Brief Information of the Compound and Protein
Compound Name
N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[(4S)-spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]butan-2-yl]acetamide
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PubChem ID
CID: 71451796
Canonical SMILES
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncccc12
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Compound Formula C23H29N3O3
Compound Structure
Protein Name
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 804 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5280 nM