Brief Information of the Compound and Protein
Compound Name
3-chloro-5-[6-(5-chloropyridin-2-yl)pyrimidin-4-yl]benzonitrile
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PubChem ID
CID: 90646779
Canonical SMILES
Clc1ccc(nc1)-c1cc(ncn1)-c1cc(Cl)cc(c1)C#N
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Compound Formula C16H8Cl2N4
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 3.162 nM
   TI
   LI
   LO
   TS
2
Ki = 1.585 nM
   TI
   LI
   LO
   TS