| Compound ID |
Compound Name |
Compound Formula |
|
CP0146670
|
N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]pyrazine-2-carboxamide
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|
C31H39F2N5O5S
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
|
CP0162418
|
pyridin-3-ylmethyl N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]carbamate
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|
C33H42F2N4O6S
|
1
|
| 1 |
EC50 = 0.6 nM
|
|
|
|
CP0161189
|
N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]pyridine-3-carboxamide
Show/Hide
|
C35H46F2N4O5S
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0203869
|
N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]pyridine-4-carboxamide
Show/Hide
|
C32H40F2N4O5S
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0217449
|
N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]pyridine-3-carboxamide
Show/Hide
|
C32H40F2N4O5S
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0144384
|
methyl N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]carbamate
Show/Hide
|
C31H45F2N3O6S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0164105
|
pyridin-4-ylmethyl N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]carbamate
Show/Hide
|
C33H42F2N4O6S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0253891
|
methyl N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]carbamate
Show/Hide
|
C28H39F2N3O6S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0161187
|
N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]-1H-imidazole-2-carboxamide
Show/Hide
|
C30H39F2N5O5S
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0164106
|
S-(oxolan-3-yl) N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]carbamothioate
Show/Hide
|
C31H43F2N3O6S2
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0202354
|
N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]cyclopropanecarboxamide
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|
C30H41F2N3O5S
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0210495
|
N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]-5-methyl-1H-pyrazole-3-carboxamide
Show/Hide
|
C31H41F2N5O5S
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0287465
|
(S)-N-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl)-3-(butylsulfonyl)-2-(2-methoxyacetamido)propanamide
Show/Hide
|
C29H41F2N3O6S
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0203872
|
pyridin-3-ylmethyl N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]carbamate
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|
C36H48F2N4O6S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0217447
|
2-cyanoethyl 1-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-ylamino)-3-(butylsulfonyl)-1-oxopropan-2-ylcarbamate
Show/Hide
|
C30H40F2N4O6S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0339556
|
pyridin-4-ylmethyl N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]carbamate
Show/Hide
|
C36H48F2N4O6S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0253889
|
(S)-N-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl)-2-acetamido-3-(butylsulfonyl)propanamide
Show/Hide
|
C28H39F2N3O5S
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0302146
|
3-[(8R)-2'-amino-1',6,6-trimethyl-5'-oxospiro[5,7-dihydronaphthalene-8,4'-imidazole]-2-yl]benzonitrile
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|
C22H22N4O
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0315955
|
(4R)-2'-amino-6-(2-fluoropyridin-3-yl)-2,2,3'-trimethylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
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|
C20H21FN4O
|
1
|
| 1 |
EC50 = 8.9 nM
|
|
|
|
CP0161190
|
N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]-3-hydroxybenzamide
Show/Hide
|
C36H47F2N3O6S
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0284890
|
2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H21ClN4O
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0210498
|
N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]-4-methoxybenzamide
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|
C37H49F2N3O6S
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0339559
|
2-acetamidoethyl (S)-1-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-ylamino)-3-(butylsulfonyl)-1-oxopropan-2-ylcarbamate
Show/Hide
|
C31H44F2N4O7S
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0157336
|
N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]benzamide
Show/Hide
|
C36H47F2N3O5S
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0302147
|
(4R)-2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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|
C19H19ClN4O2
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0795276
|
rac-2-Amino-7'-(2-fluoropyridin-3-yl)-1,3',3'-trimethyl-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one
Show/Hide
|
C20H21FN4O
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0924955
|
rac-3-(2-Amino-1,3',3'-trimethyl-5-oxo-1,3',4',5-tetrahydro-2'Hspiro[imidazole-4,1'-naphthalene]-7'-yl)benzonitrile
Show/Hide
|
C22H22N4O
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0339546
|
N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]-4-methylbenzamide
Show/Hide
|
C37H49F2N3O5S
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0210520
|
N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]-4-oxo-1H-pyridine-3-carboxamide
Show/Hide
|
C32H40F2N4O6S
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0368699
|
2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[3H-thiochromene-4,5'-imidazole]-4'-one
Show/Hide
|
C19H19ClN4OS
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0333396
|
(4R)-2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0703986
|
rac-2'-Amino-6-(5-chloropyridin-3-yl)-1',2,2-trimethylspiro-[chroman-4,4'-imidazol]-5'(1'H)-one
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|
C19H19ClN4O2
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0259787
|
3-(2'-amino-1',2,2-trimethyl-5'-oxospiro[3H-chromene-4,4'-imidazole]-6-yl)benzonitrile
Show/Hide
|
C21H20N4O2
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0284894
|
2'-amino-2,2,3'-trimethyl-6-[5-(trifluoromethyl)pyridin-3-yl]spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H19F3N4O2
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0284803
|
2'-amino-2,2,3'-trimethyl-6-(5-prop-1-ynylpyridin-3-yl)spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C22H22N4O2
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0146671
|
3-chloro-N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]benzamide
Show/Hide
|
C36H46ClF2N3O5S
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0795275
|
rac-2-Amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one
Show/Hide
|
C19H21N5O
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0333398
|
3-(2'-amino-1',2,2-trimethyl-5'-oxospiro[3H-thiochromene-4,4'-imidazole]-6-yl)benzonitrile
Show/Hide
|
C21H20N4OS
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0210524
|
N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]-2-methylbenzamide
Show/Hide
|
C37H49F2N3O5S
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0368700
|
2'-amino-6-(3-chloro-5-fluorophenyl)-2,2,3'-trimethylspiro[3H-thiochromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H19ClFN3OS
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0315956
|
3'-[(1-acetylpiperidin-4-yl)methyl]-2'-amino-6-(3-chlorophenyl)-2,2-dimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C27H31ClN4O3
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0162426
|
N-[(2S)-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-3-heptan-4-ylsulfonyl-1-oxopropan-2-yl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C37H46F5N3O5S
|
1
|
| 1 |
EC50 = 76 nM
|
|
|
|
CP0323332
|
2'-amino-6-(2-fluoro-5-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H22FN3O3
|
1
|
| 1 |
EC50 = 86 nM
|
|
|
|
CP0065927
|
2'-amino-6-[3-(difluoromethoxy)phenyl]-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
EC50 = 88 nM
|
|
|
|
CP0284891
|
2'-amino-6-(3-chloro-5-fluorophenyl)-2,2,3'-trimethylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H21ClFN3O
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0206649
|
2'-amino-6-(2-fluoropyridin-3-yl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C19H19FN4O2
|
1
|
| 1 |
EC50 = 94 nM
|
|
|
|
CP0449566
|
2'-amino-6-(3-chloro-5-fluorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H19ClFN3O2
|
1
|
| 1 |
EC50 = 95 nM
|
|
|
|
CP0368698
|
2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[3H-thiochromene-4,5'-imidazole]-4'-one
Show/Hide
|
C18H19N5OS
|
1
|
| 1 |
EC50 = 96 nM
|
|
|
|
CP0368702
|
2'-amino-2,2,3'-trimethyl-6-pyridin-3-ylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C19H20N4O2
|
1
|
| 1 |
EC50 = 98 nM
|
|
|
|
CP0315958
|
2'-amino-6-(3-chlorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H20ClN3O2
|
1
|
| 1 |
EC50 = 107 nM
|
|
|
|
CP0284892
|
2'-amino-6-(5-fluoropyridin-3-yl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C19H19FN4O2
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
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CP0065929
|
2'-amino-6-(5-chloro-2-fluorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H19ClFN3O2
|
1
|
| 1 |
EC50 = 115 nM
|
|
|
|
CP0065926
|
2'-amino-6-cyclohexyl-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H27N3O2
|
1
|
| 1 |
EC50 = 119 nM
|
|
|
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CP0368704
|
2'-amino-6-(3-fluorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H20FN3O2
|
1
|
| 1 |
EC50 = 136 nM
|
|
|
|
CP0235872
|
(6S)-9-amino-14,32-dichloro-26-oxa-2,8,10,16,19-pentazatetracyclo[25.2.2.212,15.02,6]tritriaconta-1(29),9,12,14,27,30,32-heptaene-7,17-dione
Show/Hide
|
C27H34Cl2N6O3
|
2
|
| 1 |
EC50 = 140 nM
|
|
|
| 2 |
Ki = 3.2 nM
|
|
|
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CP0449511
|
2'-amino-6-(3-fluoro-5-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H22FN3O3
|
1
|
| 1 |
EC50 = 148 nM
|
|
|
|
CP0302151
|
2'-amino-6-(3-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
EC50 = 164 nM
|
|
|
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CP0368707
|
2'-amino-2,2,3'-trimethyl-6-[3-(trifluoromethyl)phenyl]spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H20F3N3O2
|
1
|
| 1 |
EC50 = 166 nM
|
|
|
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CP0065923
|
(4R)-2,2-dimethyl-6-pyrimidin-5-ylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H20N4O
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
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CP0449442
|
2'-amino-6-(3,5-dichlorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H19Cl2N3O2
|
1
|
| 1 |
EC50 = 184 nM
|
|
|
|
CP0368701
|
N-(2'-amino-1',2,2-trimethyl-5'-oxospiro[3H-chromene-4,4'-imidazole]-6-yl)-5-methylfuran-2-carboxamide
Show/Hide
|
C20H22N4O4
|
1
|
| 1 |
EC50 = 188 nM
|
|
|
|
CP0304033
|
6-(5-fluoropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H20FN3O
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0385841
|
6-(5-chloropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H20ClN3O
|
1
|
| 1 |
EC50 = 222 nM
|
|
|
|
CP0057408
|
(6S,22E)-9-amino-14,31-dichloro-25-oxa-2,8,10,16,19-pentazatetracyclo[24.2.2.212,15.02,6]dotriaconta-1(28),9,12,14,22,26,29,31-octaene-7,17-dione
Show/Hide
|
C26H30Cl2N6O3
|
3
|
| 1 |
EC50 = 230 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
| 3 |
Ki = 110 nM
|
|
|
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CP0304034
|
2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
EC50 = 232 nM
|
|
|
|
CP0368695
|
6-(2-fluoropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H20FN3O
|
1
|
| 1 |
EC50 = 316 nM
|
|
|
|
CP0781787
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rac-3,3-Dimethyl-7-(pyrimidin-5-yl)-3,4-dihydro-2H,5'H-spiro-[naphthalene-1,4'-oxazol]-2'-amine
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C18H20N4O
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1
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| 1 |
EC50 = 317 nM
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CP0302152
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2'-amino-2,2,3'-trimethyl-6-phenylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C20H21N3O2
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1
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| 1 |
EC50 = 399 nM
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CP0447919
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(2S)-N-[N'-[[3,5-dichloro-4-[[2-(dimethylamino)acetyl]amino]phenyl]methyl]carbamimidoyl]-1-(4-methoxyphenyl)pyrrolidine-2-carboxamide
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C24H30Cl2N6O3
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2
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| 1 |
EC50 = 420 nM
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| 2 |
Ki = 140 nM
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CP0095147
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(6S,23E)-9-amino-14,32-dichloro-26-oxa-2,8,10,16,19-pentazatetracyclo[25.2.2.212,15.02,6]tritriaconta-1(29),9,12,14,23,27,30,32-octaene-7,17-dione
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C27H32Cl2N6O3
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3
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| 1 |
EC50 = 490 nM
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| 2 |
Ki = 25 nM
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| 3 |
Ki = 59 nM
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CP0401339
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(2S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-(4-methoxyphenyl)pyrrolidine-2-carboxamide
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C22H25Cl2N5O3
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3
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| 1 |
EC50 = 520 nM
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| 2 |
Ki = 110 nM
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| 3 |
Ki = 300 nM
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CP0374696
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(2S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-(3-methoxyphenyl)pyrrolidine-2-carboxamide
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C22H25Cl2N5O3
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3
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| 1 |
EC50 = 550 nM
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| 2 |
Ki = 260 nM
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| 3 |
Ki = 630 nM
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CP0366543
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(6S)-9-amino-14,31-dichloro-25-oxa-2,8,10,16,19-pentazatetracyclo[24.2.2.212,15.02,6]dotriaconta-1(28),9,12,14,26,29,31-heptaene-7,17-dione
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C26H32Cl2N6O3
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3
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| 1 |
EC50 = 570 nM
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| 2 |
Ki = 43 nM
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| 3 |
Ki = 92 nM
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CP0401341
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(2S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-(4-chlorophenyl)pyrrolidine-2-carboxamide
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C21H22Cl3N5O2
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3
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| 1 |
EC50 = 580 nM
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| 2 |
Ki = 150 nM
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| 3 |
Ki = 370 nM
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CP0259786
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2'-amino-6-(3-ethoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C22H25N3O3
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1
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| 1 |
EC50 = 633 nM
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CP0374704
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(2S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-phenylpyrrolidine-2-carboxamide
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C21H23Cl2N5O2
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3
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| 1 |
EC50 = 680 nM
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| 2 |
Ki = 210 nM
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| 3 |
Ki = 340 nM
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CP0041318
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(6S,21E)-9-amino-14,30-dichloro-24-oxa-2,8,10,16,19-pentazatetracyclo[23.2.2.212,15.02,6]hentriaconta-1(27),9,12,14,21,25,28,30-octaene-7,17-dione
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C25H28Cl2N6O3
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3
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| 1 |
EC50 = 880 nM
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| 2 |
Ki = 220 nM
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| 3 |
Ki = 1500 nM
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CP0368696
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6-(5-chloropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-thiazole]-2'-amine
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C19H20ClN3S
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1
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| 1 |
EC50 = 896 nM
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CP0368706
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2'-amino-2,2,3'-trimethyl-6-(3-methylsulfanylphenyl)spiro[3H-chromene-4,5'-imidazole]-4'-one
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C21H23N3O2S
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1
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| 1 |
EC50 = 932 nM
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CP0334972
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2'-amino-2,2,3'-trimethyl-6-(1,2-thiazol-5-yl)spiro[3H-chromene-4,5'-imidazole]-4'-one
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C17H18N4O2S
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1
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| 1 |
EC50 = 954 nM
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CP0385840
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6-(5-chloropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5,6-dihydro-1,3-thiazine]-2'-amine
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C20H22ClN3S
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1
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| 1 |
EC50 = 971 nM
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CP0368697
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2'-amino-6-(3-chlorophenyl)-3'-ethyl-2,2-dimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C21H22ClN3O2
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1
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| 1 |
EC50 = 1596 nM
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CP0065924
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2'-amino-6-(3-chlorophenyl)-3'-(2-methoxyethyl)-2,2-dimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C22H24ClN3O3
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1
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| 1 |
EC50 = 1643 nM
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CP0381361
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(2S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide
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C22H22Cl2F3N5O2
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3
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| 1 |
EC50 = 1700 nM
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| 2 |
Ki = 130 nM
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| 3 |
Ki = 600 nM
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CP0334971
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2'-amino-4,4-difluoro-3,3,3'-trimethyl-7-pyrimidin-5-ylspiro[2H-naphthalene-1,5'-imidazole]-4'-one
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C19H19F2N5O
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1
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| 1 |
EC50 = 1884 nM
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CP0284889
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2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[3H-naphthalene-4,5'-imidazole]-1,4'-dione
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C19H19N5O2
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1
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| 1 |
EC50 = 3208 nM
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CP0227756
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-pyrazol-1-ylphenyl)cyclohexyl]amino]butan-2-yl]acetamide
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C27H32F2N4O2
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1
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| 1 |
ED50 = 4 nM
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CP0231910
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[1-(trimethylsilylmethyl)triazol-4-yl]cyclohexyl]amino]butan-2-yl]acetamide
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C24H37F2N5O2Si
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1
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| 1 |
ED50 = 6 nM
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CP0344679
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-3-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H36F2N2O3
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1
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| 1 |
ED50 = 7.1 nM
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CP0231912
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N-[(2S,3R)-4-[[1-(3-tert-butyl-5-fluorophenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H37F3N2O2
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1
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| 1 |
ED50 = 9 nM
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CP0243876
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N-[(2S,3R)-4-[[1-(4-tert-butylthiophen-2-yl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H36F2N2O2S
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1
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| 1 |
ED50 = 10 nM
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CP0374590
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-prop-1-en-2-ylphenyl)cyclohexyl]amino]butan-2-yl]acetamide
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C27H34F2N2O2
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1
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| 1 |
ED50 = 13 nM
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CP0489511
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(1,3-thiazol-4-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C27H31F2N3O2S
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1
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| 1 |
ED50 = 13 nM
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CP0344678
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[4-(3-pyrazol-1-ylphenyl)oxan-4-yl]amino]butan-2-yl]acetamide
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C26H30F2N4O3
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1
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| 1 |
ED50 = 13 nM
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CP0166496
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N-[(2S,3R)-4-[[4-(3-tert-butylphenyl)oxan-4-yl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
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C27H36F2N2O3
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1
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| 1 |
ED50 = 15 nM
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CP0071007
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N-[(2S,3R)-4-[[1-(3-tert-butylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
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C28H38F2N2O2
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1
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| 1 |
ED50 = 17 nM
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CP0324708
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N-[(2S,3R)-4-[2-(3-tert-butylphenyl)propan-2-ylamino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
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C25H34F2N2O2
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1
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| 1 |
ED50 = 17 nM
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CP0505732
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-oxopiperidin-1-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C29H37F2N3O3
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1
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| 1 |
ED50 = 20 nM
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CP0276313
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N-[(2S,3R)-4-[[1-[3-(1,3-difluoro-2-methylpropan-2-yl)phenyl]cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
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C25H30F4N2O2
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1
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| 1 |
ED50 = 21 nM
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CP0473775
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-2-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H36F2N2O3
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1
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| 1 |
ED50 = 23 nM
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CP0146364
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[1-(2,2-dimethylpropyl)pyrazol-4-yl]cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H38F2N4O2
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1
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| 1 |
ED50 = 23 nM
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CP0505733
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(3-oxo-2-azabicyclo[2.2.1]heptan-2-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C30H37F2N3O3
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1
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| 1 |
ED50 = 25 nM
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CP0196136
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N-[(2S,3R)-4-[[1-(3-amino-5-tert-butylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H39F2N3O2
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1
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| 1 |
ED50 = 25 nM
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CP0237147
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(1-fluoro-2-methylpropan-2-yl)phenyl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H31F3N2O2
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1
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| 1 |
ED50 = 25 nM
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CP0471030
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-imidazol-1-ylphenyl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C27H32F2N4O2
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1
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| 1 |
ED50 = 26 nM
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CP0237150
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N-[(2S,3R)-4-[[1-[3-(1,1-difluoro-2-methylpropan-2-yl)phenyl]cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H30F4N2O2
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1
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| 1 |
ED50 = 26 nM
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CP0305993
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[4-[3-(oxolan-3-yl)phenyl]oxan-4-yl]amino]butan-2-yl]acetamide
Show/Hide
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C27H34F2N2O4
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1
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| 1 |
ED50 = 28 nM
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CP0233864
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N-[(2S,3R)-4-[[1-(3-acetyl-5-tert-butylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C30H40F2N2O3
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1
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| 1 |
ED50 = 33 nM
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CP0415228
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-thiophen-3-ylphenyl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H32F2N2O2S
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1
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| 1 |
ED50 = 34 nM
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CP0522079
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(furan-3-yl)phenyl]cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H32F2N2O3
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1
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| 1 |
ED50 = 36 nM
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CP0473776
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N-[(2S,3R)-4-[[1-[3-(2-cyanopropan-2-yl)phenyl]cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H35F2N3O2
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1
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| 1 |
ED50 <= 40 nM
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CP0405695
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(1-hydroxy-2-methylpropan-2-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H38F2N2O3
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1
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| 1 |
ED50 = 42 nM
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CP0405689
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(1,3-dioxepan-5-yl)phenyl]cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C29H38F2N2O4
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1
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| 1 |
ED50 = 43 nM
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CP0518746
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(1,4-oxazepan-4-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C29H39F2N3O3
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1
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| 1 |
ED50 = 43 nM
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CP0383628
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(dimethylamino)phenyl]cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H35F2N3O2
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1
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| 1 |
ED50 = 44 nM
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CP0226035
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N-[(2S,3R)-4-[[1-(3-tert-butylphenyl)cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H32F2N2O2
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1
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| 1 |
ED50 = 51 nM
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CP0237149
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[1-(2,2-dimethylpropyl)pyrazol-4-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C23H32F2N4O2
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2
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| 1 |
ED50 = 54 nM
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| 2 |
ED50 = 68 nM
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CP0505734
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-methylsulfonylphenyl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C25H32F2N2O4S
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1
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| 1 |
ED50 = 55 nM
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CP0493210
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(3-oxo-1,4-oxazepan-4-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C29H37F2N3O4
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1
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| 1 |
ED50 = 63 nM
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CP0489510
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-oxopyrrolidin-1-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H35F2N3O3
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1
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| 1 |
ED50 = 66 nM
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CP0497390
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-methyloxolan-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide
Show/Hide
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C26H32F2N2O3
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1
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| 1 |
ED50 = 66 nM
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CP0256621
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N-[(2S,3R)-4-[[1-(3-tert-butyl-5-methoxyphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
|
C29H40F2N2O3
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1
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| 1 |
ED50 = 68 nM
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CP0372218
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-oxocyclopentyl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C29H36F2N2O3
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1
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| 1 |
ED50 = 75 nM
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CP0493211
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-oxo-1,3-diazinan-1-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H36F2N4O3
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1
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| 1 |
ED50 = 76 nM
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CP0146369
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(4-propan-2-ylthiophen-2-yl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C25H34F2N2O2S
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1
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| 1 |
ED50 < 80 nM
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CP0243875
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(5-propan-2-ylthiophen-3-yl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C25H34F2N2O2S
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1
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| 1 |
ED50 < 80 nM
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CP0276319
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N-[(2S,3R)-4-[(3-tert-butylphenyl)methylamino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C23H30F2N2O2
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1
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| 1 |
ED50 = 84 nM
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CP0503882
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-iodophenyl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C24H29F2IN2O2
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1
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| 1 |
ED50 = 85 nM
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CP0146371
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(2,2-dimethylpropyl)-1,2-oxazol-5-yl]cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H37F2N3O3
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1
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| 1 |
ED50 = 88 nM
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CP0497393
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N-[(2S,3R)-4-[[1-(3-cyanophenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H29F2N3O2
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1
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| 1 |
ED50 = 93 nM
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CP0497391
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-oxoimidazolidin-1-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
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C27H34F2N4O3
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1
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| 1 |
ED50 = 97 nM
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CP0344676
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-3-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide
Show/Hide
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C25H30F2N2O3
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1
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| 1 |
ED50 = 97 nM
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CP0256617
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-(4-ethylthiophen-2-yl)cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C24H32F2N2O2S
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1
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| 1 |
ED50 = 107 nM
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CP0405690
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(3-oxomorpholin-4-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H35F2N3O4
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1
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| 1 |
ED50 = 110 nM
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CP0497392
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(furan-2-yl)phenyl]cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H32F2N2O3
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1
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| 1 |
ED50 = 110 nM
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CP0522078
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(triazol-2-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C26H31F2N5O2
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1
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| 1 |
ED50 = 110 nM
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CP0299336
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N-[(2S,3R)-4-[[1-(3-tert-butylphenyl)cyclobutyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H34F2N2O2
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1
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| 1 |
ED50 = 110 nM
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CP0489512
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N-[(2S,3R)-4-[[1-[3-[(E)-but-2-en-2-yl]phenyl]cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H36F2N2O2
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1
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| 1 |
ED50 = 120 nM
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CP0522080
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-(3-ethylphenyl)cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H34F2N2O2
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1
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| 1 |
ED50 = 120 nM
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CP0324707
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N-[(2S,3R)-4-[[(1R,2R)-1-[3-(1,1-difluoro-2-methylpropan-2-yl)phenyl]-2-methylcyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H32F4N2O2
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1
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| 1 |
ED50 = 130 nM
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CP0493212
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C27H33F2N3O4
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1
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| 1 |
ED50 = 170 nM
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CP0256615
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N-[(2S,3R)-4-[[1-(3-tert-butyl-5-iodophenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H37F2IN2O2
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1
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| 1 |
ED50 = 185 nM
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CP0497394
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-methylbutan-2-yl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C29H40F2N2O2
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1
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| 1 |
ED50 = 200 nM
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CP0146365
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N-[(2S,3R)-4-[[1-(4-tert-butylpyridin-2-yl)cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C24H31F2N3O2
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1
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| 1 |
ED50 = 229 nM
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CP0505730
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide
Show/Hide
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C26H31F2N3O3
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1
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| 1 |
ED50 = 230 nM
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CP0505735
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(2-methylpropyl)phenyl]cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H38F2N2O2
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1
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| 1 |
ED50 = 230 nM
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CP0344677
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-pyrazol-1-ylphenyl)cyclopropyl]amino]butan-2-yl]acetamide
Show/Hide
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C24H26F2N4O2
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1
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| 1 |
ED50 = 230 nM
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CP0256622
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N-[(2S,3R)-4-[[1-(1-tert-butylpyrazol-4-yl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H36F2N4O2
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1
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| 1 |
ED50 = 235 nM
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CP0332306
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N-[(2S,3R)-4-[[1-(3-tert-butyl-5-methylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C29H40F2N2O2
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1
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| 1 |
ED50 = 240 nM
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CP0471029
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxan-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide
Show/Hide
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C26H32F2N2O3
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1
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| 1 |
ED50 = 300 nM
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CP0493213
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(3-thiophen-2-ylphenyl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C28H32F2N2O2S
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1
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| 1 |
ED50 = 310 nM
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CP0231911
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[5-(2,2-dimethylpropyl)pyridin-3-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H33F2N3O2
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1
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| 1 |
ED50 = 310 nM
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CP0369926
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[4-(2,2-dimethylpropyl)thiophen-2-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C24H32F2N2O2S
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1
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| 1 |
ED50 = 346 nM
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CP0196138
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N-[(2S,3R)-4-[[1-(6-tert-butylpyrimidin-4-yl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H36F2N4O2
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2
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| 1 |
ED50 = 348 nM
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| 2 |
ED50 = 350 nM
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CP0471028
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N-[(2S,3R)-4-[[1-[3-(2-azabicyclo[2.2.1]heptan-2-yl)phenyl]cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C27H33F2N3O2
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1
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| 1 |
ED50 = 410 nM
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CP0146367
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[1-(2,2-dimethylpropyl)pyrazol-3-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C23H32F2N4O2
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1
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| 1 |
ED50 = 430 nM
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CP0332305
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N-[(2S,3R)-4-[[1-(3-bromo-5-tert-butylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H37BrF2N2O2
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1
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| 1 |
ED50 = 435 nM
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CP0071008
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(2,2-dimethylpropyl)phenyl]cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C29H40F2N2O2
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1
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| 1 |
ED50 = 440 nM
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CP0276317
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(3,3,3-trifluoroprop-1-en-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide
Show/Hide
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C24H25F5N2O2
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1
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| 1 |
ED50 = 620 nM
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CP0505731
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-[3-(oxolan-2-yl)phenyl]cyclopropyl]amino]butan-2-yl]acetamide
Show/Hide
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C25H30F2N2O3
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1
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| 1 |
ED50 = 700 nM
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CP0226036
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(2,2-dimethylpropyl)phenyl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C26H34F2N2O2
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1
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| 1 |
ED50 = 720 nM
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CP0340924
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[1-(2,2-dimethylpropyl)triazol-4-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C22H31F2N5O2
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1
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| 1 |
ED50 = 725 nM
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CP0497389
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[3-(1,4-dioxan-2-yl)phenyl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H30F2N2O4
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1
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| 1 |
ED50 = 750 nM
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CP0233865
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-(4-ethynylthiophen-2-yl)cyclohexyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C24H28F2N2O2S
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1
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| 1 |
ED50 = 757 nM
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CP0071005
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N-[(2S,3R)-4-[[1-(5-tert-butyl-1,3-oxazol-2-yl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H35F2N3O3
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1
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| 1 |
ED50 = 760 nM
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CP0332307
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[[1-(5-propan-2-ylthiophen-2-yl)cyclohexyl]amino]butan-2-yl]acetamide
Show/Hide
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C25H34F2N2O2S
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1
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| 1 |
ED50 = 1036 nM
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CP0071002
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(1-thiophen-2-ylcyclohexyl)amino]butan-2-yl]acetamide
Show/Hide
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C22H28F2N2O2S
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1
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| 1 |
ED50 = 1330 nM
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CP0306334
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[5-(2,2-dimethylpropyl)thiophen-2-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C24H32F2N2O2S
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1
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| 1 |
ED50 = 1475 nM
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CP0071009
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N-[(2S,3R)-4-[[1-(4-bromo-3-tert-butylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H37BrF2N2O2
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1
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| 1 |
ED50 = 2000 nM
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CP0071004
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N-[(2S,3R)-4-[[1-(3-tert-butyl-1,2-oxazol-5-yl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H35F2N3O3
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1
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| 1 |
ED50 = 3711 nM
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CP0340886
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[2-(2,2-dimethylpropyl)-1,3-thiazol-4-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C23H31F2N3O2S
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1
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| 1 |
ED50 = 3850 nM
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CP0243163
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3-(1-((2R,3S)-3-acetamido-4-(3,5-difluorophenyl)-2-hydroxybutylamino)cyclopropyl)-5-neopentylpyridine 1-oxide
Show/Hide
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C25H33F2N3O3
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1
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| 1 |
ED50 = 8700 nM
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CP0067282
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N-[(2S,3R)-4-[[1-(4-tert-butyl-1,3-oxazol-2-yl)cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C22H29F2N3O3
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1
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| 1 |
ED50 > 10000 nM
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CP0146366
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N-[(2S,3R)-4-[[1-(5-tert-butyl-1,3-oxazol-2-yl)cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C22H29F2N3O3
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1
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| 1 |
ED50 > 10000 nM
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CP0231909
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N-[(2S,3R)-4-[[1-(4-tert-butyl-1,3-oxazol-2-yl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C25H35F2N3O3
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1
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| 1 |
ED50 > 10000 nM
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CP0243874
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N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[1-[4-(2,2-dimethylpropyl)-1,3-thiazol-2-yl]cyclopropyl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C23H31F2N3O2S
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1
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| 1 |
ED50 > 10000 nM
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CP0326486
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(1-phenylcyclohexyl)amino]butan-2-yl]acetamide
Show/Hide
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C24H30F2N2O2
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2
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| 1 |
ED50 > 10000 nM
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| 2 |
ED50 > 1000 nM
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CP0405691
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N-[(2S,3R)-4-[[1-(3-cyclohexylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C30H40F2N2O2
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1
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| 1 |
ED50 > 1000 nM
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CP0438383
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N-[(4S,8E,11R)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraen-16-yl]-N-methylmethanesulfonamide
Show/Hide
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C35H44N4O6S
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1
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| 1 |
IC50 = 0.15 nM
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CP0551419
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5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((3R,4aS)-1-amino-3-methyl-4a-oxo-3,4,6,7,8,9-hexahydro-4a?-thia-2,5,9a-triaza-benzocyclohepten-3-yl)-4-fluoro-phenyl]-amide
Show/Hide
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C23H26FN7O3S
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1
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| 1 |
IC50 = 0.2 nM
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CP0248614
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(1S,5S,6S)-3-amino-5-[2,3-difluoro-5-[(5-prop-2-ynoxypyrazine-2-carbonyl)amino]phenyl]-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide
Show/Hide
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C23H22F2N6O3S
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1
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| 1 |
IC50 = 0.3 nM
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CP0234609
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N-[3-[(1S,5S,6S)-3-amino-1-(difluoromethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Show/Hide
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C21H17F4N5O2S
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1
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| 1 |
IC50 = 0.6 nM
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CP0349672
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N-[3-[(1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Show/Hide
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C21H18F3N5O2S
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1
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| 1 |
IC50 = 0.6 nM
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CP0362928
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(1S,5S,6S)-3-amino-5-[5-[(5-chloropyridine-2-carbonyl)amino]-2,3-difluorophenyl]-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide
Show/Hide
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C21H20ClF2N5O2S
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1
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| 1 |
IC50 = 0.7 nM
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CP0361632
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(1S,5S,6S)-3-amino-5-[5-[(5-chloropyridine-2-carbonyl)amino]-2,3-difluorophenyl]-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide
Show/Hide
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C19H16ClF2N5O2S
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1
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| 1 |
IC50 = 0.9 nM
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CP0206012
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Show/Hide
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C20H18F3N5O3
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1
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| 1 |
IC50 = 1 nM
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CP0206016
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N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C17H16ClFN4OS
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1
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| 1 |
IC50 = 1 nM
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CP0217826
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Show/Hide
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C19H16F3N5O3
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1
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| 1 |
IC50 = 1 nM
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CP0321772
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N-[3-[(4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
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C18H15F2N5O2
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1
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| 1 |
IC50 = 1 nM
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CP0209526
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N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3,5-dichloropyridine-2-carboxamide
Show/Hide
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C17H15Cl2FN4O2
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1
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| 1 |
IC50 = 1 nM
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CP0650779
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(S)-N-(3-(3-amino-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide
Show/Hide
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C18H18ClFN4O2
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1
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| 1 |
IC50 = 1 nM
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CP0823349
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(S)-N-(3-(2-amino-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydropyrimidin-4-yl)phenyl)-5-chloropicolinamide
Show/Hide
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C18H18ClN5O2
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1
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| 1 |
IC50 = 1 nM
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CP0456807
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3-Chloro-5-cyano-pyridine-2-carboxylic acid [3-((3R,4aS)-1-amino-3-methyl-4a-oxo-3,4,6,7,8,9-hexahydro-4a?-thia-2,5,9a-triaza-benzocyclohepten-3-yl)-4-fluoro-phenyl]-amide
Show/Hide
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C21H21ClFN7O2S
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1
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| 1 |
IC50 = 1 nM
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CP0544062
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N-[6-[(3R)-5-amino-3,6,6-trimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide
Show/Hide
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C19H19FN6O3S
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1
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| 1 |
IC50 = 1 nM
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CP0579778
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N-[6-[(3R,6R)-5-amino-6-(fluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyano-3-methylpyridine-2-carboxamide
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C20H20F2N6O3S
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1
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| 1 |
IC50 = 1 nM
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CP0670143
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(S)-3-(3,6-dihydro-2H-pyran-4-yl)-7-(5-(prop-1-ynyl)pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
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C27H22N4O3
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1
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| 1 |
IC50 = 1.2 nM
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CP0248620
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
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C22H21F2N5O3S
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1
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| 1 |
IC50 = 1.2 nM
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CP0356493
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-(1,3-oxazol-2-ylmethoxy)pyrazine-2-carboxamide
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C23H22F2N6O4S
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1
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| 1 |
IC50 = 1.2 nM
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CP0145710
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-(pyridin-2-ylmethoxy)pyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
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C39H49F2N5O5
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1
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| 1 |
IC50 = 1.3 nM
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CP0303143
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(1S,5S,6S)-3-amino-5-[5-[(5-chloropyridine-2-carbonyl)amino]-2,3-difluorophenyl]-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide
Show/Hide
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C20H18ClF2N5O2S
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1
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| 1 |
IC50 = 1.3 nM
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CP0273890
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C39H48F2N4O5
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1
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| 1 |
IC50 = 1.4 nM
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CP0773514
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(S)-N-(2'-amino-3-(5,6-dihydro-2H-pyran-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazole]-7-yl)-5-chloropicolinamide
Show/Hide
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C25H20ClN5O4
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1
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| 1 |
IC50 = 1.4 nM
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CP0429847
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5-Fluoro-3-methyl-pyridine-2-carboxylic acid [3-((3R,4aS)-1-amino-3-methyl-4a-oxo-3,4,6,7,8,9-hexahydro-4a?-thia-2,5,9a-triaza-benzocyclohepten-3-yl)-4-fluoro-phenyl]-amide
Show/Hide
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C21H24F2N6O2S
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1
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| 1 |
IC50 = 1.5 nM
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CP0443447
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(4aS,10R,10aS)-2'-amino-8-(2-fluoropyridin-3-yl)-3'-methylspiro[1,3,4,4a,5,10a-hexahydrobenzo[g]isochromene-10,5'-imidazole]-4'-one
Show/Hide
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C21H21FN4O2
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1
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| 1 |
IC50 = 1.6 nM
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CP0070538
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(2S)-2-[(3R)-3-acetamido-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C36H50F2N4O5
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1
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| 1 |
IC50 = 2 nM
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CP0145711
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-(pyridin-3-ylmethoxy)pyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C39H49F2N5O5
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1
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| 1 |
IC50 = 2 nM
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CP0077253
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N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
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C19H15F4N5O2
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1
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| 1 |
IC50 = 2 nM
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CP0339597
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N-[3-[(1S,7S)-3-amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl]phenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C18H17ClN4OS
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2
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| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 5 nM
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CP0420589
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US9605006, 1
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C21H22FN7O2S
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1
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| 1 |
IC50 = 2 nM
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CP0238958
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N-[3-[(1S,5S,6S)-3-amino-1-(hydroxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C19H17ClF2N4O2S
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1
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| 1 |
IC50 = 2 nM
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CP0143333
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6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile
Show/Hide
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C25H23F2N5O2S
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1
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| 1 |
IC50 = 2 nM
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CP0363206
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6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(azetidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile
Show/Hide
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C24H21F2N5OS
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1
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| 1 |
IC50 = 2 nM
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CP0577137
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N-[6-[(3R,6S)-5-amino-6-(fluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
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C20H20F2N6O3S
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1
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| 1 |
IC50 = 2 nM
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CP0578631
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US9499502, 3
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C19H22FN5O4S
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1
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| 1 |
IC50 = 2 nM
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CP0199758
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-pyridin-2-yloxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C38H47F2N5O5
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1
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| 1 |
IC50 = 2.1 nM
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CP0234607
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C20H19ClF2N4O2S
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1
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| 1 |
IC50 = 2.1 nM
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CP0762420
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(S)-3-(5,6-dihydro-2H-pyran-3-yl)-7-(5-(prop-1-ynyl)pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
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C27H22N4O3
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1
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| 1 |
IC50 = 2.2 nM
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CP0347362
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide
Show/Hide
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C23H22F2N4O3S
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1
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| 1 |
IC50 = 2.2 nM
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CP0178511
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N-[(4S,8E)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-2,13-dioxo-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraen-16-yl]-N-methylmethanesulfonamide
Show/Hide
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C29H40N4O6S
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1
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| 1 |
IC50 = 2.3 nM
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CP0670138
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(S)-3-(5-(2'-amino-3-(3,6-dihydro-2H-pyran-4-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazole]-7-yl)pyridin-3-yl)prop-2-yn-1-ol
Show/Hide
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C27H22N4O4
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1
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| 1 |
IC50 = 2.4 nM
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CP0197712
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N-[3-[(1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C19H16ClF3N4OS
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1
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| 1 |
IC50 = 2.4 nM
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CP0284390
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-pyridin-3-yloxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C38H47F2N5O5
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1
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| 1 |
IC50 = 2.5 nM
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CP0731118
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(S)-N-(2'-amino-3-(tetrahydro-2H-pyran-4-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazole]-7-yl)-5-chloropicolinamide
Show/Hide
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C25H22ClN5O4
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1
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| 1 |
IC50 = 2.5 nM
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CP0205748
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(4S)-3'-(2,2-dimethylpropoxy)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
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C24H23FN4O3
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1
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| 1 |
IC50 = 2.6 nM
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CP0293734
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C36H50F2N4O5
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1
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| 1 |
IC50 = 2.7 nM
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CP0379293
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(4S)-7'-(2-fluoropyridin-3-yl)-3'-(3-methoxy-3-methylbut-1-ynyl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
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C25H21FN4O3
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1
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| 1 |
IC50 = 2.8 nM
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CP0105113
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-4-phenylbutanamide
Show/Hide
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C38H48F2N4O5
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1
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| 1 |
IC50 = 3 nM
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CP0456244
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-[(2R,4R)-4-[(4-fluorophenyl)methylsulfonyl]pyrrolidin-2-yl]-1-hydroxypropan-2-yl]-4-phenylbutanamide
Show/Hide
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C40H49F3N4O6S
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1
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| 1 |
IC50 = 3 nM
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CP0087530
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N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
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C28H39N3O3
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1
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| 1 |
IC50 = 3 nM
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CP0202840
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N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C17H16ClFN4O2
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1
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| 1 |
IC50 = 3 nM
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CP0088992
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(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-[(3R)-3-fluoropyrrolidin-1-yl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C23H18F3N5O2
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1
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| 1 |
IC50 = 3 nM
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CP0143332
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(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide
Show/Hide
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C23H21F2N5OS
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1
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| 1 |
IC50 = 3 nM
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CP0219367
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(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide
Show/Hide
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C22H19F2N5OS
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1
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| 1 |
IC50 = 3 nM
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CP0548415
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N-[6-[(3R,6R)-5-amino-6-(difluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
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C20H19F3N6O3S
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1
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| 1 |
IC50 = 3 nM
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CP0569282
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N-[6-[(3R,6R)-5-amino-6-(fluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide
Show/Hide
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C19H18F2N6O3S
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1
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| 1 |
IC50 = 3 nM
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CP0428852
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(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-pyridin-3-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C24H15F2N5O2
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1
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| 1 |
IC50 = 3.3 nM
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CP0418581
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(4S)-3'-(3,4-dihydro-2H-pyran-5-yl)-1'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C24H18F2N4O3
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1
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| 1 |
IC50 = 3.4 nM
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CP0303129
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Show/Hide
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C21H20F5N5O3S
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1
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| 1 |
IC50 = 3.4 nM
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CP0362460
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(4S)-3'-(2,2-dimethylpropoxy)-7'-pyridin-3-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
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C24H24N4O3
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1
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| 1 |
IC50 = 3.8 nM
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CP0270279
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N-[(2S,3R)-3-hydroxy-4-[[(4S)-6-(2-methylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-phenylbutan-2-yl]acetamide
Show/Hide
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C27H37N3O3
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1
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| 1 |
IC50 = 4 nM
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CP0206014
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C17H14ClF3N4OS
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1
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| 1 |
IC50 = 4 nM
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CP0838831
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(R)-N-(3-(5-amino-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3,5-dichloropicolinamide
Show/Hide
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C17H15Cl2FN4O2
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1
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| 1 |
IC50 = 4 nM
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CP0089396
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(4S)-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluoro-7'-(3-fluoropyridin-2-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C24H18F2N4O3
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1
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| 1 |
IC50 = 4 nM
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CP0147318
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(4S)-3'-(3,3-difluoropyrrolidin-1-yl)-1'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C23H17F4N5O2
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1
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| 1 |
IC50 = 4 nM
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CP0343751
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(4S)-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C24H18F2N4O3
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1
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| 1 |
IC50 = 4 nM
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CP0143334
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5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile
Show/Hide
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C24H22F2N6O2S
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1
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| 1 |
IC50 = 4 nM
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CP0538769
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6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(pyrrolidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile
Show/Hide
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C25H23F2N5OS
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1
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| 1 |
IC50 = 4 nM
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CP0165618
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BDBM143220
Show/Hide
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C17H17F2N5O3S
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1
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| 1 |
IC50 = 4 nM
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CP0705315
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(S)-3-(2-fluoropyridin-4-yl)-7-(5-(prop-1-ynyl)pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
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C27H18FN5O2
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1
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| 1 |
IC50 = 4.1 nM
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CP0273892
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-1-[(2R,4R)-4-[(3-cyanophenyl)methoxy]pyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-4-phenylbutanamide
Show/Hide
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C41H49F2N5O5
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1
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| 1 |
IC50 = 4.2 nM
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CP0303128
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-ethoxypyrazine-2-carboxamide
Show/Hide
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C21H23F2N5O3S
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1
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| 1 |
IC50 = 4.2 nM
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CP0053615
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(4S)-7'-(2-fluoropyridin-3-yl)-3'-[2-(3-methyloxetan-3-yl)ethynyl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
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C25H19FN4O3
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1
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| 1 |
IC50 = 4.4 nM
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CP0361075
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(4S)-3'-(2,2-dimethylpropoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
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C23H23N5O3
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1
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| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0379170
|
(4S)-3'-(3,3-dimethylbut-1-ynyl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C25H21FN4O2
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0048271
|
N-[(4S,8E)-4-[(1R)-2-[(3-tert-butylphenyl)methylamino]-1-hydroxyethyl]-2,13-dioxo-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraen-16-yl]-N-methylmethanesulfonamide
Show/Hide
|
C30H42N4O6S
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0129934
|
(4S)-3'-(3,4-dihydro-2H-pyran-6-yl)-1'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C24H18F2N4O3
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0525048
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propylsulfonylpyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C36H50F2N4O6S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0524174
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
|
C28H38FN3O4
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0145618
|
N-[N'-[[4-[[2-(azetidin-1-yl)acetyl]amino]-3-chloro-5-methylphenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
|
C26H29ClN6O3S
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0129936
|
(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-morpholin-4-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C23H19F2N5O3
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0547934
|
2-[[(2S)-butan-2-yl]amino]-N-[(1R,2S)-1-hydroxy-3-phenyl-1-[(2R)-pyrrolidin-2-yl]propan-2-yl]-6-methylsulfonylpyridine-4-carboxamide;hydrochloride
Show/Hide
|
C24H35ClN4O4S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0549047
|
(4aS,10R,10aS)-2'-amino-8-(2-fluoropyridin-3-yl)-3',10a-dimethylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C21H21FN4O3
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0105542
|
(4S)-3'-(3,6-dihydro-2H-pyran-5-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C24H19FN4O3
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0537680
|
(4S)-3'-(3,6-dihydro-2H-pyran-4-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C24H19FN4O3
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0088003
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1-methylimidazol-2-yl)phenyl]butan-2-yl]-2-methoxyacetamide
Show/Hide
|
C33H45N5O4
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0169754
|
N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
|
C29H39N3O5
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0120470
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]acetamide
Show/Hide
|
C31H40N4O3S
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0489190
|
4-[(4S)-2-amino-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-3'-yl]-2-methylbut-3-yn-2-ol
Show/Hide
|
C24H19FN4O3
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0116103
|
(4aS,10S,10aR)-2'-amino-8-(2-fluoropyridin-3-yl)-3',4a-dimethylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C21H21FN4O3
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0323241
|
(2S)-N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]oxolane-2-carboxamide
Show/Hide
|
C34H44N4O4S
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0088989
|
(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-pyridin-4-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C24H15F2N5O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0088991
|
(4S)-3'-(4,4-difluoropiperidin-1-yl)-1'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C24H19F4N5O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0371654
|
(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-(6-methylpyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C25H17F2N5O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0093593
|
US8940748, 34
Show/Hide
|
C17H17ClFN5O3S
|
1
|
| 1 |
IC50 = 6.4 nM
|
|
|
|
CP0073006
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxyacetamide
Show/Hide
|
C32H42N4O4S
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0280059
|
(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-(2-fluoropyridin-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C24H14F3N5O2
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0105541
|
(4S)-3'-(6,6-dimethyl-2,3-dihydropyran-4-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C26H23FN4O3
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0459935
|
(4S)-7'-(2-fluoropyridin-3-yl)-3'-(2-methoxy-2-methylpropoxy)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C24H23FN4O4
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0388204
|
3-[(4aS,10R,10aS)-2'-amino-1',10a-dimethyl-5'-oxospiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,4'-imidazole]-8-yl]benzonitrile
Show/Hide
|
C23H22N4O3
|
1
|
| 1 |
IC50 = 6.8 nM
|
|
|
|
CP0416782
|
N-[(4S,8Z)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-12-methyl-2,13-dioxo-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl]-N-methylmethanesulfonamide
Show/Hide
|
C30H42N4O6S
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0128006
|
N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
|
C35H42F2N4O6S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0517345
|
6-((Z)-2-(3-((1S,5S,6S)-1-acetyl-3-amino-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile
Show/Hide
|
C22H18F2N4OS
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0560051
|
N-[3-[(1S,5S,6S)-3-amino-5-(fluoromethyl)-1-(methoxymethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C20H19ClF2N4O2S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0578833
|
N-[6-[(3R,6S)-5-amino-6-(fluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C19H18F2N6O3S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0088001
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-ethynylphenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C31H41N3O4
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0120472
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-ethynyl-5-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C31H40FN3O4
|
1
|
| 1 |
IC50 = 7.3 nM
|
|
|
|
CP0221613
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-[3-fluoro-5-(1,3-thiazol-2-yl)phenyl]-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C32H41FN4O4S
|
1
|
| 1 |
IC50 = 7.3 nM
|
|
|
|
CP0097523
|
US9315520, 1
Show/Hide
|
C18H19F2N5O3S2
|
1
|
| 1 |
IC50 = 7.3 nM
|
|
|
|
CP0435226
|
N-[(4S)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-2,14-dioxo-6-oxa-3,13-diazabicyclo[13.3.1]nonadeca-1(18),15(19),16-trien-17-yl]-N-methylmethanesulfonamide
Show/Hide
|
C30H44N4O6S
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0095251
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-[(3-methylbenzene)sulfonyl]piperazin-2-yl]propan-2-yl]-5-(1,1-dioxo-1,2-thiazinan-2-yl)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
|
C40H45F2N5O7S2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0143960
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C29H40FN3O5
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0427661
|
N-[N'-[[4-[[2-(azetidin-1-yl)acetyl]amino]-3,5-dichlorophenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
|
C25H26Cl2N6O3S
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0239184
|
(4aR,7aR)-2-amino-6-(3-fluorobenzoyl)-3-methyl-7a-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C26H22FN5O2S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0325334
|
(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-phenylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C25H16F2N4O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0361631
|
N-[3-[(1S,5S,6S)-3-amino-1-(difluoromethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C19H15ClF4N4OS
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0465411
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-ethoxyacetamide
Show/Hide
|
C33H44N4O4S
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0540914
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-5-yl)phenyl]butan-2-yl]-2-methoxyacetamide
Show/Hide
|
C32H42N4O4S
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0494286
|
4-[(4S)-2-amino-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-3'-yl]benzonitrile
Show/Hide
|
C26H16FN5O2
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0124822
|
US9315520, 7
Show/Hide
|
C17H18ClN5O2S2
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0473436
|
(4aS,10R,10aS)-2'-amino-8-(5-methoxypyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C21H22N4O4
|
1
|
| 1 |
IC50 = 8.3 nM
|
|
|
|
CP0303130
|
N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-propoxypyrazine-2-carboxamide
Show/Hide
|
C22H25F2N5O3S
|
1
|
| 1 |
IC50 = 8.4 nM
|
|
|
|
CP0097508
|
US9315520, 45
Show/Hide
|
C19H21F2N5O3S2
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0274908
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-[(2R,4R)-4-[(4-fluorophenyl)methoxy]pyrrolidin-2-yl]-1-hydroxypropan-2-yl]-4-phenylbutanamide
Show/Hide
|
C40H49F3N4O5
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0296172
|
1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[(dimethylsulfamoyl)(methyl)amino]-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
|
C32H41N5O5S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0185393
|
N-[3-[(4S)-2-amino-4-(difluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C18H14F3N5O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0429716
|
(9R,11R)-7-Amino-9-(2-fluoro-5-(3-(5-methoxypyrazin-2-yl)isoxazol-5-yl)phenyl)-9-methyl-2,3,4,5,9,10-hexahydro-[1,2,4]thiadiazino[1,2-a][1,2,7]thiadiazepine 11-oxide 2,2,2-trifluoroacetate
Show/Hide
|
C22H24FN7O3S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0560052
|
6-((Z)-2-(3-((1R,5S,6S)-3-amino-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile
Show/Hide
|
C21H18F2N4O2S2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0087999
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2,2-dimethoxyacetamide
Show/Hide
|
C33H44N4O5S
|
1
|
| 1 |
IC50 = 9.1 nM
|
|
|
|
CP0169755
|
N-[(2S,3R)-1-(3,4-dimethoxyphenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
|
C30H43N3O5
|
1
|
| 1 |
IC50 = 9.3 nM
|
|
|
|
CP0145708
|
(2S)-2-[(3R)-3-acetamido-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C38H46F2N4O4
|
1
|
| 1 |
IC50 = 9.5 nM
|
|
|
|
CP0386352
|
(9R,11S)-7-Amino-9-(5-(3-(5-chloropyrimidin-2-yl)isoxazol-5-yl)-2-fluorophenyl)-9-methyl-2,3,4,5,9,10-hexahydro-[1,2,4]thiadiazino[1,2-a][1,2,7]thiadiazepine 11-oxide 2,2,2-trifluoroacetate
Show/Hide
|
C21H21ClFN7O2S
|
1
|
| 1 |
IC50 = 9.5 nM
|
|
|
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CP0508733
|
6-(4-(3-((9R,11S)-7-Amino-9-methyl-11-oxido-2,3,4,5,9,10-hexahydro-[1,2,4]thiadiazino[1,2-a][1,2,7]thiadiazepin-9-yl)-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)nicotinonitrile 2,2,2-trifluoroacetate
Show/Hide
|
C22H22FN9OS
|
1
|
| 1 |
IC50 = 9.5 nM
|
|
|
|
CP0073007
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-pyridin-4-ylphenyl)butan-2-yl]-2-methoxyacetamide
Show/Hide
|
C34H44N4O4
|
1
|
| 1 |
IC50 = 9.8 nM
|
|
|
|
CP0086306
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-4-yl)phenyl]butan-2-yl]-2-methoxyacetamide
Show/Hide
|
C32H42N4O4S
|
1
|
| 1 |
IC50 = 9.8 nM
|
|
|
|
CP0544381
|
(2R)-N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide
Show/Hide
|
C33H44N4O4S
|
1
|
| 1 |
IC50 = 9.9 nM
|
|
|
|
CP0443201
|
(4aS,10R,10aS)-2'-amino-8-(2-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C20H19FN4O3
|
1
|
| 1 |
IC50 = 9.9 nM
|
|
|
|
CP0220651
|
(2S)-2-[(3R)-3-acetamido-3-(cyclopropylmethyl)-2-oxopyrrolidin-1-yl]-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-4-phenylbutanamide
Show/Hide
|
C38H46F2N4O5
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0155770
|
(2S)-2-[(3R)-3-acetamido-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-(1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C38H46F2N4O4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0062602
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]-2-fluoroacetamide
Show/Hide
|
C28H37F2N3O4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0360719
|
(2S)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(3-propan-2-ylphenyl)methylamino]butan-2-yl]-2-[(5S)-6-oxo-1-propyl-1,7-diazaspiro[4.4]nonan-7-yl]propanamide
Show/Hide
|
C33H48N4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0489563
|
N-[N'-[[3-chloro-4-[[2-(ethylamino)acetyl]amino]-5-methylphenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
|
C25H29ClN6O3S
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0124801
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
|
C28H38FN3O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0186579
|
N-[3-[(4R,5R,6S)-2-amino-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C19H14F5N5O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0206017
|
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C17H16ClFN4O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0268168
|
(4aR,7aR)-7a-[(1R,2R)-2-[2-[[(1R,2R)-2-methylcyclopropyl]methoxy]propan-2-yl]cyclopropyl]-6-pyrimidin-2-yl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C21H31N5OS
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0220657
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-hydroxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C33H44F2N4O5
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0238169
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]-4-phenylbutanamide
Show/Hide
|
C38H50N4O5
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0197801
|
(6S)-2-amino-6-[3-chloro-5-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-3,6-dimethyl-5H-pyrimidin-4-one
Show/Hide
|
C18H17ClN4OS
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0302020
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydrochromen-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
|
C28H40N2O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0120469
|
(2R)-N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]oxolane-2-carboxamide
Show/Hide
|
C34H44N4O4S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0323242
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(5-ethynyl-2-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C31H40FN3O4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0043626
|
N-[3-[(3R)-5-amino-3-methyl-6,7-dihydro-2H-1,4-oxazepin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C18H18ClFN4O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0650780
|
(S)-N-(3-(2-amino-4-methyl-4,5,6,7-tetrahydro-1,3-oxazepin-4-yl)-4-fluorophenyl)-5-chloropicolinamide
Show/Hide
|
C18H18ClFN4O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0486634
|
(4aS,10R,10aS)-2'-amino-8-(5-chloropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C20H19ClN4O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0219368
|
6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(piperidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile
Show/Hide
|
C26H25F2N5OS
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0569978
|
N-[6-[(3R,6S)-5-amino-6-(difluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
|
C20H19F3N6O3S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0576603
|
N-[6-[(3R,6R)-5-amino-6-(difluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C19H17F3N6O3S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0069951
|
1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(1-hydroxyethyl)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C34H43F2N3O5
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0382592
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C40H50F2N4O5
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0440302
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-1-[(2R,4R)-4-(benzenesulfonyl)pyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-4-phenylbutanamide
Show/Hide
|
C39H48F2N4O6S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0120473
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-ethynyl-4-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C31H40FN3O4
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0508502
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-oxazol-2-yl)phenyl]butan-2-yl]-2-methoxyacetamide
Show/Hide
|
C32H42N4O5
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0459996
|
N-[3-(3-amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl)-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C18H16ClFN4OS
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0733794
|
(S)-N-(3-(2-amino-1,4-dimethyl-1,4,5,6-tetrahydropyrimidin-4-yl)-4-fluorophenyl)-5-chloropicolinamide
Show/Hide
|
C18H19ClFN5O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0199458
|
(4aS,10S,10aR)-2'-amino-8-(2-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-2H-pyrano[3,2-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C20H19FN4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0371141
|
(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-(2-methylpyridin-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C25H17F2N5O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0447796
|
(9R,11R)-7-Amino-9-(5-(3-(5-chloropyrimidin-2-yl)isoxazol-5-yl)-2-fluorophenyl)-9-methyl-2,3,4,5,9,10-hexahydro-[1,2,4]thiadiazino[1,2-a][1,2,7]thiadiazepine 11-oxide 2,2,2-trifluoroacetate
Show/Hide
|
C21H21ClFN7O2S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0361630
|
N-[3-[(1S,5S,6S)-3-amino-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C18H15ClF2N4OS
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0578630
|
N-[3-[(3R,6R)-5-amino-6-(fluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Show/Hide
|
C19H21F2N5O4S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0289473
|
N-[(1S,2S)-1-[(2R)-4-(benzenesulfonyl)piperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
|
C34H40F2N4O6S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0285519
|
(6S)-2-amino-3,6-dimethyl-6-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5H-pyrimidin-4-one
Show/Hide
|
C18H18N4OS
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0283815
|
(4aR,7aR)-2-amino-3-methyl-6-(3-propan-2-yloxyphenyl)-7a-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C28H29N5O2S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0107367
|
N-[3-[(4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C19H14F5N5O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0184804
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Show/Hide
|
C16H13ClF5N5O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0217829
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-3,5-dichloropyridine-2-carboxamide
Show/Hide
|
C17H13Cl2F3N4O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0323226
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
Show/Hide
|
C17H14F4N4O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0443206
|
(4aS,10R,10aS)-2'-amino-3',10a-dimethyl-8-pyrimidin-5-ylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C20H21N5O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0688828
|
(S)-N-(2'-amino-3-cyclopropyl-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazole]-7-yl)-5-chloropicolinamide
Show/Hide
|
C23H18ClN5O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0308400
|
N-[(1S,2S)-1-[(2R)-4-benzylsulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
|
C35H42F2N4O6S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0057104
|
(2R)-N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-methoxypropanamide
Show/Hide
|
C31H43N3O6
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0315685
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(4-methyl-1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxyacetamide
Show/Hide
|
C33H44N4O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0180836
|
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C18H16FN5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0105540
|
(4S)-7'-(2-fluoropyridin-3-yl)-3'-(4-methylphenyl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C26H19FN4O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0065327
|
US8541427, 1
Show/Hide
|
C19H19F3N6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0547049
|
N-[3-[(3R,6S)-5-amino-6-(fluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Show/Hide
|
C19H21F2N5O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0500447
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propylsulfanylpyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C36H50F2N4O4S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0389470
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-[4-fluoro-3-(1,3-thiazol-2-yl)phenyl]-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C32H41FN4O4S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0717107
|
(S)-N-(3-(4-Amino-6-methyl-5-azaspiro[2.5]oct-4-en-6-yl)-4-fluorophenyl)-5-chloropicolinamide
Show/Hide
|
C20H20ClFN4O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0543247
|
(4S)-7'-(2-fluoropyridin-3-yl)-3'-(2-fluoropyridin-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C24H15F2N5O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0073009
|
3-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
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C22H18FN7OS
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2
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| 1 |
IC50 = 16 nM
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| 2 |
Ki = 4 nM
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CP0124486
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide
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C18H16ClF3N4O2
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1
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| 1 |
IC50 = 16 nM
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CP0432699
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(4aS,10R,10aS)-2'-amino-8-(5-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C20H19FN4O3
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1
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| 1 |
IC50 = 16 nM
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CP0205747
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(4S)-7'-(2-fluoropyridin-3-yl)-3'-morpholin-4-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
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C23H20FN5O3
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1
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| 1 |
IC50 = 16 nM
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CP0452620
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US8541427, 17
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C19H20F2N6O2
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1
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| 1 |
IC50 = 16 nM
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CP0188087
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N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
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C30H41N3O6
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1
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| 1 |
IC50 = 16.8 nM
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CP0110872
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(2S)-N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide
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C33H44N4O4S
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1
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| 1 |
IC50 = 17 nM
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CP0234403
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C17H14ClF3N4O2
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1
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| 1 |
IC50 = 17 nM
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CP0284906
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-1-(difluoromethyl)pyrazole-3-carboxamide
Show/Hide
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C16H14F5N5O2
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1
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| 1 |
IC50 = 17 nM
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CP0486635
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(1R,4aR,10R,10aR)-2'-amino-8-(2-fluoropyridin-3-yl)-1,3'-dimethylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C21H21FN4O3
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1
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| 1 |
IC50 = 17 nM
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CP0093625
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US8541427, 16
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C19H20F2N6O2
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1
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| 1 |
IC50 = 17 nM
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CP0354529
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-3-methyl-5-prop-2-ynoxypyridine-2-carboxamide
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C24H24F2N4O3S
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1
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| 1 |
IC50 = 17 nM
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CP0272553
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(2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-[(4R)-2,2-dimethyloxan-4-yl]-2-methylpropanamide
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C27H33N3O2
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1
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| 1 |
IC50 = 18 nM
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CP0283895
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N-[(2S,3R)-4-[[6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydrothieno[2,3-b]pyran-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
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C26H38N2O3S
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1
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| 1 |
IC50 = 18 nM
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CP0073004
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(2R)-N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-ethoxypropanamide
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C34H46N4O4S
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1
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| 1 |
IC50 = 18 nM
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CP0221612
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N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-[2-fluoro-5-(1,3-thiazol-2-yl)phenyl]-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
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C32H41FN4O4S
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1
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| 1 |
IC50 = 18 nM
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CP0449382
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N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-pyridin-2-ylphenyl)butan-2-yl]-2-methoxyacetamide
Show/Hide
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C34H44N4O4
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1
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| 1 |
IC50 = 18 nM
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CP0217495
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3-[5-[(4aR,7aR)-2-amino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C24H22N6O2S
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1
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| 1 |
IC50 = 18 nM
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CP0536744
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C23H20FN7O2S
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2
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| 1 |
IC50 = 18 nM
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| 2 |
Ki = 1 nM
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CP0067241
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1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
Show/Hide
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C31H37FN4O5S
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1
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| 1 |
IC50 = 19 nM
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CP0181355
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5-acetyl-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3,N3-dipropylisophthalamide
Show/Hide
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C34H41F2N3O5
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1
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| 1 |
IC50 = 19 nM
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CP0078192
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N-[(2S,3R)-4-[[(4S)-6,6-dimethyl-2-(2-methylpropyl)-5,7-dihydro-4H-indazol-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
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C25H38N4O2
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1
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| 1 |
IC50 = 19 nM
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CP0239186
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3-[5-[(4aR,7aR)-2-amino-6-benzoyl-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C25H21N5O2S
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1
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| 1 |
IC50 = 19 nM
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CP0388203
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(4aS,10R,10aS)-2'-amino-7-fluoro-8-(2-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C20H18F2N4O3
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1
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| 1 |
IC50 = 19 nM
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CP0245620
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(4S)-7'-(2-fluoropyridin-3-yl)-3'-(oxan-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
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C24H21FN4O3
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1
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| 1 |
IC50 = 19 nM
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CP0121005
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(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-(oxan-4-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C24H20F2N4O3
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1
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| 1 |
IC50 = 19 nM
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CP0131805
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(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-(6-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C24H14F3N5O2
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1
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| 1 |
IC50 = 19 nM
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CP0284925
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(3R)-8-methoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C39H48F2N4O5
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1
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| 1 |
IC50 = 20 nM
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CP0335074
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-(8-methoxy-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl]-4-phenylbutanamide
Show/Hide
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C39H48F2N4O5
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1
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| 1 |
IC50 = 20 nM
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CP0489564
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N-[N'-[[3,5-dichloro-4-[[2-(ethylamino)acetyl]amino]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
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C24H26Cl2N6O3S
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2
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| 1 |
IC50 = 20 nM
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| 2 |
Ki = 10 nM
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CP0535623
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N-[N'-[[3-chloro-4-[[2-(dimethylamino)acetyl]amino]-5-methylphenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
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C25H29ClN6O3S
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2
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| 1 |
IC50 = 20 nM
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| 2 |
Ki = 20 nM
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CP0239185
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5-[5-[(4aR,7aR)-2-amino-6-(3-fluorobenzoyl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]-2-fluorobenzonitrile
Show/Hide
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C25H19F2N5O2S
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1
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| 1 |
IC50 = 20 nM
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CP0085203
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N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
Show/Hide
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C18H16F2N4O2S
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1
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| 1 |
IC50 = 20.3 nM
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CP0030792
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
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C18H14F3N5O2
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1
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| 1 |
IC50 = 21 nM
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CP0388199
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5-[(4aS,10R,10aS)-2'-amino-1'-methyl-5'-oxospiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-imidazole]-8-yl]pyridine-3-carbonitrile
Show/Hide
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C21H19N5O3
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1
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| 1 |
IC50 = 21 nM
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CP0443207
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(4aS,10R,10aS)-2'-amino-8-[3-(difluoromethoxy)phenyl]-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C22H21F2N3O4
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1
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| 1 |
IC50 = 21 nM
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CP0436212
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4-43-49R,11R)-7-Amino-9-methyl-11-oxido-2,3,4,5,9,10-hexahydro-[1,2,4]thiadiazino[1,2-a][1,2,7]thiadiazepin-9-yl)-4-fluorophenyl)ethynyl)benzonitrile 2,2,2-trifluoroacetate
Show/Hide
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C23H22FN5OS
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1
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| 1 |
IC50 = 21 nM
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CP0731116
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(S)-7-(6-fluoropyridin-2-yl)-3-(2-fluoropyridin-4-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
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C24H15F2N5O2
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1
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| 1 |
IC50 = 21 nM
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CP0360601
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N-[(1S,2S)-1-[(2R)-4-(3-chlorophenyl)sulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
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C34H39ClF2N4O6S
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1
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| 1 |
IC50 = 22 nM
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CP0120475
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N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-1-ynylphenyl)butan-2-yl]-2-methoxyacetamide
Show/Hide
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C32H43N3O4
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1
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| 1 |
IC50 = 22 nM
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CP0087825
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyridin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C23H19FN6OS
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2
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| 1 |
IC50 = 22 nM
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| 2 |
Ki = 6 nM
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CP0206011
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Show/Hide
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C17H16F3N5O3
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1
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| 1 |
IC50 = 22 nM
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CP0188088
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N-[(2S,3R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C30H41N3O5
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1
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| 1 |
IC50 = 22.9 nM
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CP0279508
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3-[5-[(4aR,7aR)-2-amino-6-(3-methoxypyridin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C24H22N6O2S
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1
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| 1 |
IC50 = 23 nM
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CP0241120
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyrimidine-2-carboxamide
Show/Hide
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C16H13ClF3N5O2
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1
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| 1 |
IC50 = 23 nM
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CP0420920
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(4aS,10R,10aS)-8-(5-chloropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H20ClN3O3
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1
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| 1 |
IC50 = 23 nM
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CP0325335
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(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-(3-methyl-1,2-oxazol-5-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C23H15F2N5O3
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1
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| 1 |
IC50 = 23 nM
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CP0184806
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-ethynylpyridine-2-carboxamide
Show/Hide
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C19H15F3N4O2
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1
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| 1 |
IC50 = 24 nM
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CP0092905
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1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylpropane-2-sulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C33H42N4O5S
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1
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| 1 |
IC50 = 25 nM
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CP0345409
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N-[3-[(4S,5R)-2-amino-5-fluoro-4-(fluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
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C18H14F3N5O2
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1
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| 1 |
IC50 = 25 nM
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CP0684540
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(S)-N-(3-(1-amino-3-methyl-3,4-dihydroisoquinolin-3-yl)-4-fluorophenyl)-5-chloropicolinamide
Show/Hide
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C22H18ClFN4O
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1
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| 1 |
IC50 = 25 nM
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CP0042944
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(4S)-2'-(2,2-dimethylpropoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C24H24N4O3
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1
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| 1 |
IC50 = 25 nM
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CP0097529
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N-[3-[(4aR,7aS)-2-amino-4a,5,6,7-tetrahydro-4H-cyclopenta[d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
Show/Hide
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C19H18F2N4OS
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1
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| 1 |
IC50 = 25.7 nM
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CP0076131
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N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[4-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxyacetamide
Show/Hide
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C32H42N4O4S
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1
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| 1 |
IC50 = 26 nM
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CP0379867
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N-[3-[(1S,7S)-3-amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C18H16ClFN4OS
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1
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| 1 |
IC50 = 26 nM
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CP0511207
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(4S)-1'-fluoro-3',7'-bis(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
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C24H14F3N5O2
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1
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| 1 |
IC50 = 26 nM
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CP0788953
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N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(1-(hydroxyimino)ethyl)-N3,N3-dipropylisophthalamide
Show/Hide
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C34H42F2N4O5
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1
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| 1 |
IC50 = 27 nM
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CP0220655
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(2S)-2-[(3R)-3-acetamido-3-(cyclopropylmethyl)-2-oxopyrrolidin-1-yl]-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]propanamide
Show/Hide
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C31H40F2N4O5
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1
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| 1 |
IC50 = 27 nM
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CP0220656
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(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3R)-3-[(1R)-1-hydroxybutyl]-2-oxopyrrolidin-1-yl]propanamide
Show/Hide
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C29H39F2N3O5
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1
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| 1 |
IC50 = 27 nM
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CP0517483
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N-[(2R,3S)-1-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-2-hydroxyhex-5-en-3-yl]acetamide
Show/Hide
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C24H37N3O4
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1
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| 1 |
IC50 = 27 nM
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CP0141731
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N-[3-[(4R,5S)-2-amino-5-fluoro-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
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C18H15F2N5O2
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1
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| 1 |
IC50 = 27 nM
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CP0388198
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(4aS,10R,10aS)-2'-amino-8-(3-methoxyphenyl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
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C22H23N3O4
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1
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| 1 |
IC50 = 27 nM
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CP0267873
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6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile
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C22H20F2N4OS
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1
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| 1 |
IC50 = 27 nM
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CP0239180
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(2S)-N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]oxolane-2-carboxamide
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C32H43N3O6
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1
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| 1 |
IC50 = 27.5 nM
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CP0496429
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tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-6-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-5-methyl-6-oxo-1-phenylhexan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C40H61N5O7S
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1
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| 1 |
IC50 = 28 nM
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CP0121915
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US8541427, 15
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C19H19F3N6O2
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1
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| 1 |
IC50 = 28 nM
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CP0368545
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(1R,2R)-2-[(4aR,7aR)-2-amino-6-pyrimidin-2-yl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-N-[[(1R,2R)-2-methylcyclopropyl]methyl]cyclopropane-1-carboxamide
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C19H26N6OS
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1
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| 1 |
IC50 = 28 nM
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CP0702361
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N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxypropyl]-5-[methyl(methylsulfonyl)amino-N'-[(1R)-1-phenylethyl]isophthalamide
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C31H38N4O5S
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1
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| 1 |
IC50 = 29 nM
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CP0199757
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-hydroxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
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C33H44F2N4O5
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1
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| 1 |
IC50 = 29 nM
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CP0085091
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3-[5-[(4aR,7aR)-2-amino-3-methyl-6-(5-methylpyrimidin-2-yl)-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
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C23H21N7OS
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1
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| 1 |
IC50 = 29 nM
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CP0247726
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(4-methoxyphenyl)sulfanyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C39H45F2N3O5S
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1
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| 1 |
IC50 = 30 nM
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CP0548416
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N-[3-[(3R,6R)-5-amino-6-(difluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
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C19H20F3N5O4S
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1
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| 1 |
IC50 = 30 nM
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CP0457787
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3-[5-[(4aR,7aR)-2-amino-3-methyl-4-oxo-6-pyrimidin-2-yl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
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C22H19N7OS
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2
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| 1 |
IC50 = 31 nM
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| 2 |
Ki = 11 nM
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CP0796665
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N-[3-[(1S,3S,6S)-5-Amino-3-methyl-4-azabicyclo[4.1.0]hept-4-en-3-yl]-4-fluoro-phenyl]-5-chloro-pyridine-2-carboxamide
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C19H18ClFN4O
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1
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| 1 |
IC50 = 31 nM
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CP0266433
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(2-hydroxypropyl)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C35H45F2N3O5
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1
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| 1 |
IC50 = 34 nM
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CP0522010
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(2R,4S,5S)-4-hydroxy-5-[[(2S)-2-[[(2S,3S)-2-hydroxy-3-methylpentanoyl]amino]propanoyl]amino]-2-methyl-N-[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]-6-phenylhexanamide
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C33H49N5O6
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1
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| 1 |
IC50 = 35 nM
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CP0282539
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(2R)-3-[2-amino-6-(3-methylpyridin-2-yl)quinolin-3-yl]-N-(3,3-dimethylbutyl)-2-methylpropanamide
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C25H32N4O
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1
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| 1 |
IC50 = 35 nM
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CP0493839
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3-[(4aS,10R,10aS)-2'-amino-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-8-yl]benzonitrile
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C22H21N3O3
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1
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| 1 |
IC50 = 35 nM
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CP0108509
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US8541427, 8
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C19H18F4N6O2
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1
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| 1 |
IC50 = 35 nM
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CP0182930
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(4S)-2'-(2-methylpropoxy)-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
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C23H22N4O3
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1
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| 1 |
IC50 = 36 nM
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CP0351174
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5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-methyl-6-methylsulfanylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophene-2-carbonitrile
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C18H18FN7OS2
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1
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| 1 |
IC50 = 36 nM
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CP0503358
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(S)-4-(S)-Hydroxy-5-[(S)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-propionylamino]-2-methyl-6-phenyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide
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C33H48N4O6
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1
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| 1 |
IC50 = 37 nM
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CP0818881
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N-(3-(6-amino-2,4-dimethyl-2,3,4,5-tetrahydropyrazin-2-yl)phenyl)-5-chloropicolinamide
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C18H20ClN5O
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1
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| 1 |
IC50 = 37 nM
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CP0271715
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(4aR,10S,10aS)-2'-amino-8-(2-fluoropyridin-3-yl)-3',4a-dimethylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,5'-imidazole]-4'-one
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C21H21FN4O3
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1
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| 1 |
IC50 = 37 nM
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CP0414366
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(4aS,10R,10aR)-8-(5-chloropyridin-3-yl)-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H20ClN3O3
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1
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| 1 |
IC50 = 37 nM
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CP0308389
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N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-3-(ethylamino)-5-[methyl(methylsulfonyl)amino]benzamide
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C31H39F2N5O6S2
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1
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| 1 |
IC50 = 38 nM
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CP0248739
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N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
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C25H33N3O3
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1
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| 1 |
IC50 = 39 nM
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CP0388197
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(4aS,10R,10aS)-2'-amino-3'-methyl-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C19H19N5O3
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1
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| 1 |
IC50 = 39 nM
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CP0091270
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5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophene-2-carbonitrile
Show/Hide
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C18H18FN7O2S
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1
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| 1 |
IC50 = 40 nM
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CP0484540
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tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate
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C37H56N6O7
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1
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| 1 |
IC50 = 41 nM
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CP0160247
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N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C28H38FN3O4
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1
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| 1 |
IC50 = 41 nM
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CP0388072
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(4aS,10R,10aS)-8-(3-chloro-5-fluorophenyl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
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C21H20ClFN2O3
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1
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| 1 |
IC50 = 41 nM
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CP0521961
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tert-butyl N-[(2S,3R)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamate
Show/Hide
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C38H58N6O7
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1
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| 1 |
IC50 = 42 nM
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CP0281933
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-[(Z)-N-methoxy-C-methylcarbonimidoyl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C35H44F2N4O5
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1
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| 1 |
IC50 = 42 nM
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CP0342362
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(6S)-2-amino-3,6-dimethyl-6-[5-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5H-pyrimidin-4-one
Show/Hide
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C18H18N4OS
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1
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| 1 |
IC50 = 42 nM
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CP0174600
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(4aS,10R,10aS)-2'-amino-8-(3-chloro-5-fluorophenyl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C21H19ClFN3O3
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1
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| 1 |
IC50 = 44 nM
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CP0484541
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tert-butyl N-[(2S)-4,4-difluoro-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]carbamate
Show/Hide
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C36H52F2N6O7
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1
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| 1 |
IC50 = 45 nM
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CP0392672
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(S)-5-[(S)-5,5-Difluoro-2-((2S,3S)-2-hydroxy-3-methyl-pentanoylamino)-pentanoylamino]-2-(3,3-difluoro-propyl)-4-(S)-hydroxy-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
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C37H53F4N5O6
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1
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| 1 |
IC50 = 45 nM
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CP0086719
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5-(1-acetamidoethyl)-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3,N3-dipropylisophthalamide
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C36H46F2N4O5
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1
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| 1 |
IC50 = 45 nM
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CP0495858
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-propylsulfonylpyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
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C36H50F2N4O6S
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1
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| 1 |
IC50 = 45 nM
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CP0349706
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N-[3-[(1S,5S,6S)-3-amino-1-cyano-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
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C19H14ClF2N5OS
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1
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| 1 |
IC50 = 45 nM
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CP0037496
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C35H44F2N4O5S
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1
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| 1 |
IC50 = 48 nM
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CP0169350
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(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-2-[(3R)-3-[(1R)-1-hydroxybutyl]-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C34H47F2N3O5
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1
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| 1 |
IC50 = 48 nM
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CP0073013
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2-[(4aR,7aR)-2-amino-7a-[4-(3-cyanophenyl)thiophen-2-yl]-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-6-yl]pyridine-3-carbonitrile
Show/Hide
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C24H19N7OS
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1
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| 1 |
IC50 = 48 nM
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CP0157768
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(4aS,10S,10aR)-8-(5-chloropyridin-3-yl)-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
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C20H20ClN3O2S
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1
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| 1 |
IC50 = 48 nM
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CP0535370
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(S)-5-{(S)-2-[(S)-2-((S)-2-Amino-4-carboxy-butyrylamino)-3-methyl-butyrylamino]-3-(S)-carbamoyl-1-(S)-oxo-propylamino}-6-cyclohexyl-4-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-hexanoic acid(R)-4-((R)-2-Amino-propionylamino)-4-((R)-1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid
Show/Hide
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C46H72N8O15
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1
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| 1 |
IC50 = 49 nM
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CP0489772
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N-[(4S)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-2,13-dioxo-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),14(18),15-trien-16-yl]-N-methylmethanesulfonamide
Show/Hide
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C29H42N4O6S
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1
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| 1 |
IC50 = 49 nM
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CP0108512
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US8541427, 11
Show/Hide
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C19H19F3N6O2
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1
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| 1 |
IC50 = 49 nM
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CP0073015
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3-[5-[(4aR,7aR)-2-amino-3-methyl-4-oxo-6-pyridin-2-yl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C23H20N6OS
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1
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| 1 |
IC50 = 50 nM
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CP0448895
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N-[3-(3-amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl)phenyl]-5-chloropyridine-2-carboxamide
Show/Hide
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C18H17ClN4OS
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1
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| 1 |
IC50 = 50 nM
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CP0256774
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3-[5-[(4aR,7aR)-2-amino-6-(5-chloropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C22H18ClN7OS
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1
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| 1 |
IC50 = 51 nM
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CP0133088
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(4aR,7aR)-2-amino-7a-(5-chlorothiophen-2-yl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
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C17H18ClFN6O2S
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1
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| 1 |
IC50 = 51 nM
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CP0302925
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(E)-N-methoxy-C-methylcarbonimidoyl]-5-[methyl(methylsulfonyl)amino]benzamide
Show/Hide
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C30H36F2N4O6S
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1
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| 1 |
IC50 = 52 nM
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CP0046198
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(4S)-2'-propoxy-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C22H20N4O3
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1
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| 1 |
IC50 = 52 nM
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CP0894559
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rac-N-(3-(3-amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl)-4-fluorophenyl)-5-cyanopicolinamide
Show/Hide
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C19H16FN5OS
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1
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| 1 |
IC50 = 52 nM
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CP0731120
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(S)-N-(2'-amino-3-methoxy-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazole]-7-yl)-5-chloropicolinamide
Show/Hide
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C21H16ClN5O4
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1
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| 1 |
IC50 = 52 nM
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CP0354528
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N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Show/Hide
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C22H21F5N4O3S
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1
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| 1 |
IC50 = 52 nM
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CP0296009
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(2-hydroxyethyl)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C34H43F2N3O5
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1
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| 1 |
IC50 = 53 nM
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CP0325120
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N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(1-methylimidazol-4-yl)sulfonylpiperazin-2-yl]propan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
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C32H40F2N6O6S
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1
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| 1 |
IC50 = 53 nM
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CP0174582
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(trifluoromethoxy)pyridine-2-carboxamide
Show/Hide
|
C18H14F6N4O3
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0733851
|
(S)-N-(2'-amino-3-methyl-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazole]-7-yl)-5-chloropicolinamide
Show/Hide
|
C21H16ClN5O3
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0515689
|
(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpiperidin-4-yl)amino]-propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
Show/Hide
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C40H49N5O5S
|
1
|
| 1 |
IC50 = 54.6 nM
|
|
|
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CP0284926
|
(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-2-[(3R)-3-[(1R)-1-hydroxybutyl]-2-oxopyrrolidin-1-yl]propanamide
Show/Hide
|
C27H41F2N3O5
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0057103
|
(2R)-N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-fluoropropanamide
Show/Hide
|
C30H40FN3O5
|
1
|
| 1 |
IC50 = 55.5 nM
|
|
|
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CP0116108
|
(4aS,10R,10aR)-4a-methyl-8-pyrimidin-5-ylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H20N4O3
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0129734
|
N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-methoxy-5-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]benzamide
Show/Hide
|
C35H40F2N4O6
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0364219
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-[(2R)-4-(2,3-dimethylimidazol-4-yl)sulfonylpiperazin-2-yl]-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C33H44F2N6O5S
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0091268
|
US8541427, 12
Show/Hide
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C19H21FN6O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0539116
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Show/Hide
|
C39H60N6O7S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0380417
|
(S)-2-Ethyl-4-(S)-hydroxy-5-[(S)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-propionylamino]-6-phenyl-hexanoic acid [(S)-2-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-propyl]-amide
Show/Hide
|
C35H52N4O6
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0469409
|
N-[3-[(1S,7S)-3-amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C19H16FN5OS
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0366742
|
(4aS,10R,10aR)-8-(2-fluoropyridin-3-yl)-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H20FN3O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0197615
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyridine-2-carboxamide
Show/Hide
|
C18H17F3N4O3
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0473437
|
(4aS,10R,10aS)-8-(5-chloropyridin-3-yl)-7-fluoro-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H19ClFN3O3
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0037500
|
N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamide
Show/Hide
|
C33H41F2N5O6S2
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0524541
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
Show/Hide
|
C38H58N6O7
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0364218
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(2-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C35H44F2N4O5S
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0368952
|
N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-fluoropyridine-3-carboxamide
Show/Hide
|
C33H39FN4O5
|
1
|
| 1 |
IC50 = 64.3 nM
|
|
|
|
CP0283908
|
N-[(2S,3R)-4-[[2-(2,2-dimethylpropyl)-6,6-dimethyl-5,7-dihydro-4H-indazol-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
|
C26H40N4O2
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0349671
|
N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-(3,3,3-trifluoropropoxy)pyrazine-2-carboxamide
Show/Hide
|
C22H22F5N5O3S
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0376480
|
(S)-5-[(S)-5-Fluoro-2-((2S,3S)-2-hydroxy-3-methyl-pentanoylamino)-pentanoylamino]-2-(3-fluoro-propyl)-4-(S)-hydroxy-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
|
C37H55F2N5O6
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0091366
|
(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3S)-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]propanamide
Show/Hide
|
C29H39F2N3O4
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0338386
|
(6S)-2-amino-6-[2-chloro-5-(5-prop-1-ynylpyridin-3-yl)thiophen-3-yl]-3,6-dimethyl-5H-pyrimidin-4-one
Show/Hide
|
C18H17ClN4OS
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0733793
|
N-(3-(4-amino-2-methyl-2H-benzo[e][1,3]oxazin-2-yl)-4-fluorophenyl)-5-chloropicolinamide
Show/Hide
|
C21H16ClFN4O2
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0574200
|
(1R,2R)-2-[(4aR,7aR)-2-amino-6-pyrimidin-2-yl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-N-butylcyclopropane-1-carboxamide
Show/Hide
|
C18H26N6OS
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0266610
|
N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]pyridine-3-carboxamide
Show/Hide
|
C33H40N4O5
|
1
|
| 1 |
IC50 = 67.6 nM
|
|
|
|
CP0271513
|
N-[(1S,2S)-1-[(2R)-4-(5-chlorothiophen-2-yl)sulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
|
C32H37ClF2N4O6S2
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0091368
|
(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]propanamide
Show/Hide
|
C27H41F2N3O4
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0456243
|
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propylsulfonylpyrrolidin-2-yl]propan-2-yl]-5-(1,3-oxazol-2-yl)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C33H42F2N4O6S
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0280477
|
3-[5-[(4S)-2-amino-1,4-dimethyl-6-oxo-5H-pyrimidin-4-yl]thiophen-3-yl]benzonitrile
Show/Hide
|
C17H16N4OS
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0127015
|
(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-2-[(3S)-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
|
C34H47F2N3O4
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0118765
|
N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-6-fluoropyridine-3-carboxamide
Show/Hide
|
C33H39FN4O5
|
1
|
| 1 |
IC50 = 69.5 nM
|
|
|
|
CP0488311
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C39H60N6O7S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0061957
|
N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-pyridin-2-ylsulfonylpiperazin-2-yl]propan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
|
C33H39F2N5O6S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0379876
|
N-[N'-[[4-[[2-(benzylamino)acetyl]amino]-3-chloro-5-methylphenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
|
C30H31ClN6O3S
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0489565
|
N-[N'-[[3,5-dichloro-4-[[2-(dimethylamino)acetyl]amino]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
|
C24H26Cl2N6O3S
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0093551
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-[[3-(trifluoromethyl)phenyl]methoxy]pyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C41H49F5N4O5
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0296010
|
5-acetyl-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3-((R)-1-phenylethyl)isophthalamide
Show/Hide
|
C36H37F2N3O5
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0416784
|
N-[(4S,8E)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-2,14-dioxo-6-oxa-3,13-diazabicyclo[13.3.1]nonadeca-1(18),8,15(19),16-tetraen-17-yl]-N-methylmethanesulfonamide
Show/Hide
|
C30H42N4O6S
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0214775
|
N-[3-[(1S,7R)-3-amino-5-oxa-2-azabicyclo[5.1.0]oct-2-en-1-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C18H16ClFN4O2
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0485176
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]carbamate
Show/Hide
|
C36H54N6O7
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0333779
|
N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
|
C35H40F2N4O5
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0577098
|
N-[6-[(3R,6S)-5-amino-6-(difluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C19H17F3N6O3S
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0553854
|
(4aR,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
|
C19H18ClN3O2S
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0535517
|
N-[(1S,2S)-3-(3,5-difluorophenyl)-1-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-1-hydroxypropan-2-yl]acetamide;hydrochloride
Show/Hide
|
C21H33ClF2N2O4
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0130047
|
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[methyl(methylsulfonyl)amino]benzamide
Show/Hide
|
C27H31F2N3O5S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0139079
|
(1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-methoxybenzylamino)-propyl]-5-methyl-N,N-dipropylisophthalamide
Show/Hide
|
C33H41F2N3O4
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0275471
|
1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C32H39F2N3O4
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0248354
|
(2R)-3-[2-amino-6-(3-chloropyridin-2-yl)quinolin-3-yl]-N-(3,3-dimethylbutyl)-2-methylpropanamide
Show/Hide
|
C24H29ClN4O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0284387
|
(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]propanamide
Show/Hide
|
C29H39F2N3O4
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0366763
|
(4aS,10S,10aR)-4a-methyl-8-pyrimidin-5-ylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
|
C19H20N4O2S
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0180418
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C37H56N6O7
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0152088
|
3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-[(Z)-N-methoxy-C-methylcarbonimidoyl]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
|
C37H40F2N4O5
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0249495
|
(5R)-2-amino-5-cyclopropyl-3-methyl-5-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]imidazol-4-one
Show/Hide
|
C21H20N4O
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0037497
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-thiophen-2-ylsulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C32H40F2N4O5S2
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0236662
|
(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C34H47F2N3O4
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0231060
|
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(E)-N-methoxy-C-methylcarbonimidoyl]-5-(N-methylsulfonylanilino)benzamide
Show/Hide
|
C35H38F2N4O6S
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
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CP0411426
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(4aS,10S,10aR)-8-(2-fluoropyridin-3-yl)-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
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C20H20FN3O2S
|
1
|
| 1 |
IC50 = 86 nM
|
|
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CP0174583
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methylpyridine-2-carboxamide
Show/Hide
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C18H17F3N4O2
|
1
|
| 1 |
IC50 = 87 nM
|
|
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CP0670144
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(S)-7-(5-(cyclopropylethynyl)pyridin-3-yl)-3-(3,6-dihydro-2H-pyran-4-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
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C29H24N4O3
|
1
|
| 1 |
IC50 = 87 nM
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|
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CP0330911
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3-((Z)-1-(benzyloxyimino)ethyl)-N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)benzamide
Show/Hide
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C41H42F2N4O6S
|
1
|
| 1 |
IC50 = 88 nM
|
|
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CP0213101
|
(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-2-[(3R)-3-(methoxymethyl)-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C32H43F2N3O5
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
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CP0293733
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(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3R)-3-[(1R)-1-hydroxybutyl]-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C36H45F2N3O5
|
1
|
| 1 |
IC50 = 90 nM
|
|
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CP0481678
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N-[N'-[[3-chloro-4-[[2-(dimethylamino)acetyl]amino]-5-methylphenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C25H29ClN6O4
|
2
|
| 1 |
IC50 = 90 nM
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|
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| 2 |
Ki = 50 nM
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CP0529539
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(4aS,10R,10aS)-7-fluoro-8-(2-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H19F2N3O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
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CP0145126
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5-acetyl-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3-(1-(4-fluorophenyl)ethyl)isophthalamide
Show/Hide
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C36H36F3N3O5
|
1
|
| 1 |
IC50 = 91 nM
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|
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CP0791921
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N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-3-(1-(hydroxyimino)ethyl)-5-(N-phenylmethylsulfonamido)benzamide
Show/Hide
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C34H36F2N4O6S
|
1
|
| 1 |
IC50 = 91 nM
|
|
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CP0275474
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3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(1-hydroxyethyl)-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C36H39F2N3O5
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
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CP0432700
|
(4aS,10R,10aS)-8-(2-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H20FN3O3
|
1
|
| 1 |
IC50 = 92 nM
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|
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CP0328543
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(4aS,10R,10aR)-8-(3-chloro-5-fluorophenyl)-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C21H20ClFN2O3
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
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CP0065326
|
US8541427, 29
Show/Hide
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C19H17F5N6O2
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1
|
| 1 |
IC50 = 93 nM
|
|
|
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CP0069952
|
1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(4-fluorophenoxy)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C38H42F3N3O5
|
1
|
| 1 |
IC50 = 94 nM
|
|
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CP0515690
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
Show/Hide
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C42H53N5O5S
|
1
|
| 1 |
IC50 = 98.7 nM
|
|
|
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CP0145709
|
(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-2-[(3R)-2-oxo-3-propan-2-ylpyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
|
C33H45F2N3O4
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
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CP0204332
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-ethynylphenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C31H41N3O4
|
1
|
| 1 |
IC50 = 99 nM
|
|
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CP0420916
|
(4aS,10R,10aS)-8-(5-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H20FN3O3
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
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CP0443205
|
(4aS,10R,10aS)-2'-amino-8-[3-(difluoromethoxy)phenyl]-7-fluoro-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C22H20F3N3O4
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
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CP0390063
|
N-[(1S,2S)-1-[(3R,5S,6R)-6-(cyclohexylmethoxy)-5-methylmorpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide;hydrochloride
Show/Hide
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C23H35ClF2N2O4
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
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CP0520133
|
(S)-2-Ethyl-4-(S)-hydroxy-5-[(S)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-propionylamino]-6-phenyl-hexanoic acid [(S)-2-methyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-amide
Show/Hide
|
C35H52N4O6
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0061960
|
N-[(1S,2S)-1-[(2R)-4-cyclopropylsulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
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C31H40F2N4O6S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0317940
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(1-methylimidazol-4-yl)sulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C32H42F2N6O5S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
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CP0073005
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-[2-fluoro-3-(1,3-thiazol-2-yl)phenyl]-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C32H41FN4O4S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0447010
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(2,2,3,3-tetrafluoropropoxy)pyridine-2-carboxamide
Show/Hide
|
C20H17F7N4O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
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CP0705356
|
(S)-3-(3,6-dihydro-2H-pyran-4-yl)-7-(5-((3-methyloxetan-3-yl)ethynyl)pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
|
C30H26N4O4
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0088990
|
(4S)-1'-fluoro-7'-(2-fluoropyridin-3-yl)-3'-(oxan-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
Show/Hide
|
C24H20F2N4O3
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
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CP0173062
|
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-[(2R,4S)-4-ethoxypiperidin-2-yl]-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C31H43F2N3O4
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0310999
|
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-(2-methoxyethoxy)piperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C32H45F2N3O5
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
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CP0296051
|
3-[6-(2-acetylphenyl)-2-aminoquinolin-3-yl]-N-(3,3-dimethylbutyl)-2-methylpropanamide
Show/Hide
|
C27H33N3O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
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CP0168505
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C38H46F2N4O4
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0298538
|
(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-2-[(3S)-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]propanamide
Show/Hide
|
C27H41F2N3O4
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0274732
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-(1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C38H46F2N4O4
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0159868
|
(6S)-2-amino-3,6-dimethyl-6-[5-(5-prop-1-ynylpyridin-3-yl)thiophen-3-yl]-5H-pyrimidin-4-one
Show/Hide
|
C18H18N4OS
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0284907
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-1-methylpyrazole-3-carboxamide
Show/Hide
|
C16H16F3N5O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0323225
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Show/Hide
|
C18H15F6N5O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0121487
|
(4aS,10S,10aR)-8-(3-chloro-5-fluorophenyl)-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
|
C21H20ClFN2O2S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0825788
|
N-[(1S,2R)-1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-3-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-5-{1-[hydroxyimino]-ethyl}-benzamide
Show/Hide
|
C31H36F2N4O6S
|
1
|
| 1 |
IC50 = 117 nM
|
|
|
|
CP0523971
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]carbamate
Show/Hide
|
C36H54N6O8
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0330901
|
5-(1-(allyloxyimino)ethyl)-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3,N3-dipropylisophthalamide
Show/Hide
|
C37H46F2N4O5
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0037767
|
1-N-[(1S,2S)-1-[(2R)-4-(benzenesulfonyl)piperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C34H42F2N4O5S
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0339168
|
3-[5-[(4S)-2-amino-1,4-dimethyl-6-oxo-5H-pyrimidin-4-yl]thiophen-2-yl]benzonitrile
Show/Hide
|
C17H16N4OS
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0388201
|
(4aR,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H18ClN3O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0731119
|
(S)-3-chloro-7-(5-(prop-1-ynyl)pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
|
C22H15ClN4O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0090489
|
1-N-[(1R,2S)-1-[(2R,4S)-4-(cyclopropylmethoxy)piperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C33H45F2N3O4
|
1
|
| 1 |
IC50 = 121 nM
|
|
|
|
CP0345155
|
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1-hydroxyethyl)-5-[methyl(methylsulfonyl)amino]benzamide
Show/Hide
|
C29H35F2N3O6S
|
1
|
| 1 |
IC50 = 122 nM
|
|
|
|
CP0404206
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-4-methoxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C39H60N6O8
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0272937
|
(2S,3S)-4-Hydroxy-5-[(S)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-propionylamino]-2-methyl-6-phenyl-hexanoic acid {2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
|
C32H47N5O6
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0121486
|
(4aR,10R,10aS)-8-(2-fluoropyridin-3-yl)-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H20FN3O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0345407
|
N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-4-chloro-1-methylpyrazole-3-carboxamide
Show/Hide
|
C16H15ClF3N5O2
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0247817
|
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(N-methylsulfonylanilino)benzamide
Show/Hide
|
C32H33F2N3O5S
|
1
|
| 1 |
IC50 = 137 nM
|
|
|
|
CP0094662
|
N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]pyridine-3-carboxamide
Show/Hide
|
C33H37F2N5O5
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0335073
|
(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-(8-propoxy-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C41H52F2N4O5
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0427918
|
N-[N'-[[4-[[2-(benzylamino)acetyl]amino]-3,5-dichlorophenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
|
C29H28Cl2N6O3S
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
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CP0758053
|
5-Chloro-pyridine-2-carboxylic acid [3-((1SR,6RS)-3-amino-4-thia-2-aza-bicyclo[4.1.0]hept-2-en-1-yl)-phenyl]-amide
Show/Hide
|
C17H15ClN4OS
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0271716
|
3-[(4aS,10S,10aR)-2'-amino-4a-methylspiro[2,3,4,10a-tetrahydropyrano[3,2-b]chromene-10,4'-5H-1,3-thiazole]-8-yl]benzonitrile
Show/Hide
|
C22H21N3O2S
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0210812
|
N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-ethynyl-2-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
Show/Hide
|
C31H40FN3O4
|
1
|
| 1 |
IC50 = 144 nM
|
|
|
|
CP0367761
|
5-(benzenesulfonyl)-1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C38H43F2N3O6S
|
1
|
| 1 |
IC50 = 148 nM
|
|
|
|
CP0050860
|
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C35H43F2N3O4
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1
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| 1 |
IC50 = 150 nM
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CP0267481
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(5R)-2-amino-5-[3-(5-chloropyridin-3-yl)phenyl]-5-cyclopropyl-3-methylimidazol-4-one
Show/Hide
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C18H17ClN4O
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1
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| 1 |
IC50 = 150 nM
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CP0345408
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N-[3-[(4R,5R,6R)-2-amino-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
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C19H14F5N5O2
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1
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| 1 |
IC50 = 150 nM
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CP0407454
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5-[(4aR,7aR)-2-amino-6-[5-fluoro-4-methyl-6-(methylamino)pyrimidin-2-yl]-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophene-2-carbonitrile
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C18H19FN8OS
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1
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| 1 |
IC50 = 157 nM
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CP0379496
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1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypiperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C33H47F2N3O4
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1
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| 1 |
IC50 = 160 nM
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CP0334302
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(4S,8E,11R)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-16-methyl-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraene-2,13-dione
Show/Hide
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C34H41N3O4
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1
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| 1 |
IC50 = 160 nM
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CP0295882
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3-(1-(allyloxyimino)ethyl)-N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)benzamide
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C37H40F2N4O6S
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1
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| 1 |
IC50 = 162 nM
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CP0226084
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3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-1-N-[1-(4-fluorophenyl)ethyl]-5-(1-hydroxyethyl)benzene-1,3-dicarboxamide
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C36H38F3N3O5
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1
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| 1 |
IC50 = 164 nM
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CP0079755
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1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C34H41F2N3O4
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1
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| 1 |
IC50 = 165 nM
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CP0248350
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(2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-2-methyl-N-(oxan-4-ylmethyl)propanamide
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C26H31N3O2
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1
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| 1 |
IC50 = 170 nM
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CP0388071
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(1R,4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)-1-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
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C20H20FN3O2S
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1
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| 1 |
IC50 = 170 nM
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CP0388202
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(1R,4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)-1-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H20FN3O3
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1
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| 1 |
IC50 = 170 nM
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CP0578252
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N-[3-[(3R,6S)-5-amino-6-(difluoromethyl)-3,6-dimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Show/Hide
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C19H20F3N5O4S
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1
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| 1 |
IC50 = 171 nM
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CP0375074
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(S)-4-(S)-Hydroxy-5-[(S)-2-((2S,3S)-2-hydroxy-3-methyl-pentanoylamino)-4-methyl-pentanoylamino]-2-isobutyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
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C39H61N5O6
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1
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| 1 |
IC50 = 176 nM
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CP0265845
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N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-1-butyl-5-oxopyrrolidine-3-carboxamide
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C29H36F2N4O4
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1
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| 1 |
IC50 = 180 nM
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CP0420917
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(4aS,10R,10aS)-4a-methyl-8-pyrimidin-5-ylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C19H20N4O3
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1
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| 1 |
IC50 = 180 nM
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CP0443204
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(4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
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C19H18FN3O2S
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1
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| 1 |
IC50 = 180 nM
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CP0330909
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1,1-dioxothiazinan-2-yl)benzamide
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C29H33F2N3O5S
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1
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| 1 |
IC50 = 182 nM
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CP0295881
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(Z)-C-methyl-N-propoxycarbonimidoyl]-5-(N-methylsulfonylanilino)benzamide
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C37H42F2N4O6S
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1
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| 1 |
IC50 = 184 nM
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CP0501202
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(S)-5-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-oxo-propylamino]-4-(S)-hydroxy-2-methyl-6-phenyl-hexanoic acid {(R)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
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C32H48N6O5
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1
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| 1 |
IC50 = 190 nM
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CP0273891
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-1-[(2R,4S)-4-aminopyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-4-phenylbutanamide
Show/Hide
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C33H45F2N5O4
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1
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| 1 |
IC50 = 190 nM
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CP0234425
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(4aR,7aR)-2-amino-7a-(5-chlorothiophen-2-yl)-6-(5-fluoro-4-methoxy-6-propylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
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C19H22ClFN6O2S
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1
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| 1 |
IC50 = 190 nM
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CP0670142
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(S)-N-(2'-amino-3-chloro-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazole]-7-yl)-5-chloropicolinamide
Show/Hide
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C20H13Cl2N5O3
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1
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| 1 |
IC50 = 190 nM
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CP0239183
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3-[5-[(4aR,7aR)-2-amino-6-(4-fluorophenyl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C24H20FN5OS
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2
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| 1 |
IC50 = 191 nM
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| 2 |
Ki = 26 nM
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CP0048754
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3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C34H35F2N3O4
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1
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| 1 |
IC50 = 198 nM
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CP0823348
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(R)-N-(3-(2-amino-4-methyl-4,5-dihydrooxazol-4-yl)phenyl)-5-chloropicolinamide
Show/Hide
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C16H15ClN4O2
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1
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| 1 |
IC50 = 200 nM
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CP0191947
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(4aR,7aR)-2-amino-7a-(5-chlorothiophen-2-yl)-6-(4-ethyl-5-fluoro-6-methoxypyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
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C18H20ClFN6O2S
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1
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| 1 |
IC50 = 203 nM
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CP0048755
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-[(Z)-C-methyl-N-propoxycarbonimidoyl]benzamide
Show/Hide
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C34H42F2N4O6S
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1
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| 1 |
IC50 = 205 nM
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CP0323732
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(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3R)-3-(methoxymethyl)-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C34H41F2N3O5
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1
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| 1 |
IC50 = 210 nM
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CP0459183
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N-[N'-[[3,5-dichloro-4-[[2-(dimethylamino)acetyl]amino]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C24H26Cl2N6O4
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2
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| 1 |
IC50 = 210 nM
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| 2 |
Ki = 50 nM
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CP0740736
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(R)-N-(3-(3-amino-1-methyl-1H-isoindol-1-yl)phenyl)-5-chloropicolinamide
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C21H17ClN4O
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1
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| 1 |
IC50 = 210 nM
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CP0330910
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[methyl(methylsulfonyl)amino]-5-[(Z)-C-methyl-N-propoxycarbonimidoyl]benzamide
Show/Hide
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C32H40F2N4O6S
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1
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| 1 |
IC50 = 217 nM
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CP0460842
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(S)-4-(S)-Hydroxy-2-methyl-6-phenyl-5-[(S)-2-((S)-4,4,4-trifluoro-2-hydroxy-butyrylamino)-propionylamino]-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
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C31H42F3N5O6
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1
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| 1 |
IC50 = 220 nM
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CP0308402
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N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-methylsulfonylpiperazin-2-yl]propan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
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C29H38F2N4O6S
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1
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| 1 |
IC50 = 220 nM
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CP0169330
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(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3R)-2-oxo-3-propan-2-ylpyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C35H43F2N3O4
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1
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| 1 |
IC50 = 220 nM
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CP0284927
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(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-hydroxypyrrolidin-2-yl]propan-2-yl]-2-[(3R)-3-[(1R)-1-hydroxybutyl]-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C31H41F2N3O5
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1
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| 1 |
IC50 = 220 nM
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CP0362768
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(4S,8E)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-16-methyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraene-2,13-dione
Show/Hide
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C28H37N3O4
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1
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| 1 |
IC50 = 220 nM
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CP0390061
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N-[(1S,2S)-1-[(3R,6R)-6-(cyclohexylmethoxy)morpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide;2,2,2-trifluoroacetic acid
Show/Hide
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C24H33F5N2O6
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1
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| 1 |
IC50 = 220 nM
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CP0484573
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(S)-4-(S)-Hydroxy-5-[(S)-2-((S)-2-hydroxy-4-methyl-pentanoylamino)-propionylamino]-2-methyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
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C33H49N5O6
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1
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| 1 |
IC50 = 230 nM
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CP0335482
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N-[(2S,3R)-4-[[2-(2,2-dimethylpropyl)-6,6-dimethyl-1,4,5,7-tetrahydrobenzimidazol-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
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C26H40N4O2
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1
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| 1 |
IC50 = 230 nM
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CP0284908
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]pyridine-2-carboxamide
Show/Hide
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C17H15F3N4O2
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1
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| 1 |
IC50 = 230 nM
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CP0345410
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N-[3-[(4S,6R)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
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C19H15F4N5O2
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1
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| 1 |
IC50 = 230 nM
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CP0388070
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(4aS,10R,10aS)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C19H18ClN3O3
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1
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| 1 |
IC50 = 230 nM
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CP0304797
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US8541427, 40
Show/Hide
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C19H18F4N6O2
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1
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| 1 |
IC50 = 234 nM
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CP0204964
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5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophene-2-carbonitrile
Show/Hide
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C17H16FN7O2S
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1
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| 1 |
IC50 = 238 nM
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CP0368450
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N-[(2S,3R)-1-[3,4-bis(difluoromethoxy)phenyl]-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
Show/Hide
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C30H39F4N3O5
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1
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| 1 |
IC50 = 238.4 nM
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CP0080546
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(4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
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C15H14F2N4S
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2
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| 1 |
IC50 = 239 nM
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| 2 |
IC50 = 240 nM
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CP0129792
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1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-piperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C29H39F2N3O3
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1
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| 1 |
IC50 = 240 nM
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CP0291278
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(4R)-N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-1-butyl-4-ethyl-5-oxopyrrolidine-3-carboxamide
Show/Hide
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C31H40F2N4O4
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1
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| 1 |
IC50 = 240 nM
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CP0302659
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1-N-[(1S,2S)-1-[(2R)-4-(3-chlorophenyl)sulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C34H41ClF2N4O5S
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1
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| 1 |
IC50 = 240 nM
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CP0075549
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(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3S)-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C36H45F2N3O4
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1
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| 1 |
IC50 = 240 nM
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CP0284389
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(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3R)-2-oxo-3-propan-2-ylpyrrolidin-1-yl]propanamide
Show/Hide
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C28H37F2N3O4
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1
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| 1 |
IC50 = 240 nM
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CP0459188
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N-[N'-[(4-acetamido-3-chloro-5-methylphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
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C23H24ClN5O3S
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2
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| 1 |
IC50 = 240 nM
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| 2 |
Ki = 20 nM
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CP0226087
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3-Acetyl-N-[(1S,2R)-1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-5-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-benzamide
Show/Hide
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C31H35F2N3O6S
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1
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| 1 |
IC50 = 248 nM
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CP0069645
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1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C31H38N4O5S
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1
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| 1 |
IC50 = 250 nM
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CP0152299
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(2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-(3,3-dimethylbutyl)-2-methylpropanamide
Show/Hide
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C26H33N3O
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1
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| 1 |
IC50 = 250 nM
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CP0152302
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3-[2-amino-6-(3-methoxypyridin-2-yl)quinolin-3-yl]-N-(3,3-dimethylbutyl)-2-methylpropanamide
Show/Hide
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C25H32N4O2
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1
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| 1 |
IC50 = 250 nM
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CP0362769
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N-[(4S,8E,11S)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraen-16-yl]-N-methylmethanesulfonamide
Show/Hide
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C35H44N4O6S
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1
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| 1 |
IC50 = 260 nM
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CP0533183
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(1S,5S,6S)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-(fluoromethyl)-1-(methoxymethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine
Show/Hide
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C21H19ClF3N3OS
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1
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| 1 |
IC50 = 260 nM
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CP0296011
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3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-1-N-[1-(4-fluorophenyl)ethyl]benzene-1,3-dicarboxamide
Show/Hide
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C34H34F3N3O4
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1
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| 1 |
IC50 = 266 nM
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CP0224926
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N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-5-oxopentanamide
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C31H42F2N4O6S
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1
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| 1 |
IC50 = 270 nM
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CP0093550
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-1-[(2R,4R)-4-aminopyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-4-phenylbutanamide
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C33H45F2N5O4
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1
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| 1 |
IC50 = 270 nM
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CP0443203
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(4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
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C19H18FN3O3
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1
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| 1 |
IC50 = 270 nM
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CP0226086
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3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-1-N-[1-(4-fluorophenyl)ethyl]-5-[(Z)-N-methoxy-C-methylcarbonimidoyl]benzene-1,3-dicarboxamide
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C37H39F3N4O5
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1
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| 1 |
IC50 = 276 nM
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CP0429867
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tert-butyl N-[(2S)-4,4,5,5-tetrafluoro-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate
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C37H52F4N6O7
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1
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| 1 |
IC50 = 281 nM
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CP0234402
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
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C19H16F6N4O3
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1
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| 1 |
IC50 = 290 nM
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CP0271012
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1-N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C35H42F2N4O4
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1
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| 1 |
IC50 = 300 nM
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CP0276437
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(1-hydroxyethyl)benzamide
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C31H37F2N3O6S
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1
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| 1 |
IC50 = 305 nM
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CP0217496
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3-[5-[(4aR,7aR)-2-amino-3-methyl-4-oxo-6-(3-propan-2-yloxyphenyl)-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
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C27H27N5O2S
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1
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| 1 |
IC50 = 308 nM
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CP0481039
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N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
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C22H21Cl2N5O3S
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2
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| 1 |
IC50 = 310 nM
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| 2 |
Ki = 5 nM
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CP0336629
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1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-pyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C28H37F2N3O3
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1
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| 1 |
IC50 = 330 nM
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CP0391035
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(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-pyridin-2-yloxypyrrolidin-2-yl]propan-2-yl]-2-[(3S)-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]propanamide
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C29H38F2N4O4
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1
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| 1 |
IC50 = 330 nM
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CP0459187
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N-[N'-[[3-chloro-4-(cyclopropanecarbonylamino)-5-methylphenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
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C25H26ClN5O4
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2
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| 1 |
IC50 = 330 nM
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| 2 |
Ki = 20 nM
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CP0708881
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N-(3-(2-amino-1,4-dimethyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)-5-chloropicolinamide
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C17H16ClN5O2
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1
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| 1 |
IC50 = 340 nM
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CP0152092
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-[(Z)-N-methoxy-C-methylcarbonimidoyl]benzamide
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C32H38F2N4O6S
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1
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| 1 |
IC50 = 345 nM
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CP0501142
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(S)-4-(S)-Hydroxy-5-[(S)-3-hydroxy-2-((S)-2-hydroxy-3-methyl-butyrylamino)-propionylamino]-2-methyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
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C32H47N5O7
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1
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| 1 |
IC50 = 350 nM
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CP0523821
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(S)-4-(S)-Hydroxy-5-[(S)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-4-methylsulfanyl-butyrylamino]-2-methyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
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C34H51N5O6S
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1
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| 1 |
IC50 = 350 nM
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CP0220652
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(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-4-phenylbutanamide
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C36H45F2N3O4
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1
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| 1 |
IC50 = 350 nM
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CP0399362
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(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-pyridin-2-yloxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
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C36H44F2N4O4
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1
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| 1 |
IC50 = 360 nM
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CP0091269
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5-[(4aR,7aR)-2-amino-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophene-2-carbonitrile
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C19H20FN7O2S
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1
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| 1 |
IC50 = 361 nM
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CP0233908
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3-(1-(allyloxyimino)ethyl)-N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(N-methylmethylsulfonamido)benzamide
Show/Hide
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C32H38F2N4O6S
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1
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| 1 |
IC50 = 363 nM
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CP0145125
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-[(Z)-C-methyl-N-(2-methylpropoxy)carbonimidoyl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C38H50F2N4O5
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1
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| 1 |
IC50 = 367 nM
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CP0062405
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2-amino-5-[3-(5-chloropyridin-3-yl)phenyl]-5-cyclopropyl-3-methylimidazol-4-one
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C18H17ClN4O
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1
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| 1 |
IC50 = 380 nM
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CP0650778
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N-(2'-amino-2,3-dihydro-5'H-spiro[indene-1,4'-thiazole]-6-yl)-5-chloropicolinamide
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C17H15ClN4OS
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1
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| 1 |
IC50 = 380 nM
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CP0298251
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(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propoxypyrrolidin-2-yl]propan-2-yl]-2-[(3R)-2-oxo-3-propan-2-ylpyrrolidin-1-yl]propanamide
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C26H39F2N3O4
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1
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| 1 |
IC50 = 390 nM
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CP0126610
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2-amino-5-cyclopropyl-5-[3-(5-methoxypyridin-3-yl)phenyl]-3-methylimidazol-4-one
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C19H20N4O2
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1
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| 1 |
IC50 = 390 nM
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CP0247727
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(4-methoxyphenyl)sulfonyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C39H45F2N3O7S
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1
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| 1 |
IC50 = 392 nM
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CP0289431
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1-N-[(2S,3R)-4-(ethylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
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C30H37FN4O5S
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1
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| 1 |
IC50 = 396 nM
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CP0274689
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-pyridin-4-ylsulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C33H41F2N5O5S
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1
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| 1 |
IC50 = 400 nM
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CP0093548
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(2S)-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-2-[(3R)-3-(methoxymethyl)-2-oxopyrrolidin-1-yl]propanamide
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C27H35F2N3O5
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1
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| 1 |
IC50 = 400 nM
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CP0159870
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3-[4-[(4S)-2-amino-1,4-dimethyl-6-oxo-5H-pyrimidin-4-yl]thiophen-2-yl]benzonitrile
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C17H16N4OS
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1
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| 1 |
IC50 = 400 nM
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CP0368738
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N-[3-[(4S)-2-amino-5,5-difluoro-4-(fluoromethyl)-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
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C18H13F4N5O2
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1
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| 1 |
IC50 = 400 nM
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CP0444116
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(4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)-10a-methylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
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C20H20FN3O3
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1
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| 1 |
IC50 = 400 nM
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CP0303687
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(2R)-N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-hydroxypropanamide
Show/Hide
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C32H42N4O4S
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1
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| 1 |
IC50 = 408 nM
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CP0145127
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(4-methoxyphenoxy)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C39H45F2N3O6
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1
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| 1 |
IC50 = 412 nM
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CP0217863
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N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]propanamide
Show/Hide
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C32H42N4O3S
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1
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| 1 |
IC50 = 414 nM
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CP0496639
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tert-butyl N-[(2S)-6,6,6-trifluoro-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamate
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C38H55F3N6O7
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1
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| 1 |
IC50 = 419 nM
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CP0706733
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N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-3-(1-(hydroxyimino)ethyl)-5-(N-methylmethylsulfonamido)benzamide
Show/Hide
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C29H34F2N4O6S
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1
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| 1 |
IC50 = 429 nM
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CP0086605
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3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-2-methyl-N-(1,3-thiazol-5-ylmethyl)propanamide
Show/Hide
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C24H24N4OS
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1
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| 1 |
IC50 = 430 nM
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CP0500110
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N-[N'-[(4-benzamido-3-chloro-5-methylphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
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C28H26ClN5O3S
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2
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| 1 |
IC50 = 430 nM
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| 2 |
Ki = 30 nM
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CP0325119
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methoxyphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C35H44F2N4O6S
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1
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| 1 |
IC50 = 440 nM
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CP0316147
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N-[(2S,3R)-4-[[(4S)-2-(2,2-dimethylpropyl)-6,6-dimethyl-5,7-dihydro-4H-pyrazolo[1,5-a]pyridin-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
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C26H40N4O2
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1
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| 1 |
IC50 = 440 nM
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CP0085535
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3-[3-[(4S)-2-amino-1,4-dimethyl-6-oxo-5H-pyrimidin-4-yl]phenyl]benzonitrile
Show/Hide
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C19H18N4O
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1
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| 1 |
IC50 = 450 nM
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CP0080717
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(6S)-2-amino-3,6-dimethyl-6-(3-pyridin-3-ylphenyl)-5H-pyrimidin-4-one
Show/Hide
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C17H18N4O
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1
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| 1 |
IC50 = 460 nM
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CP0286032
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(6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
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C21H25N3O2
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1
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| 1 |
IC50 = 470 nM
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CP0197613
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N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-ethoxypyridine-2-carboxamide
Show/Hide
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C19H19F3N4O3
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1
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| 1 |
IC50 = 480 nM
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CP0310998
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1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-[(2R,4S)-4-[2-(dimethylamino)ethoxy]piperidin-2-yl]-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C33H48F2N4O4
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1
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| 1 |
IC50 = 482 nM
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CP0064442
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(2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-2-methyl-N-(pyrazin-2-ylmethyl)propanamide
Show/Hide
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C25H25N5O
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1
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| 1 |
IC50 = 490 nM
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CP0201434
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5-(1-(allyloxyimino)ethyl)-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3-((R)-1-phenylethyl)isophthalamide
Show/Hide
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C39H42F2N4O5
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1
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| 1 |
IC50 = 500 nM
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CP0291279
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N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-oxo-1-propylpyrrolidine-3-carboxamide
Show/Hide
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C28H34F2N4O4
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1
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| 1 |
IC50 = 510 nM
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CP0456624
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(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-pyridin-2-yloxypyrrolidin-2-yl]propan-2-yl]-2-[(3S)-3-(2-methylpropyl)-2-oxopyrrolidin-1-yl]-4-phenylbutanamide
Show/Hide
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C36H44F2N4O4
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1
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| 1 |
IC50 = 510 nM
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CP0079754
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1-N-[(1R,2S)-1-[(2R,4S)-4-benzylpiperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C36H45F2N3O3
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1
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| 1 |
IC50 = 522 nM
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CP0371022
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N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-1-(cyclopropylmethyl)-5-oxopyrrolidine-3-carboxamide
Show/Hide
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C29H34F2N4O4
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1
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| 1 |
IC50 = 530 nM
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CP0152091
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5-(1-(allyloxyimino)ethyl)-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3-(1-(4-fluorophenyl)ethyl)isophthalamide
Show/Hide
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C39H41F3N4O5
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1
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| 1 |
IC50 = 530 nM
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CP0330902
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5-(1-(benzyloxyimino)ethyl)-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3,N3-dipropylisophthalamide
Show/Hide
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C41H48F2N4O5
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1
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| 1 |
IC50 = 534 nM
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CP0239771
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(4S)-2'-methoxy-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C20H16N4O3
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1
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| 1 |
IC50 = 534 nM
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CP0510019
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(S)-4-(S)-Hydroxy-5-[(S)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-pentanoylamino]-2-methyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
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C34H51N5O6
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1
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| 1 |
IC50 = 550 nM
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CP0156140
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2S)-4-[(2-methoxyphenyl)methyl]-3-oxopiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C36H44F2N4O5
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1
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| 1 |
IC50 = 550 nM
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CP0529538
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(4aR,10S,10aR)-2'-amino-8-(2-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C20H19FN4O3
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1
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| 1 |
IC50 = 550 nM
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CP0234538
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(4aR,10S,10aS)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-2H-pyrano[3,2-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
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C19H18FN3O2S
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1
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| 1 |
IC50 = 550 nM
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CP0296012
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3-acetyl-N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(N-methylmethylsulfonamido)benzamide
Show/Hide
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C29H33F2N3O6S
|
1
|
| 1 |
IC50 = 559 nM
|
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CP0281477
|
3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-2-methyl-N-(pyridin-3-ylmethyl)propanamide
Show/Hide
|
C26H26N4O
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
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CP0476099
|
N-[(4S,8E)-4-[(1R)-2-(benzylamino)-1-hydroxyethyl]-2,13-dioxo-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraen-16-yl]-N-methylmethanesulfonamide
Show/Hide
|
C26H34N4O6S
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
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CP0050858
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1-N-[(1R,2S)-1-[(2R,4S)-4-(cyclohexylmethoxy)piperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C36H51F2N3O4
|
1
|
| 1 |
IC50 = 567 nM
|
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|
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CP0333061
|
5-[3-(2-amino-4-cyclopropyl-1-methyl-5-oxoimidazol-4-yl)phenyl]pyridine-3-carbonitrile
Show/Hide
|
C19H17N5O
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
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CP0433418
|
N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-ethyl-2-oxo-1-propylimidazolidine-4-carboxamide
Show/Hide
|
C29H37F2N5O4
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
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CP0237877
|
(5R)-2-amino-3-methyl-5-phenyl-5-(3-pyridin-3-ylphenyl)imidazol-4-one
Show/Hide
|
C21H18N4O
|
1
|
| 1 |
IC50 = 630 nM
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|
|
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CP0379875
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N-[N'-[(4-amino-3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
|
C20H19Cl2N5O2S
|
2
|
| 1 |
IC50 = 630 nM
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|
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| 2 |
Ki = 40 nM
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CP0296892
|
2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydro-3H-pyrimidin-4-one
Show/Hide
|
C21H25N3O2
|
1
|
| 1 |
IC50 = 640 nM
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|
|
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CP0201431
|
5-(1-aminoethyl)-N1-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-N3,N3-dipropylisophthalamide
Show/Hide
|
C34H44F2N4O4
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
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CP0237878
|
2-amino-5-cyclopropyl-3-methyl-5-[3-(5-methylpyridin-3-yl)phenyl]imidazol-4-one
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
IC50 = 640 nM
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|
|
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CP0489566
|
N-[N'-[[3-chloro-5-methyl-4-(3-methylsulfanylpropanoylamino)phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C25H28ClN5O4S
|
2
|
| 1 |
IC50 = 640 nM
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|
|
| 2 |
Ki = 30 nM
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CP0130559
|
(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-hydroxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C31H41F2N3O4
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
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CP0421425
|
(4aS,10R,10aS)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H18N4O3
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0174599
|
(4aS,10R,10aS)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H18FN3O3
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
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CP0540834
|
(9R,118)-7-Amino-9-(2-fluoro-5-(3-(5-methoxypyrazin-2-yl)isoxazol-5-yl)phenyl)-9-methyl-2,3,4,5,9,10-hexahydro-[1,2,4]thiadiazino[1,2-a][1,2,7]thiadiazepine 11-oxide 2,2,2-trifluoroacetate
Show/Hide
|
C22H24FN7O3S
|
1
|
| 1 |
IC50 = 694 nM
|
|
|
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CP0206725
|
N-[(1S,2S)-1-[(4S)-1-benzyl-5-oxoimidazolidin-4-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
Show/Hide
|
C34H38F2N4O5
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
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CP0495037
|
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methoxy-1-oxobutan-2-yl]carbamate
Show/Hide
|
C37H56N6O8
|
1
|
| 1 |
IC50 = 705 nM
|
|
|
|
CP0168567
|
(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]propan-2-yl]propanamide
Show/Hide
|
C29H37F2N3O3
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0213102
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(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-hydroxypyrrolidin-2-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C31H41F2N3O4
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
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CP0337091
|
1-N-[(1S,2S)-1-[(2R)-4-[(2-chlorophenyl)methyl]piperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C35H43ClF2N4O3
|
1
|
| 1 |
IC50 = 755 nM
|
|
|
|
CP0414355
|
(4aR,10R,10aS)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-2H-pyrano[3,2-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H18FN3O3
|
1
|
| 1 |
IC50 = 759 nM
|
|
|
|
CP0081369
|
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-methoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C29H39F2N3O4
|
1
|
| 1 |
IC50 = 780 nM
|
|
|
|
CP0413748
|
N-[N'-[[3-chloro-5-methyl-4-(propanoylamino)phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C24H26ClN5O4
|
2
|
| 1 |
IC50 = 780 nM
|
|
|
| 2 |
Ki = 40 nM
|
|
|
|
CP0371021
|
N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-2-oxo-1,3-dipropyl-1,3-diazinane-5-carboxamide
Show/Hide
|
C31H41F2N5O4
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0379878
|
N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C22H21Cl2N5O4
|
2
|
| 1 |
IC50 = 790 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0062412
|
2-amino-5-cyclopropyl-5-[3-(5-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
|
C18H17FN4O
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0246121
|
N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[(4S)-spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]butan-2-yl]acetamide
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
IC50 = 804 nM
|
|
|
|
CP0169753
|
N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-methylpropanamide
Show/Hide
|
C31H43N3O5
|
1
|
| 1 |
IC50 = 812 nM
|
|
|
|
CP0247720
|
3-{1-[Benzyloxyimino]-ethyl}-N-[(1S,2R)-1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-5-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-benzamide
Show/Hide
|
C38H42F2N4O6S
|
1
|
| 1 |
IC50 = 821 nM
|
|
|
|
CP0731117
|
(S)-3-chloro-7-(6-fluoropyridin-2-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
|
C19H12ClFN4O2
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0280478
|
(6S)-2-amino-6-[3-(3-methoxyphenyl)phenyl]-3,6-dimethyl-5H-pyrimidin-4-one
Show/Hide
|
C19H21N3O2
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0371455
|
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-propan-2-yloxypiperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C32H45F2N3O4
|
1
|
| 1 |
IC50 = 858 nM
|
|
|
|
CP0273888
|
(2S)-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-hydroxypyrrolidin-2-yl]propan-2-yl]-2-[(3R)-3-[(1R)-1-hydroxybutyl]-2-oxopyrrolidin-1-yl]propanamide
Show/Hide
|
C24H35F2N3O5
|
1
|
| 1 |
IC50 = 870 nM
|
|
|
|
CP0211266
|
2-amino-5-cyclopropyl-3-methyl-5-(3-pyridin-3-ylphenyl)imidazol-4-one
Show/Hide
|
C18H18N4O
|
1
|
| 1 |
IC50 = 880 nM
|
|
|
|
CP0156141
|
1-N-[(1S,2S)-1-[(2S)-4-(cyclopropylmethyl)-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C32H42F2N4O4
|
1
|
| 1 |
IC50 = 915 nM
|
|
|
|
CP0126609
|
3-[3-(2-amino-4-cyclopropyl-1-methyl-5-oxoimidazol-4-yl)phenyl]benzonitrile
Show/Hide
|
C20H18N4O
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0174453
|
(4aR,10R,10aR)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H18N4O3
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0533321
|
(4R)-4-benzyl-N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-1-butyl-5-oxopyrrolidine-3-carboxamide
Show/Hide
|
C36H42F2N4O4
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0337092
|
1-N-[(1S,2S)-1-[(2R)-4-[(2-cyanophenyl)methyl]piperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C36H43F2N5O3
|
1
|
| 1 |
IC50 = 970 nM
|
|
|
|
CP0339570
|
(1R,2R)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-N-[[(1R,2R)-2-methylcyclopropyl]methyl]cyclopropane-1-carboxamide
Show/Hide
|
C15H23N3O2S
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0214777
|
N-[3-(3-amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C18H18ClN5O2
|
1
|
| 1 |
IC50 = 1040 nM
|
|
|
|
CP0430473
|
tert-butyl N-[(2S)-1-[[(2R)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C37H56N6O7
|
1
|
| 1 |
IC50 = 1058 nM
|
|
|
|
CP0173059
|
1-N-[(1S,2S)-1-[(4S)-1-benzyl-5-oxoimidazolidin-4-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C34H40F2N4O4
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0327039
|
N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-2-oxo-3-propan-2-yl-1-propylimidazolidine-4-carboxamide
Show/Hide
|
C30H39F2N5O4
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0258460
|
(S)-5-[(S)-2-((S)-2-Fluoro-3-methyl-butyrylamino)-propionylamino]-4-(S)-hydroxy-2-methyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
|
C32H46FN5O5
|
1
|
| 1 |
IC50 = 1130 nM
|
|
|
|
CP0368451
|
N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-fluorobenzamide
Show/Hide
|
C34H40FN3O5
|
1
|
| 1 |
IC50 = 1150 nM
|
|
|
|
CP0675934
|
N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxypropyl]-N'[(1R)-1-(4-fluorophenyl)ethyl]-5-(methylsulfonyl)amino]isophthalamide
Show/Hide
|
C30H35FN4O5S
|
1
|
| 1 |
IC50 = 1180 nM
|
|
|
|
CP0307442
|
1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-propylpiperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C32H45F2N3O3
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0458938
|
(4aS,10R,10aS)-2'-amino-8-bromo-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C15H16BrN3O3
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0345154
|
3-{1-[Allyloxyimino]-ethyl}-N-[(1S,2R)-1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-5-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-benzamide
Show/Hide
|
C34H40F2N4O6S
|
1
|
| 1 |
IC50 = 1232 nM
|
|
|
|
CP0315919
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(4-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C35H44F2N4O5S
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0315920
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-[(2R)-4-(3,4-dimethoxyphenyl)sulfonylpiperazin-2-yl]-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C36H46F2N4O7S
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0740735
|
N-(2'-amino-2,3-dihydro-5'H-spiro[indene-1,4'-oxazole]-6-yl)-5-chloropicolinamide
Show/Hide
|
C17H15ClN4O2
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0390065
|
N-[(1R,2S)-1-[(2R,5R)-5-(cyclohexylmethoxy)piperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide;hydrochloride
Show/Hide
|
C23H35ClF2N2O3
|
1
|
| 1 |
IC50 = 1320 nM
|
|
|
|
CP0279472
|
2'-(4-fluoropyridin-3-yl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
|
C21H16FN3O3
|
1
|
| 1 |
IC50 = 1330 nM
|
|
|
|
CP0224927
|
1-butyl-N-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-4-(m-tolylsulfonyl)piperazin-2-yl)propan-2-yl)-5-oxopyrrolidine-3-carboxamide
Show/Hide
|
C29H38F2N4O5S
|
1
|
| 1 |
IC50 = 1350 nM
|
|
|
|
CP0052507
|
(4R)-7'-(2,2-dimethylpropoxy)-3'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 1350 nM
|
|
|
|
CP0352386
|
1-benzyl-N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
Show/Hide
|
C32H34F2N4O4
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0284921
|
(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]propan-2-yl]-4-phenylbutanamide
Show/Hide
|
C36H43F2N3O3
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0293736
|
(2S)-2-[(3S)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-hydroxypyrrolidin-2-yl]propan-2-yl]propanamide
Show/Hide
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C24H35F2N3O4
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1
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| 1 |
IC50 = 1400 nM
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CP0379877
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N-[N'-[[3-chloro-4-(furan-2-carbonylamino)-5-methylphenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
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C26H24ClN5O5
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2
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| 1 |
IC50 = 1400 nM
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| 2 |
Ki = 60 nM
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CP0558626
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N-[(1R,2S)-1-[(2R,4R)-4-(cyclohexylmethoxy)pyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide;hydrochloride
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C22H33ClF2N2O3
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1
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| 1 |
IC50 = 1400 nM
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CP0182929
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2'-methoxy-7'-pyrimidin-5-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
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C20H16N4O3
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1
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| 1 |
IC50 = 1430 nM
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CP0321372
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1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-hydroxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C28H37F2N3O4
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1
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| 1 |
IC50 = 1450 nM
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CP0535720
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N-[(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-1-(2-methoxyethyl)-5-oxopyrrolidine-3-carboxamide
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C28H34F2N4O5
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1
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| 1 |
IC50 = 1500 nM
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CP0224923
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1-N-[(1S,2S)-1-[(2R)-4-(3,4-dichlorophenyl)sulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C34H40Cl2F2N4O5S
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1
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| 1 |
IC50 = 1500 nM
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CP0107591
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US9353089, 330
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C20H21N3O2
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1
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| 1 |
IC50 = 1600 nM
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CP0379882
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N-[N'-[(3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
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C20H18Cl2N4O3
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2
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| 1 |
IC50 = 1600 nM
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| 2 |
Ki = 670 nM
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CP0459184
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N-[N'-[[3,5-dichloro-4-(cyclopropanecarbonylamino)phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C24H23Cl2N5O4
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2
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| 1 |
IC50 = 1600 nM
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| 2 |
Ki = 50 nM
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CP0507542
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(1S,5S,6S)-5-(5-((E)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-(fluoromethyl)-1-(methoxymethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine
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C21H19ClF3N3OS
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1
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| 1 |
IC50 = 1600 nM
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CP0535516
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1-N-[(1R,2S)-1-hydroxy-3-phenyl-1-[(2R)-pyrrolidin-2-yl]propan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide;hydrochloride
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C27H38ClN3O3
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1
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| 1 |
IC50 = 1670 nM
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CP0286033
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2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
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C20H23N3O
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1
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| 1 |
IC50 = 1700 nM
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CP0224922
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1-N-[(1S,2S)-1-[(2R)-4-(4-chlorophenyl)sulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C34H41ClF2N4O5S
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1
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| 1 |
IC50 = 1700 nM
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CP0152303
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3-[2-amino-6-(3-cyanopyridin-2-yl)quinolin-3-yl]-N-(3,3-dimethylbutyl)-2-methylpropanamide
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C25H29N5O
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1
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| 1 |
IC50 = 1700 nM
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CP0239055
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(4R)-4-[4-(difluoromethoxy)phenyl]-4-[3-(2-fluoropyridin-3-yl)phenyl]-5H-1,3-oxazol-2-amine
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C21H16F3N3O2
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1
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| 1 |
IC50 = 1700 nM
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CP0650777
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N-(3-(2-amino-4-methyl-4,5-dihydrothiazol-4-yl)phenyl)picolinamide
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C16H16N4OS
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1
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| 1 |
IC50 = 1720 nM
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CP0307466
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(S)-4-(S)-Hydroxy-2-methyl-5-[(S)-2-(3-methyl-butyrylamino)-propionylamino]-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
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C32H47N5O5
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1
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| 1 |
IC50 = 1740 nM
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CP0224925
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-propylsulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C31H44F2N4O5S
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1
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| 1 |
IC50 = 1800 nM
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CP0311000
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1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-(2-phenylethyl)piperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C37H47F2N3O3
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1
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| 1 |
IC50 = 1850 nM
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CP0118640
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N-[(2S,3R)-4-[[(4S)-6-chlorospiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
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C23H28ClN3O3
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1
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| 1 |
IC50 = 1880 nM
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CP0152923
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2-amino-5-[3-(3-chlorophenyl)phenyl]-5-cyclopropyl-3-methylimidazol-4-one
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C19H18ClN3O
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1
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| 1 |
IC50 = 1900 nM
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CP0381305
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N-[N'-[[3,5-dichloro-4-[(2-methylsulfonylacetyl)amino]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C23H23Cl2N5O6S
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2
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| 1 |
IC50 = 1900 nM
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| 2 |
Ki = 30 nM
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CP0116102
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(4aR,10S,10aS)-2'-amino-8-(2-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-2H-pyrano[3,2-b]chromene-10,5'-imidazole]-4'-one
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C20H19FN4O3
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1
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| 1 |
IC50 = 1900 nM
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CP0090492
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1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-[(4-methoxyphenyl)methyl]piperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C37H47F2N3O4
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1
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| 1 |
IC50 = 2000 nM
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CP0251118
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1-N-[(1R,2S)-1-[(2R,4S)-4-(cyclohexylmethyl)piperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C36H51F2N3O3
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1
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| 1 |
IC50 = 2000 nM
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CP0333775
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2S)-4-(2-methylpropyl)-3-oxopiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C32H44F2N4O4
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1
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| 1 |
IC50 = 2000 nM
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CP0427917
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N-[N'-[[3,5-dichloro-4-[(2-methylsulfanylacetyl)amino]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C23H23Cl2N5O4S
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2
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| 1 |
IC50 = 2000 nM
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| 2 |
Ki = 50 nM
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CP0270294
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2'-(2-fluoropyridin-3-yl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C21H16FN3O3
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1
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| 1 |
IC50 = 2000 nM
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CP0152093
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-[(Z)-C-methyl-N-(2-methylpropoxy)carbonimidoyl]benzamide
Show/Hide
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C35H44F2N4O6S
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1
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| 1 |
IC50 = 2098 nM
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CP0067231
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1-N-[(2S,3R)-4-(tert-butylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
Show/Hide
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C32H41FN4O5S
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1
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| 1 |
IC50 = 2122 nM
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CP0535174
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(1S,5S,6S)-5-[5-[(E)-2-(5-chloropyridin-2-yl)ethenyl]-2-fluorophenyl]-5-(fluoromethyl)-1-(methoxymethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine
Show/Hide
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C21H20ClF2N3OS
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1
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| 1 |
IC50 = 2200 nM
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CP0186931
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2'-(2-fluoro-3-methoxyphenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C23H19FN2O4
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1
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| 1 |
IC50 = 2230 nM
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CP0363815
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2'-(4-chloro-2-fluorophenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C22H16ClFN2O3
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1
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| 1 |
IC50 = 2240 nM
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CP0264988
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-methylsulfonylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C29H40F2N4O5S
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1
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| 1 |
IC50 = 2300 nM
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CP0152920
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(5R)-2-amino-5-[3-(3-methoxyphenyl)phenyl]-3-methyl-5-phenylimidazol-4-one
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C23H21N3O2
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1
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| 1 |
IC50 = 2300 nM
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CP0377520
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(4S,8E,11S)-4-[(1R)-1-hydroxy-2-[(3-propan-2-ylphenyl)methylamino]ethyl]-16-methyl-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraene-2,13-dione
Show/Hide
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C34H41N3O4
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1
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| 1 |
IC50 = 2300 nM
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CP0170288
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2-amino-5-cyclopropyl-5-[3-(3,5-dichlorophenyl)phenyl]-3-methylimidazol-4-one
Show/Hide
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C19H17Cl2N3O
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1
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| 1 |
IC50 = 2400 nM
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CP0283828
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2'-(4-chlorophenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C22H17ClN2O3
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1
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| 1 |
IC50 = 2420 nM
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CP0239052
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2'-(2-chlorophenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C22H17ClN2O3
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1
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| 1 |
IC50 = 2470 nM
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CP0057151
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2'-(3-chlorophenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C22H17ClN2O3
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1
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| 1 |
IC50 = 2510 nM
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CP0175874
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2'-methoxy-7'-phenylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C22H18N2O3
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1
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| 1 |
IC50 = 2520 nM
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CP0523936
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tert-butyl N-[(2S)-3-(dimethylamino)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamate
Show/Hide
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C37H57N7O7
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1
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| 1 |
IC50 = 2530 nM
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CP0371454
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1-N-[(1R,2S)-1-[(2R)-azetidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C27H35F2N3O3
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1
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| 1 |
IC50 = 2800 nM
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CP0163684
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2-amino-5-[3-(3-chlorophenyl)phenyl]-5-cyclobutyl-3-methylimidazol-4-one
Show/Hide
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C20H20ClN3O
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1
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| 1 |
IC50 = 2800 nM
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CP0192042
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2'-methoxy-7'-pyridin-4-ylspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C21H17N3O3
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1
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| 1 |
IC50 = 2820 nM
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CP0264987
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-[(5-methyl-1,2-oxazol-4-yl)sulfonyl]piperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C32H41F2N5O6S
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1
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| 1 |
IC50 = 2900 nM
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CP0239053
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2'-(5-chloro-2-fluoro-4-methylphenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C23H18ClFN2O3
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1
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| 1 |
IC50 = 2980 nM
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CP0251117
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[(2R,4S)-2-[(1R,2S)-3-(3,5-difluorophenyl)-2-[[3-(dipropylcarbamoyl)-5-methylbenzoyl]amino]-1-hydroxypropyl]piperidin-4-yl] acetate
Show/Hide
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C31H41F2N3O5
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1
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| 1 |
IC50 = 3000 nM
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CP0451990
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(S)-2-(2,2-Difluoro-ethyl)-5-[(S)-4,4-difluoro-2-((2S,3S)-2-hydroxy-3-methyl-pentanoylamino)-butyrylamino]-4-(S)-hydroxy-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
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C35H49F4N5O6
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1
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| 1 |
IC50 = 3180 nM
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CP0125947
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2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methylbut-2-enyl)chromen-4-one
Show/Hide
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C25H26O6
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1
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| 1 |
IC50 = 3400 nM
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CP0079800
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2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-dihydro-3H-pyrimidin-4-one
Show/Hide
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C12H13Cl2N3O
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1
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| 1 |
IC50 = 3500 nM
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CP0192043
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2'-methoxy-7'-(4-methylphenyl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C23H20N2O3
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1
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| 1 |
IC50 = 3630 nM
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CP0246122
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2'-methoxy-7'-[4-(trifluoromethoxy)phenyl]spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C23H17F3N2O4
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1
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| 1 |
IC50 = 3690 nM
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CP0187511
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2'-(2-fluoro-5-methoxyphenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C23H19FN2O4
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1
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| 1 |
IC50 = 3720 nM
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CP0165838
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2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrimidin-4-one
Show/Hide
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C12H15N3O
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1
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| 1 |
IC50 = 3800 nM
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CP0129731
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1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2S)-3-oxo-4-propylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C31H42F2N4O4
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1
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| 1 |
IC50 = 4000 nM
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CP0050859
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1-N-[(1R,2S)-1-[(2R,4S)-4-cyclohexylpiperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C35H49F2N3O3
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1
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| 1 |
IC50 = 4200 nM
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CP0103196
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2'-methoxy-7'-(2-methylphenyl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C23H20N2O3
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1
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| 1 |
IC50 = 4220 nM
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CP0285326
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2'-(5-chloro-2-fluorophenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C22H16ClFN2O3
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1
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| 1 |
IC50 = 4290 nM
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CP0224928
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N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]acetamide
Show/Hide
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C22H27F2N3O4S
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1
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| 1 |
IC50 = 4350 nM
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CP0163685
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2-amino-5-[3-(3-chlorophenyl)phenyl]-3-methyl-5-pyridin-3-ylimidazol-4-one
Show/Hide
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C21H17ClN4O
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1
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| 1 |
IC50 = 4400 nM
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CP0539740
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(S)-5-[(S)-3-tert-Butoxy-2-((S)-2-hydroxy-3-methyl-butyrylamino)-propionylamino]-4-(S)-hydroxy-2-methyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
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C36H55N5O7
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1
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| 1 |
IC50 = 4490 nM
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CP0114200
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2'-methoxy-7'-(3-methylphenyl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
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C23H20N2O3
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1
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| 1 |
IC50 = 4540 nM
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CP0152922
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2-amino-5-[3-(3-chlorophenyl)phenyl]-3-methyl-5-propan-2-ylimidazol-4-one
Show/Hide
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C19H20ClN3O
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1
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| 1 |
IC50 = 4600 nM
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CP0436740
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(S)-4-(S)-Hydroxy-5-[(S)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-3-methyl-butyrylamino]-2-methyl-6-phenyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propyl}-amide
Show/Hide
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C34H51N5O6
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1
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| 1 |
IC50 = 4640 nM
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CP0759579
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(S)-3-chloro-7-(5-fluoropyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Show/Hide
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C19H12ClFN4O2
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1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0343390
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-3,5-dimethylimidazol-4-one
Show/Hide
|
C17H16ClN3O
|
1
|
| 1 |
IC50 = 4800 nM
|
|
|
|
CP0272117
|
(2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-benzyl-2-methylpropanamide
Show/Hide
|
C27H27N3O
|
1
|
| 1 |
IC50 = 5100 nM
|
|
|
|
CP0057149
|
4-[3-(2-fluoropyridin-3-yl)phenyl]-4-(4-methoxyphenyl)-5H-1,3-oxazol-2-amine
Show/Hide
|
C21H18FN3O2
|
1
|
| 1 |
IC50 = 5100 nM
|
|
|
|
CP0654610
|
Kuwanon A
Show/Hide
|
C25H24O6
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0152921
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-5-ethyl-3-methylimidazol-4-one
Show/Hide
|
C18H18ClN3O
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0090050
|
1-N-[(2S,3R)-4-amino-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
Show/Hide
|
C28H33FN4O5S
|
1
|
| 1 |
IC50 = 5389 nM
|
|
|
|
CP0176013
|
4-(4-methoxyphenyl)-4-(3-pyridin-3-ylphenyl)-5H-1,3-oxazol-2-amine
Show/Hide
|
C21H19N3O2
|
1
|
| 1 |
IC50 = 5500 nM
|
|
|
|
CP0186929
|
2'-(2-chloropyridin-4-yl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
|
C21H16ClN3O3
|
1
|
| 1 |
IC50 = 5800 nM
|
|
|
|
CP0170258
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-3-methyl-5-pyridin-2-ylimidazol-4-one
Show/Hide
|
C21H17ClN4O
|
1
|
| 1 |
IC50 = 5900 nM
|
|
|
|
CP0333060
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-3-methyl-5-(1-methylcyclopropyl)imidazol-4-one
Show/Hide
|
C20H20ClN3O
|
1
|
| 1 |
IC50 = 6000 nM
|
|
|
|
CP0447197
|
1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide;hydrochloride
Show/Hide
|
C27H38ClN3O3
|
1
|
| 1 |
IC50 = 6300 nM
|
|
|
|
CP0301121
|
2'-methoxy-7'-[3-(trifluoromethoxy)phenyl]spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
|
C23H17F3N2O4
|
1
|
| 1 |
IC50 = 6410 nM
|
|
|
|
CP0330216
|
(1R,2R)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-N-butylcyclopropane-1-carboxamide
Show/Hide
|
C14H23N3O2S
|
1
|
| 1 |
IC50 = 6640 nM
|
|
|
|
CP0183014
|
2'-(3-chloro-2-fluorophenyl)-7'-methoxyspiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
Show/Hide
|
C22H16ClFN2O3
|
1
|
| 1 |
IC50 = 6750 nM
|
|
|
|
CP0152925
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-5-cyclopentyl-3-methylimidazol-4-one
Show/Hide
|
C21H22ClN3O
|
1
|
| 1 |
IC50 = 6900 nM
|
|
|
|
CP0173050
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2S)-4-methyl-3-oxopiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C29H38F2N4O4
|
1
|
| 1 |
IC50 = 7000 nM
|
|
|
|
CP0129733
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2S)-3-oxopiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C28H36F2N4O4
|
1
|
| 1 |
IC50 = 7500 nM
|
|
|
|
CP0399262
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,6-dimethyl-1-(methylsulfonyl)-4-propyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C33H44N4O6S
|
1
|
| 1 |
IC50 = 8100 nM
|
|
|
|
CP0046194
|
4-[3-(6-fluoropyridin-3-yl)phenyl]-4-(4-methoxyphenyl)-5H-1,3-oxazol-2-amine
Show/Hide
|
C21H18FN3O2
|
1
|
| 1 |
IC50 = 8300 nM
|
|
|
|
CP0509258
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-isopropoxy-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C35H46N4O6
|
1
|
| 1 |
IC50 = 9000 nM
|
|
|
|
CP0476436
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-4-ethyl-2,6-dimethyl-1-(methylsulfonyl)-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C32H42N4O6S
|
1
|
| 1 |
IC50 = 9500 nM
|
|
|
|
CP0126606
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-5-(cyclopropylmethyl)-3-methylimidazol-4-one
Show/Hide
|
C20H20ClN3O
|
1
|
| 1 |
IC50 = 9500 nM
|
|
|
|
CP0129850
|
1-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-phenylpiperazin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
|
C34H42F2N4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0362794
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-3-methyl-5-pyrimidin-2-ylimidazol-4-one
Show/Hide
|
C20H16ClN5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0362795
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-3-methyl-5-(1,3-thiazol-2-yl)imidazol-4-one
Show/Hide
|
C19H15ClN4OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0416680
|
(4S,8E)-4-[(1R)-2-(benzylamino)-1-hydroxyethyl]-16-methyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),8,14(18),15-tetraene-2,13-dione
Show/Hide
|
C25H31N3O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0416681
|
N-[(4S)-4-[(1R)-2-(benzylamino)-1-hydroxyethyl]-2,13-dioxo-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(17),14(18),15-trien-16-yl]-N-methylmethanesulfonamide
Show/Hide
|
C26H36N4O6S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0257166
|
N-[(2S,3R)-4-[[2-(2,2-dimethylpropyl)-6,6-dimethyl-5,7-dihydro-4H-1,3-benzoxazol-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
Show/Hide
|
C26H39N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0499994
|
N-[(2S)-4-[[(4S)-6,6-dimethyl-2-(2-methylpropyl)-5,7-dihydro-4H-indazol-4-yl]amino]-3-oxo-1-phenylbutan-2-yl]acetamide
Show/Hide
|
C25H36N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0333777
|
N-[(1S,2S)-1-[(4S)-1-benzyl-5-oxoimidazolidin-4-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-oxo-1-propylpyrrolidine-3-carboxamide
Show/Hide
|
C27H32F2N4O4
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0496173
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-4-isopropyl-2,6-dimethyl-1-(methylsulfonyl)-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C33H44N4O6S
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0348802
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-5-cyclohexyl-3-methylimidazol-4-one
Show/Hide
|
C22H24ClN3O
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0492005
|
(4R)-N-((1S,2S)-1-((S)-1-benzyl-5-oxoimidazolidin-4-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-1-butyl-4-ethyl-5-oxopyrrolidine-3-carboxamide
Show/Hide
|
C30H38F2N4O4
|
1
|
| 1 |
IC50 = 12000 nM
|
|
|
|
CP0239054
|
4-[3-(5-chloro-2-fluorophenyl)phenyl]-4-(4-methoxyphenyl)-5H-1,3-oxazol-2-amine
Show/Hide
|
C22H18ClFN2O2
|
1
|
| 1 |
IC50 = 12000 nM
|
|
|
|
CP0040161
|
2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one
Show/Hide
|
C15H10O7
|
1
|
| 1 |
IC50 = 12300 nM
|
|
|
|
CP0315812
|
4-(4-methoxyphenyl)-4-(3-pyrimidin-5-ylphenyl)-5H-1,3-oxazol-2-amine
Show/Hide
|
C20H18N4O2
|
1
|
| 1 |
IC50 = 13000 nM
|
|
|
|
CP0572028
|
(1R,2R)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-N-propylcyclopropane-1-carboxamide
Show/Hide
|
C13H21N3O2S
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0467432
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethyl-1-(methylsulfonyl)-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C31H40N4O6S
|
1
|
| 1 |
IC50 = 14900 nM
|
|
|
|
CP0506179
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-methoxy-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C33H42N4O6
|
1
|
| 1 |
IC50 = 15200 nM
|
|
|
|
CP0421610
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-ethoxy-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C34H44N4O6
|
1
|
| 1 |
IC50 = 15500 nM
|
|
|
|
CP0476437
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-isopropoxy-2-oxoethyl)-2,4-dimethyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C34H43N3O6
|
1
|
| 1 |
IC50 = 16100 nM
|
|
|
|
CP0506177
|
5-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-2,4,6-trimethyl-1-methylsulfonyl-3-N-[(1R)-1-phenylethyl]-4H-pyridine-3,5-dicarboxamide
Show/Hide
|
C32H42N4O5S
|
1
|
| 1 |
IC50 = 16100 nM
|
|
|
|
CP0506178
|
5-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-4-ethyl-2,6-dimethyl-1-methylsulfonyl-3-N-(1-phenylethyl)-4H-pyridine-3,5-dicarboxamide
Show/Hide
|
C33H44N4O5S
|
1
|
| 1 |
IC50 = 16200 nM
|
|
|
|
CP0118639
|
4-[3-(3-chlorophenyl)phenyl]-4-(4-methoxyphenyl)-5H-1,3-oxazol-2-amine
Show/Hide
|
C22H19ClN2O2
|
1
|
| 1 |
IC50 = 18000 nM
|
|
|
|
CP0249494
|
2-amino-5-[3-(3-chlorophenyl)phenyl]-3-methyl-5-pyrimidin-5-ylimidazol-4-one
Show/Hide
|
C20H16ClN5O
|
1
|
| 1 |
IC50 = 21000 nM
|
|
|
|
CP0469752
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,6-dimethyl-1-(methylsulfonyl)-4-phenyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C36H42N4O6S
|
1
|
| 1 |
IC50 = 21400 nM
|
|
|
|
CP0333776
|
N-[(1S,2S)-1-[(4S)-1-benzyl-5-oxoimidazolidin-4-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-1-butyl-5-oxopyrrolidine-3-carboxamide
Show/Hide
|
C28H34F2N4O4
|
1
|
| 1 |
IC50 = 21500 nM
|
|
|
|
CP0213680
|
(4S)-4-methyl-4-phenyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C11H14N2S
|
1
|
| 1 |
IC50 = 22000 nM
|
|
|
|
CP0504357
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]carbamoyl]-2,6-dimethyl-4-propyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C36H49N3O6
|
1
|
| 1 |
IC50 = 23200 nM
|
|
|
|
CP0509259
|
tert-butyl 5-[[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-1-(2-oxo-2-propan-2-yloxyethyl)-4-propyl-4H-pyridine-3-carboxylate
Show/Hide
|
C32H47N3O6
|
1
|
| 1 |
IC50 = 24600 nM
|
|
|
|
CP0469755
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]carbamoyl]-2,4-dimethyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C33H43N3O6
|
1
|
| 1 |
IC50 = 26100 nM
|
|
|
|
CP0399263
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-4-(3-fluoroanilino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-2,4,6-trimethyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C32H40FN3O5
|
1
|
| 1 |
IC50 = 26400 nM
|
|
|
|
CP0506180
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-3-hydroxy-4-(3-methoxyanilino)-1-phenylbutan-2-yl]carbamoyl]-2,6-dimethyl-4-propyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C35H47N3O6
|
1
|
| 1 |
IC50 = 26600 nM
|
|
|
|
CP0514528
|
Benzyl 1-(3-acetoxypropyl)-5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C35H45N3O6
|
1
|
| 1 |
IC50 = 26900 nM
|
|
|
|
CP0399265
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-4-(3-fluoroanilino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-2,6-dimethyl-4-propyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C34H44FN3O5
|
1
|
| 1 |
IC50 = 27100 nM
|
|
|
|
CP0491008
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-(isopropyl(methyl)amino)-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C36H48N4O5
|
1
|
| 1 |
IC50 = 28200 nM
|
|
|
|
CP0505761
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethyl-1-(2-morpholino-2-oxoethyl)-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C36H46N4O6
|
1
|
| 1 |
IC50 = 28400 nM
|
|
|
|
CP0386481
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-2,4,6-trimethyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C29H41N3O5
|
1
|
| 1 |
IC50 = 29300 nM
|
|
|
|
CP0504358
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-4-(3-fluoroanilino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-2,4-dimethyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C31H38FN3O5
|
1
|
| 1 |
IC50 = 29300 nM
|
|
|
|
CP0399225
|
propan-2-yl 2-[3-[[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-5-(1-phenylethylcarbamoyl)-4-propyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C36H48N4O5
|
1
|
| 1 |
IC50 = 29600 nM
|
|
|
|
CP0505763
|
tert-butyl 5-[[(2S,3R)-3-hydroxy-4-(3-methoxyanilino)-1-phenylbutan-2-yl]carbamoyl]-1-(2-oxo-2-propan-2-yloxyethyl)-4-propyl-4H-pyridine-3-carboxylate
Show/Hide
|
C36H49N3O7
|
1
|
| 1 |
IC50 = 30400 nM
|
|
|
|
CP0399267
|
propan-2-yl 2-[3-[[(2S,3R)-3-hydroxy-4-(3-methoxyanilino)-1-phenylbutan-2-yl]carbamoyl]-5-(1-phenylethylcarbamoyl)-4-propyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C40H50N4O6
|
1
|
| 1 |
IC50 = 31200 nM
|
|
|
|
CP0505762
|
tert-butyl 5-[[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-4-methyl-1-(2-oxo-2-propan-2-yloxyethyl)-4H-pyridine-3-carboxylate
Show/Hide
|
C30H43N3O6
|
1
|
| 1 |
IC50 = 31900 nM
|
|
|
|
CP0421611
|
propan-2-yl 2-[3-[[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-4-methyl-5-(1-phenylethylcarbamoyl)-4H-pyridin-1-yl]acetate
Show/Hide
|
C34H44N4O5
|
1
|
| 1 |
IC50 = 32800 nM
|
|
|
|
CP0399264
|
propan-2-yl 2-[3-acetyl-5-[[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]-2,6-dimethyl-4-propyl-4H-pyridin-1-yl]acetate
Show/Hide
|
C31H45N3O5
|
1
|
| 1 |
IC50 = 33100 nM
|
|
|
|
CP0399266
|
Benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-(dimethylamino)-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Show/Hide
|
C34H44N4O5
|
1
|
| 1 |
IC50 = 39100 nM
|
|
|
|
CP0268166
|
(1R,2R)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-N-ethylcyclopropane-1-carboxamide
Show/Hide
|
C12H19N3O2S
|
1
|
| 1 |
IC50 = 58000 nM
|
|
|
|
CP0039970
|
2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
Show/Hide
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C25H24O6
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1
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| 1 |
IC50 = 59400 nM
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CP0082526
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2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
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C15H10O6
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1
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| 1 |
IC50 = 60600 nM
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CP0437122
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tert-butyl N-[(2S)-4-(dimethylamino)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]carbamate
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C38H59N7O7
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1
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| 1 |
IC50 = 89000 nM
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CP0057109
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2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]-3-methylpyrimidin-4(3H)-one
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C20H21N3O2
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1
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| 1 |
IC50 = 91000 nM
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CP0165837
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2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydro-3H-pyrimidin-4-one
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C19H21N3O2
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1
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| 1 |
IC50 = 91000 nM
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CP0268167
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(1R,2R)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide
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C15H17FN4O2S
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1
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| 1 |
IC50 = 92400 nM
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CP0268165
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N-[(1S,2S)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]cyclopropyl]-5-fluoropyridine-2-carboxamide
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C15H17FN4O2S
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1
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| 1 |
IC50 > 100000 nM
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CP0572029
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N-[(1R,2R)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]cyclopropyl]pentanamide
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C14H23N3O2S
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1
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| 1 |
IC50 > 100000 nM
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CP0345156
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3-acetyl-N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)benzamide
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C34H35F2N3O6S
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1
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| 1 |
IC50 > 263 nM
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CP0405950
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(2S)-2-[(3R)-3-butyl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-propylsulfonylpyrrolidin-2-yl]propan-2-yl]propanamide
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C27H41F2N3O5S
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1
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| 1 |
IC50 > 330 nM
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CP0146562
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-phenoxy-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C38H43F2N3O5
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1
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| 1 |
IC50 > 333 nM
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CP0231059
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3-(1-(benzyloxyimino)ethyl)-N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(N-methylmethylsulfonamido)benzamide
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C36H40F2N4O6S
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1
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| 1 |
IC50 > 333 nM
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CP0234095
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-phenylsulfanyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
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C38H43F2N3O4S
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1
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| 1 |
IC50 > 333 nM
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CP0093549
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(2S)-2-[(3S)-3-acetamido-3-butan-2-yl-2-oxopyrrolidin-1-yl]-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4S)-4-hydroxypyrrolidin-2-yl]propan-2-yl]propanamide
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C26H38F2N4O5
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1
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| 1 |
IC50 > 660 nM
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CP0226088
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1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-(2-methoxyphenoxy)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C39H45F2N3O6
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1
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| 1 |
IC50 > 666 nM
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CP0275476
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-[(Z)-C-methyl-N-(2-methylpropoxy)carbonimidoyl]-5-[methyl(methylsulfonyl)amino]benzamide
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C33H42F2N4O6S
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1
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| 1 |
IC50 > 666 nM
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CP0333988
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1,3,5-trisubstituted aromatic scaffold, 2a
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C27H30FN3O5S
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1
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| 1 |
IC50 < 1000 nM
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CP0371916
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3-N-[(4S,5S,7R)-8-[(1-benzylpiperidin-4-yl)amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide
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C40H54FN5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0372466
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1-N-[(2S)-4-[(1-benzylpiperidin-4-yl)amino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-5-nitro-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C36H45N5O6
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1
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| 1 |
IC50 < 1000 nM
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CP0372467
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3-N-[(4S,5S,7R)-8-[(4-benzylpiperazin-1-yl)amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide
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C39H53FN6O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0372950
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3-N-[(4S,5S,7R)-8-[(4-benzylpiperazin-1-yl)amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C39H54N6O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0387543
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3-N-[(2S)-4-[(1-benzylpiperidin-4-yl)amino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C40H47N5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0418961
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-N',N'-dipropyl-5-[methyl(methylsulfonyl)amino]isophthalamide
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C40H57N5O5S
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1
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| 1 |
IC50 < 1000 nM
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CP0418962
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-N'-[(R)-1-phenylethyl]isophthalamide
Show/Hide
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C40H48N4O3
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1
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| 1 |
IC50 < 1000 nM
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CP0418963
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3-N-[(2S)-4-[2-(1-benzylpiperidin-4-yl)ethylamino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide
Show/Hide
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C42H50FN5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0421774
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1-N-[(2S)-4-[2-(1-benzylpiperidin-4-yl)ethylamino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-5-nitro-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C38H49N5O6
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1
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| 1 |
IC50 < 1000 nM
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CP0427223
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpiperidin-4-yl)methylamino]-propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
Show/Hide
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C41H51N5O5S
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1
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| 1 |
IC50 < 1000 nM
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CP0427224
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3-N-[(2S)-4-[2-(1-benzylpiperidin-4-yl)ethylamino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C42H51N5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0493299
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3-N-[(4S,5S,7R)-8-[(1-benzylpiperidin-4-yl)amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C40H55N5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0493300
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1-N-[(2S)-4-[(1-benzylpiperidin-4-yl)methylamino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-5-nitro-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
Show/Hide
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C37H47N5O6
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1
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| 1 |
IC50 < 1000 nM
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CP0493929
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-N',N'-dipropylisophthalamide
Show/Hide
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C38H52N4O3
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1
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| 1 |
IC50 < 1000 nM
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CP0493930
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-5-[methyl(methylsulfonyl)-amino]-N'-[(R)-1-(4-fluorophenyl)ethyl]isophthalamide
Show/Hide
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C42H52FN5O5S
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1
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| 1 |
IC50 < 1000 nM
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CP0503558
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3-N-[(4S,5S,7R)-8-[2-(1-benzylpiperidin-4-yl)ethylamino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide
Show/Hide
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C42H58FN5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0503559
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-N'-[(R)-1-(4-fluorophenyl)ethyl]-isophthalamide
Show/Hide
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C40H47FN4O3
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1
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| 1 |
IC50 < 1000 nM
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CP0503560
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-nitroisophthalamide
Show/Hide
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C40H46FN5O5
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1
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| 1 |
IC50 < 1000 nM
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CP0506384
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3-N-[(2S)-4-[(1-benzylpiperidin-4-yl)methylamino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide
Show/Hide
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C41H48FN5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0506595
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3-N-[(2S)-4-[(1-benzylpiperidin-4-yl)amino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide
Show/Hide
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C40H46FN5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0506596
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpiperidin-4-yl)amino]-propyl}-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
Show/Hide
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C40H48FN5O5S
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1
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| 1 |
IC50 < 1000 nM
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CP0506597
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3-N-[(4S,5S,7R)-8-[(1-benzylpiperidin-4-yl)methylamino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzene-1,3-dicarboxamide
Show/Hide
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C41H56FN5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0509417
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3-N-[(2S)-4-[(1-benzylpiperidin-4-yl)methylamino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C41H49N5O6S
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1
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| 1 |
IC50 < 1000 nM
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CP0509419
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[(1-benzylpiperidin-4-yl)methylamino]-propyl}-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
Show/Hide
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C41H50FN5O5S
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1
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| 1 |
IC50 < 1000 nM
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|
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CP0521356
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-5-nitro-N'-[(R)-1-phenylethyl]isophthalamide
Show/Hide
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C40H47N5O5
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1
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| 1 |
IC50 < 1000 nM
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CP0521357
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(1S,2R)-N-{1-Benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl}-N',N'-dipropyl-5-nitroisophthalamide
Show/Hide
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C38H51N5O5
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1
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| 1 |
IC50 < 1000 nM
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CP0379879
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N-[N'-[(3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
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C20H18Cl2N4O2S
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2
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| 1 |
IC50 > 5000 nM
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| 2 |
Ki = 290 nM
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CP0421156
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C24H22FN7O2S
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1
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| 1 |
Ki = 0.7 nM
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CP0558187
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-methylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C23H20FN7OS
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1
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| 1 |
Ki = 0.7 nM
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CP0389345
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]-5-methoxybenzonitrile
Show/Hide
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C23H20FN7O2S
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1
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| 1 |
Ki = 1 nM
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CP0426276
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-morpholin-4-ylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C26H25FN8O2S
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1
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| 1 |
Ki = 1 nM
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CP0426277
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3-[5-[(4aR,7aR)-2-amino-6-(4-ethoxy-5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C24H22FN7O2S
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1
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| 1 |
Ki = 1 nM
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CP0457786
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoro-4,6-dimethylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C24H22FN7OS
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1
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| 1 |
Ki = 1 nM
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CP0476744
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-propoxypyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C25H24FN7O2S
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1
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| 1 |
Ki = 1 nM
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CP0558186
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3-[5-[(4aR,7aR)-2-amino-6-(4-ethyl-5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C24H22FN7OS
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1
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| 1 |
Ki = 1 nM
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CP0561893
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(4aR,7aR)-2-amino-7a-[4-(3-chlorophenyl)thiophen-2-yl]-6-(5-fluoropyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
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C21H18ClFN6OS
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1
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| 1 |
Ki = 1 nM
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CP0198194
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N-[3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
Show/Hide
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C21H23F2N5O4S2
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1
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| 1 |
Ki = 1.9 nM
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CP0552562
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]-5-fluorobenzonitrile
Show/Hide
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C22H17F2N7OS
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1
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| 1 |
Ki = 2 nM
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CP0078176
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tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
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C37H63N5O7S
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1
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| 1 |
Ki = 2.5 nM
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CP0552556
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3-[5-[(4aR,7aR)-2-amino-6-(5-fluoro-4-pyrrolidin-1-ylpyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile
Show/Hide
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C26H25FN8OS
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1
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| 1 |
Ki = 3 nM
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CP0558189
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5-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]-2-fluorobenzonitrile
Show/Hide
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C22H17F2N7OS
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1
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| 1 |
Ki = 4 nM
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CP0075806
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N-[3-[(5R)-3-amino-9,9-difluoro-5-methyl-2-thia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
Show/Hide
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C22H23F4N5O2S
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1
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| 1 |
Ki = 4 nM
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CP0265376
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N-[3-[(5R)-3-amino-5-methyl-9-oxa-2-thia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
Show/Hide
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C21H23F2N5O3S
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1
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| 1 |
Ki = 6.5 nM
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CP0476745
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5-[5-[(4aR,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]-2-chlorobenzonitrile
Show/Hide
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C22H17ClFN7OS
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1
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| 1 |
Ki = 10 nM
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CP0484400
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(4aR,7aR)-2-amino-7a-[4-(3,5-difluorophenyl)thiophen-2-yl]-6-(5-fluoropyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
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C21H17F3N6OS
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1
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| 1 |
Ki = 10 nM
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CP0229888
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CHEMBL4070299
Show/Hide
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C22H26N4O2
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1
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| 1 |
Ki = 16 nM
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CP0852591
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{3-((1r,1'R,4R)-2''-Amino-4-methoxy-3'H,5''H-dispiro-[cyclohexane-1,2'-indene-1',4''-oxazol]-6'-yl-5'',5''-d2)-5-chlorobenzonitrile}
Show/Hide
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C24H24ClN3O2
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1
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| 1 |
Ki = 18 nM
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CP0389197
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CHEMBL4084381
Show/Hide
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C25H27N3O3
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1
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| 1 |
Ki = 23 nM
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CP0517966
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CHEMBL4100832
Show/Hide
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C25H27N3O3
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1
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| 1 |
Ki = 23 nM
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CP0085955
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CHEMBL4097477
Show/Hide
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C23H28N4O2
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1
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| 1 |
Ki = 25 nM
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CP0485752
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CHEMBL4072118
Show/Hide
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C24H24ClN3O2
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1
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| 1 |
Ki = 38 nM
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CP0331641
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CHEMBL4067413
Show/Hide
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C23H28N4O2
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1
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| 1 |
Ki = 45 nM
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CP0470883
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CHEMBL4085364
Show/Hide
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C23H28N4O2
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1
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| 1 |
Ki = 45 nM
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CP0415727
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(2S,4R)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-4-methoxy-1-phenylpyrrolidine-2-carboxamide
Show/Hide
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C22H25Cl2N5O3
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2
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| 1 |
Ki = 78 nM
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| 2 |
Ki = 390 nM
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CP0401316
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N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-3-phenyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Show/Hide
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C22H23Cl2N5O2
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2
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| 1 |
Ki = 100 nM
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| 2 |
Ki = 360 nM
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CP0392374
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(4aR,7aR)-2-amino-7a-(4-bromothiophen-2-yl)-6-(5-fluoropyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one
Show/Hide
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C15H14BrFN6OS
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1
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| 1 |
Ki = 100 nM
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CP0229887
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CHEMBL4103296
Show/Hide
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C22H26N4O2
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1
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| 1 |
Ki = 118 nM
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CP0488042
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N-[N'-[(4-amino-3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C20H19Cl2N5O3
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1
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| 1 |
Ki = 120 nM
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CP0517965
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CHEMBL4065448
Show/Hide
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C21H24N4O2
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1
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| 1 |
Ki = 134 nM
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CP0379881
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N-[N'-[[3-chloro-5-[(E)-4-hydroxybut-1-enyl]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C24H25ClN4O4
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1
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| 1 |
Ki = 140 nM
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CP0413749
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N-[N'-[[3-chloro-5-[(E)-3-methoxyprop-1-enyl]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C24H25ClN4O4
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1
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| 1 |
Ki = 150 nM
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CP0500111
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N-[N'-[(3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C20H19Cl2N5O2
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1
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| 1 |
Ki = 210 nM
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CP0468638
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N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-phenylpiperidine-2-carboxamide
Show/Hide
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C22H25Cl2N5O2
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2
|
| 1 |
Ki = 230 nM
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| 2 |
Ki = 420 nM
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CP0499414
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N-[N'-[(3-bromo-5-chlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C20H18BrClN4O3
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1
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| 1 |
Ki = 270 nM
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CP0379880
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N-[N'-[[3,5-dichloro-4-(methanesulfonamido)phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide
Show/Hide
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C21H21Cl2N5O4S2
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1
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| 1 |
Ki = 280 nM
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CP0569471
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N-[N'-[(3,5-dimethylphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C22H24N4O3
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1
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| 1 |
Ki = 280 nM
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CP0447918
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(2S,4R)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-phenyl-4-phenylmethoxypyrrolidine-2-carboxamide
Show/Hide
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C28H29Cl2N5O3
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1
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| 1 |
Ki = 420 nM
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CP0427938
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N-[N'-[(3-chloro-5-ethenylphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C22H21ClN4O3
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1
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| 1 |
Ki = 430 nM
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CP0470882
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CHEMBL4074071
Show/Hide
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C22H25N3O2
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1
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| 1 |
Ki = 430 nM
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CP0411370
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(2S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-(4-fluorophenyl)pyrrolidine-2-carboxamide
Show/Hide
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C21H22Cl2FN5O2
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2
|
| 1 |
Ki = 450 nM
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| 2 |
Ki = 7200 nM
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CP0491250
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N-[N'-[(3,5-dichloro-4-hydroxyphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C20H18Cl2N4O4
|
1
|
| 1 |
Ki = 480 nM
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CP0447920
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N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-2-phenylpyrazole-3-carboxamide
Show/Hide
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C20H18Cl2N6O2
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2
|
| 1 |
Ki = 490 nM
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| 2 |
Ki = 12000 nM
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CP0427939
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3-(4-methoxyphenyl)-5-methyl-N-[N'-(naphthalen-1-ylmethyl)carbamimidoyl]-1,2-thiazole-4-carboxamide
Show/Hide
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C24H22N4O2S
|
1
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| 1 |
Ki = 500 nM
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CP0468642
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(2S,4R)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1,4-diphenylpyrrolidine-2-carboxamide
Show/Hide
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C27H27Cl2N5O2
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1
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| 1 |
Ki = 530 nM
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CP0468639
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(1R,4S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-2-phenyl-2-azabicyclo[2.2.1]heptane-3-carboxamide
Show/Hide
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C23H25Cl2N5O2
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1
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| 1 |
Ki = 560 nM
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CP0411369
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(2S,4R)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-4-hydroxy-1-phenylpyrrolidine-2-carboxamide
Show/Hide
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C21H23Cl2N5O3
|
1
|
| 1 |
Ki = 610 nM
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CP0406455
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N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-phenylpyrrole-2-carboxamide
Show/Hide
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C21H19Cl2N5O2
|
2
|
| 1 |
Ki = 710 nM
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| 2 |
Ki = 4000 nM
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CP0468643
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(2S,4S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-4-hydroxy-1-phenylpyrrolidine-2-carboxamide
Show/Hide
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C21H23Cl2N5O3
|
1
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| 1 |
Ki = 790 nM
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CP0427919
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N-[N'-[[3-chloro-5-[(E)-pent-1-enyl]phenyl]methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C25H27ClN4O3
|
1
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| 1 |
Ki = 850 nM
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CP0489569
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N-[N'-[(3,5-dichlorophenyl)methyl]carbamimidoyl]-5-(4-methoxyphenyl)-3-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C20H18Cl2N4O3
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1
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| 1 |
Ki = 860 nM
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CP0459189
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3-(4-methoxyphenyl)-5-methyl-N-[N'-(naphthalen-2-ylmethyl)carbamimidoyl]-1,2-thiazole-4-carboxamide
Show/Hide
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C24H22N4O2S
|
1
|
| 1 |
Ki = 870 nM
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CP0427940
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N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C20H18Cl2N4O3
|
1
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| 1 |
Ki = 910 nM
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CP0401344
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N-[4-[[[amino-[[(1S)-1-phenylethyl]carbamoylamino]methylidene]amino]methyl]-2,6-dichlorophenyl]acetamide
Show/Hide
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C19H21Cl2N5O2
|
2
|
| 1 |
Ki = 990 nM
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| 2 |
Ki = 2400 nM
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CP0485736
|
CHEMBL4093123
Show/Hide
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C23H27N3O2
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1
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| 1 |
Ki = 1179 nM
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CP0467269
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N-[N'-[(3-chloro-5-thiophen-3-ylphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C24H21ClN4O3S
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1
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| 1 |
Ki = 1200 nM
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CP0447912
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(2S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-(4-methylphenyl)pyrrolidine-2-carboxamide
Show/Hide
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C22H25Cl2N5O2
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2
|
| 1 |
Ki = 1400 nM
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| 2 |
Ki = 3400 nM
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CP0379893
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3-(4-methoxyphenyl)-5-methyl-N-[N'-(naphthalen-1-ylmethyl)carbamimidoyl]-1,2-oxazole-4-carboxamide
Show/Hide
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C24H22N4O3
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1
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| 1 |
Ki = 1700 nM
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CP0379895
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3-(4-fluorophenyl)-5-methyl-N-[N'-(naphthalen-1-ylmethyl)carbamimidoyl]-1,2-oxazole-4-carboxamide
Show/Hide
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C23H19FN4O2
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1
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| 1 |
Ki = 1800 nM
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CP0489568
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N-[N'-[(3-chloro-5-pyridin-3-ylphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C25H22ClN5O3
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1
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| 1 |
Ki = 1800 nM
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CP0381372
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(2S,4S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-phenyl-4-phenylmethoxypyrrolidine-2-carboxamide
Show/Hide
|
C28H29Cl2N5O3
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1
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| 1 |
Ki = 1800 nM
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CP0411367
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(2S,4S)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-4-phenoxy-1-phenylpyrrolidine-2-carboxamide
Show/Hide
|
C27H27Cl2N5O3
|
1
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| 1 |
Ki = 1900 nM
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CP0499423
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N-[N'-[(3,5-dichlorophenyl)methyl]carbamimidoyl]-3-(4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C19H15Cl2FN4O2
|
1
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| 1 |
Ki = 2200 nM
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CP0530923
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N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-2-(4-methoxyphenyl)pyrrolidine-1-carboxamide
Show/Hide
|
C22H25Cl2N5O3
|
1
|
| 1 |
Ki = 2300 nM
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CP0381306
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N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-3-(4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C19H15Cl2FN4O2
|
1
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| 1 |
Ki = 2400 nM
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CP0374695
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(2R)-N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]-1-phenylpyrrolidine-2-carboxamide
Show/Hide
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C21H23Cl2N5O2
|
2
|
| 1 |
Ki = 2500 nM
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| 2 |
Ki = 3100 nM
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CP0471595
|
CHEMBL4092875
Show/Hide
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C24H24ClN3O2
|
1
|
| 1 |
Ki = 2700 nM
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CP0488588
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5-methyl-N-[N'-(naphthalen-1-ylmethyl)carbamimidoyl]-3-phenyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C23H20N4O2
|
1
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| 1 |
Ki = 2800 nM
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CP0386762
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N-[N'-[(3,5-dichlorophenyl)methyl]carbamimidoyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
Show/Hide
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C19H16Cl2N4O2
|
1
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| 1 |
Ki = 3900 nM
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CP0489570
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N-(N'-benzylcarbamimidoyl)-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
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C20H20N4O3
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1
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| 1 |
Ki = 4000 nM
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CP0491251
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N-[N'-[(3,5-dichlorophenyl)methyl]carbamimidoyl]-5-(4-methoxyphenyl)-1,3-dimethylpyrazole-4-carboxamide
Show/Hide
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C21H21Cl2N5O2
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1
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| 1 |
Ki = 4000 nM
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CP0468641
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benzyl N-[N'-[(4-acetamido-3,5-dichlorophenyl)methyl]carbamimidoyl]carbamate
Show/Hide
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C18H18Cl2N4O3
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2
|
| 1 |
Ki = 7000 nM
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| 2 |
Ki > 30000 nM
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CP0500112
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N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C19H16Cl2N4O2
|
1
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| 1 |
Ki = 8800 nM
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CP0468640
|
N-[4-[[[amino-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoylamino]methylidene]amino]methyl]-2,6-dichlorophenyl]acetamide
Show/Hide
|
C21H23Cl2N5O2
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2
|
| 1 |
Ki = 9100 nM
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| 2 |
Ki = 13000 nM
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CP0489571
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N-(N'-benzylcarbamimidoyl)-3-(4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C19H17FN4O2
|
1
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| 1 |
Ki > 10000 nM
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CP0569472
|
N-(N'-benzylcarbamimidoyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C19H18N4O2
|
1
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| 1 |
Ki > 10000 nM
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CP0374703
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N-[4-[[[amino-[[(1S)-2,3-dihydro-1H-inden-1-yl]carbamoylamino]methylidene]amino]methyl]-2,6-dichlorophenyl]acetamide
Show/Hide
|
C20H21Cl2N5O2
|
2
|
| 1 |
Ki = 10000 nM
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| 2 |
Ki = 14000 nM
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CP0489567
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N-[N'-[(3,5-dichloro-4-propoxyphenyl)methyl]carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C23H24Cl2N4O4
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1
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| 1 |
Ki > 5000 nM
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