Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4R,5R)-5-(2,5-Difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one
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 PubChem ID
CID: 57330204
SID: 136332427
Canonical SMILES
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cc(F)ccc2F)O1
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Compound Formula C22H14F2N2O2
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  5
1
EC50 = 2.6 nM
   TI
   LI
   LO
   TS
2
EC50 > 30000 nM
   TI
   LI
   LO
   TS
3
EC50 > 3000 nM
   TI
   LI
   LO
   TS
4
IC50 = 3 nM
   TI
   LI
   LO
   TS
5
Ki = 1.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.6 nM