General Information of the Compound
Compound ID
CP0145125
Compound Name
1-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-[(Z)-C-methyl-N-(2-methylpropoxy)carbonimidoyl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
    Show/Hide
Structure
Formula
C38H50F2N4O5
Molecular Weight
680.837
Canonical SMILES
CCCN(CCC)C(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(OC)c1)C(\C)=N/OCC(C)C
    Show/Hide
InChI
InChI=1S/C38H50F2N4O5/c1-7-12-44(13-8-2)38(47)31-19-29(26(5)43-49-24-25(3)4)18-30(20-31)37(46)42-35(17-28-14-32(39)21-33(40)15-28)36(45)23-41-22-27-10-9-11-34(16-27)48-6/h9-11,14-16,18-21,25,35-36,41,45H,7-8,12-13,17,22-24H2,1-6H3,(H,42,46)/b43-26-/t35-,36+/m0/s1
    Show/Hide
InChIKey
VBJUCOJBBOEXIG-VFMGFIPGSA-N
Physicochemical Property
logP
6.124
Rotatable Bonds
19
Heavy Atom Count
49
Polar Areas
112.49
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
49

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 45271466
ChEMBL ID
CHEMBL540730
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 367 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 55 nM