| Compound ID |
Compound Name |
Compound Formula |
|
CP0900064
|
5-(2,6-Diamino-purin-9-yl)-2-ethynyl-2-hydroxymethyl-tetrahydro-furan-3-ol
Show/Hide
|
C12H14N6O3
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0132912
|
4-[[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C29H30N6O3S2
|
7
|
| 1 |
EC50 = 0.958 nM
|
|
|
| 2 |
EC50 = 1.34 nM
|
|
|
| 3 |
EC50 = 2.7 nM
|
|
|
| 4 |
EC50 = 4.74 nM
|
|
|
| 5 |
EC50 = 5 nM
|
|
|
| 6 |
EC50 = 5.45 nM
|
|
|
| 7 |
EC50 = 5.5 nM
|
|
|
|
CP0043833
|
(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
Show/Hide
|
C14H9ClF3NO2
|
23
|
| 1 |
EC50 = 1 nM
|
|
|
| 2 |
EC50 = 2.85 nM
|
|
|
| 3 |
EC50 = 4 nM
|
|
|
| 4 |
EC50 = 5 nM
|
|
|
| 5 |
EC50 = 5.19 nM
|
|
|
| 6 |
EC50 = 5.2 nM
|
|
|
| 7 |
EC50 = 8.2 nM
|
|
|
| 8 |
EC50 = 16 nM
|
|
|
| 9 |
EC50 = 29 nM
|
|
|
| 10 |
EC50 = 38 nM
|
|
|
| 11 |
EC50 = 44 nM
|
|
|
| 12 |
EC50 = 57 nM
|
|
|
| 13 |
EC50 = 80.1 nM
|
|
|
| 14 |
EC50 = 115 nM
|
|
|
| 15 |
EC50 = 160 nM
|
|
|
| 16 |
EC50 = 200 nM
|
|
|
| 17 |
EC50 = 224 nM
|
|
|
| 18 |
EC50 = 300 nM
|
|
|
| 19 |
EC50 = 308 nM
|
|
|
| 20 |
EC50 = 348 nM
|
|
|
| 21 |
EC50 = 514 nM
|
|
|
| 22 |
IC50 = 4 nM
|
|
|
| 23 |
IC50 = 6 nM
|
|
|
|
CP0405685
|
4-[[4-[[4-(4-cyano-2,6-dimethylphenoxy)-5H-pyrrolo[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C27H29N7O3S
|
9
|
| 1 |
EC50 = 1.03 nM
|
|
|
| 2 |
EC50 = 2.44 nM
|
|
|
| 3 |
EC50 = 3.95 nM
|
|
|
| 4 |
EC50 = 4.24 nM
|
|
|
| 5 |
EC50 = 4.8 nM
|
|
|
| 6 |
EC50 = 7.16 nM
|
|
|
| 7 |
EC50 = 17.8 nM
|
|
|
| 8 |
EC50 = 85 nM
|
|
|
| 9 |
IC50 = 75 nM
|
|
|
|
CP0450974
|
4-[[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C29H31N7O2S2
|
3
|
| 1 |
EC50 = 1.2 nM
|
|
|
| 2 |
EC50 = 5 nM
|
|
|
| 3 |
IC50 = 160 nM
|
|
|
|
CP0880599
|
2-amino-9-((2R,4S,5R)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
Show/Hide
|
C12H13N5O4
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0401715
|
4-[[4-[[4-(4-cyano-2,6-dimethylanilino)thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C27H29N7O2S2
|
2
|
| 1 |
EC50 = 1.43 nM
|
|
|
| 2 |
EC50 = 30.6 nM
|
|
|
|
CP0909537
|
3,5-Dimethyl-4-((2-((1-(4-(methylsulfonyl)benzyl)piperidin-4-yl)-amino)thieno[2,3-d]pyrimidin-4-yl)oxy)benzonitrile
Show/Hide
|
C28H29N5O3S2
|
7
|
| 1 |
EC50 = 1.64 nM
|
|
|
| 2 |
EC50 = 5.96 nM
|
|
|
| 3 |
EC50 = 7.26 nM
|
|
|
| 4 |
EC50 = 7.85 nM
|
|
|
| 5 |
EC50 = 8.68 nM
|
|
|
| 6 |
EC50 = 9.6 nM
|
|
|
| 7 |
EC50 = 42.3 nM
|
|
|
|
CP0010654
|
4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin-4-ylamino)-3,5-dimethylbenzonitrile
Show/Hide
|
C20H15BrN6O
|
11
|
| 1 |
EC50 = 2.35 nM
|
|
|
| 2 |
EC50 = 4 nM
|
|
|
| 3 |
EC50 = 5.38 nM
|
|
|
| 4 |
EC50 = 5.39 nM
|
|
|
| 5 |
EC50 = 14.4 nM
|
|
|
| 6 |
EC50 = 15.7 nM
|
|
|
| 7 |
EC50 = 17 nM
|
|
|
| 8 |
EC50 = 20.5 nM
|
|
|
| 9 |
EC50 = 29.4 nM
|
|
|
| 10 |
EC50 = 34.4 nM
|
|
|
| 11 |
EC50 = 46 nM
|
|
|
|
CP0229234
|
4-[[4-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C27H28N6O3S2
|
6
|
| 1 |
EC50 = 2.91 nM
|
|
|
| 2 |
EC50 = 3 nM
|
|
|
| 3 |
EC50 = 3.25 nM
|
|
|
| 4 |
EC50 = 3.38 nM
|
|
|
| 5 |
EC50 = 4.25 nM
|
|
|
| 6 |
EC50 = 30.6 nM
|
|
|
|
CP0855458
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(4-(methylsulfonyl)benzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C30H31N5O3S2
|
6
|
| 1 |
EC50 = 2.97 nM
|
|
|
| 2 |
EC50 = 4.51 nM
|
|
|
| 3 |
EC50 = 4.67 nM
|
|
|
| 4 |
EC50 = 4.68 nM
|
|
|
| 5 |
EC50 = 5.62 nM
|
|
|
| 6 |
EC50 = 7.93 nM
|
|
|
|
CP0857272
|
(E)-4-((4-((4-(4-(2-Cyanovinyl)-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide
Show/Hide
|
C30H30N6O2S
|
6
|
| 1 |
EC50 = 2.97 nM
|
|
|
| 2 |
EC50 = 7.2 nM
|
|
|
| 3 |
EC50 = 7.62 nM
|
|
|
| 4 |
EC50 = 8.14 nM
|
|
|
| 5 |
EC50 = 8.48 nM
|
|
|
| 6 |
EC50 = 10.8 nM
|
|
|
|
CP0906428
|
(E)-3-((4-((4-(4-(2-Cyanovinyl)-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide
Show/Hide
|
C30H30N6O2S
|
7
|
| 1 |
EC50 = 2.97 nM
|
|
|
| 2 |
EC50 = 5.12 nM
|
|
|
| 3 |
EC50 = 6.28 nM
|
|
|
| 4 |
EC50 = 6.41 nM
|
|
|
| 5 |
EC50 = 7.89 nM
|
|
|
| 6 |
EC50 = 27.4 nM
|
|
|
| 7 |
EC50 = 43.8 nM
|
|
|
|
CP0041607
|
(AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C10H13N5O4
|
14
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
EC50 = 3.75 nM
|
|
|
| 3 |
EC50 = 4.79 nM
|
|
|
| 4 |
EC50 = 5.24 nM
|
|
|
| 5 |
EC50 = 6.34 nM
|
|
|
| 6 |
EC50 = 6.6 nM
|
|
|
| 7 |
EC50 = 6.68 nM
|
|
|
| 8 |
EC50 = 7 nM
|
|
|
| 9 |
EC50 = 7.3 nM
|
|
|
| 10 |
EC50 = 8 nM
|
|
|
| 11 |
EC50 = 8.9 nM
|
|
|
| 12 |
EC50 = 11.1 nM
|
|
|
| 13 |
EC50 = 17 nM
|
|
|
| 14 |
EC50 = 38 nM
|
|
|
|
CP0862521
|
4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide
Show/Hide
|
C27H28N6O3S2
|
7
|
| 1 |
EC50 = 3.28 nM
|
|
|
| 2 |
EC50 = 4.44 nM
|
|
|
| 3 |
EC50 = 7.6 nM
|
|
|
| 4 |
EC50 = 7.63 nM
|
|
|
| 5 |
EC50 = 7.64 nM
|
|
|
| 6 |
EC50 = 8.85 nM
|
|
|
| 7 |
EC50 = 38.7 nM
|
|
|
|
CP0405683
|
4-[2-[[1-(furan-2-ylmethyl)piperidin-4-yl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
Show/Hide
|
C25H25N5O2S
|
3
|
| 1 |
EC50 = 3.55 nM
|
|
|
| 2 |
EC50 = 8.81 nM
|
|
|
| 3 |
IC50 = 82 nM
|
|
|
|
CP0852578
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(pyridin-3-ylmethyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C28H28N6OS
|
7
|
| 1 |
EC50 = 4.43 nM
|
|
|
| 2 |
EC50 = 4.46 nM
|
|
|
| 3 |
EC50 = 5.82 nM
|
|
|
| 4 |
EC50 = 6.06 nM
|
|
|
| 5 |
EC50 = 6.59 nM
|
|
|
| 6 |
EC50 = 10.7 nM
|
|
|
| 7 |
EC50 = 12.5 nM
|
|
|
|
CP0387403
|
3,5-dimethyl-4-[2-[[1-[(1-methylsulfonylimidazol-4-yl)methyl]piperidin-4-yl]amino]thieno[3,2-d]pyrimidin-4-yl]oxybenzonitrile
Show/Hide
|
C25H27N7O3S2
|
5
|
| 1 |
EC50 = 4.46 nM
|
|
|
| 2 |
EC50 = 5.67 nM
|
|
|
| 3 |
EC50 = 13.4 nM
|
|
|
| 4 |
EC50 = 2703 nM
|
|
|
| 5 |
IC50 = 53 nM
|
|
|
|
CP0496264
|
6-amino-3-[(3S,4S,5R)-5-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,6-dihydropyrimidin-2-one
Show/Hide
|
C11H15N3O5
|
1
|
| 1 |
EC50 = 4.8 nM
|
|
|
|
CP0945006
|
4-amino-1-((2R,4S,5R)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Show/Hide
|
C11H13N3O4
|
1
|
| 1 |
EC50 = 4.8 nM
|
|
|
|
CP0852584
|
4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)-5,5-dioxidothieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide
Show/Hide
|
C29H31N5O5S2
|
6
|
| 1 |
EC50 = 5.14 nM
|
|
|
| 2 |
EC50 = 13.6 nM
|
|
|
| 3 |
EC50 = 23.1 nM
|
|
|
| 4 |
EC50 = 24.6 nM
|
|
|
| 5 |
EC50 = 32.4 nM
|
|
|
| 6 |
EC50 = 189 nM
|
|
|
|
CP0862529
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(pyridin-2-ylmethyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C28H28N6OS
|
7
|
| 1 |
EC50 = 5.33 nM
|
|
|
| 2 |
EC50 = 7.46 nM
|
|
|
| 3 |
EC50 = 9.23 nM
|
|
|
| 4 |
EC50 = 18.4 nM
|
|
|
| 5 |
EC50 = 26.7 nM
|
|
|
| 6 |
EC50 = 41.7 nM
|
|
|
| 7 |
EC50 = 122 nM
|
|
|
|
CP0862526
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(4-cyanobenzyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C30H28N6OS
|
7
|
| 1 |
EC50 = 5.42 nM
|
|
|
| 2 |
EC50 = 7.36 nM
|
|
|
| 3 |
EC50 = 22.7 nM
|
|
|
| 4 |
EC50 = 29.6 nM
|
|
|
| 5 |
EC50 = 31 nM
|
|
|
| 6 |
EC50 = 33.2 nM
|
|
|
| 7 |
EC50 = 59.7 nM
|
|
|
|
CP0387402
|
4-[2-[[1-(1H-imidazol-5-ylmethyl)piperidin-4-yl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
Show/Hide
|
C24H25N7OS
|
5
|
| 1 |
EC50 = 5.49 nM
|
|
|
| 2 |
EC50 = 5.98 nM
|
|
|
| 3 |
EC50 = 12 nM
|
|
|
| 4 |
EC50 = 1168 nM
|
|
|
| 5 |
IC50 = 52 nM
|
|
|
|
CP0911131
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(pyridin-4-ylmethyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C28H28N6OS
|
7
|
| 1 |
EC50 = 5.56 nM
|
|
|
| 2 |
EC50 = 5.79 nM
|
|
|
| 3 |
EC50 = 6.35 nM
|
|
|
| 4 |
EC50 = 8.53 nM
|
|
|
| 5 |
EC50 = 14.8 nM
|
|
|
| 6 |
EC50 = 29.4 nM
|
|
|
| 7 |
EC50 = 32.2 nM
|
|
|
|
CP0401714
|
4-[[4-[[4-(4-cyano-2,6-dimethylphenoxy)-5H-pyrrolo[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzamide
Show/Hide
|
C28H29N7O2
|
3
|
| 1 |
EC50 = 5.72 nM
|
|
|
| 2 |
EC50 = 113 nM
|
|
|
| 3 |
IC50 = 108 nM
|
|
|
|
CP0450975
|
3,5-dimethyl-4-[[2-[[1-[(4-methylsulfonylphenyl)methyl]piperidin-4-yl]amino]-5H-pyrrolo[3,2-d]pyrimidin-4-yl]oxy]benzonitrile
Show/Hide
|
C28H30N6O3S
|
3
|
| 1 |
EC50 = 5.92 nM
|
|
|
| 2 |
EC50 = 116 nM
|
|
|
| 3 |
IC50 = 98 nM
|
|
|
|
CP0862552
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(3-cyanobenzyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C30H28N6OS
|
7
|
| 1 |
EC50 = 6.02 nM
|
|
|
| 2 |
EC50 = 8.04 nM
|
|
|
| 3 |
EC50 = 26.3 nM
|
|
|
| 4 |
EC50 = 26.9 nM
|
|
|
| 5 |
EC50 = 27.9 nM
|
|
|
| 6 |
EC50 = 51 nM
|
|
|
| 7 |
EC50 = 115 nM
|
|
|
|
CP0405684
|
4-[2-[[1-[(2,4-dioxo-1H-pyrimidin-6-yl)methyl]piperidin-4-yl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
Show/Hide
|
C25H25N7O3S
|
5
|
| 1 |
EC50 = 6.13 nM
|
|
|
| 2 |
EC50 = 6.95 nM
|
|
|
| 3 |
EC50 = 7.19 nM
|
|
|
| 4 |
EC50 = 8970 nM
|
|
|
| 5 |
IC50 = 22 nM
|
|
|
|
CP0902874
|
(E)-3-(4-((2-((1-(4-Fluorobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28FN5OS
|
7
|
| 1 |
EC50 = 6.38 nM
|
|
|
| 2 |
EC50 = 14.3 nM
|
|
|
| 3 |
EC50 = 27.2 nM
|
|
|
| 4 |
EC50 = 34.9 nM
|
|
|
| 5 |
EC50 = 103 nM
|
|
|
| 6 |
EC50 = 125 nM
|
|
|
| 7 |
EC50 = 155 nM
|
|
|
|
CP0852579
|
(E)-3-(4-((2-((1-(2-Fluorobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28FN5OS
|
7
|
| 1 |
EC50 = 6.88 nM
|
|
|
| 2 |
EC50 = 29.8 nM
|
|
|
| 3 |
EC50 = 30.4 nM
|
|
|
| 4 |
EC50 = 33.5 nM
|
|
|
| 5 |
EC50 = 40.6 nM
|
|
|
| 6 |
EC50 = 139 nM
|
|
|
| 7 |
EC50 = 177 nM
|
|
|
|
CP0053192
|
3-[[(4,7-Dichlorobenzoxazol-2-yl)-methyl]amino]-5-ethyl-6-methylpyridin-2(1H)-one
Show/Hide
|
C16H15Cl2N3O2
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0103806
|
(4-Chloro-phenyl)-(furan-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15ClN2O5S
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0862551
|
4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)-3-fluoropiperidin-1-yl)methyl)benzenesulfonamide
Show/Hide
|
C27H27FN6O3S2
|
7
|
| 1 |
EC50 = 7.89 nM
|
|
|
| 2 |
EC50 = 8.73 nM
|
|
|
| 3 |
EC50 = 8.94 nM
|
|
|
| 4 |
EC50 = 13.9 nM
|
|
|
| 5 |
EC50 = 17.4 nM
|
|
|
| 6 |
EC50 = 30 nM
|
|
|
| 7 |
EC50 = 37.2 nM
|
|
|
|
CP0281570
|
(4-Chloro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15ClN2O4S2
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0505302
|
(Furan-2-carbonyl)-(4-nitro-phenyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15N3O7S
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0902873
|
3-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide
Show/Hide
|
C28H28N6O2S
|
7
|
| 1 |
EC50 = 8.69 nM
|
|
|
| 2 |
EC50 = 8.88 nM
|
|
|
| 3 |
EC50 = 9.19 nM
|
|
|
| 4 |
EC50 = 10.5 nM
|
|
|
| 5 |
EC50 = 17 nM
|
|
|
| 6 |
EC50 = 25.2 nM
|
|
|
| 7 |
EC50 = 4690 nM
|
|
|
|
CP0536530
|
4-[[4-[[5-(benzenesulfonyl)-4-(4-cyano-2,6-dimethylphenoxy)pyrrolo[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C33H33N7O5S2
|
3
|
| 1 |
EC50 = 8.9 nM
|
|
|
| 2 |
EC50 = 110 nM
|
|
|
| 3 |
IC50 = 193 nM
|
|
|
|
CP0405682
|
4-[[4-[[4-[2,6-dimethyl-4-(2-pyridin-2-ylethynyl)phenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C33H32N6O3S2
|
3
|
| 1 |
EC50 = 9 nM
|
|
|
| 2 |
EC50 = 888 nM
|
|
|
| 3 |
IC50 = 290 nM
|
|
|
|
CP0471765
|
4-[[4-[[4-(4-cyano-2,6-dimethylphenoxy)-5-(phenylmethoxymethyl)pyrrolo[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C35H37N7O4S
|
3
|
| 1 |
EC50 = 9.51 nM
|
|
|
| 2 |
EC50 = 484 nM
|
|
|
| 3 |
IC50 = 163 nM
|
|
|
|
CP0902867
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(4-nitrobenzyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C29H28N6O3S
|
7
|
| 1 |
EC50 = 9.66 nM
|
|
|
| 2 |
EC50 = 26.3 nM
|
|
|
| 3 |
EC50 = 30.7 nM
|
|
|
| 4 |
EC50 = 40.8 nM
|
|
|
| 5 |
EC50 = 106 nM
|
|
|
| 6 |
EC50 = 111 nM
|
|
|
| 7 |
EC50 = 117 nM
|
|
|
|
CP0225156
|
7-[2-(1H-Imidazol-l-yl)-5-methylimidazo[1,5-b]pyridazin-7-yl]-1-phenyl-1-heptanone
Show/Hide
|
C23H25N5O
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0225177
|
7-[5-methyl-2-(5-methyl-1H-imidazol-1-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C24H27N5O
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0436820
|
(4-Iodo-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15IN2O4S2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0504802
|
(4-Nitro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15N3O6S2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0907764
|
4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidin-2-one
Show/Hide
|
C12H15N3O4
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0870775
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(4-methylbenzyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C30H31N5OS
|
7
|
| 1 |
EC50 = 11.2 nM
|
|
|
| 2 |
EC50 = 29.7 nM
|
|
|
| 3 |
EC50 = 31.9 nM
|
|
|
| 4 |
EC50 = 32.3 nM
|
|
|
| 5 |
EC50 = 129 nM
|
|
|
| 6 |
EC50 = 138 nM
|
|
|
| 7 |
EC50 = 146 nM
|
|
|
|
CP0946314
|
(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol
Show/Hide
|
C12H13N5O3
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0857270
|
Ethyl(E)-4-((4-((4-(4-(2-Cyanovinyl)-2,6-dimethylphenoxy)thieno-[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzoate
Show/Hide
|
C32H33N5O3S
|
7
|
| 1 |
EC50 = 13.2 nM
|
|
|
| 2 |
EC50 = 26.8 nM
|
|
|
| 3 |
EC50 = 32.9 nM
|
|
|
| 4 |
EC50 = 37.4 nM
|
|
|
| 5 |
EC50 = 85.2 nM
|
|
|
| 6 |
EC50 = 163 nM
|
|
|
| 7 |
EC50 = 165 nM
|
|
|
|
CP0450997
|
3,5-dimethyl-4-[2-[[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]piperidin-4-yl]amino]thieno[3,2-d]pyrimidin-4-yl]oxybenzonitrile
Show/Hide
|
C24H26N8O2S
|
3
|
| 1 |
EC50 = 13.7 nM
|
|
|
| 2 |
EC50 = 17058 nM
|
|
|
| 3 |
IC50 = 55 nM
|
|
|
|
CP0949301
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(2-cyanobenzyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C30H28N6OS
|
7
|
| 1 |
EC50 = 15.1 nM
|
|
|
| 2 |
EC50 = 17.5 nM
|
|
|
| 3 |
EC50 = 34.6 nM
|
|
|
| 4 |
EC50 = 37.8 nM
|
|
|
| 5 |
EC50 = 43.2 nM
|
|
|
| 6 |
EC50 = 124 nM
|
|
|
| 7 |
EC50 = 319 nM
|
|
|
|
CP0401717
|
4-[[4-[[5-(benzenesulfonyl)-4-(4-cyano-2,6-dimethylphenoxy)pyrrolo[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzamide
Show/Hide
|
C34H33N7O4S
|
3
|
| 1 |
EC50 = 16.5 nM
|
|
|
| 2 |
EC50 = 2288 nM
|
|
|
| 3 |
IC50 = 195 nM
|
|
|
|
CP0333020
|
7-[5-methyl-2-(1H-pyrrol-1-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C24H26N4O
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0047721
|
3-(5-bromopyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]thiourea hydrochloride
Show/Hide
|
C13H13BrN4S
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0870781
|
(E)-3-(4-((2-((1-(3-Fluorobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28FN5OS
|
7
|
| 1 |
EC50 = 21.1 nM
|
|
|
| 2 |
EC50 = 22 nM
|
|
|
| 3 |
EC50 = 31.6 nM
|
|
|
| 4 |
EC50 = 34.5 nM
|
|
|
| 5 |
EC50 = 56.9 nM
|
|
|
| 6 |
EC50 = 126 nM
|
|
|
| 7 |
EC50 = 159 nM
|
|
|
|
CP0857273
|
(E)-3-(3,5-Dimethyl-4-((2-((1-(2-methylbenzyl)piperidin-4-yl)-amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
Show/Hide
|
C30H31N5OS
|
7
|
| 1 |
EC50 = 24.8 nM
|
|
|
| 2 |
EC50 = 47.2 nM
|
|
|
| 3 |
EC50 = 61.4 nM
|
|
|
| 4 |
EC50 = 85.7 nM
|
|
|
| 5 |
EC50 = 128 nM
|
|
|
| 6 |
EC50 = 174 nM
|
|
|
| 7 |
EC50 = 829 nM
|
|
|
|
CP0494171
|
(4-Chloro-benzoyl)-(4-chloro-phenyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C24H16Cl2N2O4S
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0862524
|
(E)-3-(4-((2-((1-(4-Chlorobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28ClN5OS
|
7
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
EC50 = 42.8 nM
|
|
|
| 3 |
EC50 = 77.7 nM
|
|
|
| 4 |
EC50 = 108 nM
|
|
|
| 5 |
EC50 = 152 nM
|
|
|
| 6 |
EC50 = 177 nM
|
|
|
| 7 |
EC50 = 195 nM
|
|
|
|
CP0466761
|
3,5-dimethyl-4-[2-[[1-[(4-methylsulfonylphenyl)methyl]piperidin-4-yl]amino]-5-(phenylmethoxymethyl)pyrrolo[3,2-d]pyrimidin-4-yl]oxybenzonitrile
Show/Hide
|
C36H38N6O4S
|
3
|
| 1 |
EC50 = 26.3 nM
|
|
|
| 2 |
EC50 = 547 nM
|
|
|
| 3 |
IC50 = 189 nM
|
|
|
|
CP0870773
|
(E)-3-(4-((2-((1-(3-Bromobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28BrN5OS
|
7
|
| 1 |
EC50 = 28.5 nM
|
|
|
| 2 |
EC50 = 29.5 nM
|
|
|
| 3 |
EC50 = 93.6 nM
|
|
|
| 4 |
EC50 = 128 nM
|
|
|
| 5 |
EC50 = 129 nM
|
|
|
| 6 |
EC50 = 165 nM
|
|
|
| 7 |
EC50 = 216 nM
|
|
|
|
CP0857267
|
(E)-3-(4-((2-((1-(2-Chlorobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28ClN5OS
|
7
|
| 1 |
EC50 = 29.1 nM
|
|
|
| 2 |
EC50 = 30.4 nM
|
|
|
| 3 |
EC50 = 72.3 nM
|
|
|
| 4 |
EC50 = 133 nM
|
|
|
| 5 |
EC50 = 158 nM
|
|
|
| 6 |
EC50 = 165 nM
|
|
|
| 7 |
EC50 = 207 nM
|
|
|
|
CP0857268
|
Methyl 4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]-pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzoate
Show/Hide
|
C29H29N5O3S
|
7
|
| 1 |
EC50 = 29.1 nM
|
|
|
| 2 |
EC50 = 35.6 nM
|
|
|
| 3 |
EC50 = 90.7 nM
|
|
|
| 4 |
EC50 = 134 nM
|
|
|
| 5 |
EC50 = 158 nM
|
|
|
| 6 |
EC50 = 263 nM
|
|
|
| 7 |
EC50 = 15300 nM
|
|
|
|
CP0852577
|
(E)-3-(4-((2-((1-(3-Chlorobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28ClN5OS
|
7
|
| 1 |
EC50 = 29.8 nM
|
|
|
| 2 |
EC50 = 30 nM
|
|
|
| 3 |
EC50 = 68.3 nM
|
|
|
| 4 |
EC50 = 71.1 nM
|
|
|
| 5 |
EC50 = 131 nM
|
|
|
| 6 |
EC50 = 148 nM
|
|
|
| 7 |
EC50 = 170 nM
|
|
|
|
CP0902875
|
(E)-3-(4-((2-((1-(4-Bromobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28BrN5OS
|
6
|
| 1 |
EC50 = 29.9 nM
|
|
|
| 2 |
EC50 = 58.2 nM
|
|
|
| 3 |
EC50 = 127 nM
|
|
|
| 4 |
EC50 = 154 nM
|
|
|
| 5 |
EC50 = 161 nM
|
|
|
| 6 |
EC50 = 287 nM
|
|
|
|
CP0167670
|
7-(2-Chloro-5-methylimidazo[1,5-b]pyridazin-7-yl)-1-phenyl-1-heptanone
Show/Hide
|
C20H22ClN3O
|
1
|
| 1 |
EC50 < 30 nM
|
|
|
|
CP0306461
|
7-[2-(1H-imidazol-1-yl)-5-methylimidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-ol
Show/Hide
|
C23H27N5O
|
1
|
| 1 |
EC50 < 30 nM
|
|
|
|
CP0920492
|
4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidin-2-one
Show/Hide
|
C11H12FN3O4
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0439359
|
(4-Ethyl-phenyl)-(furan-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C24H20N2O5S
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0471764
|
4-[5-(benzenesulfonyl)-2-[[1-[(4-methylsulfonylphenyl)methyl]piperidin-4-yl]amino]pyrrolo[3,2-d]pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
Show/Hide
|
C34H34N6O5S2
|
3
|
| 1 |
EC50 = 30.8 nM
|
|
|
| 2 |
EC50 = 187 nM
|
|
|
| 3 |
IC50 = 380 nM
|
|
|
|
CP0494047
|
3,5-dimethyl-4-[2-[[1-[(4-pyrrolidin-1-ylphenyl)methyl]piperidin-4-yl]amino]thieno[3,2-d]pyrimidin-4-yl]oxybenzonitrile
Show/Hide
|
C31H34N6OS
|
3
|
| 1 |
EC50 = 32.8 nM
|
|
|
| 2 |
EC50 > 4362 nM
|
|
|
| 3 |
IC50 = 221 nM
|
|
|
|
CP0494048
|
4-[[4-[[4-[2,6-dimethyl-4-(2-pyridin-4-ylethynyl)phenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C33H32N6O3S2
|
3
|
| 1 |
EC50 = 33.8 nM
|
|
|
| 2 |
EC50 = 223 nM
|
|
|
| 3 |
IC50 = 860 nM
|
|
|
|
CP0472166
|
Benzoyl-(4-bromo-phenyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C24H17BrN2O4S
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0471766
|
4-[[4-[[4-(4-cyano-2,6-dimethylphenoxy)-5-(phenylmethoxymethyl)pyrrolo[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzamide
Show/Hide
|
C36H37N7O3
|
3
|
| 1 |
EC50 = 35.7 nM
|
|
|
| 2 |
EC50 = 567 nM
|
|
|
| 3 |
IC50 = 158 nM
|
|
|
|
CP0477099
|
4-[[4-[[4-[2,6-dimethyl-4-(2-pyridin-3-ylethynyl)phenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
Show/Hide
|
C33H32N6O3S2
|
3
|
| 1 |
EC50 = 40.8 nM
|
|
|
| 2 |
EC50 = 153 nM
|
|
|
| 3 |
IC50 = 280 nM
|
|
|
|
CP0870764
|
(E)-3-(4-((2-((1-(2-Bromobenzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylphenyl)acrylonitrile
Show/Hide
|
C29H28BrN5OS
|
7
|
| 1 |
EC50 = 45.1 nM
|
|
|
| 2 |
EC50 = 47.8 nM
|
|
|
| 3 |
EC50 = 89.5 nM
|
|
|
| 4 |
EC50 = 123 nM
|
|
|
| 5 |
EC50 = 145 nM
|
|
|
| 6 |
EC50 = 150 nM
|
|
|
| 7 |
EC50 = 351 nM
|
|
|
|
CP0039375
|
11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2 ,3 -e][1,4]diazepin-6-one
Show/Hide
|
C15H14N4O
|
15
|
| 1 |
EC50 = 52 nM
|
|
|
| 2 |
EC50 = 75 nM
|
|
|
| 3 |
EC50 = 124 nM
|
|
|
| 4 |
EC50 = 240 nM
|
|
|
| 5 |
EC50 = 271 nM
|
|
|
| 6 |
EC50 = 450 nM
|
|
|
| 7 |
EC50 = 2100 nM
|
|
|
| 8 |
EC50 = 3900 nM
|
|
|
| 9 |
EC50 = 5390 nM
|
|
|
| 10 |
EC50 = 9590 nM
|
|
|
| 11 |
EC50 > 15000 nM
|
|
|
| 12 |
EC50 > 15020 nM
|
|
|
| 13 |
EC50 > 7500 nM
|
|
|
| 14 |
IC50 = 250 nM
|
|
|
| 15 |
IC50 = 590 nM
|
|
|
|
CP0096367
|
1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C25H45N3O8SSi2
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0141639
|
1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2lambda6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione
Show/Hide
|
C24H43N3O8SSi2
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0396027
|
2-[1-(3,5-dimethylphenyl)sulfonylbenzimidazol-2-yl]sulfanyl-N-(4-sulfamoylphenyl)acetamide
Show/Hide
|
C23H22N4O5S3
|
6
|
| 1 |
EC50 = 60 nM
|
|
|
| 2 |
EC50 = 73 nM
|
|
|
| 3 |
EC50 = 670 nM
|
|
|
| 4 |
EC50 = 1560 nM
|
|
|
| 5 |
EC50 = 1580 nM
|
|
|
| 6 |
EC50 > 27200 nM
|
|
|
|
CP0057542
|
BHAP deriv.
Show/Hide
|
C22H28N6O3S
|
2
|
| 1 |
EC50 = 76 nM
|
|
|
| 2 |
EC50 > 23000 nM
|
|
|
|
CP0415765
|
2-[1-(3,5-dimethylphenyl)sulfonylbenzimidazol-2-yl]sulfanyl-N-(4-methylsulfonylphenyl)acetamide
Show/Hide
|
C24H23N3O5S3
|
5
|
| 1 |
EC50 = 88 nM
|
|
|
| 2 |
EC50 = 150 nM
|
|
|
| 3 |
EC50 = 1190 nM
|
|
|
| 4 |
EC50 > 10590 nM
|
|
|
| 5 |
EC50 > 770 nM
|
|
|
|
CP0215430
|
4-[(2,6-difluorophenyl)methyl]-5-methyl-2-phenylsulfanyl-1H-pyrimidin-6-one
Show/Hide
|
C18H14F2N2OS
|
4
|
| 1 |
EC50 = 90 nM
|
|
|
| 2 |
EC50 = 16700 nM
|
|
|
| 3 |
EC50 = 42500 nM
|
|
|
| 4 |
EC50 > 72700 nM
|
|
|
|
CP0215428
|
2-(4-chlorophenyl)sulfanyl-4-[(2,6-difluorophenyl)methyl]-5-methyl-1H-pyrimidin-6-one
Show/Hide
|
C18H13ClF2N2OS
|
3
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
EC50 = 8010 nM
|
|
|
| 3 |
EC50 > 66100 nM
|
|
|
|
CP0420821
|
(4-Fluoro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15FN2O4S2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0498297
|
Benzoyl-(4-chloro-phenyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C24H17ClN2O4S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0850206
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-iodo-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C25H44IN3O8SSi2
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0082036
|
1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-iodo-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C24H42IN3O8SSi2
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0852580
|
3,5-Dimethyl-4-((2-((4-((4-(methylsulfonyl)benzyl)amino)-cyclohexyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)benzonitrile
Show/Hide
|
C29H31N5O3S2
|
3
|
| 1 |
EC50 = 135 nM
|
|
|
| 2 |
EC50 = 355 nM
|
|
|
| 3 |
EC50 > 75200 nM
|
|
|
|
CP0865379
|
9-(5-Ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol
Show/Hide
|
C12H12N4O4
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0909976
|
4-(((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)cyclohexyl)amino)methyl)benzenesulfonamide
Show/Hide
|
C28H30N6O3S2
|
3
|
| 1 |
EC50 = 152 nM
|
|
|
| 2 |
EC50 = 175 nM
|
|
|
| 3 |
EC50 > 3690 nM
|
|
|
|
CP0870780
|
3,5-Dimethyl-4-((2-((4-((4-nitrobenzyl)amino)cyclohexyl)amino)-thieno[3,2-d]pyrimidin-4-yl)oxy)benzonitrile
Show/Hide
|
C28H28N6O3S
|
7
|
| 1 |
EC50 = 158 nM
|
|
|
| 2 |
EC50 = 646 nM
|
|
|
| 3 |
EC50 = 690 nM
|
|
|
| 4 |
EC50 = 1550 nM
|
|
|
| 5 |
EC50 = 11100 nM
|
|
|
| 6 |
EC50 >= 26500 nM
|
|
|
| 7 |
EC50 >= 54400 nM
|
|
|
|
CP0396029
|
methyl 4-[[2-[1-(3,5-dimethylphenyl)sulfonylbenzimidazol-2-yl]sulfanylacetyl]amino]benzoate
Show/Hide
|
C25H23N3O5S2
|
4
|
| 1 |
EC50 = 160 nM
|
|
|
| 2 |
EC50 = 170 nM
|
|
|
| 3 |
EC50 = 960 nM
|
|
|
| 4 |
EC50 > 8360 nM
|
|
|
|
CP0429448
|
2-[1-(3,5-dimethylphenyl)sulfonylbenzimidazol-2-yl]sulfanyl-N-(4-methylphenyl)acetamide
Show/Hide
|
C24H23N3O3S2
|
3
|
| 1 |
EC50 = 160 nM
|
|
|
| 2 |
EC50 = 240 nM
|
|
|
| 3 |
EC50 > 3130 nM
|
|
|
|
CP0915875
|
Ethyl4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]-pyrimidin-2-yl)amino)-1-(4-sulfamoylbenzyl)piperidine-3-carboxylate
Show/Hide
|
C30H32N6O5S2
|
7
|
| 1 |
EC50 = 186 nM
|
|
|
| 2 |
EC50 = 239 nM
|
|
|
| 3 |
EC50 = 389 nM
|
|
|
| 4 |
EC50 = 607 nM
|
|
|
| 5 |
EC50 = 1270 nM
|
|
|
| 6 |
EC50 >= 918 nM
|
|
|
| 7 |
EC50 > 4248 nM
|
|
|
|
CP0541386
|
4-[[4-[(3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C20H18N4O3
|
2
|
| 1 |
EC50 = 230 nM
|
|
|
| 2 |
EC50 > 44000 nM
|
|
|
|
CP0480919
|
4-[[4-(pyridin-2-ylmethylamino)pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C17H14N6
|
2
|
| 1 |
EC50 = 240 nM
|
|
|
| 2 |
EC50 > 8500 nM
|
|
|
|
CP0930736
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C26H47N3O8SSi2
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0901549
|
4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide
Show/Hide
|
C28H28N6O2S
|
7
|
| 1 |
EC50 = 250 nM
|
|
|
| 2 |
EC50 = 438 nM
|
|
|
| 3 |
EC50 = 529 nM
|
|
|
| 4 |
EC50 = 805 nM
|
|
|
| 5 |
EC50 = 14200 nM
|
|
|
| 6 |
EC50 > 4930 nM
|
|
|
| 7 |
EC50 > 4935 nM
|
|
|
|
CP0429446
|
N-(2-chloro-4-methylsulfonylphenyl)-2-[1-(3,5-dimethylphenyl)sulfonylbenzimidazol-2-yl]oxyacetamide
Show/Hide
|
C24H22ClN3O6S2
|
5
|
| 1 |
EC50 = 290 nM
|
|
|
| 2 |
EC50 = 670 nM
|
|
|
| 3 |
EC50 = 890 nM
|
|
|
| 4 |
EC50 = 1820 nM
|
|
|
| 5 |
EC50 > 33940 nM
|
|
|
|
CP0519307
|
4-[[4-[(2-fluorophenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C18H13FN4O
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0521098
|
4-[[4-(naphthalen-1-ylmethoxy)pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C22H16N4O
|
2
|
| 1 |
EC50 = 300 nM
|
|
|
| 2 |
EC50 > 7700 nM
|
|
|
|
CP0046192
|
4-[(2,6-difluorophenyl)methyl]-2-(2,4-difluorophenyl)sulfanyl-5-methyl-1H-pyrimidin-6-one
Show/Hide
|
C18H12F4N2OS
|
3
|
| 1 |
EC50 = 310 nM
|
|
|
| 2 |
EC50 = 25800 nM
|
|
|
| 3 |
EC50 > 65800 nM
|
|
|
|
CP0860978
|
1-(5-Ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-iodo-1H-pyrimidine-2,4-dione
Show/Hide
|
C11H11IN2O5
|
1
|
| 1 |
EC50 = 340 nM
|
|
|
|
CP0909542
|
Ethyl 4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]-pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzoate
Show/Hide
|
C30H31N5O3S
|
7
|
| 1 |
EC50 = 369 nM
|
|
|
| 2 |
EC50 = 498 nM
|
|
|
| 3 |
EC50 = 1110 nM
|
|
|
| 4 |
EC50 = 1440 nM
|
|
|
| 5 |
EC50 = 1850 nM
|
|
|
| 6 |
EC50 = 3680 nM
|
|
|
| 7 |
EC50 = 40900 nM
|
|
|
|
CP0497028
|
(3-Nitro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15N3O6S2
|
1
|
| 1 |
EC50 = 380 nM
|
|
|
|
CP0149836
|
7-[5-methyl-2-(4-methyl-1H-imidazol-1-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C24H27N5O
|
1
|
| 1 |
EC50 = 400 nM
|
|
|
|
CP0494843
|
(Thiophene-2-carbonyl)-p-tolyl-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C23H18N2O4S2
|
1
|
| 1 |
EC50 = 400 nM
|
|
|
|
CP0502770
|
Benzoyl-phenyl-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C24H18N2O4S
|
1
|
| 1 |
EC50 = 400 nM
|
|
|
|
CP0504833
|
7-[5-methyl-2-(1H-1,2,4-triazol-1-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C22H24N6O
|
1
|
| 1 |
EC50 = 440 nM
|
|
|
|
CP0460891
|
(2-Chloro-pyridine-4-carbonyl)-(4-ethoxy-phenyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C25H20ClN3O5S
|
1
|
| 1 |
EC50 = 500 nM
|
|
|
|
CP0113395
|
7-(5-Methylimidazo[1,5-b]pyridazin-7-yl)-l-phenyl-l-heptanone Hydrochloride
Show/Hide
|
C20H23N3O
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0889325
|
1-(5-Ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C12H14N2O5
|
1
|
| 1 |
EC50 = 610 nM
|
|
|
|
CP0763949
|
7-(5-Methyl-2-methylsulfanyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-one hydrochloride
Show/Hide
|
C21H26ClN3OS
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0283909
|
4-[(2,6-difluorophenyl)methyl]-2-(4-methoxyphenyl)sulfanyl-5-methyl-1H-pyrimidin-6-one
Show/Hide
|
C19H16F2N2O2S
|
2
|
| 1 |
EC50 = 670 nM
|
|
|
| 2 |
EC50 > 57500 nM
|
|
|
|
CP0149925
|
7-[5-methyl-2-(2-methyl-1H-imidazol-1-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C24H27N5O
|
1
|
| 1 |
EC50 = 700 nM
|
|
|
|
CP0298940
|
7-[5-methyl-2-(1H-1,2,3-triazol-1-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C22H24N6O
|
1
|
| 1 |
EC50 = 720 nM
|
|
|
|
CP0903508
|
4-((2-((4-(benzylamino)cyclohexyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
Show/Hide
|
C28H29N5OS
|
5
|
| 1 |
EC50 = 754 nM
|
|
|
| 2 |
EC50 = 891 nM
|
|
|
| 3 |
EC50 = 983 nM
|
|
|
| 4 |
EC50 = 1050 nM
|
|
|
| 5 |
EC50 > 2980 nM
|
|
|
|
CP0168027
|
5-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}pentyl benzoate
Show/Hide
|
C19H20ClN3O2
|
1
|
| 1 |
EC50 = 780 nM
|
|
|
|
CP0930489
|
4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)-1-(4-sulfamoylbenzyl)piperidine-3-carboxylic Acid
Show/Hide
|
C28H28N6O5S2
|
7
|
| 1 |
EC50 = 827 nM
|
|
|
| 2 |
EC50 = 1640 nM
|
|
|
| 3 |
EC50 = 2530 nM
|
|
|
| 4 |
EC50 = 2970 nM
|
|
|
| 5 |
EC50 = 3300 nM
|
|
|
| 6 |
EC50 = 3340 nM
|
|
|
| 7 |
EC50 > 27600 nM
|
|
|
|
CP0906438
|
4-(((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)cyclohexyl)amino)methyl)benzamide
Show/Hide
|
C29H30N6O2S
|
7
|
| 1 |
EC50 = 857 nM
|
|
|
| 2 |
EC50 = 895 nM
|
|
|
| 3 |
EC50 = 2860 nM
|
|
|
| 4 |
EC50 = 3880 nM
|
|
|
| 5 |
EC50 >= 4160 nM
|
|
|
| 6 |
EC50 >= 4480 nM
|
|
|
| 7 |
EC50 >= 5200 nM
|
|
|
|
CP0306561
|
( 1RS)-2-Chloro-5-methyl-alpha-phenyl-7-imidazo[1,5-b]pyridazineheptanol Hydrochloride
Show/Hide
|
C20H24ClN3O
|
1
|
| 1 |
EC50 = 860 nM
|
|
|
|
CP0857266
|
4-((2-((4-((4-Fluorobenzyl)amino)cyclohexyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
Show/Hide
|
C28H28FN5OS
|
4
|
| 1 |
EC50 = 883 nM
|
|
|
| 2 |
EC50 = 919 nM
|
|
|
| 3 |
EC50 >= 1310 nM
|
|
|
| 4 |
EC50 > 2770 nM
|
|
|
|
CP0285577
|
7-(2-Amino-5-methylimidazo[1,5-b]pyridazin-7-yl)-l-phenyl-1-heptanone
Show/Hide
|
C20H24N4O
|
1
|
| 1 |
EC50 = 890 nM
|
|
|
|
CP0889438
|
1-[4-Amino-3-bromo-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C24H42BrN3O8SSi2
|
1
|
| 1 |
EC50 = 930 nM
|
|
|
|
CP0870769
|
3-(((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)cyclohexyl)amino)methyl)benzamide
Show/Hide
|
C29H30N6O2S
|
6
|
| 1 |
EC50 = 935 nM
|
|
|
| 2 |
EC50 = 1510 nM
|
|
|
| 3 |
EC50 = 3510 nM
|
|
|
| 4 |
EC50 = 4590 nM
|
|
|
| 5 |
EC50 = 5910 nM
|
|
|
| 6 |
EC50 >= 5260 nM
|
|
|
|
CP0909975
|
4-((2-((4-((4-Bromobenzyl)amino)cyclohexyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
Show/Hide
|
C28H28BrN5OS
|
4
|
| 1 |
EC50 = 946 nM
|
|
|
| 2 |
EC50 >= 766 nM
|
|
|
| 3 |
EC50 >= 1400 nM
|
|
|
| 4 |
EC50 > 3450 nM
|
|
|
|
CP0333381
|
7-{2-chloroimidazo[1,5-a]pyridazin-7-yl}-1-phenylheptan-1-one
Show/Hide
|
C19H20ClN3O
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0221950
|
7-[5-methyl-2-(4H-1,2,4-triazol-4-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C22H24N6O
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0575648
|
4-[[4-[(3-methoxyphenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C19H16N4O2
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0541385
|
4-[[4-[(3-methylphenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C19H16N4O
|
2
|
| 1 |
EC50 = 1180 nM
|
|
|
| 2 |
EC50 > 30000 nM
|
|
|
|
CP0498866
|
(3-Bromo-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15BrN2O4S2
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0225162
|
7-[5-(benzyloxy)pentyl]-2-chloro-5-methylimidazo[1,5-a]pyridazine
Show/Hide
|
C19H22ClN3O
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0491678
|
Benzoyl-phenyl-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C23H21NO3S
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0496285
|
(Furan-2-carbonyl)-phenyl-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C21H19NO4S
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0396028
|
4-[[2-[1-(3,5-dimethylphenyl)sulfonylbenzimidazol-2-yl]sulfanylacetyl]amino]benzoic acid
Show/Hide
|
C24H21N3O5S2
|
4
|
| 1 |
EC50 = 1350 nM
|
|
|
| 2 |
EC50 = 1820 nM
|
|
|
| 3 |
EC50 = 11800 nM
|
|
|
| 4 |
EC50 = 23630 nM
|
|
|
|
CP0457069
|
(2-Phenoxy-acetyl)-phenyl-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C24H23NO4S
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0881182
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-3-phenyl-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C31H49N3O8SSi2
|
1
|
| 1 |
EC50 = 1700 nM
|
|
|
|
CP0167668
|
7-[2-(Dimethylamino)-5-methylimidazo[1,5-b]pyridazin-7-yl]-l-phenyl-l-heptanone
Show/Hide
|
C22H28N4O
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0074931
|
4-[(2,6-dichlorophenyl)methyl]-5-methyl-2-phenylsulfanyl-1H-pyrimidin-6-one
Show/Hide
|
C18H14Cl2N2OS
|
4
|
| 1 |
EC50 = 1800 nM
|
|
|
| 2 |
EC50 = 4910 nM
|
|
|
| 3 |
EC50 = 12100 nM
|
|
|
| 4 |
EC50 > 66300 nM
|
|
|
|
CP0480918
|
4-[(4-phenylmethoxypyrimidin-2-yl)amino]benzonitrile
Show/Hide
|
C18H14N4O
|
2
|
| 1 |
EC50 = 1800 nM
|
|
|
| 2 |
EC50 > 13000 nM
|
|
|
|
CP0472784
|
4-[[4-[(3-fluorophenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C18H13FN4O
|
1
|
| 1 |
EC50 = 1880 nM
|
|
|
|
CP0498655
|
O-(1-phenoxypropan-2-yl) N-phenyl-N-(thiophene-2-carbonyl)carbamothioate
Show/Hide
|
C21H19NO3S2
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0558943
|
4-[[4-[(2-methoxyphenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C19H16N4O2
|
2
|
| 1 |
EC50 = 2100 nM
|
|
|
| 2 |
EC50 > 8900 nM
|
|
|
|
CP0865389
|
5-Bromo-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
Show/Hide
|
C11H11BrN2O5
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0870939
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-3-thiophen-3-yl-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C29H47N3O8S2Si2
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0215415
|
4-[[4-[(2,6-dichlorophenyl)methyl]-5-methyl-6-oxo-1H-pyrimidin-2-yl]sulfanyl]benzonitrile
Show/Hide
|
C19H13Cl2N3OS
|
3
|
| 1 |
EC50 = 2490 nM
|
|
|
| 2 |
EC50 = 5100 nM
|
|
|
| 3 |
EC50 > 27600 nM
|
|
|
|
CP0167298
|
4-[(2,6-dichlorophenyl)methyl]-2-(6-methoxypyridin-3-yl)sulfanyl-5-methyl-1H-pyrimidin-6-one
Show/Hide
|
C18H15Cl2N3O2S
|
5
|
| 1 |
EC50 = 2720 nM
|
|
|
| 2 |
EC50 = 6520 nM
|
|
|
| 3 |
EC50 = 8680 nM
|
|
|
| 4 |
EC50 > 61300 nM
|
|
|
| 5 |
EC50 > 61700 nM
|
|
|
|
CP0891921
|
3-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-8-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-3-yl]-acrylic acid methyl ester
Show/Hide
|
C29H49N3O10SSi2
|
1
|
| 1 |
EC50 = 2900 nM
|
|
|
|
CP0874413
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-3-vinyl-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C26H45N3O8SSi2
|
1
|
| 1 |
EC50 = 3200 nM
|
|
|
|
CP0057798
|
4-[(2,6-dichlorophenyl)methyl]-2-(2,4-difluorophenyl)sulfanyl-5-methyl-1H-pyrimidin-6-one
Show/Hide
|
C18H12Cl2F2N2OS
|
3
|
| 1 |
EC50 = 3360 nM
|
|
|
| 2 |
EC50 = 44700 nM
|
|
|
| 3 |
EC50 > 60500 nM
|
|
|
|
CP0453457
|
(3-Methoxy-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C23H18N2O5S2
|
1
|
| 1 |
EC50 = 3500 nM
|
|
|
|
CP0523283
|
(3-Nitro-benzoyl)-phenyl-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C23H20N2O5S
|
1
|
| 1 |
EC50 = 3600 nM
|
|
|
|
CP0860032
|
3-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-8-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-3-yl]-acrylic acid methyl ester
Show/Hide
|
C28H47N3O10SSi2
|
1
|
| 1 |
EC50 = 3700 nM
|
|
|
|
CP0509914
|
Benzoyl-(4-fluoro-phenyl)-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C22H18FNO3S
|
1
|
| 1 |
EC50 = 4000 nM
|
|
|
|
CP0512445
|
(4-Chloro-benzoyl)-phenyl-thiocarbamic acid O-phenethyl ester
Show/Hide
|
C22H18ClNO2S
|
1
|
| 1 |
EC50 = 4000 nM
|
|
|
|
CP0857274
|
4-((2-((4-((4-Hydroxybenzyl)amino)cyclohexyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
Show/Hide
|
C28H29N5O2S
|
3
|
| 1 |
EC50 = 4020 nM
|
|
|
| 2 |
EC50 = 4600 nM
|
|
|
| 3 |
EC50 > 20100 nM
|
|
|
|
CP0512236
|
Benzoyl-phenyl-thiocarbamic acid O-phenethyl ester
Show/Hide
|
C22H19NO2S
|
1
|
| 1 |
EC50 = 4200 nM
|
|
|
|
CP0441672
|
(Furan-2-carbonyl)-phenyl-thiocarbamic acid O-phenethyl ester
Show/Hide
|
C20H17NO3S
|
1
|
| 1 |
EC50 = 4300 nM
|
|
|
|
CP0496683
|
O-(2-phenylethyl) N-phenyl-N-[(E)-3-phenylprop-2-enoyl]carbamothioate
Show/Hide
|
C24H21NO2S
|
1
|
| 1 |
EC50 = 4500 nM
|
|
|
|
CP0566070
|
4-[[4-[(3-bromophenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C18H13BrN4O
|
1
|
| 1 |
EC50 = 5000 nM
|
|
|
|
CP0909974
|
4-((3-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide
Show/Hide
|
C28H28N6O2S
|
7
|
| 1 |
EC50 = 5000 nM
|
|
|
| 2 |
EC50 = 5270 nM
|
|
|
| 3 |
EC50 = 5320 nM
|
|
|
| 4 |
EC50 = 6810 nM
|
|
|
| 5 |
EC50 = 8290 nM
|
|
|
| 6 |
EC50 > 19500 nM
|
|
|
| 7 |
EC50 >= 7700 nM
|
|
|
|
CP0903509
|
4-((2-((4-((4-Cyanobenzyl)amino)cyclohexyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
Show/Hide
|
C29H28N6OS
|
4
|
| 1 |
EC50 = 5680 nM
|
|
|
| 2 |
EC50 = 6420 nM
|
|
|
| 3 |
EC50 > 5150 nM
|
|
|
| 4 |
EC50 >= 7850 nM
|
|
|
|
CP0874546
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-hydroxy-propenyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C28H49N3O9SSi2
|
1
|
| 1 |
EC50 = 5900 nM
|
|
|
|
CP0946038
|
5-Chloro-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
Show/Hide
|
C11H11ClN2O5
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0424628
|
(3-Chloro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15ClN2O4S2
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0441696
|
(Naphthalene-2-carbonyl)-phenyl-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C27H23NO3S
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0503071
|
(2-Phenoxy-acetyl)-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C23H21NO4S
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0509910
|
(3-Acetyl-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C24H18N2O5S2
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0510956
|
(4-Nitro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C21H18N2O5S2
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0777067
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-hydroxy-propenyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C27H47N3O9SSi2
|
1
|
| 1 |
EC50 = 6600 nM
|
|
|
|
CP0897698
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-3-phenyl-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C30H47N3O8SSi2
|
1
|
| 1 |
EC50 = 6700 nM
|
|
|
|
CP0472786
|
4-[[4-[(4-methylphenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C19H16N4O
|
2
|
| 1 |
EC50 = 7200 nM
|
|
|
| 2 |
EC50 > 81000 nM
|
|
|
|
CP0500912
|
(4-Chloro-3-nitro-benzoyl)-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C22H17ClN2O5S
|
1
|
| 1 |
EC50 = 7600 nM
|
|
|
|
CP0430320
|
O-(2-phenoxyethyl) N-phenyl-N-[(E)-3-phenylprop-2-enoyl]carbamothioate
Show/Hide
|
C24H21NO3S
|
1
|
| 1 |
EC50 = 7700 nM
|
|
|
|
CP0428434
|
Benzoyl-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C22H19NO3S
|
1
|
| 1 |
EC50 = 8000 nM
|
|
|
|
CP0510123
|
(Furan-2-carbonyl)-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C20H17NO4S
|
1
|
| 1 |
EC50 = 8400 nM
|
|
|
|
CP0495426
|
O-(2-phenoxyethyl) N-phenyl-N-(thiophene-2-carbonyl)carbamothioate
Show/Hide
|
C20H17NO3S2
|
1
|
| 1 |
EC50 = 8600 nM
|
|
|
|
CP0455423
|
(3,5-Dichloro-benzoyl)-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C22H17Cl2NO3S
|
1
|
| 1 |
EC50 = 8800 nM
|
|
|
|
CP0698090
|
7-(2-Methoxy-5-methyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-one hydrochloride
Show/Hide
|
C21H26ClN3O2
|
1
|
| 1 |
EC50 = 9300 nM
|
|
|
|
CP0520349
|
Acetic acid 2-(2-phenoxy-ethoxythiocarbonyl)-phenyl-aminocarbonyl)-phenyl ester
Show/Hide
|
C24H21NO5S
|
1
|
| 1 |
EC50 = 9500 nM
|
|
|
|
CP0522469
|
O-(2-phenoxyethyl) N-phenyl-N-(3,4,5-trimethoxybenzoyl)carbamothioate
Show/Hide
|
C25H25NO6S
|
1
|
| 1 |
EC50 = 9600 nM
|
|
|
|
CP0495461
|
(4-Methyl-benzoyl)-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C23H21NO3S
|
1
|
| 1 |
EC50 = 9900 nM
|
|
|
|
CP0919368
|
1-(5-Ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione
Show/Hide
|
C11H11FN2O5
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0878059
|
3-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-8-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-3-yl]-acrylic acid ethyl ester
Show/Hide
|
C29H49N3O10SSi2
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0881070
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-chloro-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C24H42ClN3O8SSi2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0405348
|
(Thiophene-2-carbonyl)-m-tolyl-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C23H18N2O4S2
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0541387
|
4-[[4-(naphthalen-2-ylmethoxy)pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C22H16N4O
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0510442
|
(4-Chloro-benzoyl)-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C22H18ClNO3S
|
1
|
| 1 |
EC50 = 10300 nM
|
|
|
|
CP0401208
|
(3-Fluoro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15FN2O4S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0405588
|
(2-Ethyl-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C24H20N2O4S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0409151
|
(Thiophene-2-carbonyl)-o-tolyl-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C23H18N2O4S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0453068
|
(2-Chloro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C22H15ClN2O4S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0453380
|
(Thiophene-2-carbonyl)-(3-trifluoromethyl-phenyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C23H15F3N2O4S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0497861
|
(2-Methoxy-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C23H18N2O5S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0498103
|
(3-Chloro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C21H18ClNO3S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0502253
|
(4-Diethylamino-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl] ester
Show/Hide
|
C26H25N3O4S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0504782
|
(4-Chloro-phenyl)-(thiophene-2-carbonyl)-thiocarbamic acid O-(1-methyl-2-phenoxy-ethyl) ester
Show/Hide
|
C21H18ClNO3S2
|
1
|
| 1 |
EC50 = 11000 nM
|
|
|
|
CP0504803
|
(2,4-Dichloro-benzoyl)-phenyl-thiocarbamic acid O-(2-phenoxy-ethyl) ester
Show/Hide
|
C22H17Cl2NO3S
|
1
|
| 1 |
EC50 = 11600 nM
|
|
|
|
CP0575671
|
4-[[4-[(2-methylphenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C19H16N4O
|
1
|
| 1 |
EC50 > 12000 nM
|
|
|
|
CP0472788
|
4-[[4-[(4-bromophenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C18H13BrN4O
|
1
|
| 1 |
EC50 > 16000 nM
|
|
|
|
CP0847076
|
1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-hydroxymethyl-2,2-dioxo-3-vinyl-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C20H31N3O8SSi
|
1
|
| 1 |
EC50 = 23000 nM
|
|
|
|
CP0044454
|
7-[5-methyl-2-(methylamino)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C21H26N4O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0212146
|
7-{2-chloro-5-ethylimidazo[1,5-a]pyridazin-7-yl}-1-phenylheptan-1-one
Show/Hide
|
C21H24ClN3O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0264643
|
7-[5-methyl-2-(1H-pyrazol-1-yl)imidazo[1,5-a]pyridazin-7-yl]-1-phenylheptan-1-one
Show/Hide
|
C23H25N5O
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0306834
|
8-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}-1-phenyloctan-1-one
Show/Hide
|
C21H24ClN3O
|
1
|
| 1 |
EC50 = 25000 nM
|
|
|
|
CP0274879
|
4-[(2,6-dichlorophenyl)methyl]-2-(4-methoxyphenyl)sulfanyl-5-methyl-1H-pyrimidin-6-one
Show/Hide
|
C19H16Cl2N2O2S
|
2
|
| 1 |
EC50 = 26500 nM
|
|
|
| 2 |
EC50 > 61400 nM
|
|
|
|
CP0250707
|
7-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}-1-phenylheptan-2-one
Show/Hide
|
C20H22ClN3O
|
1
|
| 1 |
EC50 = 28000 nM
|
|
|
|
CP0519308
|
4-[[4-(dimethylamino)pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C13H13N5
|
1
|
| 1 |
EC50 > 34000 nM
|
|
|
|
CP0519306
|
4-[[4-[(4-bromo-2-fluorophenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
Show/Hide
|
C18H12BrFN4O
|
1
|
| 1 |
EC50 = 35810 nM
|
|
|
|
CP0500962
|
Benzoyl-phenyl-thiocarbamic acid O-furan-2-ylmethyl ester
Show/Hide
|
C19H15NO3S
|
1
|
| 1 |
EC50 > 38300 nM
|
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CP0498104
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Benzoyl-phenyl-thiocarbamic acid O-(2-phenylsulfanyl-ethyl) ester
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C22H19NO2S2
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1
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| 1 |
EC50 > 44000 nM
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CP0424626
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butyl N-(1-phenoxypropan-2-yloxycarbothioyl)-N-phenylcarbamate
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C21H25NO4S
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1
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| 1 |
EC50 = 47000 nM
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CP0859721
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1-[4-Allylamino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
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C28H49N3O8SSi2
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1
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| 1 |
EC50 > 50000 nM
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CP0885511
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1-[3-Allyl-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
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C28H49N3O8SSi2
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1
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| 1 |
EC50 > 50000 nM
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CP0439699
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O-benzyl N-(oxolane-2-carbonyl)-N-phenylcarbamothioate
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C19H19NO3S
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1
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| 1 |
EC50 = 58000 nM
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CP0472785
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4-[[4-[(4-fluorophenyl)methoxy]pyrimidin-2-yl]amino]benzonitrile
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C18H13FN4O
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1
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| 1 |
EC50 > 81000 nM
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CP0854396
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1-(5-Ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
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C11H12N2O5
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1
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| 1 |
EC50 > 100000 nM
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CP0854649
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4-Amino-5-bromo-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
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C11H12BrN3O4
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1
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| 1 |
EC50 > 100000 nM
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CP0919360
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4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-iodo-1H-pyrimidin-2-one
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C11H12IN3O4
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1
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| 1 |
EC50 > 100000 nM
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CP0947305
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4-Amino-5-chloro-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
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C11H12ClN3O4
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1
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| 1 |
EC50 > 100000 nM
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CP0857269
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3,5-Dimethyl-4-((2-((4-((4-(trifluoromethyl)benzyl)amino)cyclohexyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)benzonitrile
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C29H28F3N5OS
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1
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| 1 |
EC50 > 707 nM
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CP0852583
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4-((3-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide
Show/Hide
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C27H28N6O3S2
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1
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| 1 |
EC50 > 1170 nM
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CP0863181
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2-[9-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-4-(carbamoylmethyl-amino)-8-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-3-yl]-acetamide
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C29H51N5O10SSi2
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1
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| 1 |
EC50 > 2000 nM
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CP0870947
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1-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-3-prop-1-ynyl-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
Show/Hide
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C28H47N3O8SSi2
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1
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| 1 |
EC50 > 2000 nM
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CP0475093
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3-[[2-(4-cyanoanilino)pyrimidin-4-yl]oxymethyl]benzonitrile
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C19H13N5O
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1
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| 1 |
EC50 > 4100 nM
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CP0472791
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4-[[4-(pyridin-3-ylmethoxy)pyrimidin-2-yl]amino]benzonitrile
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C17H13N5O
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1
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| 1 |
EC50 > 6400 nM
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CP0401898
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S-[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl] 6,8-dichloro-3,4-dihydro-2H-quinoline-1-carbothioate
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C18H16Cl3N3O4S2
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2
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| 1 |
IC50 = 1 nM
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| 2 |
IC50 = 4 nM
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CP0390044
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S-[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl] 8-chloro-3,4-dihydro-2H-quinoline-1-carbothioate
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C18H17Cl2N3O4S2
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2
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| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 31 nM
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CP0401899
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S-[2-[4-(benzylcarbamoyl)-2-chloroanilino]-2-oxoethyl] 6,8-dichloro-3,4-dihydro-2H-quinoline-1-carbothioate
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C26H22Cl3N3O3S
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2
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| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 4 nM
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CP0460954
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S-[2-[4-(3-aminopropylcarbamoyl)-2-chloroanilino]-2-oxoethyl] 6,8-dichloro-3,4-dihydro-2H-quinoline-1-carbothioate
Show/Hide
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C22H23Cl3N4O3S
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2
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| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 7 nM
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CP0401901
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S-[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl] 6-methyl-3,4-dihydro-2H-quinoline-1-carbothioate
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C19H20ClN3O4S2
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2
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| 1 |
IC50 = 3 nM
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| 2 |
IC50 = 1300 nM
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CP0390085
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S-[2-(2-chloroanilino)-2-oxoethyl] 6,8-dichloro-3,4-dihydro-2H-quinoline-1-carbothioate
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C18H15Cl3N2O2S
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2
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| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 175 nM
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CP0506533
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S-[2-(2-chloro-4-methylsulfonylanilino)-2-oxoethyl] 6,8-dichloro-3,4-dihydro-2H-quinoline-1-carbothioate
Show/Hide
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C19H17Cl3N2O4S2
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2
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| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 11 nM
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CP0501342
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S-[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl] 8-methyl-3,4-dihydro-2H-quinoline-1-carbothioate
Show/Hide
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C19H20ClN3O4S2
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2
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| 1 |
IC50 = 6 nM
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| 2 |
IC50 = 61 nM
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CP0506534
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S-[2-(2-chloro-4-cyanoanilino)-2-oxoethyl] 6,8-dichloro-3,4-dihydro-2H-quinoline-1-carbothioate
Show/Hide
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C19H14Cl3N3O2S
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2
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 95 nM
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CP0384069
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S-[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl] 6-chloro-3,4-dihydro-2H-quinoline-1-carbothioate
Show/Hide
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C18H17Cl2N3O4S2
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1
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| 1 |
IC50 = 8 nM
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CP0450356
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S-[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl] N-methyl-N-(2,4,6-trimethylphenyl)carbamothioate
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C19H22ClN3O4S2
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2
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| 1 |
IC50 = 8 nM
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| 2 |
IC50 = 80 nM
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CP0501345
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[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl] 6,8-dichloro-3,4-dihydro-2H-quinoline-1-carboxylate
Show/Hide
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C18H16Cl3N3O5S
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2
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| 1 |
IC50 = 19 nM
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| 2 |
IC50 = 116 nM
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CP0406385
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2-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-5-propan-2-yl-1H-pyrimidin-6-one
Show/Hide
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C27H26N2O3S
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2
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| 1 |
IC50 = 30 nM
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| 2 |
IC50 = 5820 nM
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CP0399780
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5-ethyl-2-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C26H24N2O3S
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1
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| 1 |
IC50 = 45 nM
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CP0503449
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4-(naphthalen-1-ylmethyl)-2-phenacylsulfanyl-5-propan-2-yl-1H-pyrimidin-6-one
Show/Hide
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C26H24N2O2S
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2
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| 1 |
IC50 = 46 nM
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| 2 |
IC50 = 19600 nM
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CP0440208
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2-[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-5-propan-2-yl-1H-pyrimidin-6-one
Show/Hide
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C26H23FN2O2S
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1
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| 1 |
IC50 = 78 nM
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CP0453653
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5-ethyl-2-[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C25H21FN2O2S
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2
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| 1 |
IC50 = 78 nM
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| 2 |
IC50 = 24200 nM
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CP0402488
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2-[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl-5-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C24H19FN2O2S
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1
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| 1 |
IC50 = 180 nM
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CP0384032
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N-(2-chloro-4-sulfamoylphenyl)-4-(6,8-dichloro-3,4-dihydro-2H-quinolin-1-yl)-4-oxobutanamide
Show/Hide
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C19H18Cl3N3O4S
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1
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| 1 |
IC50 = 194 nM
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CP0384211
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2-[2-(2,4-dimethylphenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-5-propan-2-yl-1H-pyrimidin-6-one
Show/Hide
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C28H28N2O2S
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2
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| 1 |
IC50 = 240 nM
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| 2 |
IC50 = 2670 nM
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CP0415299
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2-[2-(4-methylphenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-5-propan-2-yl-1H-pyrimidin-6-one
Show/Hide
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C27H26N2O2S
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1
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| 1 |
IC50 = 240 nM
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CP0406384
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2-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-5-ethyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C25H21ClN2O2S
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2
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| 1 |
IC50 = 260 nM
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| 2 |
IC50 > 56000 nM
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CP0415369
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5-ethyl-2-[2-(4-methylphenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C26H24N2O2S
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2
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| 1 |
IC50 = 320 nM
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| 2 |
IC50 >= 5620 nM
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CP0492800
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2-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-5-propan-2-yl-1H-pyrimidin-6-one
Show/Hide
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C26H23ClN2O2S
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1
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| 1 |
IC50 = 320 nM
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CP0489671
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6,8-dichloro-N-[2-(2-chloro-4-sulfamoylanilino)-2-oxoethyl]-3,4-dihydro-2H-quinoline-1-carboxamide
Show/Hide
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C18H17Cl3N4O4S
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1
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| 1 |
IC50 = 336 nM
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CP0440210
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2-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl-5-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C25H22N2O3S
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1
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| 1 |
IC50 = 370 nM
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CP0415986
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4-(naphthalen-1-ylmethyl)-2-(2-oxopropylsulfanyl)-5-propan-2-yl-1H-pyrimidin-6-one
Show/Hide
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C21H22N2O2S
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2
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| 1 |
IC50 = 410 nM
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| 2 |
IC50 > 43100 nM
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CP0375312
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2-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-5-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C24H19ClN2O2S
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1
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| 1 |
IC50 = 550 nM
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CP0399959
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5-methyl-2-[2-(4-methylphenyl)-2-oxoethyl]sulfanyl-4-(naphthalen-1-ylmethyl)-1H-pyrimidin-6-one
Show/Hide
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C25H22N2O2S
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1
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| 1 |
IC50 = 670 nM
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CP0427343
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5-methyl-4-(naphthalen-1-ylmethyl)-2-(2-oxopropylsulfanyl)-1H-pyrimidin-6-one
Show/Hide
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C19H18N2O2S
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2
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| 1 |
IC50 = 1120 nM
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| 2 |
IC50 >= 58200 nM
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CP0406271
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ethyl 2-[[4-(naphthalen-1-ylmethyl)-6-oxo-5-propan-2-yl-1H-pyrimidin-2-yl]sulfanyl]acetate
Show/Hide
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C22H24N2O3S
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1
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| 1 |
IC50 = 1410 nM
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CP0480545
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methyl 2-[[4-(naphthalen-1-ylmethyl)-6-oxo-5-propan-2-yl-1H-pyrimidin-2-yl]sulfanyl]acetate
Show/Hide
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C21H22N2O3S
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1
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| 1 |
IC50 = 4490 nM
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CP0427357
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methyl 2-[[5-ethyl-4-(naphthalen-1-ylmethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]acetate
Show/Hide
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C20H20N2O3S
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1
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| 1 |
IC50 = 4720 nM
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CP0077991
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(HEPT) 1-(2-Hydroxy-ethoxymethyl)-5-methyl-6-phenylsulfanyl-1H-pyrimidine-2,4-dione
Show/Hide
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C14H16N2O4S
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1
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| 1 |
IC50 = 5060 nM
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CP0047923
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BMY-40900
Show/Hide
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C10H12N4O3
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2
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| 1 |
IC50 = 5370 nM
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| 2 |
IC50 = 7150 nM
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CP0377178
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methyl 2-[[5-methyl-4-(naphthalen-1-ylmethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]acetate
Show/Hide
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C19H18N2O3S
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1
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| 1 |
IC50 = 6990 nM
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CP0384275
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ethyl 2-[[5-methyl-4-(naphthalen-1-ylmethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]acetate
Show/Hide
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C20H20N2O3S
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1
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| 1 |
IC50 = 7000 nM
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