General Information of the Compound
Compound ID
CP0330911
Compound Name
3-((Z)-1-(benzyloxyimino)ethyl)-N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)benzamide
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Structure
Formula
C41H42F2N4O6S
Molecular Weight
756.872
Canonical SMILES
COc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(cc(c2)C(\C)=N/OCc2ccccc2)N(c2ccccc2)S(C)(=O)=O)c1
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InChI
InChI=1S/C41H42F2N4O6S/c1-28(46-53-27-29-11-6-4-7-12-29)32-21-33(23-37(22-32)47(54(3,50)51)36-14-8-5-9-15-36)41(49)45-39(20-31-17-34(42)24-35(43)18-31)40(48)26-44-25-30-13-10-16-38(19-30)52-2/h4-19,21-24,39-40,44,48H,20,25-27H2,1-3H3,(H,45,49)/b46-28-/t39-,40+/m0/s1
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InChIKey
PNMMECGLBBLQDQ-VHNZTDDISA-N
Physicochemical Property
logP
6.5037
Rotatable Bonds
17
Heavy Atom Count
54
Polar Areas
129.56
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
54

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45268100
ChEMBL ID
CHEMBL555916
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 88 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM