Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4R,5R)-5-(3-Fluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one
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 PubChem ID
CID: 69081596
Canonical SMILES
O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cccc(F)c2)O1
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Compound Formula C22H15FN2O2
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  6
1
EC50 = 0.8 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.83 nM
   TI
   LI
   LO
   TS
3
EC50 = 1.1 nM
   TI
   LI
   LO
   TS
4
EC50 > 30000 nM
   TI
   LI
   LO
   TS
5
EC50 > 3000 nM
   TI
   LI
   LO
   TS
6
Ki = 1.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.5 nM