Brief Information of the Compound and Protein
Compound Name
8-fluoro-5-methyl-3-(2-phenylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
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PubChem ID
CID: 118732222
Canonical SMILES
CN1Cc2c(ncn2-c2ccc(F)cc2C1=O)C#Cc1ccccc1
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Compound Formula C20H14FN3O
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 295 nM
   TI
   LI
   LO
   TS
2
Ki = 368 nM
   TI
   LI
   LO
   TS