General Information of the Compound
Compound ID
CP0486096
Compound Name
N-[5-[1-(2-hydroxyethyl)triazol-4-yl]-2-propanoylphenyl]-4-oxochromene-2-carboxamide
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Formula
C23H20N4O5
Molecular Weight
432.436
Canonical SMILES
CCC(=O)c1ccc(cc1NC(=O)c1cc(=O)c2ccccc2o1)-c1cn(CCO)nn1
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InChI
InChI=1S/C23H20N4O5/c1-2-19(29)15-8-7-14(18-13-27(9-10-28)26-25-18)11-17(15)24-23(31)22-12-20(30)16-5-3-4-6-21(16)32-22/h3-8,11-13,28H,2,9-10H2,1H3,(H,24,31)
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InChIKey
UMEYJHWTIJSWLP-UHFFFAOYSA-N
Physicochemical Property
logP
2.8888
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
127.32
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4779349
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000356 KB-V1 Homo sapiens (Human)  1
1
IC50 > 2285 nM
   TI
   LI
   LO
   TS
Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000781 MCF7/Topo Homo sapiens (Human)  1
1
IC50 > 1102 nM
   TI
   LI
   LO
   TS