General Information of the Cell Line
Cell Line ID
CL000375
Cell Line Name
C-33 A
Synonyms
C33A
C33a
C33-A
C-33-A
C-33A
C33
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1094
Tissue Information
Uterus
Disease
Human papillomavirus-independent cervical squamous cell carcinoma (NCIt: C180841)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01131, RAC-beta serine/threonine-protein kinase
Compound ID Compound Name Compound Formula
CP0169521
2,3,5-trisubstituted pyridine, 10a
   Show/Hide
C33H30N8S
 1
1
Activity = 153 nM
   TI
   LI
   LO
   TS
CP0037745
2,3,5-trisubstituted pyridine, 10b
   Show/Hide
C33H30N8S
 1
1
Activity = 300 nM
   TI
   LI
   LO
   TS
CP0058898
2,3,5-trisubstituted pyridine, 10c
   Show/Hide
C32H29N9S
 1
1
Activity = 330 nM
   TI
   LI
   LO
   TS
CP0102891
2,3,5-trisubstituted pyridine, 10f
   Show/Hide
C30H28N10S
 1
1
Activity = 416 nM
   TI
   LI
   LO
   TS
CP0058896
2,3,5-trisubstituted pyridine, 10h
   Show/Hide
C29H26N6OS
 1
1
Activity = 472 nM
   TI
   LI
   LO
   TS
CP0339412
1-[1-({4-[3-phenyl-5-(1H-1,2,4-triazol-3-yl)pyridin-2-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C30H28N10
 1
1
Activity = 666 nM
   TI
   LI
   LO
   TS
CP0169520
1-[1-({4-[5-(1,2,4-oxadiazol-3-yl)-3-phenylpyridin-2-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C30H27N9O
 1
1
Activity = 1061 nM
   TI
   LI
   LO
   TS
CP0320331
2,3,5-trisubstituted pyridine, 10d
   Show/Hide
C33H30N8S
 1
1
Activity = 1349 nM
   TI
   LI
   LO
   TS
CP0277162
2,3,5-trisubstituted pyridine, 10e
   Show/Hide
C32H29N9S
 1
1
Activity = 2028 nM
   TI
   LI
   LO
   TS
CP0169519
1-[1-({4-[3-phenyl-5-(1,3-thiazol-2-yl)pyridin-2-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C31H28N8S
 1
1
Activity = 3239 nM
   TI
   LI
   LO
   TS
CP0037741
1-[1-({4-[3-phenyl-5-(pyrimidin-2-yl)pyridin-2-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C32H29N9
 1
1
Activity = 3459 nM
   TI
   LI
   LO
   TS
CP0037742
1-[1-({4-[5-(5-amino-1,3,4-thiadiazol-2-yl)-3-phenylpyridin-2-yl]phenyl}methyl)piperidin-4-yl]-1H,2H,3H-imidazo[4,5-b]pyridin-2-one
   Show/Hide
C31H28N8OS
 1
1
Activity = 3957 nM
   TI
   LI
   LO
   TS
CP0286920
1-[1-({4-[3-phenyl-5-(pyridin-2-yl)pyridin-2-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C33H30N8
 1
1
Activity = 8110 nM
   TI
   LI
   LO
   TS
CP0058899
2,3,5-trisubstituted pyridine, 3
   Show/Hide
C29H27N11
 1
1
Activity > 50000 nM
   TI
   LI
   LO
   TS
CP0149889
6-(4-{[4-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]methyl}phenyl)-5-phenylpyridine-3-carbonitrile
   Show/Hide
C31H27N5O
 1
1
Activity > 50000 nM
   TI
   LI
   LO
   TS
CP0169523
1-[1-({4-[3-phenyl-5-(1H-1,2,3,4-tetrazol-5-yl)pyridin-2-yl]phenyl}methyl)piperidin-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one
   Show/Hide
C31H28N8O
 1
1
Activity > 50000 nM
   TI
   LI
   LO
   TS
CP0052263
2-(dimethylamino)-1-(4-(6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)ethanone
   Show/Hide
C40H43N11O
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0166638
2-(4-(1-methylazetidin-3-yl)piperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C40H43N11
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0052262
N,N-dimethyl-2-[4-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazin-1-yl]ethanamine
   Show/Hide
C40H45N11
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0213382
2-(4-(6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)ethanol
   Show/Hide
C38H40N10O
 1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
CP0069856
2-((R)-3-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C37H38N10
 1
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
CP0207122
2-(4-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C37H38N10
 1
1
IC50 = 52 nM
   TI
   LI
   LO
   TS
CP0167555
N,N-dimethyl-1-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperidin-4-amine
   Show/Hide
C39H42N10
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0086403
2-((3S,5R)-3,5-dimethylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C38H40N10
 1
1
IC50 = 101 nM
   TI
   LI
   LO
   TS
CP0243724
2-((S)-3-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C37H38N10
 1
1
IC50 = 125 nM
   TI
   LI
   LO
   TS
CP0069858
6-(4-methylpiperazin-1-yl)-3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-1,7-naphthyridine
   Show/Hide
C38H39N9
 1
1
IC50 = 133 nM
   TI
   LI
   LO
   TS
CP0207117
1-(4-(6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)ethanone
   Show/Hide
C38H38N10O
 1
1
IC50 = 145 nM
   TI
   LI
   LO
   TS
CP0069857
1-(6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidin-2-yl)piperidin-4-ol
   Show/Hide
C37H37N9O
 1
1
IC50 = 168 nM
   TI
   LI
   LO
   TS
CP0201244
N,N-dimethyl-4-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]piperazine-1-carboxamide
   Show/Hide
C39H41N11O
 1
1
IC50 = 177 nM
   TI
   LI
   LO
   TS
CP0158836
2-((2S,6R)-2,6-dimethylmorpholino)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C38H39N9O
 1
1
IC50 = 184 nM
   TI
   LI
   LO
   TS
CP0279579
2-(4-(methylsulfonyl)piperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C37H38N10O2S
 1
1
IC50 = 196 nM
   TI
   LI
   LO
   TS
CP0207119
2-((2R,5S)-2,5-dimethylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C38H40N10
 1
1
IC50 = 199 nM
   TI
   LI
   LO
   TS
CP0279580
N',N'-dimethyl-N-[6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-yl]ethane-1,2-diamine
   Show/Hide
C36H38N10
 1
1
IC50 = 223 nM
   TI
   LI
   LO
   TS
CP0236379
6-phenyl-2-(piperidin-1-yl)-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C37H37N9
 1
1
IC50 = 229 nM
   TI
   LI
   LO
   TS
CP0201242
2-morpholino-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C36H35N9O
 1
1
IC50 = 243 nM
   TI
   LI
   LO
   TS
CP0136886
7-[4-[[4-(2-methylbenzimidazol-1-yl)piperidin-1-yl]methyl]phenyl]-6-phenylpyrido[2,3-d]pyrimidin-4-amine
   Show/Hide
C33H31N7
 1
1
IC50 = 344 nM
   TI
   LI
   LO
   TS
CP0211535
1-(2-aminophenyl)-3-[({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)amino]propan-1-one
   Show/Hide
C30H27N5OS
 1
1
IC50 = 388 nM
   TI
   LI
   LO
   TS
CP0139000
(2R)-4-(6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidin-2-yl)piperazin-2-ol
   Show/Hide
C36H36N10O
 1
1
IC50 = 421 nM
   TI
   LI
   LO
   TS
CP0052265
2-(3,3-difluoropyrrolidin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C36H33F2N9
 1
1
IC50 = 462 nM
   TI
   LI
   LO
   TS
CP0136885
7-{4-[(4-{4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}piperidin-1-yl)methyl]phenyl}-6-phenylpyrido[2,3-d]pyrimidin-4-amine
   Show/Hide
C30H28N10
 1
1
IC50 = 468 nM
   TI
   LI
   LO
   TS
CP0195723
6-phenyl-7-[4-({4-[5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl]pyrido[2,3-d]pyrimidine-2-carbonitrile
   Show/Hide
C33H27N9
 1
1
IC50 = 586 nM
   TI
   LI
   LO
   TS
CP0037666
2-{5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)piperidin-4-yl]-4H-1,2,4-triazol-3-yl}pyridine
   Show/Hide
C33H30N8S
 1
1
IC50 = 589 nM
   TI
   LI
   LO
   TS
CP0211538
4-{3-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazol-5-yl}pyridine
   Show/Hide
C34H31N7S
 1
1
IC50 = 635 nM
   TI
   LI
   LO
   TS
CP0344552
2-(1H-imidazol-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C35H30N10
 1
1
IC50 = 684 nM
   TI
   LI
   LO
   TS
CP0236380
2-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine
   Show/Hide
C37H34N12
 1
1
IC50 = 735 nM
   TI
   LI
   LO
   TS
CP0256953
1-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C31H29N9S
 1
1
IC50 = 828 nM
   TI
   LI
   LO
   TS
CP0052261
N-methyl-6-phenyl-7-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-2-amine
   Show/Hide
C33H31N9
 1
1
IC50 = 899 nM
   TI
   LI
   LO
   TS
CP0256933
1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)-N-(pyridin-4-yl)piperidine-4-carboxamide
   Show/Hide
C32H30N6OS
 1
1
IC50 = 1131 nM
   TI
   LI
   LO
   TS
CP0118185
6-phenyl-7-[4-[[4-(3-pyridin-4-yl-1H-pyrazol-5-yl)piperidin-1-yl]methyl]phenyl]pyrido[2,3-d]pyrimidin-4-amine
   Show/Hide
C33H30N8
 1
1
IC50 = 1198 nM
   TI
   LI
   LO
   TS
CP0211539
5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)piperidin-4-yl]-1,3,4-thiadiazol-2-amine
   Show/Hide
C28H27N7S2
 1
1
IC50 = 1572 nM
   TI
   LI
   LO
   TS
CP0145581
7-(4-{[4-(6-fluoro-1H-1,3-benzodiazol-2-yl)piperidin-1-yl]methyl}phenyl)-6-phenylpyrido[2,3-d]pyrimidin-4-amine
   Show/Hide
C32H28FN7
 1
1
IC50 = 1811 nM
   TI
   LI
   LO
   TS
CP0256935
2-(5-{1-[(4-{2-methoxy-6-phenylpyrido[2,3-d]pyrimidin-7-yl}phenyl)methyl]piperidin-4-yl}-4H-1,2,4-triazol-3-yl)pyridine
   Show/Hide
C33H30N8O
 1
1
IC50 = 2295 nM
   TI
   LI
   LO
   TS
CP0211541
6-phenyl-7-[4-({4-[5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl]pyrido[2,3-d]pyrimidine-2-carboxamide
   Show/Hide
C33H29N9O
 1
1
IC50 = 3706 nM
   TI
   LI
   LO
   TS
CP0256860
3-[1-[[4-(4-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one
   Show/Hide
C32H29N7O
 1
1
IC50 = 5084 nM
   TI
   LI
   LO
   TS
CP0211540
3-ethyl-1-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)piperidin-4-yl]urea
   Show/Hide
C29H32N6OS
 1
1
IC50 = 5296 nM
   TI
   LI
   LO
   TS
CP0211537
1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]phenyl}methyl)piperidine-4-carboxamide
   Show/Hide
C27H27N5OS
 1
1
IC50 = 9259 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Uterus)
Cell Line Name Organism Disease
HeLa Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
H1HeLa Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
L-02 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa S3 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
SGC-7901 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa Kyoto Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HL2/3 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-V1 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-MAGI Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
BEL-7402/5-FU Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
BGC-823 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-ChR-8-5 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-MAGI-CCR5 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
P4 MAGI CCR5+ Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-3-1 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
TZM-bl Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-ChR-8-5-11 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
NCTC 2544 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HEp-2 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
SMMC-7721 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HG5LN Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
Chang Liver Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
Girardi Heart Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
MDR-KB-VCR Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
MDR-KB-VIN Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa R1-11 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-T5 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa/STAT3-luc Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HLR-CREB Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-A2A Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-A3 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-P4 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
C-4-I Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
SiHa Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
SK-E2 Homo sapiens (Human) Uterine corpus leiomyosarcoma
MES-SA/Dx5 Homo sapiens (Human) Uterine corpus sarcoma
MES-SA Homo sapiens (Human) Uterine corpus sarcoma