Brief Information of the Compound and Protein
Compound Name
3-chloro-4-fluoro-5-(6-pyrazol-1-ylpyrimidin-4-yl)benzonitrile
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PubChem ID
CID: 86280685
Canonical SMILES
Fc1c(Cl)cc(cc1-c1cc(ncn1)-n1cccn1)C#N
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Compound Formula C14H7ClFN5
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 2.512 nM
   TI
   LI
   LO
   TS
2
Ki = 0.5012 nM
   TI
   LI
   LO
   TS