General Information of the Compound
Compound ID
CP0039970
Compound Name
2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
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Structure
Formula
C25H24O6
Molecular Weight
420.461
Canonical SMILES
CC(C)=CCc1c(oc2c3C=CC(C)(C)Oc3cc(O)c2c1=O)-c1ccc(O)cc1O
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InChI
InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3
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InChIKey
XFFOMNJIDRDDLQ-UHFFFAOYSA-N
CAS
62596-29-6
Physicochemical Property
logP
5.2697
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
100.13
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5281671
SID: 15353525
ChEMBL ID
CHEMBL464006
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 59400 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 64100 nM
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 29092.9 nM
   TI
   LI
   LO
   TS
Protein ID: PT05732, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000416 INS-1E Rattus norvegicus (Rat)  1
1
IC50 = 28650 nM
   TI
   LI
   LO
   TS
Protein ID: PT03605, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000399 SR Homo sapiens (Human)  1
1
IC50 = 43570 nM
   TI
   LI
   LO
   TS