Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[[4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl]methyl]benzenesulfonamide
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 PubChem ID
CID: 129909338
Canonical SMILES
Cc1cc(\C=C\C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(cc3)S(N)(=O)=O)CC2)nc2ccsc12
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Compound Formula C29H30N6O3S2
Compound Structure
Protein Name
 Protein Info 
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4
 Cell Line Info 
Homo sapiens (Human)  7
1
EC50 = 0.958 nM
   TI
   LI
   LO
   TS
2
EC50 = 1.34 nM
   TI
   LI
   LO
   TS
3
EC50 = 2.7 nM
   TI
   LI
   LO
   TS
4
EC50 = 4.74 nM
   TI
   LI
   LO
   TS
5
EC50 = 5 nM
   TI
   LI
   LO
   TS
6
EC50 = 5.45 nM
   TI
   LI
   LO
   TS
7
EC50 = 5.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 99 nM
2 IC50 = 101 nM
3 IC50 = 106 nM
4 IC50 = 107 nM
5 IC50 = 149 nM
6 IC50 = 191 nM
7 IC50 = 301 nM
8 IC50 = 350 nM