Brief Information of the Compound and Protein
Compound Name
6-isopropyl-2-(phenylethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
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PubChem ID
CID: 54585488
Canonical SMILES
CC(C)N1CCc2nc(ccc2C1=O)C#Cc1ccccc1
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Compound Formula C19H18N2O
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 706 nM
   TI
   LI
   LO
   TS
2
Ki = 1280 nM
   TI
   LI
   LO
   TS