General Information of the Cell Line
Cell Line ID
CL000973
Cell Line Name
HLR-CREB
Synonyms
PathDetect HLR-CREB
Category
Cancer cell line
Organism
Homo sapiens (Human)
Tissue Information
Uterus
Disease
Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00856, Ribosomal protein S6 kinase alpha-3
 Protein Info 
Compound ID Compound Name Compound Formula
CP0074579
 Compound Info 
(5R)-N-[1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-5-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C26H30N6O2
  1
1
IC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0094909
 Compound Info 
N-(1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C22H21N5O2
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0094910
 Compound Info 
N-(3-ethylimidazo[4,5-b]pyridin-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C21H20N6O2
  1
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0275482
 Compound Info 
N-(6-chloro-1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C22H20ClN5O2
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298461
 Compound Info 
1-oxo-N-[1-(pyridin-4-ylmethyl)pyrazol-4-yl]-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C22H20N6O2
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169921
 Compound Info 
(5S)-N-[1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-5-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C26H30N6O2
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0355002
 Compound Info 
N-[1-(cyclohexylmethyl)pyrazol-4-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C23H27N5O2
  1
1
IC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298459
 Compound Info 
N-(3-benzyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C23H20N4O3
  1
1
IC50 = 130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298463
 Compound Info 
N-(5-chloro-1-ethylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C22H20ClN5O2
  1
1
IC50 = 130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0251135
 Compound Info 
N-[6-chloro-1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C25H27ClN6O2
  1
1
IC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298462
 Compound Info 
1-oxo-N-(1-propan-2-ylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C23H23N5O2
  1
1
IC50 = 180 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0016691
 Compound Info 
N-(1-methylbenzimidazol-2-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C21H19N5O2
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0026929
 Compound Info 
N-(3-methyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C17H16N4O3
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0228347
 Compound Info 
N-[1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C25H28N6O2
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0129063
 Compound Info 
N-(3-cyclopropyl-1,2-oxazol-5-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C19H18N4O3
  1
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0253294
 Compound Info 
N-[1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-4,4-dimethyl-1-oxo-3,5-dihydro-2H-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C27H32N6O2
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0275481
 Compound Info 
1-oxo-N-(3-phenyl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C22H18N4O3
  1
1
IC50 = 360 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0200355
 Compound Info 
1-oxo-N-[1-(pyridin-2-ylmethyl)pyrazol-4-yl]-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C22H20N6O2
  1
1
IC50 = 460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298458
 Compound Info 
1-oxo-N-(3-propan-2-yl-1,2-oxazol-5-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C19H20N4O3
  1
1
IC50 = 460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0017602
 Compound Info 
N-(1-methylpyrazol-4-yl)-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C17H17N5O2
  1
1
IC50 = 790 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0223295
 Compound Info 
1-oxo-N-(1-phenylbenzimidazol-2-yl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
   Show/Hide
C26H21N5O2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Uterus)
Cell Line Name Organism Disease
C-33 A
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-independent cervical squamous cell carcinoma
HeLa
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
H1HeLa
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
L-02
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa S3
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
SGC-7901
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa Kyoto
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HL2/3
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-V1
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-MAGI
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
BEL-7402/5-FU
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
BGC-823
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-ChR-8-5
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-MAGI-CCR5
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
P4 MAGI CCR5+
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-3-1
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
TZM-bl
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-ChR-8-5-11
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
NCTC 2544
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HEp-2
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
SMMC-7721
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HG5LN
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
Chang Liver
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
Girardi Heart
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
MDR-KB-VCR
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
MDR-KB-VIN
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa R1-11
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-T5
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa/STAT3-luc
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-A2A
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-A3
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-P4
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
C-4-I
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
SiHa
 Cell Line Info 
Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
SK-E2
 Cell Line Info 
Homo sapiens (Human) Uterine corpus leiomyosarcoma
MES-SA/Dx5
 Cell Line Info 
Homo sapiens (Human) Uterine corpus sarcoma
MES-SA
 Cell Line Info 
Homo sapiens (Human) Uterine corpus sarcoma