Brief Information of the Compound and Protein
Compound Name
Ethyl 4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]-pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzoate
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PubChem ID
CID: 129909697
Canonical SMILES
CCOC(=O)c1ccc(CN2CCC(Nc3nc(Oc4c(C)cc(C#N)cc4C)c4ccsc4n3)CC2)cc1
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Compound Formula C30H31N5O3S
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
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Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  7
1
EC50 = 369 nM
   TI
   LI
   LO
   TS
2
EC50 = 498 nM
   TI
   LI
   LO
   TS
3
EC50 = 1110 nM
   TI
   LI
   LO
   TS
4
EC50 = 1440 nM
   TI
   LI
   LO
   TS
5
EC50 = 1850 nM
   TI
   LI
   LO
   TS
6
EC50 = 3680 nM
   TI
   LI
   LO
   TS
7
EC50 = 40900 nM
   TI
   LI
   LO
   TS