 nM
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CP0418238
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[2-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
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C19H18ClN5OS
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1
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| 1 |
IC50 = 182 nM
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CP0422000
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6-methyl-2-(pyridin-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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C16H13N3O
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2
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| 1 |
IC50 = 184 nM
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| 2 |
Ki = 6240 nM
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CP0499187
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N-(5-chloropyridin-2-yl)-5-(4-fluorophenyl)-1,4-dimethylpyrazole-3-carboxamide
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C17H14ClFN4O
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1
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| 1 |
IC50 = 184 nM
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CP0418182
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3-chloro-N-[(1S,3S)-3-[(4-fluorobenzoyl)amino]cyclohexyl]benzamide
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C20H20ClFN2O2
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2
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| 1 |
IC50 = 194 nM
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| 2 |
Ki = 492 nM
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CP0481102
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N-(4-chloropyridin-2-yl)-5-(4-fluorophenyl)-1,4-dimethylpyrazole-3-carboxamide
Show/Hide
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C17H14ClFN4O
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1
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| 1 |
IC50 = 195 nM
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CP0538431
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(3-fluoro-5-methylphenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone
Show/Hide
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C19H16F2N4O
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1
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| 1 |
IC50 = 197 nM
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CP0377848
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6-cyclopentyl-2-(pyridin-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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C20H19N3O
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2
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| 1 |
IC50 = 199 nM
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| 2 |
Ki = 1770 nM
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CP0420544
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3-chloro-5-(6-pyridazin-3-ylpyrimidin-4-yl)benzonitrile
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C15H8ClN5
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2
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| 1 |
IC50 = 199.53 nM
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| 2 |
Ki = 10 nM
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CP0421073
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[2-(5-chloropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-phenylmethanone
Show/Hide
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C18H15ClN4O
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1
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| 1 |
IC50 = 201 nM
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CP0503160
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N-cyclopentyl-6-(2-pyridin-2-ylethynyl)pyridine-3-carboxamide
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C18H17N3O
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2
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| 1 |
IC50 = 227 nM
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| 2 |
Ki = 7600 nM
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CP0450230
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N-[(1S,3S)-3-benzamidocyclohexyl]-3-chlorobenzamide
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C20H21ClN2O2
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2
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| 1 |
IC50 = 228 nM
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| 2 |
Ki = 672 nM
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CP0541846
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US9029360, 2
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C17H16BrN5O2
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1
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| 1 |
IC50 = 230 nM
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CP0418181
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N-[(1R,3R)-3-[(3-cyanobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
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C20H20N4O2
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2
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| 1 |
IC50 = 231 nM
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| 2 |
Ki = 1275 nM
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CP0550215
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US9029360, 18
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C17H18ClN5OS
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1
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| 1 |
IC50 = 235 nM
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CP0538433
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phenyl-(2-pyridin-2-yl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
Show/Hide
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C18H16N4O
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1
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| 1 |
IC50 = 235 nM
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CP0128144
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2-[5-(3-Nitro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyridine
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C13H8N4O3
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1
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| 1 |
IC50 = 236 nM
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CP0520172
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6-(5-benzoyl-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-2-yl)pyridine-3-carbonitrile
Show/Hide
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C19H14N4O2
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1
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| 1 |
IC50 = 237 nM
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CP0566203
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[2-(5-methylpyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-phenylmethanone
Show/Hide
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C19H18N4O
|
1
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| 1 |
IC50 = 244 nM
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CP0575243
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(3-fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone
Show/Hide
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C18H14F2N4O
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1
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| 1 |
IC50 = 257 nM
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CP0447553
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3-chloro-N-[(1S,3S)-3-[(4-methoxybenzoyl)amino]cyclohexyl]benzamide
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C21H23ClN2O3
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2
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| 1 |
IC50 = 266 nM
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| 2 |
Ki = 674 nM
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CP0439988
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(3,5-dichlorophenyl)-(2-pyridin-2-yl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
Show/Hide
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C18H14Cl2N4O
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1
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| 1 |
IC50 = 270 nM
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CP0480907
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5-(2,3-dichlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
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C13H7Cl2N3O
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1
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| 1 |
IC50 = 274 nM
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CP0497513
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N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-6-methylpyridine-2-carboxamide
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C20H22ClN3O2
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2
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| 1 |
IC50 = 290 nM
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| 2 |
Ki = 582 nM
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CP0460698
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2-((3-methoxyphenyl)ethynyl)-6-methyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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C18H16N2O2
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2
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| 1 |
IC50 = 293 nM
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| 2 |
Ki = 3660 nM
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CP0398134
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8-fluoro-5-methyl-3-(2-phenylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
Show/Hide
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C20H14FN3O
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2
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| 1 |
IC50 = 295 nM
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| 2 |
Ki = 368 nM
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CP0447782
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N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyridine-4-carboxamide
Show/Hide
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C19H20ClN3O2
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2
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| 1 |
IC50 = 300 nM
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| 2 |
Ki = 445 nM
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CP0511237
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5-(4-fluorophenyl)-1,4-dimethyl-N-pyridin-4-ylpyrazole-3-carboxamide
Show/Hide
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C17H15FN4O
|
1
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| 1 |
IC50 = 300.5 nM
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CP0920737
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rac-N-(3-(3-chlorobenzamido)cyclohexyl)picolinamide
Show/Hide
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C19H20ClN3O2
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1
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| 1 |
IC50 = 314 nM
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CP0457392
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[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-hydroxypyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
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C21H19ClN4O2
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1
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| 1 |
IC50 = 320 nM
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CP0457398
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[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]-4-hydroxypyrrolidin-1-yl]-cyclobutylmethanone
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C21H23ClN2O2
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1
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| 1 |
IC50 = 320 nM
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CP0509036
|
US9029360, 7
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C15H12BrClN6O
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1
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| 1 |
IC50 = 340 nM
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CP0421999
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2-((4-chlorophenyl)ethynyl)-6-methyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
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C17H13ClN2O
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2
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| 1 |
IC50 = 352 nM
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| 2 |
Ki = 6150 nM
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CP0425431
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[2-[4-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
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C21H21N5O
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1
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| 1 |
IC50 = 370 nM
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CP0565946
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N-(5-chloro-2-hydroxyphenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide
Show/Hide
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C13H11ClN2O3
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1
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| 1 |
IC50 = 373 nM
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CP0537665
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[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-[3-(trifluoromethyl)phenyl]methanone
Show/Hide
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C19H14F4N4O
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1
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| 1 |
IC50 = 383 nM
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CP0399683
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3-(2-pyridin-3-ylethynyl)-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
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C17H11N3O
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2
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| 1 |
IC50 = 387 nM
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| 2 |
Ki = 255 nM
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CP0457391
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[2-[6-(3-chloro-5-fluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
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C21H18ClFN4O
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1
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| 1 |
IC50 = 390 nM
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CP0484640
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3-fluoro-5-(6-pyrazol-1-ylpyrimidin-4-yl)benzonitrile
Show/Hide
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C14H8FN5
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2
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| 1 |
IC50 = 398.11 nM
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| 2 |
Ki = 63.1 nM
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CP0562639
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3-fluoro-5-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridine-5-carbonyl]benzonitrile
Show/Hide
|
C19H12F2N4O2
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1
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| 1 |
IC50 = 403 nM
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CP0418130
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N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyrimidine-2-carboxamide
Show/Hide
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C18H19ClN4O2
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2
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| 1 |
IC50 = 425 nM
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| 2 |
Ki = 3790 nM
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CP0538382
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5-(2-chlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
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C13H8ClN3O
|
1
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| 1 |
IC50 = 436 nM
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CP0480905
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5-(3-methylphenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
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C14H11N3O
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1
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| 1 |
IC50 = 443 nM
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CP0395190
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6-methyl-2-(thiophen-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
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C15H12N2OS
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2
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| 1 |
IC50 = 451 nM
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| 2 |
Ki = 2170 nM
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CP0577405
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[2-(4-methylpyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-phenylmethanone
Show/Hide
|
C19H18N4O
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1
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| 1 |
IC50 = 451 nM
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CP0516656
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N-[(1S,3S)-3-[(3-chlorophenyl)carbamoyl]cyclohexyl]pyridine-2-carboxamide
Show/Hide
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C19H20ClN3O2
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1
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| 1 |
IC50 = 468 nM
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CP0497517
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3-chloro-N-[(1S,3S)-3-[[4-(dimethylamino)benzoyl]amino]cyclohexyl]benzamide
Show/Hide
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C22H26ClN3O2
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1
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| 1 |
IC50 = 473 nM
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CP0473156
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(2-tert-butyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-naphthalen-2-ylmethanone
Show/Hide
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C21H23N3O
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1
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| 1 |
IC50 = 477 nM
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CP0537666
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[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-(3-methoxyphenyl)methanone
Show/Hide
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C19H17FN4O2
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1
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| 1 |
IC50 = 482 nM
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CP0398055
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15-fluoro-5-(2-phenylethynyl)-2,4,8,9,11-pentazatetracyclo[11.4.0.02,6.08,12]heptadeca-1(13),3,5,9,11,14,16-heptaene
Show/Hide
|
C20H12FN5
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2
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| 1 |
IC50 = 488 nM
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| 2 |
Ki = 559 nM
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CP0377849
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6-cyclohexyl-2-(pyridin-2-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
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C21H21N3O
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2
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| 1 |
IC50 = 518 nM
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| 2 |
Ki = 2240 nM
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CP0916535
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trans-rac-N-(3-(3-cyanobenzamido)cyclohexyl)picolinamide
Show/Hide
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C20H20N4O2
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2
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| 1 |
IC50 = 531 nM
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| 2 |
Ki = 1538 nM
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CP0271152
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2-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyridine
Show/Hide
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C14H11N3O2
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1
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| 1 |
IC50 = 540 nM
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CP0550213
|
US9029360, 17
Show/Hide
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C20H18BrN5O
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1
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| 1 |
IC50 = 550 nM
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CP0538432
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[2-(6-methylpyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-phenylmethanone
Show/Hide
|
C19H18N4O
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1
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| 1 |
IC50 = 568 nM
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CP0527172
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[2-[6-(3,5-difluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C20H17F2N3OS
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1
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| 1 |
IC50 = 570 nM
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CP0380529
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N-[[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]methyl]-N-propyl-1,3-thiazole-2-carboxamide
Show/Hide
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C19H20ClN5OS
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1
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| 1 |
IC50 = 584 nM
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CP0483526
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3-fluoro-N-[(1S,3S)-3-[(3-fluorobenzoyl)amino]cyclohexyl]benzamide
Show/Hide
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C20H20F2N2O2
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1
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| 1 |
IC50 = 593 nM
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CP0515557
|
US9029360, 14
Show/Hide
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C16H14BrN5O
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1
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| 1 |
IC50 = 603 nM
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CP0424331
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2,3-dihydro-3(R)-methyl-9-(4-methylphenyl)-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
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C19H16N4O2S
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1
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| 1 |
IC50 = 609 nM
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CP0395944
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N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyridine-3-carboxamide
Show/Hide
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C19H20ClN3O2
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1
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| 1 |
IC50 = 612 nM
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CP0558441
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5-[4-(dimethylamino)phenyl]-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
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C20H23N5O
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1
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| 1 |
IC50 = 645 nM
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CP0898408
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cis/trans-N-(2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl)picolinamide
Show/Hide
|
C20H20ClN3O2
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2
|
| 1 |
IC50 = 647 nM
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| 2 |
Ki = 30 nM
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CP0450231
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N-[3-[(3-chlorobenzoyl)amino]cyclohexyl]-3-cyanopyridine-2-carboxamide
Show/Hide
|
C20H19ClN4O2
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2
|
| 1 |
IC50 = 671 nM
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| 2 |
Ki = 1246 nM
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CP0429896
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2-(3-chlorophenyl)-5-[1-(cyclobutanecarbonyl)pyrrolidin-2-yl]-1H-pyridin-4-one
Show/Hide
|
C20H21ClN2O2
|
1
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| 1 |
IC50 = 680 nM
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CP0538755
|
US9029360, 15
Show/Hide
|
C15H15BrN6O
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1
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| 1 |
IC50 = 692 nM
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CP0507767
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3-pyridin-2-yl-5-[3-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Show/Hide
|
C14H8F3N3O2
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1
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| 1 |
IC50 = 700 nM
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CP0475243
|
US9212165, 80
Show/Hide
|
C23H24N4O
|
1
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| 1 |
IC50 = 700 nM
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CP0505603
|
2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C18H14N4O2S
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1
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| 1 |
IC50 = 702 nM
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CP0395191
|
6-isopropyl-2-(phenylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C19H18N2O
|
2
|
| 1 |
IC50 = 706 nM
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| 2 |
Ki = 1280 nM
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CP0421998
|
6-methyl-2-(o-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C18H16N2O
|
2
|
| 1 |
IC50 = 776 nM
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| 2 |
Ki > 32000 nM
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CP0450234
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-3-methoxybenzamide
Show/Hide
|
C21H23ClN2O3
|
1
|
| 1 |
IC50 = 789 nM
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CP0395184
|
6-isopropyl-2-(o-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C20H20N2O
|
2
|
| 1 |
IC50 = 810 nM
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| 2 |
Ki > 32000 nM
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CP0513220
|
5-(3-fluorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
|
C13H8FN3O
|
1
|
| 1 |
IC50 = 845 nM
|
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CP0450233
|
3-chloro-N-[(1S,3S)-3-(cyclohexanecarbonylamino)cyclohexyl]benzamide
Show/Hide
|
C20H27ClN2O2
|
1
|
| 1 |
IC50 = 857 nM
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CP0398133
|
7-chloro-5-methyl-3-(2-phenylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
Show/Hide
|
C20H14ClN3O
|
2
|
| 1 |
IC50 = 872 nM
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| 2 |
Ki = 1440 nM
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CP0480165
|
5-[(4-fluorophenyl)methoxy]-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C19H19FN4O2
|
1
|
| 1 |
IC50 = 911 nM
|
|
|
|
CP0425856
|
2-((2-chlorophenyl)ethynyl)-6-methyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C17H13ClN2O
|
2
|
| 1 |
IC50 = 916 nM
|
|
|
| 2 |
Ki = 7900 nM
|
|
|
|
CP0429017
|
N-[(1S)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]butyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C19H20ClN5OS
|
1
|
| 1 |
IC50 = 978 nM
|
|
|
|
CP0395945
|
N-[(1S,3S)-3-[(3-methylbenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0516718
|
N-[(1S)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-2-methylpropyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C19H20ClN5OS
|
1
|
| 1 |
IC50 = 1055 nM
|
|
|
|
CP0515624
|
3-fluoro-5-(3-pyrimidin-2-yl-1,2,4-oxadiazol-5-yl)benzonitrile
Show/Hide
|
C13H6FN5O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0450235
|
N-[(1S,3S)-3-(pyridine-2-carbonylamino)cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C18H20N4O2
|
1
|
| 1 |
IC50 = 1150 nM
|
|
|
|
CP0541850
|
US9029360, 16
Show/Hide
|
C15H14BrN5O2S
|
1
|
| 1 |
IC50 = 1285 nM
|
|
|
|
CP0559562
|
phenyl-(2-pyridin-4-yl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
Show/Hide
|
C18H16N4O
|
1
|
| 1 |
IC50 = 1293 nM
|
|
|
|
CP0565957
|
5-(cyclohexylmethoxy)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C19H26N4O2
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0531567
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyrazine-2-carboxamide
Show/Hide
|
C18H19ClN4O2
|
1
|
| 1 |
IC50 = 1370 nM
|
|
|
|
CP0549975
|
US9029360, 3
Show/Hide
|
C15H13BrN4OS
|
1
|
| 1 |
IC50 = 1385 nM
|
|
|
|
CP0395189
|
6-methyl-2-(p-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C18H16N2O
|
2
|
| 1 |
IC50 = 1401 nM
|
|
|
| 2 |
Ki = 7450 nM
|
|
|
|
CP0554203
|
US9029360, 9
Show/Hide
|
C15H15N5OS
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0442052
|
2-[(4-fluorophenyl)methylamino]-6-(4-methoxybenzoyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile
Show/Hide
|
C23H20FN3O2S
|
1
|
| 1 |
IC50 = 1430 nM
|
|
|
|
CP0497516
|
N-[(5S,7S)-2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]-6-methylpyridine-2-carboxamide
Show/Hide
|
C21H22ClN3O2
|
1
|
| 1 |
IC50 = 1505 nM
|
|
|
|
CP0395946
|
N-[(1S,3R)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C19H20ClN3O2
|
1
|
| 1 |
IC50 = 1510 nM
|
|
|
|
CP0541848
|
US9029360, 8
Show/Hide
|
C16H16BrN5O2S
|
1
|
| 1 |
IC50 = 1545 nM
|
|
|
|
CP0410422
|
5-(2,4-dichlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
|
C13H7Cl2N3O
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0457395
|
[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,1-dioxothiolan-3-yl)methanone
Show/Hide
|
C21H23ClN2O3S
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0426644
|
[2-[6-(3,5-difluorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C21H18F2N4O
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0375558
|
[2-[6-(3-chlorophenyl)-4-(2-hydroxy-2-methylpropyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C23H24ClN3O2S
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0577406
|
(2-chlorophenyl)-(2-pyridin-2-yl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
Show/Hide
|
C18H15ClN4O
|
1
|
| 1 |
IC50 = 2477 nM
|
|
|
|
CP0397924
|
3-[2-(2-methylphenyl)ethynyl]-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
|
C19H14N2O
|
2
|
| 1 |
IC50 = 2500 nM
|
|
|
| 2 |
Ki = 1770 nM
|
|
|
|
CP0422001
|
2-((2-chlorophenyl)ethynyl)-6-isopropyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C19H17ClN2O
|
2
|
| 1 |
IC50 = 2517 nM
|
|
|
| 2 |
Ki = 5680 nM
|
|
|
|
CP0573556
|
5-(4-fluorophenyl)-1,4-dimethyl-N-(5-methyl-1,3-thiazol-2-yl)pyrazole-3-carboxamide
Show/Hide
|
C16H15FN4OS
|
1
|
| 1 |
IC50 = 2700 nM
|
|
|
|
CP0465575
|
N-[(5S,7R)-2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]pyridine-2-carboxamide
Show/Hide
|
C20H20ClN3O2
|
1
|
| 1 |
IC50 = 2910 nM
|
|
|
|
CP0513219
|
2-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)benzamide
Show/Hide
|
C14H10N4O2
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
|
CP0473518
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-4-methylpyridine-2-carboxamide
Show/Hide
|
C20H22ClN3O2
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0483447
|
2-((4-chlorophenyl)ethynyl)-6-isopropyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C19H17ClN2O
|
2
|
| 1 |
IC50 = 4228 nM
|
|
|
| 2 |
Ki = 27140 nM
|
|
|
|
CP0525475
|
3-fluoro-5-(3-pyrazin-2-yl-1,2,4-oxadiazol-5-yl)benzonitrile
Show/Hide
|
C13H6FN5O
|
1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0398013
|
2-[(3-fluorophenyl)methylamino]-6-(4-methoxybenzoyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile
Show/Hide
|
C23H20FN3O2S
|
1
|
| 1 |
IC50 = 4730 nM
|
|
|
|
CP0499290
|
N-[3-cyano-6-(5-propan-2-yl-1H-pyrazole-3-carbonyl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-4-methoxybenzamide
Show/Hide
|
C23H23N5O3S
|
1
|
| 1 |
IC50 = 4830 nM
|
|
|
|
CP0521700
|
3-chloro-N-[(1R,3R)-3-(pyridin-2-ylcarbamoyl)cyclohexyl]benzamide
Show/Hide
|
C19H20ClN3O2
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0487067
|
3-[2-(4-methylphenyl)ethynyl]-4H-imidazo[5,1-c][1,4]benzoxazine
Show/Hide
|
C19H14N2O
|
2
|
| 1 |
IC50 = 5600 nM
|
|
|
| 2 |
Ki = 2840 nM
|
|
|
|
CP0507451
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-3-methylpyridine-2-carboxamide
Show/Hide
|
C20H22ClN3O2
|
1
|
| 1 |
IC50 = 7840 nM
|
|
|
|
CP0489968
|
(4-chlorophenyl)-(2-pyridin-2-yl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
Show/Hide
|
C18H15ClN4O
|
1
|
| 1 |
IC50 = 9469 nM
|
|
|
|
CP0473517
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-3-fluorobenzamide
Show/Hide
|
C20H20ClFN2O2
|
1
|
| 1 |
IC50 = 9600 nM
|
|
|
|
CP0039561
|
9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one
Show/Hide
|
C18H16N4O2S
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0460999
|
8-(4-methoxyphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-7(8H)-one
Show/Hide
|
C18H12N4O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0477471
|
4-[2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidine-1-carbonyl]-1-methylpyrrolidin-2-one
Show/Hide
|
C22H24ClN3O2
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0188657
|
5-(3,4-dichlorophenyl)-3-(2-pyridinyl)-1,2,4-oxadiazole
Show/Hide
|
C13H7Cl2N3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0501077
|
5-(4-chlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
|
C13H8ClN3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0513218
|
5-[3,5-bis(trifluoromethyl)phenyl]-3-pyridin-2-yl-1,2,4-oxadiazole
Show/Hide
|
C15H7F6N3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0395947
|
N-[(1S,3S)-3-[(3-cyanobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C20H20N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0418131
|
N-[(1S,3R)-3-[(3-cyanobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C20H20N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0438448
|
3-chloro-N-[(1S,3S)-3-[(2-pyridin-2-ylacetyl)amino]cyclohexyl]benzamide
Show/Hide
|
C20H22ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0452409
|
3-chloro-N-[3-[(3-chlorobenzoyl)-methylamino]cyclohexyl]-N-methylbenzamide
Show/Hide
|
C22H24Cl2N2O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0465576
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C19H20ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0497514
|
N-[2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]pyridine-3-carboxamide
Show/Hide
|
C20H20ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0499173
|
3-chloro-N-[3-[(3-chlorobenzoyl)-methylamino]cyclohexyl]benzamide
Show/Hide
|
C21H22Cl2N2O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0507445
|
N-[(1S,3S)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-3-(dimethylamino)benzamide
Show/Hide
|
C22H26ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0521701
|
3-cyano-N-[(1R,3R)-3-(pyridin-2-ylcarbamoyl)cyclohexyl]benzamide
Show/Hide
|
C20H20N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0531392
|
N-[2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]pyridine-4-carboxamide
Show/Hide
|
C20H20ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0540769
|
N-[3-[(3-methoxybenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
Show/Hide
|
C20H23N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0360030
|
N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
Show/Hide
|
C22H15ClN2O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0530139
|
3-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carbonyl]benzonitrile
Show/Hide
|
C19H14FN5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0537676
|
[2-(3-methylpyridin-2-yl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]-phenylmethanone
Show/Hide
|
C19H18N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0537677
|
phenyl-(2-pyridin-3-yl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)methanone
Show/Hide
|
C18H16N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0499120
|
methyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate
Show/Hide
|
C13H13NO2S
|
1
|
| 1 |
IC50 = 30000 nM
|
|
|
|
CP0426982
|
9-(4-chlorophenyl)-2,3-dihydro-3(S)-methyl-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C18H13ClN4O2S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0426984
|
2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C18H14N4O3S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0427971
|
2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C19H16N4O3S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0471391
|
9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C18H13ClN4O2S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0471392
|
9-(4-chlorophenyl)-2,3-dihydro-2(R)-methyl-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C18H13ClN4O2S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0485808
|
8-(4-methylphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-7(8H)-one
Show/Hide
|
C18H12N4OS
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0505601
|
9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C18H13ClN4O2S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0509313
|
9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one
Show/Hide
|
C17H11ClN4O2S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0507813
|
1-methyl-N-(6-methylpyridin-2-yl)indazole-3-carboxamide
Show/Hide
|
C15H14N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0571605
|
2-methyl-N-(6-methylpyridin-2-yl)-4,5,6,7-tetrahydroindazole-3-carboxamide
Show/Hide
|
C15H18N4O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0444630
|
N-[(1S)-1-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]propyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C18H18ClN5OS
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0544131
|
N-[(S)-[5-chloro-6-[(6-methylpyridin-3-yl)amino]pyridin-3-yl]-cyclobutylmethyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C20H20ClN5OS
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0690303
|
[2-3H]-3-Fluoro-5-[3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl]-benzonitrile
Show/Hide
|
C14H6F2N4O
|
4
|
| 1 |
Kd = 2.25 nM
|
|
|
| 2 |
Kd = 3.8 nM
|
|
|
| 3 |
Kd = 5.5 nM
|
|
|
| 4 |
Kd = 7.2 nM
|
|
|
|
CP0420546
|
4-fluoro-3-(6-pyrazol-1-ylpyrimidin-4-yl)benzonitrile
Show/Hide
|
C14H8FN5
|
1
|
| 1 |
Ki = 251.19 nM
|
|
|
|
CP0447794
|
3-(6-pyrazol-1-ylpyrimidin-4-yl)benzonitrile
Show/Hide
|
C14H9N5
|
1
|
| 1 |
Ki = 794.33 nM
|
|
|
|
CP0392588
|
4-(3-fluorophenyl)-6-pyrazol-1-ylpyrimidine
Show/Hide
|
C13H9FN4
|
1
|
| 1 |
Ki = 7943.28 nM
|
|
|
|
CP0498941
|
N-methyl-6-(2-phenylethynyl)pyridine-3-carboxamide
Show/Hide
|
C15H12N2O
|
1
|
| 1 |
Ki = 15000 nM
|
|
|
|
CP0460702
|
6-isopropyl-2-(pyridin-3-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
Show/Hide
|
C18H17N3O
|
1
|
| 1 |
Ki = 19550 nM
|
|
|
|
CP0509272
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6-cyclohexyl-2-((3-methoxyphenyl)ethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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C23H24N2O2
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1
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| 1 |
Ki = 23150 nM
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CP0498943
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6-cyclohexyl-2-(p-tolylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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C23H24N2O
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1
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| 1 |
Ki = 27150 nM
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CP0421994
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6-methyl-2-(pyridin-3-ylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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C16H13N3O
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1
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| 1 |
Ki = 27380 nM
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CP0377843
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2-((4-chlorophenyl)ethynyl)-6-cyclohexyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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C22H21ClN2O
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1
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| 1 |
Ki > 32000 nM
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CP0392589
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3-fluoro-5-(6-pyrazol-1-ylpyrimidin-4-yl)benzamide
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C14H10FN5O
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1
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| 1 |
Ki > 63095.73 nM
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CP0504459
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4-(3-fluoro-5-methoxyphenyl)-6-pyrazol-1-ylpyrimidine
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C14H11FN4O
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1
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| 1 |
Ki > 63095.73 nM
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