General Information of the Compound
Compound ID
CP0505763
Compound Name
tert-butyl 5-[[(2S,3R)-3-hydroxy-4-(3-methoxyanilino)-1-phenylbutan-2-yl]carbamoyl]-1-(2-oxo-2-propan-2-yloxyethyl)-4-propyl-4H-pyridine-3-carboxylate
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Structure
Formula
C36H49N3O7
Molecular Weight
635.802
Canonical SMILES
CCCC1C(=CN(CC(=O)OC(C)C)C=C1C(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNc1cccc(OC)c1
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InChI
InChI=1S/C36H49N3O7/c1-8-13-28-29(21-39(23-33(41)45-24(2)3)22-30(28)35(43)46-36(4,5)6)34(42)38-31(18-25-14-10-9-11-15-25)32(40)20-37-26-16-12-17-27(19-26)44-7/h9-12,14-17,19,21-22,24,28,31-32,37,40H,8,13,18,20,23H2,1-7H3,(H,38,42)/t28?,31-,32+/m0/s1
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InChIKey
XMXITDLPCGBKLS-VICIGFPDSA-N
Physicochemical Property
logP
4.9885
Rotatable Bonds
15
Heavy Atom Count
46
Polar Areas
126.43
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46704413
SID: 98461867
ChEMBL ID
CHEMBL1163426
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 30400 nM
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