Brief Information of the Compound and Protein
Compound Name
2-chloro-4-[2-[1-(2,4-difluorophenyl)-2,5-dimethylimidazol-4-yl]ethynyl]pyridine
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PubChem ID
CID: 11688761
SID: 16793110
Canonical SMILES
Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1F
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Compound Formula C18H12ClF2N3
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
2
Ki = 33 nM
   TI
   LI
   LO
   TS