Brief Information of the Compound and Protein
Compound Name
4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide
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PubChem ID
CID: 129908975
Canonical SMILES
Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(C(N)=O)cc3)CC2)nc2sccc12
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Compound Formula C28H28N6O2S
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  7
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
2
EC50 = 438 nM
   TI
   LI
   LO
   TS
3
EC50 = 529 nM
   TI
   LI
   LO
   TS
4
EC50 = 805 nM
   TI
   LI
   LO
   TS
5
EC50 = 14200 nM
   TI
   LI
   LO
   TS
6
EC50 > 4930 nM
   TI
   LI
   LO
   TS
7
EC50 > 4935 nM
   TI
   LI
   LO
   TS