Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
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 PubChem ID
CID: 44251605
SID: 85286240
Canonical SMILES
C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1
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Compound Formula C15H14F2N4S
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000008 H4
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 239 nM
   TI
   LI
   LO
   TS
2
IC50 = 240 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 173 nM
2 IC50 = 239 nM
3 IC50 = 240 nM
4 IC50 = 260 nM
5 IC50 = 270 nM
6 IC50 = 620 nM