General Information of the Cell Line
Cell Line ID
CL000356
Cell Line Name
KB-V1
Synonyms
KB-v1
KB-V-1
KBV1
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2089
Tissue Information
Uterus
Disease
Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01546, ATP-dependent translocase ABCB1
Compound ID Compound Name Compound Formula
CP0254388
5-Methoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic acid {4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-amide
   Show/Hide
C34H33N3O5
 1
1
IC50 = 193 nM
   TI
   LI
   LO
   TS
CP0116921
1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]phenyl}-4,5-dimethoxy-2-(3-quinolylcarboxamido)benzamide
   Show/Hide
C38H38N4O6
 2
1
IC50 = 223 nM
   TI
   LI
   LO
   TS
2
IC50 = 356 nM
   TI
   LI
   LO
   TS
CP0417560
methyl 4-[4-[[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]methyl]phenyl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C42H45N3O8
 1
1
IC50 = 1230 nM
   TI
   LI
   LO
   TS
CP0531226
N-[5-[1-(2-morpholin-4-ylethyl)triazol-4-yl]-2-propanoylphenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C27H27N5O5
 1
1
IC50 = 1342 nM
   TI
   LI
   LO
   TS
CP0542883
methyl 4-[1-[4-[2-[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]triazol-4-yl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C45H48N6O8
 1
1
IC50 = 1623 nM
   TI
   LI
   LO
   TS
CP0455202
methyl 4-[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-2-(quinoline-6-carbonylamino)benzoate
   Show/Hide
C34H29N3O3
 1
1
IC50 = 4490 nM
   TI
   LI
   LO
   TS
CP0469410
methyl 4-[4-[2-[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C43H47N3O8
 1
1
IC50 = 5420 nM
   TI
   LI
   LO
   TS
CP0455199
methyl 4-[4-[2-[6,7-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C49H59N3O11
 1
1
IC50 = 5990 nM
   TI
   LI
   LO
   TS
CP0386291
5-[(4-bromophenyl)methoxy]-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-oxochromene-2-carboxamide
   Show/Hide
C28H23BrN2O5
 1
1
IC50 = 6756 nM
   TI
   LI
   LO
   TS
CP0462999
N-(3-morpholin-4-ylpropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
   Show/Hide
C26H27N5O2
 1
1
IC50 = 6800 nM
   TI
   LI
   LO
   TS
CP0373409
methyl 4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-(quinoline-3-carbonylamino)benzoate
   Show/Hide
C38H36N4O6
 1
1
IC50 = 9450 nM
   TI
   LI
   LO
   TS
CP0394488
methyl 4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-(quinoline-6-carbonylamino)benzoate
   Show/Hide
C38H36N4O6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0542882
methyl 4-[1-[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]triazol-4-yl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C38H34N6O5
 1
1
IC50 >= 10730 nM
   TI
   LI
   LO
   TS
CP0455200
methyl 4-[4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]-2-(quinoline-6-carbonylamino)benzoate
   Show/Hide
C36H33N3O5
 1
1
IC50 = 10900 nM
   TI
   LI
   LO
   TS
CP0415114
methyl 4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C38H36N4O6
 2
1
IC50 >= 12080 nM
   TI
   LI
   LO
   TS
2
IC50 > 29000 nM
   TI
   LI
   LO
   TS
CP0423799
methyl 4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-(pyridine-3-carbonylamino)benzoate
   Show/Hide
C34H34N4O6
 1
1
IC50 > 14000 nM
   TI
   LI
   LO
   TS
CP0394487
N-[3-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-5-methoxyphenyl]quinoline-3-carboxamide
   Show/Hide
C37H36N4O5
 1
1
IC50 > 15000 nM
   TI
   LI
   LO
   TS
CP0462357
N-[5-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-methylphenyl]quinoline-3-carboxamide
   Show/Hide
C37H36N4O4
 1
1
IC50 > 15000 nM
   TI
   LI
   LO
   TS
CP0398446
2-(4-benzylpiperazine-1-carbonyl)-5-phenylmethoxychromen-4-one
   Show/Hide
C28H26N2O4
 1
1
IC50 = 15800 nM
   TI
   LI
   LO
   TS
CP0502250
N-[5-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2,3-dimethoxyphenyl]quinoline-3-carboxamide
   Show/Hide
C38H38N4O6
 1
1
IC50 > 17000 nM
   TI
   LI
   LO
   TS
CP0417519
methyl 4-[4-[[7-methoxy-6-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]methyl]phenyl]-2-(quinoline-6-carbonylamino)benzoate
   Show/Hide
C42H45N3O8
 1
1
IC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0531223
N-[5-[1-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]triazol-4-yl]-2-propanoylphenyl]-6-oxo-1H-pyridine-2-carboxamide
   Show/Hide
C36H36N6O5
 1
1
IC50 > 18450 nM
   TI
   LI
   LO
   TS
CP0462358
methyl 4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-(pyrazine-2-carbonylamino)benzoate
   Show/Hide
C33H33N5O6
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0490349
N-[5-[1-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]triazol-4-yl]-2-(2-methylpropanoyl)phenyl]quinoline-2-carboxamide
   Show/Hide
C41H40N6O4
 1
1
IC50 >= 21830 nM
   TI
   LI
   LO
   TS
CP0488947
methyl 4-[1-[4-[[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]methyl]phenyl]triazol-4-yl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C44H46N6O8
 1
1
IC50 >= 25030 nM
   TI
   LI
   LO
   TS
CP0141589
3-((3S,6S)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butyl ester
   Show/Hide
C26H35N3O5
 1
1
IC50 >= 25520 nM
   TI
   LI
   LO
   TS
CP0508791
5,7-dimethoxy-2-[4-[[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]chromen-4-one
   Show/Hide
C23H23F3N2O4
 1
1
IC50 = 31300 nM
   TI
   LI
   LO
   TS
CP0474629
5,7-dimethoxy-2-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]chromen-4-one
   Show/Hide
C22H23N3O6
 1
1
IC50 = 32800 nM
   TI
   LI
   LO
   TS
CP0433316
5,7-dimethoxy-2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]chromen-4-one
   Show/Hide
C23H25N3O6
 1
1
IC50 = 33000 nM
   TI
   LI
   LO
   TS
CP0382010
methyl 4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-(quinoxaline-2-carbonylamino)benzoate
   Show/Hide
C37H35N5O6
 1
1
IC50 > 34000 nM
   TI
   LI
   LO
   TS
CP0483165
5,7-dimethoxy-2-[4-[[4-(trifluoromethylsulfanyl)phenyl]methyl]piperazin-1-yl]chromen-4-one
   Show/Hide
C23H23F3N2O4S
 1
1
IC50 = 36600 nM
   TI
   LI
   LO
   TS
CP0488948
methyl 4-[1-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]triazol-4-yl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C37H32N6O3
 1
1
IC50 >= 38270 nM
   TI
   LI
   LO
   TS
CP0490350
N-[5-[1-[4-[2-[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]triazol-4-yl]-2-propanoylphenyl]quinoline-2-carboxamide
   Show/Hide
C46H50N6O7
 1
1
IC50 >= 44460 nM
   TI
   LI
   LO
   TS
CP0373171
methyl 4-[[4-[2-[7-methoxy-6-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]carbamoyl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C44H48N4O9
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0437995
methyl 4-[[4-[2-[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]carbamoyl]-2-(quinoline-2-carbonylamino)benzoate
   Show/Hide
C44H48N4O9
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0465345
methyl 4-[[4-[2-[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]carbamoyl]-2-(quinoline-6-carbonylamino)benzoate
   Show/Hide
C44H48N4O9
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0898202
N-{4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2-[(quinoline-2-carbonyl)-amino]-terephthalamic acid trifluoroacetic acid
   Show/Hide
C39H35F3N4O8
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0904106
N-{4-[2-(6-Methoxy-7-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2-[(quinoline-6-carbonyl)-amino]-terephthalamic acid trifluoroacetic acid
   Show/Hide
C45H47F3N4O11
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0904107
N-{4-[2-(7-Methoxy-6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2-[(quinoline-6-carbonyl)-amino]-terephthalamic acid trifluoroacetic acid
   Show/Hide
C45H47F3N4O11
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0459693
methyl 4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-[(5-methylpyrazine-2-carbonyl)amino]benzoate
   Show/Hide
C34H35N5O6
 1
1
IC50 > 57000 nM
   TI
   LI
   LO
   TS
CP0434377
5,7-dimethoxy-2-[4-[(4-nitrophenyl)methyl]piperazine-1-carbonyl]chromen-4-one
   Show/Hide
C23H23N3O7
 1
1
IC50 = 58200 nM
   TI
   LI
   LO
   TS
CP0390463
2-[4-[(3,4-difluorophenyl)methyl]piperazin-1-yl]-5,7-dimethoxychromen-4-one
   Show/Hide
C22H22F2N2O4
 1
1
IC50 = 58500 nM
   TI
   LI
   LO
   TS
CP0530501
(Z)-2-(3,4-dimethoxyphenyl)-3-[5-(4-hydroxypiperidin-1-yl)thiophen-2-yl]prop-2-enenitrile
   Show/Hide
C20H22N2O3S
 1
1
IC50 >= 65480 nM
   TI
   LI
   LO
   TS
CP0406173
5,7-dimethoxy-2-[4-[2-(4-nitrophenyl)ethyl]piperazine-1-carbonyl]chromen-4-one
   Show/Hide
C24H25N3O7
 1
1
IC50 = 83900 nM
   TI
   LI
   LO
   TS
CP0437996
methyl 4-[[4-[2-[7-methoxy-6-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]ethyl]phenyl]carbamoyl]-2-(quinoline-6-carbonylamino)benzoate
   Show/Hide
C44H48N4O9
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0878929
N-{4-[2-(6-Methoxy-7-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2-[(quinoline-2-carbonyl)-amino]-terephthalamic acid trifluoroacetic acid
   Show/Hide
C45H47F3N4O11
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0898201
N-{4-[2-(7-Methoxy-6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2-[(quinoline-2-carbonyl)-amino]-terephthalamic acid trifluoroacetic acid
   Show/Hide
C45H47F3N4O11
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0390465
methyl 4-[[4-(5,7-dimethoxy-4-oxochromen-2-yl)piperazin-1-yl]methyl]benzoate
   Show/Hide
C24H26N2O6
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0406172
5,7-dimethoxy-2-[4-[(2-nitrophenyl)methyl]piperazin-1-yl]chromen-4-one
   Show/Hide
C22H23N3O6
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0462997
5,7-dimethoxy-2-[4-[[4-(trifluoromethylsulfonyl)phenyl]methyl]piperazin-1-yl]chromen-4-one
   Show/Hide
C23H23F3N2O6S
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0497740
4-[[4-(5,7-dimethoxy-4-oxochromen-2-yl)piperazin-1-yl]methyl]benzonitrile
   Show/Hide
C23H23N3O4
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0906528
N-{4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-2-[(quinoline-6-carbonyl)-amino]-terephthalamic acid trifluoroacetic acid
   Show/Hide
C39H35F3N4O8
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0486097
N-[5-methyl-2-[1-(2-morpholin-4-ylethyl)triazol-4-yl]phenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C25H25N5O4
 1
1
IC50 > 1601 nM
   TI
   LI
   LO
   TS
CP0486096
N-[5-[1-(2-hydroxyethyl)triazol-4-yl]-2-propanoylphenyl]-4-oxochromene-2-carboxamide
   Show/Hide
C23H20N4O5
 1
1
IC50 > 2285 nM
   TI
   LI
   LO
   TS
CP0563376
N-[5-[1-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]triazol-4-yl]-2-propanoylphenyl]-5-methoxypyridine-2-carboxamide
   Show/Hide
C37H38N6O5
 1
1
IC50 > 2775 nM
   TI
   LI
   LO
   TS
CP0382011
N-[5-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-2-methoxyphenyl]quinoline-3-carboxamide
   Show/Hide
C37H36N4O5
 1
1
IC50 > 6000 nM
   TI
   LI
   LO
   TS
CP0531227
N-[5-[1-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]triazol-4-yl]-2-propanoylphenyl]-6-methylpyridine-2-carboxamide
   Show/Hide
C37H38N6O4
 1
1
IC50 > 9972 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Uterus)
Cell Line Name Organism Disease
C-33 A Homo sapiens (Human) Human papillomavirus-independent cervical squamous cell carcinoma
HeLa Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
H1HeLa Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
L-02 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa S3 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
SGC-7901 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa Kyoto Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HL2/3 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-MAGI Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
BEL-7402/5-FU Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
BGC-823 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-ChR-8-5 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-MAGI-CCR5 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
P4 MAGI CCR5+ Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-3-1 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
TZM-bl Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
KB-ChR-8-5-11 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
NCTC 2544 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HEp-2 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
SMMC-7721 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HG5LN Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
Chang Liver Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
Girardi Heart Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
MDR-KB-VCR Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
MDR-KB-VIN Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa R1-11 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-T5 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa/STAT3-luc Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HLR-CREB Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-A2A Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-A3 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
HeLa-P4 Homo sapiens (Human) Human papillomavirus-related cervical adenocarcinoma
C-4-I Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
SiHa Homo sapiens (Human) Human papillomavirus-related cervical squamous cell carcinoma
SK-E2 Homo sapiens (Human) Uterine corpus leiomyosarcoma
MES-SA/Dx5 Homo sapiens (Human) Uterine corpus sarcoma
MES-SA Homo sapiens (Human) Uterine corpus sarcoma