General Information of the Compound
Compound ID
CP0486097
Compound Name
N-[5-methyl-2-[1-(2-morpholin-4-ylethyl)triazol-4-yl]phenyl]-4-oxochromene-2-carboxamide
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Formula
C25H25N5O4
Molecular Weight
459.506
Canonical SMILES
Cc1ccc(-c2cn(CCN3CCOCC3)nn2)c(NC(=O)c2cc(=O)c3ccccc3o2)c1
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InChI
InChI=1S/C25H25N5O4/c1-17-6-7-18(21-16-30(28-27-21)9-8-29-10-12-33-13-11-29)20(14-17)26-25(32)24-15-22(31)19-4-2-3-5-23(19)34-24/h2-7,14-16H,8-13H2,1H3,(H,26,32)
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InChIKey
QDMNYDIHPHLOQL-UHFFFAOYSA-N
Physicochemical Property
logP
2.94442
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
102.49
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4743740
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000356 KB-V1 Homo sapiens (Human)  1
1
IC50 > 1601 nM
   TI
   LI
   LO
   TS
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000781 MCF7/Topo Homo sapiens (Human)  1
1
IC50 = 188 nM
   TI
   LI
   LO
   TS