Brief Information of the Compound and Protein
Compound Name
(4R,5R)-5-(2,6-difluorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
    Show/Hide
PubChem ID
CID: 69281818
Canonical SMILES
Fc1cccc(F)c1[C@H]1OC(=O)N[C@@H]1c1cncc(c1)C#Cc1ccccc1
    Show/Hide
Compound Formula C22H14F2N2O2
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS
2
IC50 = 27 nM
   TI
   LI
   LO
   TS
3
Ki = 2.7 nM
   TI
   LI
   LO
   TS