General Information of the Compound
Compound ID
CP0268165
Compound Name
N-[(1S,2S)-2-[(4aS,7aR)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]cyclopropyl]-5-fluoropyridine-2-carboxamide
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Structure
Formula
C15H17FN4O2S
Molecular Weight
336.392
Canonical SMILES
NC1=N[C@]2(COC[C@H]2CS1)[C@H]1C[C@@H]1NC(=O)c1ccc(F)cn1
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InChI
InChI=1S/C15H17FN4O2S/c16-9-1-2-11(18-4-9)13(21)19-12-3-10(12)15-7-22-5-8(15)6-23-14(17)20-15/h1-2,4,8,10,12H,3,5-7H2,(H2,17,20)(H,19,21)/t8-,10-,12-,15-/m0/s1
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InChIKey
OWWIYTVWTQBRDL-FGAILIKWSA-N
Physicochemical Property
logP
0.7857
Rotatable Bonds
3
Heavy Atom Count
23
Polar Areas
89.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145704715
ChEMBL ID
CHEMBL4637568
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS